MES. multi-effect still
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1 MES multi-effect still
2 MES multi-effect stills Spirax Sarco's range of multi-effect stills are designed for use within the biopharmaceutical industry and to meet all the requisites that this industry demands. With over 100 years of experience in steam control and heat transfer technology we have the knowledge and expertise to optimize the design of our MES to consistently provide you with pyrogen free pharmaceutical grade Water For Injection. Spirax Sarco's MES will satisfy the requirements of International Pharmacopeia standards, whilst offering you exceptionally low cost of ownership and guaranteed performance. Manufacturing and design standards European Pressure Equipment Directive 97 / 23 / EC ASME - Section VIII Div I Optional FDA 21 CFR Part 11 compliance GAMP Optimised plant steam control and ancillaries cgmp ASME BPE First effect PID level control for safe consistent performance cgmp design and regulatory compliance Unique optimised multi-tube downcomer cgmp double tube sheet heat exchanger on first effect Capacity range from 100 kg / h Designed and manufactured by Spirax Sarco
3 Key features and benefits Key features Key benefit Distillate / WFI production Consistently provides pyrogen free pharmaceutical grade Water For Injection. Produced WFI complies, as a minimum, with USP, EP, JP and other international Pharmacopeia standards. Compliant to all International Pharmacopeia and Standards The MES complies with: US, European and Japanese Pharmacopeia, FDA, ASME BPE and ISPE Baseline Guides. Effects selection based on energy efficency Dedicated software to calculate optimised number of effects for maximised plant steam efficiency. PID level control Unique sanitary PID level control guarantees consistent system efficency and performance. Fully documented factory acceptance test as standard. Full validation documentation available Site acceptance test services available to aid in system commissioning and qualification. Extensive protocol templates for Installation and Qualification activities are available. Spirax Sarco quality components ISO 9001:2008 management system Spirax Sarco components ensure overall system quality / integrity. Spare parts available worldwide with short lead times. High purity team with vast application knowledge and understanding of WFI loop We guarantee to deliver your high grade WFI every time. Part of a dedicated high purity range from Spirax Sarco Providing customers with a single source of supply for all your high purity needs.
4 MES range at a glance Production and consumption When the available steam pressure = 7 bar g Model Number of effects WFI actual production (kg / h) Plant steam consumption (kg / h) MES100 / MES200 / MES400 / MES600 / MES1000 / MES1500 / MES2000 / MES3000 / MES5000 / Please note - Higher capacities and additional effects to further enhance your life cycle costs are available on request, please contact your Spirax Sarco high purity specialist who will be pleased to discuss your requirements. Optimised design Evaporation chamber dimensions optimised for enhanced separation eliminating carryover. Through the employment of specific software calculations your individual requirements are used to ensure the optimal number of effects with increased energy efficency. First effect PID level control guarantees system efficiency and operation consistency throughout the operating range of the unit. Unique column design with external multi-tube configuration maximises heat transfer, increasing the performance and energy efficiency of the unit. Three distinct and optimised separation techniques guarantee the consistent production of pyrogen free pharmaceutical grade Water for Injection.
5 MES operating principles The Spirax Sarco MES employs the multi-effect distillation principle 1. Feedwater is supplied to the first effect column via the distillate cooler and pre-heater double tube sheet heat exchangers. 2. Plant steam is applied to the first effect evaporation column where the feedwater is vaporized and pure steam produced. 3. Pure steam produced inside the first effect is applied to the following effects to preheat and produce pure steam. The condensed pure steam forms the WFI product. 4. Pure steam produced in the final effect is condensed by passing through the feedwater preheater and final cooling heat exchanger. 5. Distillate / WFI is released at the outlet. 4 1 Feedwater Cooling water supply Cooling water return Water for injection Plant steam Water for injection drain Condensate Blowdown MES options To supplement our standard MES we offer pre-engineered options, ensuring a solution specifically optimised for your process. A complete list of available options is detailed within the MES Technical Information (TI) sheet available on our website, alternatively contact your local Spirax Sarco High Purity representative.
6 Group companies Sales offices Distributors Africa Australasia Africa Africa Asia South Africa Americas Argentina Brazil Canada Mexico USA Asia China India Japan Korea Malaysia Singapore Taiwan Thailand Australia New Zealand Europe Austria Belgium Czech Republic Denmark Finland France Germany Italy Norway Poland Portugal Russia Slovak Republic Spain Sweden Switzerland Turkey UK Egypt Kenya Nigeria Americas Colombia Venezuela Asia Hong Kong Indonesia Pakistan Philippines Vietnam Europe Austria Hungary Ireland Middle East UAE Algeria Cameroon Ethiopia Ghana Ivory Coast Libya Malawi Mauritius Morocco Namibia Senegal Sudan Tanzania Tunisia Uganda Zambia Zimbabwe Americas Bolivia Chile Colombia Costa Rica Dominican Republic Ecuador El Salvador Guatemala Honduras Jamaica Nicaragua Panama Paraguay Peru Trinidad and Tobago Uruguay Venezuela Bangladesh Australasia Fiji Europe Bulgaria Croatia Cyprus Estonia Greece Iceland Latvia Lithuania Malta Netherlands Romania Slovenia Middle East Bahrain Iran Israel Jordan Kuwait Lebanon Oman Qatar Saudi Arabia Syria Some products, services or solutions may not be available in certain markets Spirax-Sarco Limited Cheltenham UK GL53 8ER t: +44 (0) f: +44 (0) / industries / pharmaceutical.asp SB-P CH Issue 1 Copyright 2010 Spirax Sarco is a registered trademark of Spirax-Sarco Limited
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