Safe Nano Design Molecule Manufacturing Market

Size: px
Start display at page:

Download "Safe Nano Design Molecule Manufacturing Market"

Transcription

1 August 14 16, 212 College of Nanoscale Science & Engineering (CNSE) of the University at Albany National Institute for Occupational Safety and Health (NIOSH) Prevention through Design Program Safe Nano Design Molecule Manufacturing Market Session 1: Design of safer nano molecules Panel Discussion on Screening, Characterizing, and Detecting Nanomaterials How molecular design drives biological effects Christie Sayes, PhD Center for Aerosol and Nanomaterials Engineering RTI International

2 DISEASE-FREE CONCEPT 1: Themes in Nanotoxicology that Influence Other Fields Approach: The scale of health using the hierarchical oxidative stress model Level of Oxidative Stress Increasing DISEASED no observable adverse effects no extended adverse effects immunological response Increasing Particle Concentration Xiao GG, et al (23) Journal of Biological Chemistry 278(5): Barzilai A;, et al (24) DNA Repair 3(8-9): Sayes CM, et al (29) Systems Biology. Ed. Saura C. Sahu, Johns Wiley and Sons Ltd.

3 CONCEPT 1: Some Thoughts Many of the markers of toxicity are also pro-inflammatory mediators. This type of induced response is desirable in some cases - like a vaccine. Individual parameters may be associated with specific phenomena Caspase and oxygenase Extracellular cytoplasm leakage caused by peroxy radical formation on cellular membranes However, these acellular markers may not be indicative of the entire tissue system it is important to consider the combined response in terms of magnitude and duration of each cellular response as a signature of transition from reversible transient to irreversible toxic response. Example = glutathione (indicative of this transition from normal transient phenomenon to toxic cell response)

4 A Life-Cycle Approach: Possibly Applicable to Medicine and Consumer Products Raw Materials Production Product Manufacturing Consumer Use Product End of Life Step 1: Material Characterization of Pristine Engineered Nanomaterial Step 2: Formulate Nanocomposite or Other Nano-Enabled Material Step 3: Simulate Wear-and-Tear or Weathering Conditions Step 4: Measure Exposures Step 5: Perform Focused Toxicity Testing Step 6: Assess and Manage Risks

5 CONCEPT 2: Influence of Zeta Potential Effects of ph on a metal oxide nanoparticle Berg JM, Romoser A, Banerjee N, Zebda R, Sayes CM; (29) Nanotoxicology, 3(4):

6 Cellular viability (%) Cellular viability (%) Cellular viability (%) Zeta potential (mv) Size (nm) CONCEPT 2: Influence of Zeta Potential 8 model NP 25 6 TiO Al 2 O ph control cells ph TiO ph Al 2 O hr 24hr 48hr Exposure time 1hr 24hr 48hr Exposure time 1hr 24hr 48hr Exposure time

7 CONCEPT 2: Material Characterization & Physiologically Relevant Fluids Can we predict how nanomaterials would behave in physiological compartments? Gastric Acid Lysosomal Fluid Intestine & Urine Blood ph Level < Metal oxide nanomaterial Zeta potential (mv) / Average agglomerate size (nm) TiO 2 +46/ /186 +7/239-37/46 ZnO +5/36 +44/ /12-3/117 Al 2 O 3 +45/ / /24-4/35 CeO / /234 +2/259-6/285 Fe 2 O /18-9/174-15/17-47/83 TiO 2 and Fe 2 O 3 nanoparticles demonstrate strongly charged agglomerates at ph=7.4

8 Zeta Potential (mv) CONCEPT 2: Influence of Zeta Potential on Different Samples but Same Composition ZnO 1 ZnO 2 ZnO 3 1 nm 1 nm 1 nm ZnO 1 ZnO 2 ZnO Size (nm) ph ph ph

9 CONCEPT 2: More Thoughts Conclusions from the literature have led to the premise that there are two primary physicochemical properties of small particles, including nanoparticles, which influence their stability, mobility, and toxicity. These two primary physicochemical properties are as follows: Surface modification or conjugation to other molecules Physical contact with cells The former influences particle aggregation state, determines individual particle suspendability, and affects susceptibility to degradation. The latter affects cellular uptake mechanism substantially.

10 CONCEPT 3: Differential Cellular Uptake Mechanisms Sayes CM, Romoser A, Banerjee N; (29) The Role of Oxidative Stress in Nanotoxicology. Systems Biology. Ed. Saura C. Sahu, Johns Wiley and Sons Ltd.

11 CONCEPT 3: Can the Surface Make a Difference? Aim Determine if surface modification (in this case oxidation) has an effect on cell viability. Conclusion Co-exposure to carbon black and Fe 2 O 3 particles can cause oxidative stress that is significantly greater than the additive effects of exposures to either particle type alone. The observed oxidative stress is mitigated if the freshly prepared carbon black is oxidized before exposure to cells. Berg JM, Ho S, Hwang W, Zebda R, Cummins K, Soriaga M, Taylor R, Guo B, Sayes CM. (21) Chemical Research in Toxicology, 23(12):

12 CONCEPT 3: Conclusions Ultimately, most particles sequester in membrane-bound vesicles where the acidification process begins. The acidification process usually breaks the particle down into their ions or molecules, releasing then in a concentrated dose to specific tissues most vulnerable to particle deposition. While not all mechanisms are known within this general field of study, most agree that cellular uptake, surface charge, and propensity to dissociate into ions or molecule plays a large role in a cell s and a tissue s response to particles.

What is nanotoxicology?

What is nanotoxicology? What is nanotoxicology? How to estimate the potential hazard related to nanoparticles? Dissemination report October 2008 DR-225 200810-5 Project ID NMP2-CT-2005-515843 An European Integrated Project Supported

More information

Applications of nanotechnology: Cosmetics

Applications of nanotechnology: Cosmetics Applications of nanotechnology: Cosmetics Course on Health Effects of Engineered Nanomaterials Finnish Institute of Occupational Health, 23 April 2013 Sari Karjomaa Finnish Cosmetic, Toiletry and Detergent

More information

Assessing the risks of engineered nanomaterials

Assessing the risks of engineered nanomaterials ICON Research Needs Assessment January 9 2007, Bethesda, MD Assessing the risks of engineered nanomaterials Setting the Scene Andrew D. Maynard Chief Science Advisor Defining Nanotechnology Richard Smalley

More information

Nanoinformatics Issues and Tools for Safe and Sustainable Nano-enhanced Remediation

Nanoinformatics Issues and Tools for Safe and Sustainable Nano-enhanced Remediation Nanoinformatics Issues and Tools for Safe and Sustainable Nano-enhanced Remediation Mark D. Hoover, PhD, CHP, CIH 304-285-6374 mark.hoover@cdc.hhs.gov National Institute for Occupational Safety and Health

More information

Absorption of Drugs. Transport of a drug from the GI tract

Absorption of Drugs. Transport of a drug from the GI tract Absorption of Drugs Absorption is the transfer of a drug from its site of administration to the bloodstream. The rate and efficiency of absorption depend on the route of administration. For IV delivery,

More information

ZETA POTENTIAL ANALYSIS OF NANOPARTICLES

ZETA POTENTIAL ANALYSIS OF NANOPARTICLES ZETA POTENTIAL ANALYSIS OF NANOPARTICLES SEPTEMBER 2012, V 1.1 4878 RONSON CT STE K SAN DIEGO, CA 92111 858-565 - 4227 NANOCOMPOSIX.COM Note to the Reader: We at nanocomposix have published this document

More information

Blootstelling aan nano op de werkplek: een werkelijk gevaar? Josje Arts AkzoNobel PS&RA

Blootstelling aan nano op de werkplek: een werkelijk gevaar? Josje Arts AkzoNobel PS&RA Blootstelling aan nano op de werkplek: een werkelijk gevaar? Josje Arts AkzoNobel PS&RA Definition of nanomaterial EU definition: "Nanomaterial" means a natural, incidental or manufactured material containing

More information

External stakeholder events and projects on nanomaterials and nanotechnologies

External stakeholder events and projects on nanomaterials and nanotechnologies BUSINESS AND INDUSTRY ADVISORY COMMITTEE (BIAC) PART I: ACC The American Chemistry Council Nanotechnology Panel (Panel) presented at numerous national and international presentations and workshops on nanotechnology

More information

Transport Phenomena in Cell Biology

Transport Phenomena in Cell Biology Transport Phenomena in Cell Biology Eric R. Dufresne Department Mechanical Engineering Department of Chemical Engineering Department of Physics Yale University 1 Background and Societal Impact Cells are

More information

CHEMICAL SENSORS 1. DEFINITION

CHEMICAL SENSORS 1. DEFINITION CHEMICAL SENSORS 1. DEFINITION A chemical sensor is a device that transforms chemical information (composition, presence of a particular element or ion, concentration, chemical activity, partial pressure

More information

Safety Assessment of Nanomaterials at the Joint Research Centre

Safety Assessment of Nanomaterials at the Joint Research Centre 3 RD CIAA NANOTECHNOLOGY DIAOLOGUE MEETING, Brussels, 23 rd March 2010 1 Safety Assessment of Nanomaterials at the Joint Research Centre Hermann Stamm Institute for Health and Consumer Protection Joint

More information

Ultrastructure and biochemical organization of an eukaryotic cell. General considerations Cell membrane Organelles with membrane

Ultrastructure and biochemical organization of an eukaryotic cell. General considerations Cell membrane Organelles with membrane Ultrastructure and biochemical organization of an eukaryotic cell General considerations Cell membrane Organelles with membrane Functions must be understood in terms of structures; structures must be understood

More information

Safe Nanotechnology EU Industrial Research

Safe Nanotechnology EU Industrial Research Safe Nanotechnology EU Industrial Research Georgios Katalagarianakis EC, Research DG Industrial Technologies Directorate G4 Nanoscience - Nanotechnology 1 summary Policy; Towards a second Action Plan 2010-2015

More information

Silver Nanoparticles: No Threat to the Environment. George J. Maass, Ph.D. (Colloidal Science Laboratories)

Silver Nanoparticles: No Threat to the Environment. George J. Maass, Ph.D. (Colloidal Science Laboratories) Abstract: Silver Nanoparticles: No Threat to the Environment George J. Maass, Ph.D. (Colloidal Science Laboratories) Silver is an effective germ fighter and silver nanoparticles are widely recognized as

More information

Nano-pesticide Research in CAAS

Nano-pesticide Research in CAAS Nano-pesticide Research in CAAS Dr. Haixin Cui Institute of Environment and Sustainable Development in Agriculture, Chinese Academy of Agricultural Sciences cuihaixin@caas.cn 2014.11.18 Pesticides are

More information

AAGPs TM Anti-Aging Glyco Peptides. Enhancing Cell, Tissue and Organ Integrity Molecular and biological attributes of lead AAGP molecule

AAGPs TM Anti-Aging Glyco Peptides. Enhancing Cell, Tissue and Organ Integrity Molecular and biological attributes of lead AAGP molecule AAGPs TM Anti-Aging Glyco Peptides Enhancing Cell, Tissue and Organ Integrity Molecular and biological attributes of lead AAGP molecule 1 Acknowledgements This presentation was prepared by Dr. Samer Hussein

More information

Anatomy and Physiology Placement Exam 2 Practice with Answers at End!

Anatomy and Physiology Placement Exam 2 Practice with Answers at End! Anatomy and Physiology Placement Exam 2 Practice with Answers at End! General Chemical Principles 1. bonds are characterized by the sharing of electrons between the participating atoms. a. hydrogen b.

More information

Unit 2 Metabolism and Survival Summary

Unit 2 Metabolism and Survival Summary Unit 2 Metabolism and Survival Summary 1 Metabolism pathways and their control (a) Introduction to metabolic pathways This involves integrated and controlled pathways of enzymecatalysed reactions within

More information

Biological cell membranes

Biological cell membranes Unit 14: Cell biology. 14 2 Biological cell membranes The cell surface membrane surrounds the cell and acts as a barrier between the cell s contents and the environment. The cell membrane has multiple

More information

Managing Joint Venture Arrangements Between Two Biotech Companies: A Case Report. Dr. Jan Mous Midatech / PharMida May 21 st 2014

Managing Joint Venture Arrangements Between Two Biotech Companies: A Case Report. Dr. Jan Mous Midatech / PharMida May 21 st 2014 Managing Joint Venture Arrangements Between Two Biotech Companies: A Case Report Dr. Jan Mous Midatech / PharMida May 21 st 2014 1 Midatech Ltd. Corporate verview Founded 2000 in xford, England Drug development

More information

5.Transport, Endocytosis, and Phagocytosis

5.Transport, Endocytosis, and Phagocytosis 5.Transport, Endocytosis, and Phagocytosis VIBS 443 and VIBS 602 Undergraduate Graduate Histology Lecture Series Larry Johnson, Professor Veterinary Integrative Biosciences Texas A&M University College

More information

Compartmentalization of the Cell. Objectives. Recommended Reading. Professor Alfred Cuschieri. Department of Anatomy University of Malta

Compartmentalization of the Cell. Objectives. Recommended Reading. Professor Alfred Cuschieri. Department of Anatomy University of Malta Compartmentalization of the Cell Professor Alfred Cuschieri Department of Anatomy University of Malta Objectives By the end of this session the student should be able to: 1. Identify the different organelles

More information

& the Engineer. Guest Lecture Introduction to Engineering 160 November 17 & 18, 2004 University of Wisconsin, Madison

& the Engineer. Guest Lecture Introduction to Engineering 160 November 17 & 18, 2004 University of Wisconsin, Madison Nanotechnology, Society, & the Engineer Guest Lecture Introduction to Engineering 160 November 17 & 18, 2004 University of Wisconsin, Madison Outline for Today Introduction to Nano [Charlie Tahan] Group

More information

Exploratory Brief on Nanomedicine or the Application of Nanotechnology in Human Healthcare

Exploratory Brief on Nanomedicine or the Application of Nanotechnology in Human Healthcare Exploratory Brief on Nanomedicine or the Application of Nanotechnology in Human Healthcare Paula Corabian, Dagmara Chojecki March 6, 2012 Objectives Provincial Health Technology Assessment (HTA) Program

More information

Best Practices for Handling Nanomaterials in Laboratories

Best Practices for Handling Nanomaterials in Laboratories Best Practices for Handling Nanomaterials in Laboratories Much of the toxicology of nanomaterials is currently uncertain or unknown. Some nanosized particles are more toxic than their respective micron

More information

AUVA, workers safety and Nanoparticles. Dipl. Ing. Robert Piringer

AUVA, workers safety and Nanoparticles. Dipl. Ing. Robert Piringer AUVA, workers safety and Nanoparticles Dipl. Ing. Robert Piringer Work Accident Insurance Institutes in Austria General Worker s Compensation Board AUVA ~ 4,3 Mio Insurants Social Insurance for Farmers

More information

HETEROGENEOUS ELECTROPHOTOCATALYSIS ON NANOSTRUCTURED TiO 2 FOR REFRACTORY POLLUTANTS AND RESISTANT PATHOGENS REMOVAL FROM WATER AND WASTEWATER

HETEROGENEOUS ELECTROPHOTOCATALYSIS ON NANOSTRUCTURED TiO 2 FOR REFRACTORY POLLUTANTS AND RESISTANT PATHOGENS REMOVAL FROM WATER AND WASTEWATER DIIAR - Environmental Engineering Section HETEROGENEOUS ELECTROPHOTOCATALYSIS ON NANOSTRUCTURED TiO 2 FOR REFRACTORY POLLUTANTS AND RESISTANT PATHOGENS REMOVAL FROM WATER AND WASTEWATER SIDISA Summer School

More information

Pharmacology of the Respiratory Tract: COPD and Steroids

Pharmacology of the Respiratory Tract: COPD and Steroids Pharmacology of the Respiratory Tract: COPD and Steroids Dr. Tillie-Louise Hackett Department of Anesthesiology, Pharmacology and Therapeutics University of British Columbia Associate Head, Centre of Heart

More information

Lubricant and Fuel Additives. Essential Products in Modern Life. ATC Document 87

Lubricant and Fuel Additives. Essential Products in Modern Life. ATC Document 87 Lubricant and Fuel Additives Essential Products in Modern Life ATC Document 87 December 2006 LUBRICANT AND FUEL ADDITIVES ESSENTIAL PRODUCTS IN MODERN LIFE Lubricants and fuels are absolutely essential

More information

Basic Characteristics of Cells. Cell Structure and Function. Each Cell Has Three Primary Regions. Basic Characteristics of Cells. The Plasma Membrane

Basic Characteristics of Cells. Cell Structure and Function. Each Cell Has Three Primary Regions. Basic Characteristics of Cells. The Plasma Membrane Basic Characteristics of Cells Cell Structure and Function Chapter 3 Smallest living subdivision of the human body Diverse in structure and function Small Basic Characteristics of Cells Each Cell Has Three

More information

Consumer exposure to silver (nanoparticles) in consumer products

Consumer exposure to silver (nanoparticles) in consumer products Consumer exposure to silver (nanoparticles) in consumer products Natalie von Goetz ETH Zurich, Institute of Chemical and Bioengineering The blue man Paul Karason after 15 years of oral intake of colloidal

More information

[Image removed due to copyright concerns]

[Image removed due to copyright concerns] Radiation Chemistry Ionizing radiation produces abundant secondary electrons that rapidly slow down (thermalize) to energies below 7.4 ev, the threshold to produce electronic transitions in liquid water.

More information

RADIOPHARMACEUTICALS BASED ON MONOCLONAL ANTIBODIES

RADIOPHARMACEUTICALS BASED ON MONOCLONAL ANTIBODIES RADIOPHARMACEUTICALS BASED ON MONOCLONAL ANTIBODIES Guideline Title Radiopharmaceuticals based on Monoclonal Antibodies Legislative basis Directives 65/65/EEC, 75/318/EEC as amended, Directive 89/343/EEC

More information

Nanotechnology and Pesticides

Nanotechnology and Pesticides Nanotechnology and Pesticides Pesticide Program Dialogue Committee April 29, 2010 William Jordan Senior Policy Adviser Office of Pesticide Programs Session I Today s Presentation Review of nanotechnology

More information

Comprehensive Environmental Assessment of Nanomaterials: A Meta-Assessment Approach

Comprehensive Environmental Assessment of Nanomaterials: A Meta-Assessment Approach Comprehensive Environmental Assessment of Nanomaterials: A Meta-Assessment Approach J. Michael Davis, PhD Private Consultant (Retired Senior Science Advisor National Center for Environmental Assessment

More information

Biochemistry. Entrance Requirements. Requirements for Honours Programs. 148 Bishop s University 2015/2016

Biochemistry. Entrance Requirements. Requirements for Honours Programs. 148 Bishop s University 2015/2016 148 Bishop s University 2015/2016 Biochemistry The Biochemistry program at Bishop s is coordinated through an interdisciplinary committee of chemists, biochemists and biologists, providing students with

More information

Cells Need to Exchange Materials with the Extracellular Fluid. Membrane Transport. Plasma Membrane. Cells Must Control Movements of Materials

Cells Need to Exchange Materials with the Extracellular Fluid. Membrane Transport. Plasma Membrane. Cells Must Control Movements of Materials Membrane Transport Chapter 6 Cells Need to Exchange Materials with the Extracellular Fluid Take in nutrients O 2 energy substrates building materials cofactors Dispose of wastes CO 2 Urea Cells Must Control

More information

High Efficiency Black Polymer Solar Cells November 2012 Annual Report

High Efficiency Black Polymer Solar Cells November 2012 Annual Report High Efficiency Black Polymer Solar Cells November 2012 Annual Report PI: Dr. Franky So External Collaborators: John Reynolds, Georgia Tech Industry Partner: Sestar Technologies, LLC Students: Cephas Small

More information

The Physiology of Hyperbaric Oxygen Therapy. Free Radicals and Reactive Oxygen Species. I. Introduction Definition, Source, function and Purpose

The Physiology of Hyperbaric Oxygen Therapy. Free Radicals and Reactive Oxygen Species. I. Introduction Definition, Source, function and Purpose The Physiology of Hyperbaric Oxygen Therapy Free Radicals and Reactive Oxygen Species I. Introduction Definition, Source, function and Purpose A. Definition of free radicals and reactive oxygen species

More information

NANOCOMPOSIX'S GUIDE TO ICP-MS MEASUREMENT

NANOCOMPOSIX'S GUIDE TO ICP-MS MEASUREMENT NANOCOMPOSIX'S GUIDE TO ICP-MS MEASUREMENT AND ANALYSIS SEPTEMBER 2012, V 1.1 4878 RONSON CT STE K SAN DIEGO, CA 92111 858-565 - 4227 NANOCOMPOSIX.COM Note to the Reader: We at nanocomposix have published

More information

M.Sc. in Nano Technology with specialisation in Nano Biotechnology

M.Sc. in Nano Technology with specialisation in Nano Biotechnology M.Sc. in Nano Technology with specialisation in Nano Biotechnology Nanotechnology is all about designing, fabricating and controlling materials, components and machinery with dimensions on the nanoscale,

More information

AP Biology. The Cell Membrane

AP Biology. The Cell Membrane The Cell Membrane Phospholipids Phosphate head hydrophilic Fatty acid tails hydrophobic Arranged as a bilayer Phosphate attracted to water Fatty acid repelled by water Aaaah, one of those structure function

More information

Draft NIEHS Strategic Plan. Mission, Vision, Strategic Pillars, Strategic Goals. Draft Mission Statement

Draft NIEHS Strategic Plan. Mission, Vision, Strategic Pillars, Strategic Goals. Draft Mission Statement Draft NIEHS Strategic Plan Mission, Vision, Strategic Pillars, Strategic Goals Draft Mission Statement The mission of the National Institute of Environmental Health Sciences is to discover how the environment

More information

to isolate specialized chemical processes in specific parts of the cell

to isolate specialized chemical processes in specific parts of the cell Intracellular transport in eukaryotes Overview Compartmentalization and inner membranes enables eukaryotic cells to be 1000-10000 times larger than prokaryotes to isolate specialized chemical processes

More information

Exposure and Control of Ten High Priority MSHA Contaminants in Metal Mines. Presented by: Shannon E. Newton, MPH, CIH

Exposure and Control of Ten High Priority MSHA Contaminants in Metal Mines. Presented by: Shannon E. Newton, MPH, CIH Exposure and Control of Ten High Priority MSHA Contaminants in Metal Mines Presented by: Shannon E. Newton, MPH, CIH Topics What are these hazards? How can they harm you? Why do we care? How do we tell

More information

A. Definition of biology - Biology is the study of life.

A. Definition of biology - Biology is the study of life. Introduction to Biology and Chemistry Outline I. Introduction to biology A. Definition of biology - Biology is the study of life. B. Characteristics of Life 1. Form and size are characteristic. e.g. A

More information

4. Biology of the Cell

4. Biology of the Cell 4. Biology of the Cell Our primary focus in this chapter will be the plasma membrane and movement of materials across the plasma membrane. You should already be familiar with the basic structures and roles

More information

Acetic acid production rate in EVA encapsulant and its influence on performance of PV modules

Acetic acid production rate in EVA encapsulant and its influence on performance of PV modules 2 nd Atlas/NIST PV Materials Durability Workshop November 13 14 Acetic acid production rate in EVA encapsulant and its influence on performance of PV modules Tsuyoshi Shioda Mitsui Chemicals, Inc. Outline

More information

A FDA Perspective on Nanomedicine Current Initiatives in the US

A FDA Perspective on Nanomedicine Current Initiatives in the US A FDA Perspective on Nanomedicine Current Initiatives in the US Carlos Peña, PhD Office of the Commissioner FDA September 3, 2010 Outline Context Nanotechnology Task Force report summary Identification

More information

Cellular Respiration An Overview

Cellular Respiration An Overview Why? Cellular Respiration An Overview What are the phases of cellular respiration? All cells need energy all the time, and their primary source of energy is ATP. The methods cells use to make ATP vary

More information

Uses of Flow Cytometry

Uses of Flow Cytometry Uses of Flow Cytometry 1. Multicolour analysis... 2 2. Cell Cycle and Proliferation... 3 a. Analysis of Cellular DNA Content... 4 b. Cell Proliferation Assays... 5 3. Immunology... 6 4. Apoptosis... 7

More information

Department of Environmental Engineering

Department of Environmental Engineering Department of Environmental Engineering Master of Engineering Program in Environmental Engineering (International Program) M.Eng. (Environmental Engineering) Plan A Option 1: (1) Major courses: minimum

More information

1.1.2. thebiotutor. AS Biology OCR. Unit F211: Cells, Exchange & Transport. Module 1.2 Cell Membranes. Notes & Questions.

1.1.2. thebiotutor. AS Biology OCR. Unit F211: Cells, Exchange & Transport. Module 1.2 Cell Membranes. Notes & Questions. thebiotutor AS Biology OCR Unit F211: Cells, Exchange & Transport Module 1.2 Cell Membranes Notes & Questions Andy Todd 1 Outline the roles of membranes within cells and at the surface of cells. The main

More information

Biology Chapter 7 Practice Test

Biology Chapter 7 Practice Test Biology Chapter 7 Practice Test Multiple Choice Write the letter that best answers the question or completes the statement on the line provided. 1. The work of Schleiden and Schwann can be summarized by

More information

NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES Division of Extramural Research and Training

NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES Division of Extramural Research and Training NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES Division of Extramural Research and Training NATIONAL ADVISORY ENVIRONMENTAL HEALTH SCIENCES COUNCIL May 12-13, 2010 Concept Clearance Small Business

More information

Nanoscience Course Descriptions

Nanoscience Course Descriptions Nanoscience Course Descriptions NANO*1000 Introduction to Nanoscience This course introduces students to the emerging field of nanoscience. Its representation in popular culture and journalism will be

More information

Barrier between plasma and. ECF and ICF. Homeostasis: process of maintaining consistent composition of body s extracellular fluid

Barrier between plasma and. ECF and ICF. Homeostasis: process of maintaining consistent composition of body s extracellular fluid : process of maintaining consistent composition of body s extracellular fluid Extracellular fluid (ECF) Fluid in which the cells live (fluid outside the cells) Major components: Plasma interstitial fluid

More information

For additional information on the program, see the current university catalog.

For additional information on the program, see the current university catalog. For information call: Tel: (818) 77-81 Fax: (818) 77-08 E-mail: chemistry.office@csun.edu Website: http://www.csun.edu/chemistry Or write: Department of Chemistry and Biochemistry California State University,

More information

7.2 Cell Structure. Lesson Objectives. Lesson Summary. Cell Organization Eukaryotic cells contain a nucleus and many specialized structures.

7.2 Cell Structure. Lesson Objectives. Lesson Summary. Cell Organization Eukaryotic cells contain a nucleus and many specialized structures. 7.2 Cell Structure Lesson Objectives Describe the structure and function of the cell nucleus. Describe the role of vacuoles, lysosomes, and the cytoskeleton. Identify the role of ribosomes, endoplasmic

More information

2011 Annual Report T H E NANOTECHNOLOGY I N S T I T U T E

2011 Annual Report T H E NANOTECHNOLOGY I N S T I T U T E 2011 Annual Report T H E NANOTECHNOLOGY TM I N S T I T U T E The Nanotechnology Institute The Nanotechnology Institute (NTI) is southeastern Pennsylvania s first multi-institutional partnership created

More information

Extended experimental investigation: The effect of sunlight on the chlorine levels in pools

Extended experimental investigation: The effect of sunlight on the chlorine levels in pools Chemistry (2007) Sample assessment instrument and student response Extended experimental investigation: The effect of sunlight on the chlorine levels in pools This sample is intended to inform the design

More information

Supporting Information

Supporting Information Supporting Information Copyright Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, 2013 A Study of Commercial Nanoparticulate g-al 2 O 3 Catalyst Supports Yahaya Rozita, [a] Rik Brydson,* [a] Tim P. Comyn,

More information

I. What is the structure of the plasma membrane and what functions does it make possible?

I. What is the structure of the plasma membrane and what functions does it make possible? Subquestions: I. What is the structure of the plasma membrane and what functions does it make possible? A. What is the structure of the membrane? B. What are the following terms, how does the membrane

More information

Introduction, Noncovalent Bonds, and Properties of Water

Introduction, Noncovalent Bonds, and Properties of Water Lecture 1 Introduction, Noncovalent Bonds, and Properties of Water Reading: Berg, Tymoczko & Stryer: Chapter 1 problems in textbook: chapter 1, pp. 23-24, #1,2,3,6,7,8,9, 10,11; practice problems at end

More information

Total body water ~(60% of body mass): Intracellular fluid ~2/3 or ~65% Extracellular fluid ~1/3 or ~35% fluid. Interstitial.

Total body water ~(60% of body mass): Intracellular fluid ~2/3 or ~65% Extracellular fluid ~1/3 or ~35% fluid. Interstitial. http://www.bristol.ac.uk/phys-pharm/teaching/staffteaching/sergeykasparov.htmlpharm/teaching/staffteaching/sergeykasparov.html Physiology of the Cell Membrane Membrane proteins and their roles (channels,

More information

Cell Membranes Part 1: Review of Membrane Structure and Changes with Aging By Dan Carter, ND

Cell Membranes Part 1: Review of Membrane Structure and Changes with Aging By Dan Carter, ND Introduction Does cell membrane physiology degrade over time? Can the physiologic function of cell membranes be improved? If cell membrane functionality can be improved, is there clinical benefit to patients?

More information

Lesson 5: Culminating Activities. Teacher Materials

Lesson 5: Culminating Activities. Teacher Materials Lesson 5: Culminating Activities Teacher Materials Contents Culminating Activities: Teacher Lesson Plan Consumer Choice Project: Teacher Instructions & Grading Rubric The Science Behind the Sunscreen Quiz:

More information

Chemistry 51 Chapter 8 TYPES OF SOLUTIONS. A solution is a homogeneous mixture of two substances: a solute and a solvent.

Chemistry 51 Chapter 8 TYPES OF SOLUTIONS. A solution is a homogeneous mixture of two substances: a solute and a solvent. TYPES OF SOLUTIONS A solution is a homogeneous mixture of two substances: a solute and a solvent. Solute: substance being dissolved; present in lesser amount. Solvent: substance doing the dissolving; present

More information

Alharith Hassan. Q 10 Method of Shelf-life estimation. Methods of Chemical stabilisation 11/20/2015

Alharith Hassan. Q 10 Method of Shelf-life estimation. Methods of Chemical stabilisation 11/20/2015 Q 10 Method of Shelf-life estimation Q 10 approach is an old concept that could be useful for estimating the shelf-life at room temperature of products recommended for cold storage. Calculations are based

More information

Bio Europe Munich. November 4, 2015 TSX-V: SBM

Bio Europe Munich. November 4, 2015 TSX-V: SBM Bio Europe Munich November 4, 2015 TM Sirona s Fluorination Chemistry Technology The Solution to Unstable Carbohydrate Molecules Carbohydrate molecules are unstable by nature Our technology stabilizes

More information

William Shaw, Ph.D. The Great Plains Laboratory, Inc., Lenexa, Kansas, USA

William Shaw, Ph.D. The Great Plains Laboratory, Inc., Lenexa, Kansas, USA Inhibition of dopamine conversion to norepinephrine by Clostridia metabolites appears to be a (the) major cause of autism, schizophrenia, and other neuropsychiatric disorders. All these factors can now

More information

FIGURE 2.18. A. The phosphate end of the molecule is polar (charged) and hydrophilic (attracted to water).

FIGURE 2.18. A. The phosphate end of the molecule is polar (charged) and hydrophilic (attracted to water). PLASMA MEMBRANE 1. The plasma membrane is the outermost part of a cell. 2. The main component of the plasma membrane is phospholipids. FIGURE 2.18 A. The phosphate end of the molecule is polar (charged)

More information

SAMPLE. HLTAP501C Analyse health information. HLT07 Health Training Package. Learner resource. Version 2. Product Code: 5655

SAMPLE. HLTAP501C Analyse health information. HLT07 Health Training Package. Learner resource. Version 2. Product Code: 5655 HLT07 Health Training Package HLTAP501C Analyse health information Learner resource Version 2 Training and Education Support Industry Skills Unit Meadowbank Product Code: 5655 Acknowledgments The TAFE

More information

Cell Biology Questions and Learning Objectives

Cell Biology Questions and Learning Objectives Cell Biology Questions and Learning Objectives (with hypothetical learning materials that might populate the objective) The topics and central questions listed here are typical for an introductory undergraduate

More information

CHAPTER 9 BODY ORGANIZATION

CHAPTER 9 BODY ORGANIZATION CHAPTER 9 BODY ORGANIZATION Objectives Identify the meaning of 10 or more terms relating to the organization of the body Describe the properties of life Describe the function for the structures of the

More information

Chapter 8: Water and Electrolytes-Striking a Balance

Chapter 8: Water and Electrolytes-Striking a Balance Chapter 8: Water and Electrolytes-Striking a Balance Fluids are substances composed of freely moving molecules that have the ability to conform to the shape of their container. There are different types

More information

The human respiratory system includes the nose, the larynx, and the lungs. This body system helps maintain homeostasis by

The human respiratory system includes the nose, the larynx, and the lungs. This body system helps maintain homeostasis by Study Island 1. During heatstroke, the body can't dispose of excess heat. As a result, the homeostatic balance is disturbed, and internal body temperatures can reach as much as 110. Heatstroke is dangerous

More information

FACULTY OF MEDICAL SCIENCE

FACULTY OF MEDICAL SCIENCE Doctor of Philosophy in Biochemistry FACULTY OF MEDICAL SCIENCE Naresuan University 73 Doctor of Philosophy in Biochemistry The Biochemistry Department at Naresuan University is a leader in lower northern

More information

Nano-Titanium Dioxide in Sunscreens. Gerald Renner, Colipa

Nano-Titanium Dioxide in Sunscreens. Gerald Renner, Colipa Nano-Titanium Dioxide in Sunscreens Gerald Renner, Colipa Cosmetic Use of Nanomaterials In 2008, a survey of nanomaterials sold in EU cosmetic products amongst member companies of Colipa and national trade

More information

RAD 223. Radiography physiology. Lecture Notes. First lecture: Cell and Tissue

RAD 223. Radiography physiology. Lecture Notes. First lecture: Cell and Tissue RAD 223 Radiography physiology Lecture Notes First lecture: Cell and Tissue Physiology: the word physiology derived from a Greek word for study of nature. It is the study of how the body and its part work

More information

Let s get started. So, what is science?

Let s get started. So, what is science? Let s get started So, what is science? Well Science Science is the observation of phenomena and the theoretical explanation of it. Simply, it is the state of knowing. Biology Biology is the study of life.

More information

Introduction to Enteris BioPharma

Introduction to Enteris BioPharma Introduction to Enteris BioPharma Enteris BioPharma Intelligent Solutions for Oral Drug Delivery Privately held, New Jersey based biotech company Owned solely by Victory Park Capital, a large Chicago based

More information

Ch. 8 - The Cell Membrane

Ch. 8 - The Cell Membrane Ch. 8 - The Cell Membrane 2007-2008 Phospholipids Phosphate head hydrophilic Fatty acid tails hydrophobic Arranged as a bilayer Phosphate attracted to water Fatty acid repelled by water Aaaah, one of those

More information

Physiology Chapter 1 Lecture

Physiology Chapter 1 Lecture Physiology Chapter 1 Lecture I. Anatomy and Physiology - structure and function. *many subdivisions in both areas. See Table 1.1, page 2 *structure and function are interrelated, the structure often determines

More information

COURSE TITLE COURSE DESCRIPTION

COURSE TITLE COURSE DESCRIPTION COURSE TITLE COURSE DESCRIPTION CH-00X CHEMISTRY EXIT INTERVIEW All graduating students are required to meet with their department chairperson/program director to finalize requirements for degree completion.

More information

Introduction to Body Fluids

Introduction to Body Fluids Introduction to Body Fluids Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com) Page 1: Introduction to Body Fluids The fluids in your body

More information

CELLULAR RESPIRATION 29 MAY 2013

CELLULAR RESPIRATION 29 MAY 2013 CELLULAR RESPIRATION 29 MAY 2013 Lesson Description In this lesson, we: Define cellular respiration Define aerobic respiration o The role of glycolysis in aerobic respiration o The role of the Kreb s cycle

More information

CHEMISTRY STANDARDS BASED RUBRIC ATOMIC STRUCTURE AND BONDING

CHEMISTRY STANDARDS BASED RUBRIC ATOMIC STRUCTURE AND BONDING CHEMISTRY STANDARDS BASED RUBRIC ATOMIC STRUCTURE AND BONDING Essential Standard: STUDENTS WILL UNDERSTAND THAT THE PROPERTIES OF MATTER AND THEIR INTERACTIONS ARE A CONSEQUENCE OF THE STRUCTURE OF MATTER,

More information

Bottlenecks in Clinical Source Material Acquisition. Aby J. Mathew, PhD May 5, 2009 ISCT Annual Meeting San Diego, CA amathew@biolifesolutions.

Bottlenecks in Clinical Source Material Acquisition. Aby J. Mathew, PhD May 5, 2009 ISCT Annual Meeting San Diego, CA amathew@biolifesolutions. Bottlenecks in Clinical Source Material Acquisition Aby J. Mathew, PhD May 5, 2009 ISCT Annual Meeting San Diego, CA amathew@biolifesolutions.com Biopreservation What s the issue? Biopreservation considerations

More information

Coagulation-Flocculation-Jar Test. Assoc. Prof. Kozet YAPSAKLI

Coagulation-Flocculation-Jar Test. Assoc. Prof. Kozet YAPSAKLI Coagulation-Flocculation-Jar Test Assoc. Prof. Kozet YAPSAKLI Turbidity Turbidity particles (sand, silt, clay, bacteria, viruses) in the initial source water that need to be removed to improve treatment.

More information

Graduate and Postdoctoral Affairs School of Biomedical Sciences College of Medicine. Graduate Certificate. Metabolic & Nutritional Medicine

Graduate and Postdoctoral Affairs School of Biomedical Sciences College of Medicine. Graduate Certificate. Metabolic & Nutritional Medicine Graduate and Postdoctoral Affairs School of Biomedical Sciences College of Medicine Graduate Certificate in Metabolic & Nutritional Medicine Graduate Certificate Metabolic & Nutritional Medicine Purpose

More information

Biol 101 Exam 2: Cells & Cell Membranes Fall 2008

Biol 101 Exam 2: Cells & Cell Membranes Fall 2008 MULTIPLE CHOICE. There are 60 questions on this exam. All answers go on the Scantron. Choose the one alternative that best completes the statement or answers the question. 1. The cell theory is one of

More information

called a cell wall. The cell wall protects against mechanical stress and keeps the cell from becoming over-filled with water.

called a cell wall. The cell wall protects against mechanical stress and keeps the cell from becoming over-filled with water. What are Cells? By: Byron Norelius About Cells A cell is the basic unit of life. All living organisms are composed of one (unicellular) or more (multicellular) cells. In unicellular organisms, like many

More information

Pulsed laser deposition of organic materials

Pulsed laser deposition of organic materials Pulsed laser deposition of organic materials PhD theses Gabriella Kecskeméti Department of Optics and Quantum Electronics University of Szeged Supervisor: Dr. Béla Hopp senior research fellow Department

More information

Protein Function. After the Folding. Lecture 3

Protein Function. After the Folding. Lecture 3 Protein Function After the Folding Lecture 3 Gene to gene product (protein) Protein folding of nascent polypeptide chain - Immediate folding amplification Proteins mediate virtually all cellular functions

More information

Wireless Radiation in the Etiology and Treatment of Autism: Clinical Observations and Mechanisms

Wireless Radiation in the Etiology and Treatment of Autism: Clinical Observations and Mechanisms Wireless Radiation in the Etiology and Treatment of Autism: Clinical Observations and Mechanisms 1 Journal of the Australasian College of Nutritional & Environmental Medicine Tamara J Mariea and George

More information

Division Ave High School AP Biology

Division Ave High School AP Biology The Cell Membrane https://youtu.be/y31dlj6ugge Journal Diagrams Shark book pg. 82 Wolves book pg. 88-89 Membrane Proteins Copy table Cell Membrane Proteins Fluid Mosaic Model Cell Membrane Phospholipids

More information

IN VITRO ANALYSIS OF SUBLINGUAL VITAMIN B 12 PERMEATION

IN VITRO ANALYSIS OF SUBLINGUAL VITAMIN B 12 PERMEATION IN VITRO ANALYSIS OF SUBLINGUAL VITAMIN B 12 PERMEATION Cardiff School of Pharmacy and Pharmaceutical Sciences Cardiff University 2012 Prepared by: DM Houston, CM Heard Jan 2013 Vitamin B12 is a water-soluble

More information

Advanced Treatment of Hazardous Wastes(1) Advanced Treatment of Hazardous Wastes(2) Advanced Environmental Chemistry. Design of Solid Waste Landfill

Advanced Treatment of Hazardous Wastes(1) Advanced Treatment of Hazardous Wastes(2) Advanced Environmental Chemistry. Design of Solid Waste Landfill Course Description (전체 개설 교과목 개요) Advanced Treatment of Hazardous Wastes(1) This course is concerned with the management of hazardous materials and wastes in depth. We will deal with the physico-chemical

More information

Chapter 9 Cellular Respiration

Chapter 9 Cellular Respiration Chapter 9 Cellular Respiration Electrons carried in NADH Mitochondrion Glucose Glycolysis Pyruvic acid Krebs Cycle Electrons carried in NADH and FADH 2 Electron Transport Chain Cytoplasm Mitochondrion

More information