- Selection of the most relevant publications in the area of nanobiomedicine:

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1 MANUEL RICARDO IBARRA GARCÍA Born in Baza (Granada, Spain), January 5th 1955 Address: - Departamento de Física de la Materia Condensada, Facultad de Ciencias, Universidad de Zaragoza (C/. Pedro Cerbuna, 12, Zaragoza Spain) I T Web: - Instituto de Nanociencia de Aragón. C/. Mariano Esquillor, s/n, Edificio I+D, Zaragoza Spain I T ibarra@unizar.es PRESENT POSITION Full Professor at the Condensed Matter Physics Department in the University of Zaragoza since Director of the Institute of Nanoscience of Aragon since Director of the Advanced Microscopy Laboratory (LMA) (ICTS Singular Scientific Technical Installation) since Member of the Coordination Committee of the Integrated Electronic Microscopy Network (ELECMI), since Managing partner and scientific consultant of NanoScale Biomagnetics, Spin off of the University of Zaragoza, since 2008; Nanoimmunotech, Spin off of the University of Zaragoza and University of Vigo since 2009; and Graphene Nanotech, EBT linked to the University of Zaragoza and CSIC since Head of the Magnetism Section of the European Physical Society since EDUCATION: Physics Degree. University of Granada PhD in Physics. University of Zaragoza Doctor Honoris Causa. AGH University. Krakow (Poland) RESEARCH ACTIVITY: Along the past few years his research activity is focused on the magnetic properties of nanostructured materials and the application of nanotechnology in biomedicine. Most relevant contributions: Magnetic anisotropy in rare earth intermetallics Colossal magnetoresistance in mixed valent magnetic oxides Giant magnetocaloric effect alloys Magnetic thin films and magnetic nanoparticles Applications of nanoparticles in biomedicine and magnetoresistive sensors PUBLICATIONS (most relevant of the 5 past years) First author or co-author of more than 400 publications, 414 papers belonging to the Science Citation Index (18 of them cited more than 100 times). In general, his papers have been cited a total of times. He has an H-index of 49 according to the ISI Web of Knowledge database on 26 October Selection of the most relevant publications in the area of nanobiomedicine: Asín, L.; Ibarra, M. R.; Tres, A.; Goya, G. F. Controlled Cell Death by Magnetic Hyperthermia: Effects of Exposure Time, Field Amplitude, and Nanoparticle Concentration Pharmaceutical Research, 29, Serrate, D.; De Teresa, J. M.; Marquina, C.; Marzo, J.; Saurel, D.; Cardoso, F. A.; Cardoso, S.; Freitas, P. P.; Ibarra, M. R. Quantitative biomolecular sensing station based on magnetoresistive patterned arrays Biosensors and bioelectronics, 35,

2 Sanz, V.; Conde. J.; Hernández, Y.; Baptista, P. V.; Ibarra, M. R.; de la Fuente, J. M. Effect of PEG Biofunctional spacers and TAT peptide on dsrna loading on gold nanoparticles Journal of nanoparticle research, 14, Escribano, E.; Fernandez-Pacheco, R.; Gabriel Valdivia, J.; Ibarra, M. R; Marquina, C.; Queralt, J. Effect of Magnet Implant on Iron Biodistribution of Nanoparticles in the Mouse Archives of Pharmacal Research, 35 (1), Riggio, C.; Calatayud, M. P.; Hosking, C.; Pinkernelle, J.; Sanz, B.; Torres, T. E.; Ibarra, M. R.; Wang, L.; Keilhoff, G.; Goya, G. F.; Raffa, V.; Cuschieri, A. Poly-l-lysine-coated magnetic nanoparticles as intracellular actuators for neural guidance International Journal of Nanomedicine, 7, Grazú, V.; Silber, A. M.; Moros, M.; Asín, L.; Torres, T. E.; Marquina, C.; Ibarra, M. R.; Goya, G. F. Application of magnetically induced hyperthermia in the model protozoan Crithidia fasciculata as a potencial therapy against parasitic infections International Journal of Nanomedicine, 7, Conde, J.; Tian, F. R.; Hernandez, Y.; Bao, C. C.; Cui, C. X.; Janssen, K. P.; Ibarra, M. R.; Baptista, P. V.; Stoeger, T.; de la Fuente, J. M. In vivo tumor targeting via nanoparticle-mediated therapeutic sirna coupled to inflammatory response in lung cancer mouse models Biomaterials, 34 (31), Goya, G. F.; Asín, L.; Ibarra, M. R. Cell death induced by AC magnetic fields and magnetic nanoparticles: Current state and perspectives International Journal of Hyperthermia, 29 (8), Calatayud, M. P.; Riggio, C.; Raffa, V.; Sanz, B.; Torres, T. E.; Ibarra, M. R.; Hoskins, C.; Cuschieri, A.; Wang, L.; Pinkernelle, J.; Keihofff, G.; Goya, G. F. Neuronal cells loaded with PEI-coated Fe 3 O 4 nanoparticles for magnetically guided nerve regeneration Journal of Materials Chemistry B, 1 (29), Conde, J.; Ambrosone, A.; Hernandez Y.; Marchesano, V.; Tian, F.; Ibarra, M. R.; Baptista, P. V.; Tortiglione, C.; de la Fuente, J. M. Designing Gold Nanoparticles for in vivo Gene Silencing as a New Therapeutic Tool Human Gene Therapy, 24, A24-A Rispail, N.; De Matteis, L.; Santos, R.; Miguel, A. S.; Custardoy, L.; Testillano, P. S.; Risuenõ, M. C.; Peŕez-de-Luque, A.; Maycock, C.; Fevereiro, P.; Oliva, A.; Fernańdez-Pacheco, R.; Ibarra, M. R.; M. de la Fuente, J.; Marquina, C.; Rubiales, D.; Prats, E. Quantum Dot and Superparamagnetic Nanoparticle Interaction with Pathogenic Fungi: Internalization and Toxicity Profile ACS Applied Materials Interfaces, 6, Calatayud, P.; Sanz, B.; Raffa, V.; Riggio, C.; Ibarra, M. R.; Goya, G. F. The effect of surface charge of functionalized Fe3O4 nanoparticles on protein adsorption and cell uptake Biomaterials, 35 (24), Riggio, C.; Calatayud, P.; Giannaccini, M.; Sanz, B.; Torres, T.; Fernández-Pacheco, R.; Ripoli, A.; Ibarra, M. R.; Dente, L.; Cuschieri, A.; Goya, G. F.; Raffa, V. The orientation of the neuronal growth process can be directed via magnetic nanoparticles under an applied magnetic field Nanomedicine-Nanotechnology Biology And Medicine, 10 (7), , Goya, G. F.; Calatayud, M. P.; Sanz, B.; Giannaccini, M.; Raffa, V.; Torres, T. E.; Ibarra, M. R. Magnetic nanoparticles for magnetically guided therapies against neural diseases MRS Bulletin, 39 (11), Lima Jr., E.; De Biasi, E.; Zysler, R. D.; Vasquez Mansilla, M.; Mojica-Pisciotti, M. L.; Torres, T. E.; Calatayud, M. P.; Marquina, C.; Ibarra, M. R.; Goya, G. F. Relaxation time diagram for identifying heat generation mechanisms in magnetic fluid hyperthermia Journal of Nanoparticle Research, 16: Radovic, M.; Calatayud, M. P.; Goya, G. F.; Ibarra, M. R.; Antic, B.; Spasojevic, V.; Nikolic, N.; Jankovic, D.; Mirkovic, M.; Vranjes-Duric, S. Preparation and in vivo evaluation of multifunctional Y-90-labeled magnetic nanoparticles designed for cancer therapy Journal of Biomedical Materials Research Part A, 103 (1),

3 Sanz, B.; Calatayud, P.; Cassinelli, N.; Ibarra, M. R.; Goya, G. F. Long-Term Stability and Reproducibility of Magnetic Colloids are Key Issues for Steady Values of Specific Power Absorption Over Time European Journal of Inorganic Chemistry, Article first published online: 2 JUN Most relevant publications in area of physical phenomena at the nanoscale: Fernandez-Pacheco, A.; Serrano-Ramon, L. E.; Tyliszczak, T.; Chou, K. W.; Cordoba, R.; Szkudlarek, A.; O Brien, L.; Kapusta, C.; Ibarra, M. R.; De Teresa, J. M. Correlation between the magnetic imaging of cobalt nanoconstrictions and their magnetoresistance response Nanotechnology, 23, Córdoba, R.; Lavrijsen, R.; Fernandez-Pacheco, A.; Ibarra, M. R.; Schoenaker, F.; Ellis, T.; Barcones- Campo, B.; Kohlhepp, J. T.; Swagten, H. J. M.; Koopmans, B.; Mulders, J. J. L.; De Teresa, J. M. Giant anomalous Hall effect in Fe-based microwires grown by focused-electron-beam-induced deposition Journal of Physics D-Applied Physics, 45, De Matteis, L.; Custardoy, L.; Fernandez-Pacheco, R.; Magen, C.; De La Fuente, J. M.; Marquina, C.; Ibarra, M. R. Ultrathin MgO Coating of Superparamagnetic MagnetiteNanoparticles by Combined Coprecipitation and Sol Gel Synthesis Chemistry of Materials, 24, Fernández-Pacheco, A.; Serrano-Ramón, L.; Michalik, J. M.; Ibarra, M. R.; De Teresa, J. M.; O Brien, L.; Petit, D.; Lee, J.; Cowburn, R. P. Three dimensional magnetic nanowires grown by focused electron-beam induced deposition Scientific Reports (npg), Sangiao, S.; Michalik, J. M.; Casado, L.; Martínez-Velarte, M. C.; Morellón, L.; Ibarra, M. R.; De Teresa, J. M. Conductance steps in electromigrated Bi nanoconstrictions Physical Chemistry Chemical Physics, 15 (14), Ramos, R.; Kikkawa, T.; Uchida, K.; Adachi, H.; Lucas, I.; Aguirre, M. H.; Algarabel, P.; Morellón, L.; Maekawa, S.; Saitoh, E.; Ibarra, M. R. Observation of the spin Seebeck effect in epitaxial Fe 3 O 4 thin films Applied Physics Letters, 102 (7) Lima, E. Jr.; Torres, T. E.; Rossi, L. M.; Rechenberg, H. R.; Berquo, T. S.; Ibarra, A.; Marquina, C.; Ibarra, M. R.; Goya, G. F. Size dependence of the magnetic relaxation and specific power absorption in iron oxide nanoparticles Journal Of Nanoparticle Research, 15 (5) Rodríguez, L. A.; Magén, C.; Snoeck, E.; Gatel, C.; Marín, L.; Serrano-Ramón, L.; Prieto, J. L.; Muñoz, M.; Algarabel, P. A.; Morellón, L.; de Teresa, J. M.; Ibarra, M. R. Quantitative in situ magnetization reversal studies in Lorentz microscopy and electronholography Ultramicroscopy, 134, Serrano-Ramón, L.; Fernández-Pacheco, A.; Córdoba, R.; Magén, C.; Rodríguez, L. A.; Petit, D.; Cowburn, R. P.; Ibarra, M. R.; de Teresa, M. J. Improvement of domain wall conduit properties in cobalt nanowires by global gallium irradiation Nanotechnology, 24 (34) De Matteis, L.; Fernández-Pacheco, R.; Marquina, C.; Ibarra, M. R.; de la Fuente, J. M. Nanostructural Characterization of Biomagnetic Cobalt Ferrite Alginate Nanospheres Particle & Particle Systems Characterization, 30, Marcano, N.; Algarabel, P. A.; Rodríguez Fernández, J.; Magén, C.; Morellón, L.; Singh, K. N.; Gschneidner, K. A.; Pecharsky, V. K.; Ibarra, M. R. Effects of pressure on the magnetic-structural and Griffiths-like transitions in Dy 5 Si 3 Ge Physical Review B, 88, Serrate, D.; Moro-Lagares, M.; Piantek, M.; Pascual, J. I; Ibarra, M. R. Enhanced Hydrogen Dissociation by Individual Co Atoms Supported on Ag(111) Journal of Physical Chemistry C, 118 (11),

4 Badía Romano, L.; Rubín, J.; Magén, C.; Bartolomé, F.; Sesé, J.; Ibarra, M. R.; Bartolomé, J.; Hierro- Rodríguez, A.; Martín, J. I.; Alameda, J. M.; Bürgler, D. E.; Varnakov, S. N.; Komogortsev, S. V.; Ovchinnikov, S. G. Thermomagnetic behaviour and compositional irreversibility on (Fe/Si) 3 multilayer films Journal of Magnetism and Magnetic Materials, 364, De Matteis, L.; Fernandez-Pacheco, R.; Custardoy, L.; García-Martín, M. L.; de la Fuente, J. M.; Marquina, C.; Ibarra, M. R. Influence of a Silica Interlayer on the Structural and Magnetic Properties of Sol-Gel TiO2-Coated Magnetic Nanoparticles Langmuir, 30 (18), Piantek, M.; Serrate, D.; Moro-Lagares, M.; Algarabel, P.; Pascual, J. I.; Ibarra, M. R. Mn-Phthalocyaninies Derivatives Synthesized by On-Surface Cyclo-Tetramerization The Journal of Physical Chemistry C Fernandes, C.; Pereira, C.; Fernández-García, M. P.; Pereira, A. M.; Guedes, A.; Fernández- Pacheco, R.; Ibarra, A.; Ibarra, M. R.; Arújo, J. P.; Freire, C. Tailored design of CoxMn1 xfe2o4 nanoferrites: a new route for dual control of size and magnetic properties Journal of Materials Chemistry C, 2, Rodríguez, L. A.; Magén, C.; Snoeck, E.; Gatel, C.; Castán-Guerrero, C.; Sesé, J.; García, L. M.; Herrero-Albillos, J.; Bartolomé, J.; Bartolomé, F.; Ibarra, M. R. High-resolution imaging of remanent state and magnetization reversal of superdomain structures in high-density cobalt antidote arrays Nanotechnology, 25, Pires, A. L.; Belo, J. H.; Lima Lopes, A. M.; Gomes, I. T.; Morellón, L.; Magén, C.; Algarabel, P. A.; Ibarra, M. R.; Pereira, A. M.; Araujo, J. P. Phase Competitions behind the Giant Magnetic Entropy Variation: Gd5Si2Ge2 and Tb5Si2Ge2 Case Studies Entropy, 7 (16), Guillamón, I.; Suderow, H.; Kulkarni, P.; Vieira, S.; Córdoba, R.; Sesé, J.; De Teresa, J. M.; Ibarra, M. R.; Shaw, G.; Bannerjee, S. S. Nanostructuring superconducting vortex matter with focused ion beams Physica C-Superconductivity and its applications, 503, Ramos, R.; Aguirre, M. H.; Anadón, A.; Blasco, J.; Lucas, I.; Uchida, K.; Algarabel, P. A.; Morellón, L.; Saitoh, E.; Ibarra, M. R. Anomalous Nernst effect of Fe3O4 single crystal Physical Review B, 90, Marín, L.; Rodríguez, L. A.; Magén, C.; Snoeck, E.; Arras, R.; Lucas, I.; Morellón, L.; Algarabel, P. A.; de Teresa, J. M.; Ibarra, M. R. Observation of the Strain Induced Magnetic Phase Segregation in Manganite Thin Films Nano Letters, 15 (1), Maurel, L.; Marcano, N.; Prokscha, T.; Langenberg, E.; Blasco, J.; Guzman, R.; Suter, A.; Magen, C.; Morellón, L.; Ibarra, M. R.; Pardo, J. A.; Algarabel, P. A. Nature of antiferromagnetic order in epitaxially strained multiferroic SrMnO3 thin films Physical Review B, 92 (2), Serrano-Esparza, I.; Córdobac, R.; Muldersd, J. J. L.; Ibarra, M. R.; De Teresa, J. M. Precursor competition in focused-ion-beam-induced co-deposition from W(CO)6 and C10H8 Science Letters, 4: Serrano-Esparza, I.; Córdobac, R.; Muldersd, J. J. L.; Ibarra, M. R.; De Teresa, J. M. Epitaxial stabilization of the perovskite phase in (Sr1-xBax)MnO3 thin films ACS Appl. Mater. Interfaces, Online MOST RELEVANT SCIENTIFIC PUBLICATIONS Ibarra, M. R.; Algarabel, P. A.; Marquina, C.; Blasco, J.; Garcia, J. Large Magnetovolume Effect in Yttrium Doped La-Ca-Mn-O Perovskite Physical Review Letters, 75 (19), De Teresa, J. M.; Ibarra, M. R.; Algarabel, P. A.; Ritter, C.; Marquina, C.; Blasco, J.; Garcia, J.; de Moral, A.; Arnold, Z. Evidence for magnetic polarons in the magnetoresistive perovskites Nature, 386 (6622),

5 Morellón, L.; Arnold, Z.; Magen, C.; Ritter, C.; Prokhnenko, O.; Skorokhod, Y.; Algarabel, P. A.; Ibarra, M. R.; Kamarad, J. Pressure Enhancement of the Giant Magnetocaloric Effect in Tb 5 Si 2 Ge 2 Physical Review Letters, 93 (15) Arruebo, M.; Fernandez-Pacheco, R.; Ibarra, M. R.; Santamaría, J. Magnetic nanoparticles for drug delivery Nano Today, 2 (3), Guillamón, I.; Suderow, H.; Fernandez-Pacheco, A.; Sese, J.; Cordoba, R.; De Teresa, J. M.; Ibarra, M. R.; Vieira, S. Direct observation of melting in a two-dimensional superconducting vortex lattice Nature Physics, 5 (9), Conde, J.; Ambrosone, A.; Sanz, V.; Hernández, Y.; Marchesano, V.; Tian, F. R.; Child, H.; Berry, C. C.; Ibarra, M. R.; Baptista, P. V.; Tortiglione, C.; De la Fuente, J. M. Design of Multifunctional Gold Nanoparticles for In Vitro and In Vivo Gene Silencing ACS Nano, 6 (9), Córdoba, R.; Baturina, T. I.; Sesé, J.; Yuminorov, A. Y.; De Teresa, J. M.; Ibarra, M. R.; Nasimov, D. A.; Gutakovskii, A. K.; Latyshev, A. V.; Guillamón, I.; Suderow, H.; Vieira, S.; Baklanov, M. R.; Palacios, J. J.; Vinokur, V. M. Magnetic field-induced dissipation-free state in superconducting nanostructures Nature Communications, 4, Arenal, R.; De Matteis, L.; Custardoy, L.; Mayoral, A.; Tence, M.; Grazu, V.; De La Fuente, J. M.; Marquina, C.; Ibarra, M. R. Spatially-Resolved EELS Analysis of Antibody Distribution on Bio-Functionalized Magnetic Nanoparticles ACS Nano, 7 (5), Marín, L.; Morellón, L.; Algarabel, P. A.; Rodríguez, L. A.; Magén, C.; de Teresa, J. M.; Ibarra, M. R. Enhanced Magnetotransport in Nanopatterned Manganite Nanowires Nano Letters, 14, Guillamon, I.; Cordoba, R.; Sese, J.; De Teresa, J. M.; Ibarra, M. R.; Vieira, S.; Suderow, H. Enhancement of long-range correlations in a 2D vortex lattice by an incommensurate 1D disorder potential Nature Physics, 10 (11), CONFERENCES & LECTURES (ACADEMIC PRESENTATIONS IN CONGRESSES, WORKSHOPS ) In the 5 past years he has been invited to give conferences in 25 congresses, symposia, and workshops, both national and international. The most relevant ones are: The EMN (Energy Materials Nanotechnology) East Meeting 2013 in Beijing (China); 12 th Inter-American Microscopy Congress (CIASEM 2013) in Cartagena de Indias (Colombia); The Spintronics Workshop, organized by the Foundation Advanced Technology Institute in Tokyo (Japan) in 2014; 29 th Annual Meeting of the European Society for Hyperthermic Oncology (ESHO 2014) in Torino (Italy); and 14th International onference on Electrorheological Fluids and Magnetorheological Suspensions (ERMR 2014) in Granada (Spain). Furthermore, he has given lectures at the summer courses of the University of Zaragoza and the Menéndez Pelayo International University, and seminars in several international centres such as the Tohoku University (Sendai) and the Advanced Science Research Center (ASRC) Japan Atomic Energy Agency (JAEA) (Tokai) both in Japan-, or The Hong Kong University of Science and Technology, as well as in different Spanish Universities (Autonomous of Madrid, Cantabria, Granada, Lleida, and Public of Navarre). RESEARCH PROJECTS AS MAIN RESEARCHER (most relevant of the 5 past years) Title: Nanotecnología en Biomedicina (NANOBIOMED). Funded by the MEC, Consolider Program. CSD Duration: Budget: Title: Integrated Lab-On-Chip Platforms for Medical Diagnostics. Funded by the MICINN, National R&D Internationalisation Programme, Subprogramme EUROINVESTIGACIÓN. EUI Duration: Budget: Title: Train 2 Trans-Pyrenees Action on Advanced Infrastructures for Nanoscience and Nanotechnologies. Funded by the European Union, Interreg IV B SUDOE. TRAIN2-SOE2/P1/E-280. Duration: Budget:

6 Title: Nanociencia y nuevos materiales para desafíos medioambientales. Funded by the MINECO, National R&D Internationalisation Programme, International Projects Subprogramme, Spain-Japan International Bilateral Project. PRI-PIBJP Duration: Budget: Title: Thermo-Spintronic: High performance energy by the interplay between thermoelectricity and spin Seebeck effect. Funded by the European Commission. PUI/ Duration: Budget: Title: ESTEEM2. Enabling Science and Technology through European Electron Microscopy. Funded by the European Union, FP7 on Research Infrastructures. Duration: Budget: TECHNOLOGY TRANSFER - Managing partner and scientific consultant of two companies: NanoScale Biomagnetics, spin off of the University of Zaragoza. Nanoimmunotech, spin off of the University of Zaragoza and University of Vigo. Graphene Nanotech, EBT linked to the University of Zaragoza and CSIC since He has the copyright of 10 patents, 3 of them PCT and one in explotaition. PhD THESIS ADVISOR (5 past years) - Title: Biomedical applications of magnetic nanoparticles: magnetic hyperthermia in dendritic cells and magnetofection on brain cells PhD Student: Laura Asín Pardo University: Zaragoza Faculty: Sciences Year: Title: Cobalt nanostructures grown by focused electron beam induced deposition for spintronic applications PhD Student: Luis Enrique Serrano Ramón University: Zaragoza Faculty: Sciences Year: 2014 PARTICIPATION IN INTERNATIONAL COMMITTEES (5 past years) Member of the Advisory Committee of the International Conference on Magnetism. Karlsruhe (Germany) in 2009 and Busan (Korea) in Member of the Program Committee of the Conference of the Condensed Matter Division of the European Physical Society. Warsaw (Poland) in 2010 and Paris (France) in Member of the Scientific Committee of the XIV Congress of the Spanish Society for Cell Biology. Málaga (Spain) Member of the Programme Committee of JEMS 2012 Joint European Magnetic Symposia. Parma (Italy) Member of the CMD/CMMP Committee on Magnetism / Spintronics / Inter-Metallic Phases of the 24 th Conference of the EPS Condensed Matter Division (CMD-24). Edinburgh (UK) Organizer of the Symposium Medical, biomedical, biomagnetic and biotechnology applications. JEMS 2013 European Magnetic Symposia. Rhodes (Greece) Organizer of the Symposium Biological Application of Magnetic Nanoparticles. EUROMAT 2013 European Congress and Exhibition on Advanced Materials and Processes. Seville (Spain) Member of the Program Committee Condensed Matter in Paris. 14 th Journées de la Matière Condensée (JMC14) and The 25 th Conference of the Condensed Matter Division of the EPS (CMD25). Paris (France) Member of the Scientific Committee of the Workshop on Oxide Materials: Novel Multifunctional Properties. Santiago de Cali (Colombia) Member of the Organizing Committee of the Workshop NanoMath Zaragoza (Spain) Member of the Scientific Committee of the 8 th Annual Concertation and Consultation Workshop on Micro-Nano-Bio Convergence Systems, MNBS Toulouse (France) Chairman of the Organizing Committee of the Workshop on Thermospin Effects. Zaragoza (Spain) Member of the Programme Committee of The 20 th International Conference on Magnetism. Coordinator of Topic 5: Magnetic Materials and Technologies for: energy, information & life. Barcelona (Spain) Member of the International Advisory Committee of the JEMS 2016 Joint European Magnetic Symposia. Glasgow (United Kingdom)

7 AWARDS AND DISTINCTIONS (5 past years) Institute of Nanoscience of Aragon: Award Aragoneses del Año in the Science and Technology category, grated by El Periódico de Aragón Plaque of Honour AEC-2014, awarded by the Spanish Scientists Association