Adrenergic agonists. R. A. Nimmi Dilsha Department of pharmacy Faculty of Health Sciences The Open University of Sri Lanka

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "Adrenergic agonists. R. A. Nimmi Dilsha Department of pharmacy Faculty of Health Sciences The Open University of Sri Lanka"

Transcription

1 Adrenergic agonists R. A. Nimmi Dilsha Department of pharmacy Faculty of Health Sciences The Open University of Sri Lanka

2 Outline Recall Introduction to adrenergic agonists Classification of adrenergic agonists Catecholamine Non catecholamine Direct acting adrenergic agonist Indirect acting adrenergic agonist

3 Recalling. Before the study of adrenergic agonist you should be able to recall the followings, Classification of Autonomic nervous system Adrenergic transmission Adrenergic receptors

4 Autonomic Nervous System

5 Adrenergic transmission

6

7 Adrenergic Receptors

8 Introduction to Adrenergic agonists/ Sympathomimetics An adrenergic agonist is a drug that stimulates a response from the adrenergic receptors Two major classification of sympathomimetics 1. According to the chemical nature a)catecholamines b)non Catecholamines 2. basis of their sites of action a. direct acting adrenoceptor agonists- directly interact & activate adrenoceptors b. indirect acting by causing a release of noradrenaline from stores at nerve endings c.both direct & indirect acting Some drugs have both direct & indirect actions

9

10 Catecholamines Compounds containing a catechol moiety(3,4-dihydroxybenzene group) & an amine side-chain Noradrenaline (norepinephrine (NE) transmitter released by sympathetic nerve terminals Adrenaline (epinephrine) hormone secreted by adrenal medulla endogenous + Dopamine metabolic precursor of noradrenaline & adrenaline, also a transmitter/neuromodulator in CNS exogenous Isoproterenol (previously isoprenaline) - a synthetic derivative of noradrenaline, not present in body

11

12 Non catecholamines Compounds lacking the catechol hydroxyl group, but induces the sympathetic nerve actions Eg; Salbutmol Salmeterol Ephedrine Amphetamine Phenylepinephrine

13 Direct acting adrenergic agonists Adrenalin (epinephrine) Directly binding to the receptors It is a non selective adrenoceptor agonist Acts on both Alpha & beta receptors Administration SC, IM, IV, Inhalation Clinical Uses of adrenaline 1. Cardiac arrest Beta 1 effect given IV or into the endotracheal tube 2. Prolong the effect of local anaesthetic drugs 3. As a mydriatic (dilatation of the pupil) 4. Anaphylaxis

14 Noradrenalin (norepinephrine) Act directly binding to the receptor Mainly alpha effect with slight beta effect Clinical uses Acute hypotension(iv infusion) Metraminol, methoxamine hydrochloride have similar effects

15 Dopamine Action of the drug is base on dose D1 receptor CNS, renal & vascular beds (dialator) D2 receptor Presynaptic (suppress NAD release) small doses Β1 receptors heart α1 receptor vasoconstrictor high doses Uses Management of cardiogenic shock after MI

16 Dobutamine Primarily a beta 1 receptor agonist. Some alpha effects Greater inotropic than chronotropic effects Used in management of shock(cardiogenic & septic) Isoprenalin Nonselective beta agonist acting on both Beta 1 & 2 receptor Used in the treatment of heart block or severe bradycardia. Salbutamol Selective beta 2 agonist Uses Treatment of bronchial asthma Management of premature labour

17 Clonidine Treatment of hypertension, migraine & menopausal flushing Partial agonist Agonist at alpha 2 receptor in the brain (postsynaptic) and peripheral alpha 2 receptors (presynaptic autoreceptors) on the adrenergic nerve endings Overdose stimulate alpha 1 (postsynaptic) receptor

18 Adverse effect of direct acting adrenergic agonist 1. (α) tissue necrosis due to intense vasoconstriction as a result of leakage from IV infusion 2. Heart (β1) tachycardia, palpitations, cardiac dysarhythmias 3. (β2) muscle tremor 4. (β2) hypokalaemia

19 False transmission by methyldopa Methyldopa Mechanism Taken up by the noradrenergic neuron & converted into a false transmitter alpha methyl noradrenalin Alpha methyl noradrenalin is secreted in the same way as NAD Alpha methyl noradrenalin less active on alpha receptors causing less vasoconstriction Stimulate alpha 2 receptors more than NAD Above two actions reduce the BP Used in the treatment of hypertension in pregnancy

20 Indirect acting sympathomimetic drugs Ephedrine Mechanism Weak action on adrenoceptors Transported into the nerve terminal Taken up by the vesicles NAD escape into cytosol Action Bronchodilatation, BP, Vasoconstriction Develop tachyphylaxis/ anxiety,insomnia, tremor and nausea So this central effects limits its use a sympathomometic in asthma

21 Amfetamines Resistant MAO Their peripheral actions (eg; tachycardia, hypertension) and central stimulant actions are mainly caused by catecholamine release. Dexamfetamine and methylphenidate are sometimes used in hyperkinetic children. Dexamfetamine and modafinil may be beneficial in narcolepsy. Dependance is common

22 Cocaine A local anaesthetic, also a sympathomometic because it inhibits the reuptake of NAD by nerves terminals. It has an intense cental stimulant effect that has made it a popular drug of abuse. Tricyclic antidepressants Inhibits the reuptake of NAD by nerves terminals

23 Drug that effect the sympathomimetic drug action & NAD storage Reserpine Block the storage of amines within the vesicles present at the end of nerve terminals. It depletes the stores of the releasable transmitter

24 Thank you

ADRENERGIC RECEPTOR AGONIST,CLASSIFICATION AND MECHANISM OF ACTION.

ADRENERGIC RECEPTOR AGONIST,CLASSIFICATION AND MECHANISM OF ACTION. ADRENERGIC RECEPTOR AGONIST,CLASSIFICATION AND MECHANISM OF ACTION. LEARNING OBJECTIVES At the end of lecture students should be able to know, Adrenergic receptor agonist, Classification and mechanism

More information

Pharmacology - Problem Drill 06: Autonomic Pharmacology - Adrenergic System

Pharmacology - Problem Drill 06: Autonomic Pharmacology - Adrenergic System Pharmacology - Problem Drill 06: Autonomic Pharmacology - Adrenergic System Question No. 1 of 10 Instructions: (1) Read the problem and answer choices carefully, (2) Work the problems on paper as 1. What

More information

PHC 313 The 7 th. Lecture. Adrenergic Agents

PHC 313 The 7 th. Lecture. Adrenergic Agents PHC 313 The 7 th. Lecture Adrenergic Agents Introduction Introduction Adrenergic agents are a broad class of agents employed in the treatment of many disorders. They are those chemical agents that exert

More information

Adrenergic agonists:-

Adrenergic agonists:- Adrenergic agonists:- A.) Catecholamines They are called catecholamines because they contain a catechol group, they are water-soluble and are 50% bound to plasma proteins, so they circulate in the bloodstream.

More information

1. The potential sites of action for sympathomimetics and the difference between a direct and indirect acting agonist.

1. The potential sites of action for sympathomimetics and the difference between a direct and indirect acting agonist. 1 OBI 836 The Autonomic Nervous System-Sympathomimetics M.T. Piascik August 29, 2012 Learning Objectives Lecture II The student should be able to explain or describe 1. The potential sites of action for

More information

Adrenergic receptors lec 9, part 2. 16/10/2014 Dr. Laila M. Matalqah Rama Kamal Ali Treany

Adrenergic receptors lec 9, part 2. 16/10/2014 Dr. Laila M. Matalqah Rama Kamal Ali Treany Adrenergic receptors lec 9, part 2 16/10/2014 Dr. Laila M. Matalqah Rama Kamal Ali Treany Pharmacology of ANS Adrenergic Agonists Adrenergic receptors:- - It is a receptor which is located in the peripheral

More information

ADRENERGIC AND ANTI-ADRENERGIC DRUGS. Mr. D.Raju, M.pharm, Lecturer

ADRENERGIC AND ANTI-ADRENERGIC DRUGS. Mr. D.Raju, M.pharm, Lecturer ADRENERGIC AND ANTI-ADRENERGIC DRUGS Mr. D.Raju, M.pharm, Lecturer SYMPATHETIC NERVOUS SYSTEM Fight or flight response results in: 1. Increased BP 2. Increased blood flow to brain, heart and skeletal muscles

More information

Adrenoceptor -activating & other sympathomimetic drugs

Adrenoceptor -activating & other sympathomimetic drugs Adrenoceptor -activating & other sympathomimetic drugs Three Neurotransmitters of Sympathetic Nervous System NE, E, DA Adrenoceptor agonists Sympathomimetics : Directly acting Indirectly acting Mixed action

More information

Adrenergic, Adrenergic Blockers, Cholinergic and Cholinergic Blockers

Adrenergic, Adrenergic Blockers, Cholinergic and Cholinergic Blockers Adrenergic, Adrenergic Blockers, Cholinergic and Cholinergic Blockers Objective 1: Explain the difference between the sympathetic and parasympathetic nervous systems Autonomic Nervous System Sympathetic

More information

LESSON ASSIGNMENT. 7-4. Given a group of statements, select the best definition of the term adrenergic (sympathomimetic) drug.

LESSON ASSIGNMENT. 7-4. Given a group of statements, select the best definition of the term adrenergic (sympathomimetic) drug. LESSON ASSIGNMENT LESSON 7 Adrenergic Agents. TEXT ASSIGNMENT Paragraphs 7-1 through 7-6. LESSON OBJECTIVES 7-1. Given a group of statements, select the mechanism(s) of action of drugs which stimulate

More information

Key Points. Autonomic Nervous System Drugs. Autonomic effects Sympathetic. Drugs can modify ANS activity by: Autonomic Nervous System

Key Points. Autonomic Nervous System Drugs. Autonomic effects Sympathetic. Drugs can modify ANS activity by: Autonomic Nervous System Key Points Autonomic Nervous System Drugs Autonomic drugs work at the synapses, Drugs either suppress or magnify the sympathetic or parasympathetic effect, Drugs don t work on a single target organ so

More information

Adrenaline (epinephrine) 1:1000 Injection BP Summary of Product Characteristics

Adrenaline (epinephrine) 1:1000 Injection BP Summary of Product Characteristics Adrenaline (epinephrine) 1:1000 Injection BP Summary of Product Characteristics 1. NAME OF THE MEDICINAL PRODUCT Adrenaline (epinephrine) 1:1000 Injection BP 2. QUALITATIVE AND QUANTITATIVE COMPOSITION

More information

Inotropes/Vasoactive Agents Hina N. Patel, Pharm.D., BCPS Cathy Lawson, Pharm.D., BCPS

Inotropes/Vasoactive Agents Hina N. Patel, Pharm.D., BCPS Cathy Lawson, Pharm.D., BCPS Inotropes/Vasoactive Agents Hina N. Patel, Pharm.D., BCPS Cathy Lawson, Pharm.D., BCPS 1. Definition -an agent that affects the contractility of the heart -may be positive (increases contractility) or

More information

The somatic nervous system regulates conscious movements via efferent nerves exit from the CNS to skeletal muscles.

The somatic nervous system regulates conscious movements via efferent nerves exit from the CNS to skeletal muscles. Lecture 1 Nervous system The nervous system is divided into the central nervous system (CNS; brain and spinal cord) and peripheral nervous system (somatic and autonomic nervous systems; comprised of nerves

More information

AUTONOMIC NERVOUS SYSTEM. c. CNS (central nervous system) control: voluntary (but has involuntary components; e.g. reflexes)

AUTONOMIC NERVOUS SYSTEM. c. CNS (central nervous system) control: voluntary (but has involuntary components; e.g. reflexes) page 1 INTRODUCTION A. Divisions of the Peripheral Nervous System 1. Somatic nervous system (voluntary) a. tissues innervated: skeletal muscle b. action: always excitatory (cause muscle contraction) c.

More information

ANNE ARUNDEL MEDICAL CENTER CRITICAL CARE MEDICATION MANUAL DEPARTMENT OF NURSING AND PHARMACY. Guidelines for Use of Intravenous Isoproterenol

ANNE ARUNDEL MEDICAL CENTER CRITICAL CARE MEDICATION MANUAL DEPARTMENT OF NURSING AND PHARMACY. Guidelines for Use of Intravenous Isoproterenol ANNE ARUNDEL MEDICAL CENTER CRITICAL CARE MEDICATION MANUAL DEPARTMENT OF NURSING AND PHARMACY Guidelines for Use of Intravenous Isoproterenol Major Indications Status Asthmaticus As a last resort for

More information

Sign up to receive ATOTW weekly - email worldanaesthesia@mac.com

Sign up to receive ATOTW weekly - email worldanaesthesia@mac.com ADRENALINE (EPINEPHRINE) ANAESTHESIA TUTORIAL OF THE WEEK 226 6 TH JUNE 2011 Prof. John Kinnear Southend University Hospital NHS Foundation Trust, UK Correspondence to John.Kinnear@southend.nhs.uk QUESTIONS

More information

Mammalian Physiology. Autonomic Nervous System UNLV. PHYSIOLOGY, Chapter 11 Berne, Levy, Koeppen, Stanton UNIVERSITY OF NEVADA LAS VEGAS

Mammalian Physiology. Autonomic Nervous System UNLV. PHYSIOLOGY, Chapter 11 Berne, Levy, Koeppen, Stanton UNIVERSITY OF NEVADA LAS VEGAS Mammalian Physiology Autonomic Nervous System UNLV 1 UNIVERSITY OF NEVADA LAS VEGAS PHYSIOLOGY, Chapter 11 Berne, Levy, Koeppen, Stanton Objectives Describe the organization of the autonomic nervous system

More information

PHENYLEPHRINE HYDROCHLORIDE INJECTION USP

PHENYLEPHRINE HYDROCHLORIDE INJECTION USP PRESCRIBING INFORMATION PHENYLEPHRINE HYDROCHLORIDE INJECTION USP 10 mg/ml Sandoz Canada Inc. Date of Preparation: September 1992 145 Jules-Léger Date of Revision : January 13, 2011 Boucherville, QC, Canada

More information

Adrenomimetic Drugs. Tony J.-F. Lee and Robert E. Stitzel MECHANISM OF ACTION CHEMISTRY

Adrenomimetic Drugs. Tony J.-F. Lee and Robert E. Stitzel MECHANISM OF ACTION CHEMISTRY 10 Adrenomimetic Drugs Tony J.-F. Lee and Robert E. Stitzel DRUG LIST GENERIC NAME AGE GENERIC NAME AGE Albuterol 105 Amphetamine 106 Dobutamine 105 Dopamine 103 Ephedrine 105 Epinephrine 101 Isoproterenol

More information

Vasopressors. Judith Hellman, M.D. Associate Professor Anesthesia and Perioperative Care University of California, San Francisco

Vasopressors. Judith Hellman, M.D. Associate Professor Anesthesia and Perioperative Care University of California, San Francisco Vasopressors Judith Hellman, M.D. Associate Professor Anesthesia and Perioperative Care University of California, San Francisco Overview Define shock states Review drugs commonly used to treat hypotension

More information

Autonomic Receptor Functions

Autonomic Receptor Functions Part II Autonomic Receptor Functions Summary of ANS overview Pharmacological classification of ANS is based on neurotransmitters: cholinergic, adrenergic, and dopaminergic. Major sites for pharmacological

More information

ACLS PHARMACOLOGY 2011 Guidelines

ACLS PHARMACOLOGY 2011 Guidelines ACLS PHARMACOLOGY 2011 Guidelines ADENOSINE Narrow complex tachycardias or wide complex tachycardias that may be supraventricular in nature. It is effective in treating 90% of the reentry arrhythmias.

More information

9/17/2013. Introduction. Diagnosis and Management of Hypotension. Introduction. Blood Pressure Physiology

9/17/2013. Introduction. Diagnosis and Management of Hypotension. Introduction. Blood Pressure Physiology Diagnosis and Management of Hypotension McGee Leonard, DVM Critical Care Resident Introduction Hypotension, or low arterial blood pressure, is not a disease. It is a clinical manifestation of many different

More information

Sedative-Hypnotics & the Treatment of Hypersomnia. Glossary

Sedative-Hypnotics & the Treatment of Hypersomnia. Glossary Sedative-Hypnotics & the Treatment of Hypersomnia April 17, 2014 Mark Beenhakker, Pharmacology markbeen@virginia.edu Glossary Anxiolytic: decreases anxiety Sedative: (1) decreases activity, (2) moderates

More information

DIPHENHYDRAMINE (Benadryl)

DIPHENHYDRAMINE (Benadryl) DIPHENHYDRAMINE (Benadryl) Classification: Antihistamine (H1 blocker) Antihistamine; appear to compete with histamine for cell receptor sites on effector cells. Therapeutic Relieves effects of histamine

More information

Autonomic (ANS) Pharmacology. Sympathetic Nervous System

Autonomic (ANS) Pharmacology. Sympathetic Nervous System Autonomic (ANS) Pharmacology Sympathetic Nervous System Autonomic and Somatic Innervation Skeletal muscle is innervated by somatic nerves, controlling voluntary actions All other innervated structures

More information

Drugs affecting the autonomic nervous system. Objectives. Autonomic Nervous System (ANS) 12/23/2014

Drugs affecting the autonomic nervous system. Objectives. Autonomic Nervous System (ANS) 12/23/2014 Drugs affecting the autonomic nervous system N231 Nursing Pharmacology Objectives Analyze the implementation of the nursing process in the promotion and maintenance of system stability for individuals

More information

D.U.C. Assist. Lec. Faculty of Dentistry General Physiology Ihsan Dhari. The Autonomic Nervous System

D.U.C. Assist. Lec. Faculty of Dentistry General Physiology Ihsan Dhari. The Autonomic Nervous System The Autonomic Nervous System The portion of the nervous system that controls most visceral functions of the body is called the autonomic nervous system. This system helps to control arterial pressure,

More information

Chapter 15. The Autonomic Nervous. The Autonomic Nervous System. Autonomic Motor Pathways. ANS vs. SNS

Chapter 15. The Autonomic Nervous. The Autonomic Nervous System. Autonomic Motor Pathways. ANS vs. SNS The Autonomic Nervous System Chapter 15 The subconscious involuntary nervous system Regulates activity of smooth muscle, cardiac muscle & certain glands The Autonomic Nervous System 1 2 ANS vs. SNS Somatic

More information

Autonomic Nervous System

Autonomic Nervous System MOST FREQUENTLY USED DRUG CATEGORIES FOR AUTONOMIC SYSTEM THERAPY Beta 1 Adrenergic Blockers (Anatgonists) - Work on the Heart Beta 1 Adrenergic receptors are typically found on the heart and is a means

More information

Modified epinephrine selective for beta 1 and beta 3 adrenergic receptors and its use as a tocolytic. Morgan Connolly COSMOS, Cluster 8

Modified epinephrine selective for beta 1 and beta 3 adrenergic receptors and its use as a tocolytic. Morgan Connolly COSMOS, Cluster 8 Modified epinephrine 1 Running head: Epinephrine modified to be an improved tocolytic. Modified epinephrine selective for beta 1 and beta 3 adrenergic receptors and its use as a tocolytic. Morgan Connolly

More information

Chapter 16. Learning Objectives. Learning Objectives 9/11/2012. Shock. Explain difference between compensated and uncompensated shock

Chapter 16. Learning Objectives. Learning Objectives 9/11/2012. Shock. Explain difference between compensated and uncompensated shock Chapter 16 Shock Learning Objectives Explain difference between compensated and uncompensated shock Differentiate among 5 causes and types of shock: Hypovolemic Cardiogenic Neurogenic Septic Anaphylactic

More information

Drugs, The Brain, and Behavior

Drugs, The Brain, and Behavior Drugs, The Brain, and Behavior John Nyby Department of Biological Sciences Lehigh University What is a drug? Difficult to define Know it when you see it Neuroactive vs Non-Neuroactive drugs Two major categories

More information

Chapter 13. Sympathetic Nervous System. Basic Functions of the Nervous System. Divisions of the Peripheral Nervous System

Chapter 13. Sympathetic Nervous System. Basic Functions of the Nervous System. Divisions of the Peripheral Nervous System Chapter 13 Drugs Affecting the Autonomic Basic Functions of the Recognizing changes in Internal environment External environment Processing and integrating changes Reacting to changes Upper Saddle River,

More information

CHAPTER 5 DISCUSSION

CHAPTER 5 DISCUSSION CHAPTER 5 DISCUSSION The present study demonstrated that isolated atria and tracheas from guinea-pigs received chronic pretreatment with cocaine for 14 days, developed supersensitivity to both epinephrine

More information

Physiology and Pharmacology

Physiology and Pharmacology Pharmacokinetics Physiology and Pharmacology Pharmacokinetics of Local Anesthetics Uptake Oral Route Topical Route Injection Distribution Metabolism (Biotransformation) Excretion Uptake So what? Vasoactivity

More information

Stress & Catecholamines - Overview

Stress & Catecholamines - Overview Stress & Catecholamines - Overview UNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DISCIPLINE OF BIOCHEMISTRY AND MOLECULAR BIOLOGY PBL MBBS YEAR II SEMINAR VJ Temple Stress can due to: What is

More information

Epinephrine Administration by the EMT

Epinephrine Administration by the EMT Epinephrine Administration by the EMT Pilot Project for the Administration of Epinephrine by Washington EMTs Tamara Coulter BS, FF/PM and Captain/MSO Steven Engle North Kitsap Fire & Rescue Objectives

More information

2 QUALITATIVE AND QUANTITATIVE COMPOSITION

2 QUALITATIVE AND QUANTITATIVE COMPOSITION SUMMARY OF PRODUCT CHARACTERISTICS 1 NAME OF THE MEDICINAL PRODUCT Anapen 500 micrograms in 03ml solution for injection in a pre-filled syringe 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each millilitre

More information

Chapter 4. The Adrenal Medulla

Chapter 4. The Adrenal Medulla Chapter 4 The Adrenal Medulla Introduction Induction of cortisol production requires several minutes, and full elaboration of cortisol action requires several hours. In contrast, the adrenal medullary

More information

Sign up to receive ATOTW weekly email worldanaesthesia@mac.com

Sign up to receive ATOTW weekly email worldanaesthesia@mac.com INTRODUCTION TO CARDIOVASCULAR PHYSIOLOGY ANAESTHESIA TUTORIAL OF THE WEEK 125 16 TH MARCH 2009 Toby Elkington, Specialist Registrar Carl Gwinnutt, Consultant Department of Anaesthesia, Salford Royal NHS

More information

The Autonomic Nervous System Part II - Basic Pharmacology

The Autonomic Nervous System Part II - Basic Pharmacology Dr Oliver Pratt, Specialist Registrar Dr Carl Gwinnutt, Consultant Department of Anaesthesia, Hope Hospital, Salford M6 8HD, UK. e mail: carl.gwinnutt@srht.nhs.uk Tutorial Of The Week The Autonomic Nervous

More information

Chapter 15: The Autonomic Nervous System

Chapter 15: The Autonomic Nervous System Chapter 15: The Autonomic Nervous System Chapter Objectives COMPARISON OF SOMATIC AND AUTONOMIC NERVOUS SYSTEMS 1. List the structural and functional characteristics of the autonomic nervous system. 2.

More information

Chapter 28. Drug Treatment of Parkinson s Disease

Chapter 28. Drug Treatment of Parkinson s Disease Chapter 28 Drug Treatment of Parkinson s Disease 1. Introduction Parkinsonism Tremors hands and head develop involuntary movements when at rest; pin rolling sign (finger and thumb) Muscle rigidity arthritis

More information

1 What Anapen is and what it is used for?

1 What Anapen is and what it is used for? PACKAGE LEAFLET: INFORMATION FOR THE USER Anapen 500 micrograms in 0.3 ml solution for injection (pre-filled syringe) Adrenaline (Epinephrine) Auto-Injector Read all of this leaflet carefully before you

More information

Milwaukee School of Engineering Gerrits@msoe.edu. Case Study: Factors that Affect Blood Pressure Instructor Version

Milwaukee School of Engineering Gerrits@msoe.edu. Case Study: Factors that Affect Blood Pressure Instructor Version Case Study: Factors that Affect Blood Pressure Instructor Version Goal This activity (case study and its associated questions) is designed to be a student-centered learning activity relating to the factors

More information

Autonomic Nervous System Dr. Ali Ebneshahidi

Autonomic Nervous System Dr. Ali Ebneshahidi Autonomic Nervous System Dr. Ali Ebneshahidi Nervous System Divisions of the nervous system The human nervous system consists of the central nervous System (CNS) and the Peripheral Nervous System (PNS).

More information

Chapter 15. Neurotransmitters of the ANS

Chapter 15. Neurotransmitters of the ANS Chapter 15 Neurotransmitters of the ANS Neurotransmitters and Receptors How can the same ANS neurons create different effects on different target tissue? Variety of neurotransmitters Secondly, different

More information

Amino acids as drug targets.

Amino acids as drug targets. Amino acids as drug targets. Learning bjectives: To appreciate how many amino acids are modified to produce hormones and neurotransmitters To give examples; catecholamines, thyroxin, serotonin, histamine,

More information

Arrest. What s a Nurse to do?

Arrest. What s a Nurse to do? Benzo s, Blockers, Coma & Cardiac Arrest What s a Nurse to do? Objectives Review of ACLS Algorithms for Cardiac Arrest Management Discuss the toxicology of Beta Blocker Poisoning Describe the clinical

More information

Summary of Product Characteristics

Summary of Product Characteristics 1 NAME OF THE MEDICINAL PRODUCT Summary of Product Characteristics Anapen Junior 150 micrograms in 0.3ml solution for injection in a pre- filled syringe. 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each

More information

2 QUALITATIVE AND QUANTITATIVE COMPOSITION

2 QUALITATIVE AND QUANTITATIVE COMPOSITION 1. Trade Name of the Medicinal Product Dilute Adrenaline (Epinephrine) Injection 1:10,000 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each ml of the solution for injections contains 100 micrograms of Adrenaline

More information

STAGES OF SHOCK. IRREVERSIBLE SHOCK Heart deteriorates until it can no longer pump and death occurs.

STAGES OF SHOCK. IRREVERSIBLE SHOCK Heart deteriorates until it can no longer pump and death occurs. STAGES OF SHOCK SHOCK : A profound disturbance of circulation and metabolism, which leads to inadequate perfusion of all organs which are needed to maintain life. COMPENSATED NONPROGRESSIVE SHOCK 30 sec

More information

Cost-effective emergency treatment of anaphylaxis NEW. 500mcg dose. adrenaline (epinephrine) Right dose. First time.

Cost-effective emergency treatment of anaphylaxis NEW. 500mcg dose. adrenaline (epinephrine) Right dose. First time. Cost-effective emergency treatment of anaphylaxis NEW 500mcg dose The Anapen range Anapen can provide the right dose for every patient at risk of anaphylaxis. Intuitive to use and virtually painless Shown

More information

PHARMACOLOGY OF VNS VARIANT 1 1) Anti-ChEs: contraindications and precautions. 2) Examples of Cholinesterase reactivators. 3) Cholinoblockers-natural

PHARMACOLOGY OF VNS VARIANT 1 1) Anti-ChEs: contraindications and precautions. 2) Examples of Cholinesterase reactivators. 3) Cholinoblockers-natural VARIANT 1 Anti-ChEs: contraindications and precautions. Examples of Cholinesterase reactivators. Cholinoblockers-natural alkaloids (examples). 4) GIT-effects of Atropine. 5) Pharmacologic characteristic

More information

Crash Cart Drugs Drugs used in CPR. Dr. Layla Borham Professor of Clinical Pharmacology Umm Al Qura University

Crash Cart Drugs Drugs used in CPR. Dr. Layla Borham Professor of Clinical Pharmacology Umm Al Qura University Crash Cart Drugs Drugs used in CPR Dr. Layla Borham Professor of Clinical Pharmacology Umm Al Qura University Introduction A list of the drugs kept in the crash carts. This list has been approved by the

More information

Pharmacology Drug Chart

Pharmacology Drug Chart Pharmacology Drug Chart Cholinergic Agonists Acetylcholine Muscarinic HR, CO and BP Salivary Secretions Secretions and Motility in the GIT Bronchiolar Secretions Miosis (Constriction of the Pupil) Pharmacology

More information

Integration and Coordination of the Human Body. Nervous System

Integration and Coordination of the Human Body. Nervous System I. General Info Integration and Coordination of the Human Body A. Both the and system are responsible for maintaining 1. Homeostasis is the process by which organisms keep internal conditions despite changes

More information

Autonomic Nervous System Drugs

Autonomic Nervous System Drugs adistockshutterstock, Inc. CHAPTER 5 Autonomic Nervous System Drugs William Mark Enlow Sue Greenfield Cliff Roberson KEY TERMS Acetylcholine Acetylcholinesterase Adrenal medulla Adrenergic agonists Adrenergic

More information

Response to Stress Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.

Response to Stress Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc. Response to Stress Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com) Page 1. Introduction When there is an overwhelming threat to the

More information

PREPARATIONS: Adrenaline 1mg in 1ml (1:1000) Adrenaline 100micrograms in 1ml (1:10,000)

PREPARATIONS: Adrenaline 1mg in 1ml (1:1000) Adrenaline 100micrograms in 1ml (1:10,000) ADRENALINE Acute hypotension Via a CENTRAL venous line Initially 100-300 nanograms/kg/minute 0.1-0.3 microgram/kg/minute adjusted according to response up to a maximum of 1.5 micrograms/kg/minute. Increase

More information

Chapter 15. Autonomic Nervous System (ANS) and Visceral Reflexes. general properties Anatomy. Autonomic effects on target organs

Chapter 15. Autonomic Nervous System (ANS) and Visceral Reflexes. general properties Anatomy. Autonomic effects on target organs Chapter 15 Autonomic Nervous System (ANS) and Visceral Reflexes general properties Anatomy Autonomic effects on target organs Central control of autonomic function 15-1 Copyright (c) The McGraw-Hill Companies,

More information

The Autonomic Nervous System Physiology Study Guide, Chapter 9

The Autonomic Nervous System Physiology Study Guide, Chapter 9 Name: The Autonomic Nervous System Physiology Study Guide, Chapter 9 Lab Time: 1 Part I. Clinical Applications and Short Essay 1. After surgery, patients are often temporarily unable to urinate, and bowel

More information

CONTROL OF BLOOD FLOW AND BLOOD PRESSURE (Lectures 3b and 4)

CONTROL OF BLOOD FLOW AND BLOOD PRESSURE (Lectures 3b and 4) CONTROL OF BLOOD FLOW AND BLOOD PRESSURE (Lectures 3b and 4) 63 CONTROL OF BLOOD FLOW 1) REASON: Body needs different levels of nutrient delivery and metabolic removal for differing levels of activities

More information

Choosing a vasopressor for the pregnant patient

Choosing a vasopressor for the pregnant patient Choosing a vasopressor for the pregnant patient CAROLYN J. NICHOLSON, CRNA THOMAS H. JOYCE III, MD Cincinnati, Ohio Sometimes it is necessary to administer a vasopressor to the obstetrical patient. However,

More information

Septic Shock: Pharmacologic Agents for Hemodynamic Support. Nathan E Cope, PharmD PGY2 Critical Care Pharmacy Resident

Septic Shock: Pharmacologic Agents for Hemodynamic Support. Nathan E Cope, PharmD PGY2 Critical Care Pharmacy Resident Septic Shock: Pharmacologic Agents for Hemodynamic Support Nathan E Cope, PharmD PGY2 Critical Care Pharmacy Resident Objectives Define septic shock and briefly review pathophysiology Outline receptor

More information

Dr. RAJENDRAN S INSTITUTE OF MEDICAL EDUCATION

Dr. RAJENDRAN S INSTITUTE OF MEDICAL EDUCATION Page 1 of 7 Dr. RAJENDRAN S INSTITUTE OF MEDICAL EDUCATION AIIMS NOVEMBER 2012 - QUESTIONS AND ANSWERS PHYSIOLOGY This contains only 3 out of 7 questions. For complete questions with explanatory answers,

More information

Self-Injectable Epinephrine Agents 9/24/2009

Self-Injectable Epinephrine Agents 9/24/2009 9/24/2009 Copyright 2009 by Provider Synergies, L.L.C. All rights reserved. Printed in the United States of America. All rights reserved. No part of this publication may be reproduced or transmitted in

More information

Please read chapter 15, The Autonomic Nervous System, complete this study guide, and study this material BEFORE coming to the first class.

Please read chapter 15, The Autonomic Nervous System, complete this study guide, and study this material BEFORE coming to the first class. Please read chapter 15,, complete this study guide, and study this material BEFORE coming to the first class. I. Introduction to the autonomic nervous system: Briefly describe the autonomic nervous system.

More information

The Ideal Local Anesthetic. Pain and Anxiety. Percent Solution. Contents cont: Contents of a dental cartridge

The Ideal Local Anesthetic. Pain and Anxiety. Percent Solution. Contents cont: Contents of a dental cartridge The Ideal Local Anesthetic Pain and Anxiety University of Minnesota Division of Oral and Maxillofacial Surgery Ma Ann C. Sabino, DDS PhD Water soluble/stable in solution Non-irritating to nerve Low systemic

More information

Adult Drug Reference. Dopamine Drip Chart. Pediatric Drug Reference. Pediatric Drug Dosage Charts DRUG REFERENCES

Adult Drug Reference. Dopamine Drip Chart. Pediatric Drug Reference. Pediatric Drug Dosage Charts DRUG REFERENCES Adult Drug Reference Dopamine Drip Chart Pediatric Drug Reference Pediatric Drug Dosage Charts DRUG REFERENCES ADULT DRUG REFERENCE Drug Indication Adult Dosage Precautions / Comments ADENOSINE Paroxysmal

More information

Hormones & Chemical Signaling

Hormones & Chemical Signaling Hormones & Chemical Signaling Part 2 modulation of signal pathways and hormone classification & function How are these pathways controlled? Receptors are proteins! Subject to Specificity of binding Competition

More information

Adrenergic receptors: Anatomy, physiology, and pharmacological interactions

Adrenergic receptors: Anatomy, physiology, and pharmacological interactions Adrenergic receptors: Anatomy, physiology, and pharmacological interactions SANDRA M. MAREE, BS, CRNA Winston-Salem, North Carolina The author presents a review of the peripheral autonomic nervous system

More information

Pediatric Pharmacotherapy A Monthly Newsletter for Health Care Professionals Children s Medical Center at the University of Virginia

Pediatric Pharmacotherapy A Monthly Newsletter for Health Care Professionals Children s Medical Center at the University of Virginia Pediatric Pharmacotherapy A Monthly Newsletter for Health Care Professionals Children s Medical Center at the University of Virginia Volume 2 Number 12 December 1996 Medications for Neonatal and Pediatric

More information

The h0rmones of adrenal medulla. University of Debrecen, Department of Physiology

The h0rmones of adrenal medulla. University of Debrecen, Department of Physiology The h0rmones of adrenal medulla University of Debrecen, Department of Physiology Introduction Adrenal gland (6-10 g) Cortex (5-9 g) Medulla ( 1 g) Chromaffin cells alarm (Selye 1936) flight or fight (Cannon

More information

Hormones of the Adrenal Medulla. M.Sc BCH 560

Hormones of the Adrenal Medulla. M.Sc BCH 560 Hormones of the Adrenal Medulla M.Sc BCH 560 2006 Adrenal glands -The two adrenal glands are located immediately anterior to the kidneys, encased in a connective tissue capsule and usually partially

More information

PRESCRIBING INFORMATION PRODUCT MONOGRAPH ADRENALIN* Adrenalin* Chloride Solution (Epinephrine Injection U.S.P) 1:1000 (1 mg/ml)

PRESCRIBING INFORMATION PRODUCT MONOGRAPH ADRENALIN* Adrenalin* Chloride Solution (Epinephrine Injection U.S.P) 1:1000 (1 mg/ml) PRESCRIBING INFORMATION PRODUCT MONOGRAPH ADRENALIN* Adrenalin* Chloride Solution (Epinephrine Injection U.S.P) 1:1000 (1 mg/ml) Adrenalin* Chloride Injection (Epinephrine Injection U.S.P.) 1:1000, 30

More information

Social phobia following maprotiline: The first case report. Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran

Social phobia following maprotiline: The first case report. Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran Social phobia following maprotiline: The first case report Seyed Hamzeh Hosseini (MD) 1*, Ebraheim Salehifar (PharmD) 2 1* Associate professor of Psychiatry, Department of Psychiatry, Faculty of Medicine,

More information

Medical Direction and Practices Board WHITE PAPER

Medical Direction and Practices Board WHITE PAPER Medical Direction and Practices Board WHITE PAPER Use of Pressors in Pre-Hospital Medicine: Proper Indication and State of the Science Regarding Proper Choice of Pressor BACKGROUND Shock is caused by a

More information

A systematic review of the uses and contraindications of epinephrine in local anesthesia in the dermatologic setting

A systematic review of the uses and contraindications of epinephrine in local anesthesia in the dermatologic setting A systematic review of the uses and contraindications of epinephrine in local anesthesia in the dermatologic setting Syril Keena Que, MD; James Whalen, MD University of Connecticut Health Center Department

More information

Chapter 15 Anatomy and Physiology Lecture

Chapter 15 Anatomy and Physiology Lecture 1 THE AUTONOMIC NERVOUS SYSTEM Chapter 15 Anatomy and Physiology Lecture 2 THE AUTONOMIC NERVOUS SYSTEM Autonomic Nervous System (ANS) regulates the activity of smooth muscles, cardiac muscles, and certain

More information

Pharm Cardiovascular Paragraph

Pharm Cardiovascular Paragraph BEGIN DRUGS OF PARASYMPATHETIC SYSTEM Cholinomimetics Nicotinic Agonists Muscarinic Agonists Anticholinesterase Related Nictotine Succinylcholine Pilocarpine Bethanecol Reversible Irreversible 2 PAM Physostigmine

More information

Jeopardy Topics: THE CLOT STOPS HERE (anticoagulants) SUGAR, SUGAR, HOW D YOU GET SO HIGH (insulins)

Jeopardy Topics: THE CLOT STOPS HERE (anticoagulants) SUGAR, SUGAR, HOW D YOU GET SO HIGH (insulins) Jeopardy Topics: THE CLOT STOPS HERE (anticoagulants) SUGAR, SUGAR, HOW D YOU GET SO HIGH (insulins) I HEAR YA KNOCKING BUT YOU CAN T COME IN (electrolytes) TAKE MY BREATH AWAY (Opiates-morphine) OUT WITH

More information

Section 02: The Cardiovascular System

Section 02: The Cardiovascular System Section 02: The Cardiovascular System Chapter 15 The Cardiovascular System Chapter 16 Cardiovascular Regulation and Integration Chapter 17 Functional Capacity of the Cardiovascular System HPHE 6710 Exercise

More information

From the Text. History & Development. History & Development. Clinical Indications. Clinical Indications. RSPT 2317 Sympathomimetics - Part 1

From the Text. History & Development. History & Development. Clinical Indications. Clinical Indications. RSPT 2317 Sympathomimetics - Part 1 RSPT 2217 Adrenergic Bronchodilators (Sympathomimetics) Gardenhire Chapter 6 From the Text Key Terms and Definitions Page 104 Current Adrenergic Bronchodilators Table 6-1; page 106 Effects & Characteristics

More information

PACKAGE LEAFLET: INFORMATION FOR THE USER. ADRENALINE (TARTRATE) STEROP 1 mg/1 ml Solution for injection. Adrenaline (Levorenine, Epinephrine)

PACKAGE LEAFLET: INFORMATION FOR THE USER. ADRENALINE (TARTRATE) STEROP 1 mg/1 ml Solution for injection. Adrenaline (Levorenine, Epinephrine) PACKAGE LEAFLET: INFORMATION FOR THE USER ADRENALINE (TARTRATE) STEROP 1 mg/1 ml Solution for injection Adrenaline (Levorenine, Epinephrine) Read all of this leaflet carefully before you start using this

More information

Patentamt JEuropaisches. European Patent Office Office europeen des brevets. @ Publication number: 0 1 2 6 3 2 7 A1

Patentamt JEuropaisches. European Patent Office Office europeen des brevets. @ Publication number: 0 1 2 6 3 2 7 A1 Patentamt JEuropaisches European Patent Office Office europeen des brevets @ Publication number: 0 1 2 6 3 2 7 A1 EUROPEAN PATENT APPLICATION Application number: 84104655.0 Date of filing: 25.04.84 int.

More information

8/6/2010. Name of medication Concentration (1:1,000 or 1mg/1ml) Expiration date

8/6/2010. Name of medication Concentration (1:1,000 or 1mg/1ml) Expiration date Learning Objectives: Anaphylaxis & Epinephrine Administration by the EMT Adapted with permission from the Pilot Project for the Administration of Epinephrine by Washington EMTs With successful completion

More information

Brain & Mind. Bicester Community College Science Department

Brain & Mind. Bicester Community College Science Department B6 Brain & Mind B6 Key Questions How do animals respond to changes in their environment? How is information passed through the nervous system? What can we learn through conditioning? How do humans develop

More information

Dr Kenneth Tan. MBBS MMed(Anaes) MRCP(UK) EDIC FCCP Anesthesia and Intensive Care Services Mount Elizabeth Hospital

Dr Kenneth Tan. MBBS MMed(Anaes) MRCP(UK) EDIC FCCP Anesthesia and Intensive Care Services Mount Elizabeth Hospital Dr Kenneth Tan MBBS MMed(Anaes) MRCP(UK) EDIC FCCP Anesthesia and Intensive Care Services Mount Elizabeth Hospital Adrenergic receptor agnoists Adrenaline Noradernaline Dobutamine Dopamine Phosphodiesterase

More information

BLOCKADE OF THE BIOCHEMICAL CORRELATES OF CONTRACTION AND RELAXATION IN UTERINE AND INTESTINAL SMOOTH MUSCLE*

BLOCKADE OF THE BIOCHEMICAL CORRELATES OF CONTRACTION AND RELAXATION IN UTERINE AND INTESTINAL SMOOTH MUSCLE* BLOCKADE OF THE BOCHEMCAL CORRELATES OF CONTRACTON AND RELAXATON N UTERNE AND NTESTNAL SMOOTH MUSCLE* Theodore M. Brodyt and Jack Diamond$ Department of Pharmacology, University of Michigan Medical School,

More information

Hypertension and Heart Failure Medications. Dr William Dooley

Hypertension and Heart Failure Medications. Dr William Dooley Hypertension and Heart Failure Medications Dr William Dooley Plan Heart Failure Acute vs. chronic Mx Hypertension Common drugs used Method of action Choice of medications Heart Failure Aims; Short term:

More information

VASOPRESSOR AGENTS IN SEPTIC SHOCK

VASOPRESSOR AGENTS IN SEPTIC SHOCK VASOPRESSOR AGENTS IN SEPTIC SHOCK Daniel De Backer Head Dept Intensive Care, CHIREC hospitals, Belgium Professor of Intensive Care, Université Libre de Bruxelles President European Society of Intensive

More information

Routes of Use. Overdose and EMS. Injection. Ingestion. Inhalation. Absorption 1/2/2013. Injection Ingestion Inhalation Absorption.

Routes of Use. Overdose and EMS. Injection. Ingestion. Inhalation. Absorption 1/2/2013. Injection Ingestion Inhalation Absorption. Routes of Use Overdose and EMS Injection Ingestion Inhalation Absorption Shaun Pitts, AEMT Venomous bites Common drugs Heroin Cocaine Meth Injection Ingestion Cleaning solutions Household plants Medications

More information

Additional Supplements

Additional Supplements Additional Supplements The following additional supplements are included here because they are the most popular at this time. This section is not intended as an endorsement to take these products, but

More information

Here is a drug list that you need to know before taking the NREMT-P exam!! Taken from the book EMS NOTES.com

Here is a drug list that you need to know before taking the NREMT-P exam!! Taken from the book EMS NOTES.com Here is a drug list that you need to know before taking the NREMT-P exam!! Taken from the book EMS NOTES.com Special thanks to the number #1 internet training site id44.com and also to (NOTE) Please remember

More information

MEDICATIONS USED IN ADULT CODE BLUE EMERGENCIES. Source: ACLS Provider Manual. American Heart Association. 2001, 2002. Updated 2003.

MEDICATIONS USED IN ADULT CODE BLUE EMERGENCIES. Source: ACLS Provider Manual. American Heart Association. 2001, 2002. Updated 2003. MEDICATIONS USED IN ADULT CODE BLUE EMERGENCIES Source: ACLS Provider Manual. American Heart Association. 2001, 2002. Updated 2003. 1 ET Administration Atropine o First drug for symptomatic sinus bradycardia

More information

Anti-Parkinsonism Drugs

Anti-Parkinsonism Drugs Anti-Parkinsonism Drugs Pharma Team 429 Fahad Alrumaih Ibrahim Alshiddi Sultan Alsalem Ismail Raslan Suhail Asiri Parkinsonism - Could be: primary [idiopathic] or secondary [viral infection or drug induced

More information

Alabama Medications. Christopher J. Colvin January 2010

Alabama Medications. Christopher J. Colvin January 2010 Alabama Medications Christopher J. Colvin p January 2010 Activated Charcoal Used to absorb toxins ingested before they can be absorbed in the GI system. Contraindicated in AMS patients who cannot control

More information