Controlled Release Theory
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1 Controlled Release Theory Last time: tailoring the structure of degradable polymers Fundamental concepts in controlled release Today: Theory of degradable polymer-based controlled release Reading: Charlier et al., Release of mifepristone from biodegradable matrices: experimental and theoretical evaluations, Int. J. Pharm. 200, (2000) ANNOUNCEMENTS: Lecture 4 Spring
2 Last time Lecture 4 Spring
3 Therapeutic index: tailoring materials to provide release kinetics matching the therapeutic window Bolus drug injection: Amount of drug in tissue or circulation time Lecture 4 Spring
4 Mechanisms of controlled release Lecture 4 Spring
5 Drug diffusion-controlled release Advantage: Disadvantages: Lecture 4 Spring
6 Release kinetics for diffusion-controlled release 600 Testosterone Release Rate (mg cm -2 day -1 ) µ 64 µ 132 µ µ Time (days) Release rate of testosterone from cylindrical reservoir devices of different membrane thickness made from silicone rubber. Figure by MIT OCW. (Fan and Singh, 1989) Lecture 4 Spring
7 Release kinetics for diffusion-controlled release Q time Lecture 4 Spring
8 Water-influx controlled release Example: poly(ethylene-co-vinyl acetate) Lecture 4 Spring
9 Regulated/triggered release: mechanical Osmotic engine: (one form) Water driven into engine ; swelling drives piston to push drug out other end Favorable Smix Lecture 4 Spring
10 Regulated/triggered release: mechanical Semipermeable membrane Osmotic engine Piston Drug reservoir Designed to provide continuous release of drugs up to one year Delivery orifice Figure by MIT OCW. Titanium rod casing Lecture 4 Spring
11 eroding matrix Continuous release: Amount of drug released time burst release: Amount of drug released Non-erodible capsule time Lecture 4 Spring
12 eroding matrix Advantages: Disadvantages: Non-erodible capsule Lecture 4 Spring
13 Designing eroding release devices Surface-eroding matrix Protein or Small-molecule drug bulk-eroding matrix Lecture 4 Spring
14 Typical release profiles Surface-eroding matrix Bulk-eroding matrix Poly(dioxepanone-co-lactide) Poly(methyl vinyl ether-co maleic anhydride) Cumulative Hydrocortisone Released (%) Figure by MIT OCW. 20 R = Time (hrs) Amount of Drug Released (%) Time (Days) Release of a therapeutic substance from P(L-LA-co-DXO), PDLLA-PDXO, and PDLLA-PDXO microspheres with a L-LA/DXO molar ratio of 90:10 Garcia, J. T., M.J. Dorta, O. Munguia, M. Lllabres, and J. B. Farina. Figure by MIT OCW. "Biodegradable Laminar Implants for Sustained Release of Recombinant Human Growth Hormone." Biomaterials 23 (2002): Lecture 4 Spring
15 Characteristics of surface vs. bulk-eroding controlled release: (why not always use surface-eroding polymers?) surface erosion: bulk erosion Lecture 4 Spring
16 Surface-eroding matrix Poly(methyl vinyl ether-co maleic anhydride) Bulk-eroding matrix Poly(dioxepanone-co-lactide) Lecture 4 Spring
17 Examination of one approach to drug delivery using eroding matrices in detail: degradable microspheres (1) (2) (3) (4) Lecture 4 Spring
18 imiting factors: ph gradients within degradable devices Fu, K., D. W. Pack, A. M. Klibanov, R. Langer. Visual Evidence of Acidic Environment within Degrading Poly(lactic-co-glycolicacid) (PLGA) Microspheres. Pharm Res. 17, no. 1 (January 2000): Lecture 4 Spring
19 Limiting factors: Contact with hydrophobic surfaces/organic interfaces Lecture 4 Spring
20 Modeling an important controlled release system: single emulsion encapsulation of small molecule drugs in degradable polymers (Edlund 2002) Faisant N., J. Siepmann, and J. P. Benoit. PLGA-based Microparticles: Elucidation of Mechanisms and a New, Simple Mathematical Model Quantifying Drug Release." Eur. J Pharm Sci. 15, no.4 (May 2002): Lecture 4 Spring
21 Theory of controlled release from degradable solids: physical basis of the model Lecture 4 Spring 2006 (Charlier et al. 2000) 21
22 Theory of controlled release from degradable solids: physical basis of the model Lecture 4 Spring 2006 (Charlier et al. 2000) 22
23 Theory of controlled release from degradable solids: physical basis of the model Lecture 4 Spring 2006 (Charlier et al. 2000) 23
24 C 1. List of parameters: Q(t) A device surface area Cs concentration of drug soluble in matrix C 0 initial concentration of drug encapsulated in device M(t) molecular weight of matrix at time t M 0 initial molecular weight of matrix D Diffusion coefficient of drug in polymer matrix h thickness of diffusion region in releasing sample total mass of drug released from dispersed phase from time 0 to time t Amount of drug freed to diffuse as front moves into matrix by dh: 0 x Fick s first law in pseudo-steady-state diffusion region: Lecture 4 Spring
25 Diffusion-controlled release for nondegradable solid: Higuchi equation Lecture 4 Spring
26 Further Reading 1. Kumamoto, T. et al. Induction of tumor-specific protective immunity by in situ Langerhans cell vaccine. Nat Biotechnol 20, 64-9 (2002). 2. Dash, P. R. & Seymour, L. W. in Biomedical Polymers and Polymer Therapeutics (eds. Chiellini, E., Sunamoto, J., Migliaresi, C., Ottenbrite, R. M. & Cohn, D.) (Kluwer, New York, 2001). 3. Baldwin, S. P. & Saltzman, W. M. Materials for protein delivery in tissue engineering. Adv Drug Deliv Rev 33, (1998). 4. Okada, H. et al. Drug delivery using biodegradable microspheres. J. Contr. Rel. 121, (1994). 5. Santini Jr, J. T., Richards, A. C., Scheidt, R., Cima, M. J. & Langer, R. Microchips as Controlled Drug-Delivery Devices. Angew Chem Int Ed Engl 39, (2000). 6. Garcia, J. T., Dorta, M. J., Munguia, O., Llabres, M. & Farina, J. B. Biodegradable laminar implants for sustained release of recombinant human growth hormone. Biomaterials 23, (2002). 7. Jiang, G., Woo, B. H., Kang, F., Singh, J. & DeLuca, P. P. Assessment of protein release kinetics, stability and protein polymer interaction of lysozyme encapsulated poly(d,l-lactide-co-glycolide) microspheres. J Control Release 79, (2002). 8. Edlund, U. & Albertsson, A.-C. Degradable polymer microspheres for controlled drug delivery. Advances in Polymer Science 157, (2002). 9. Siepmann, J. & Gopferich, A. Mathematical modeling of bioerodible, polymeric drug delivery systems. Adv Drug Deliv Rev 48, (2001). 10. Charlier, A., Leclerc, B. & Couarraze, G. Release of mifepristone from biodegradable matrices: experimental and theoretical evaluations. Int J Pharm 200, (2000). 11. Fan, L. T. & Singh, S. K. Controlled Release: A Quan titative Treatment (eds. Cantow, H.-J. et al.) (Springer-Verlag, New York, 1989). Lecture 4 Spring
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