GCT PREMIER MASS SPECTROMETER

Transcription

1 GCT PREMIER MASS SPECTROMETER Do You Need: Wide dynamic range for characterization of complex mixtures? Rapid spectral acquisition rates to profile narrow chromatographic peaks? Highly specific exact mass measurement for structural elucidation? Selectivity of high resolution to provide low determination limits? High sensitivity full scan spectra to maximize sample information? A comprehensive suite of post-processing software to maximize productivity and information output? Take GC/MS to the Highest Level The Waters Micromass GCT Premier Mass Spectrometer combines the proven elevated resolution and exact mass performance of the classic GCT with extended dynamic range. These unmatched capabilities (in addition to the high full scan sensitivity and rapid spectral acquisition rates) are ideal for full characterization and profiling of components in a whole range of sample types. Use the GCT Premier for Characterization and Profiling in the following Application Areas: Metabolomics Metabonomics Synthetics confirmation and QC Natural products research Pesticide residues monitoring Unknown environmental contaminants ID Food research and QC Flavors and fragrances research and QC Material emissions monitoring and research Homeland security chemical monitoring Polymer research Petrochemicals Materials research and monitoring Waters Micromass GCT Premier Mass Spectrometer

2 Enhance Your Lab s GC/MS Capabilities with the GCT Premier Technology Platform Increase Productivity with Rapid Spectral Sampling and Acquisition Rate The GCT Premier is a powerful orthogonal acceleration time-of-flight (oa-tof) GC/MS that offers fast acquisition of full spectrum data Maximize Detection Capabilities with Dynamic Range Enhancement (DRE) with high sensitivity, extended dynamic range and elevated resolution. The GCT Premier s elevated resolution minimizes the likelihood The advantage of the full mass range spectra produced by the spectral skew associated with scanning instruments, which means that accurate spectra and quantitative of mass interference. Exact mass capability, which leads to elemental composition determination, offers another dimension over GCT Premier enables a wide range of components, both known data can be obtained with fewer scans over the chromatographic peak. In addition, the high spectral acquisition rate traditional GC/MS. and unknown, to be detected with high sensitivity. Full mass range (up to 20 spectra per second) enables narrow chromatographic peaks to be processed. In combination with Waters spectra are beneficial when trying to characterize samples in terms deconvolution algorithm, pure spectra can be obtained from partially co-eluting components in complex chromatograms. With the GCT Premier, your lab will benefit from: of identity and quantity. Compact Size: Powerful oa-tof with reflectron technology The extended dynamic range of the GCT Premier delivers up to four The GCT Premier samples the source ion beam at 25,000 times per second. This eliminates the orders of magnitude for exact mass measurement and quantitative minimizing linear bench space without sacrificing performance studies allowing you to maximize information produced from a Elevated Resolution: 7000 FWHM single analysis. Exact Mass Measurement: Sub-5 ppm RMS with internal lock Figure 3. This example of hexachlorobenzene (500 fg to 8 ng on column) demonstrates >4 orders of linear mass correction dynamic range with DRE enabled. Sensitivity: High duty cycle compared to scanning instruments providing low- and sub-picogram sensitivity with full spectra Dynamic Range: Enhanced up to four orders for both exact measurement and quantitative analysis High Spectral Sampling Rate: Ion beam sampled up to 25,000 times per second eliminating spectral skew associated with Figure 1. Proven oa-tof technology in a compact bench top traditional scanning instruments GC/MS system. High Spectral Acquisition Rate: Up to 20 spectra per second can be acquired to disk, enabling narrow chromatographic peaks to be accommodated and enhancing the performance of spectral deconvolution routines Versatile Range of Sources and Probes: A full range of source and probe options are available, including Electron Impact (EI), Chemical Ionization (CI), Desorption Chemical Ionization (DCI), Field Ionization (FI), Field Desorption (FD) and Direct Insertion Probe (DIP) Compound 1 thujopsene GC and AutoSampler Control: Integrated control of Agilent 6890N GC and Agilent 7683, and CTC-GCPal and CTCCombiPal autosamplers ChromaLynx Application Manager: Facilitates the rapid detection, identification and semi-quantitative determination of components Figure 2. Exact mass MS measurement enables compounds in complex mixtures while enabling the comparison of sample to be more easily identified. Confirming a measured m/z to and control extracts within 5 ppm significantly increases confidence in assigning MarkerLynx db Application Manager: Dynamic statistical elemental composition. processing and visualization of complex data sets for metabolomic and metabonomic applications TargetLynx Application Manager: Dedicated target compound quantitation software allowing easy method setup and a full range of regulatory QC checks OpenLynx Compound 2 fruitate Compound 3 cyclamen aldehyde Application Manager: Automated exact mass processing for batch confirmation of synthetics Figure 4. Example of spectral deconvolution of overlapping peaks in a complex chromatogram. This processing was performed Figure 5. Illustration of the absence of spectral skew from the GCT Premier Mass using ChromaLynx Application Manager. Spectrometer as chromatographic intensity changes.

3 Enhance Your Lab s GC/MS Capabilities with the GCT Premier Technology Platform Increase Productivity with Rapid Spectral Sampling and Acquisition Rate The GCT Premier is a powerful orthogonal acceleration time-of-flight (oa-tof) GC/MS that offers fast acquisition of full spectrum data Maximize Detection Capabilities with Dynamic Range Enhancement (DRE) with high sensitivity, extended dynamic range and elevated resolution. The GCT Premier s elevated resolution minimizes the likelihood The advantage of the full mass range spectra produced by the spectral skew associated with scanning instruments, which means that accurate spectra and quantitative of mass interference. Exact mass capability, which leads to elemental composition determination, offers another dimension over GCT Premier enables a wide range of components, both known data can be obtained with fewer scans over the chromatographic peak. In addition, the high spectral acquisition rate traditional GC/MS. and unknown, to be detected with high sensitivity. Full mass range (up to 20 spectra per second) enables narrow chromatographic peaks to be processed. In combination with Waters spectra are beneficial when trying to characterize samples in terms deconvolution algorithm, pure spectra can be obtained from partially co-eluting components in complex chromatograms. With the GCT Premier, your lab will benefit from: of identity and quantity. Compact Size: Powerful oa-tof with reflectron technology The extended dynamic range of the GCT Premier delivers up to four The GCT Premier samples the source ion beam at 25,000 times per second. This eliminates the orders of magnitude for exact mass measurement and quantitative minimizing linear bench space without sacrificing performance studies allowing you to maximize information produced from a Elevated Resolution: 7000 FWHM single analysis. Exact Mass Measurement: Sub-5 ppm RMS with internal lock Figure 3. This example of hexachlorobenzene (500 fg to 8 ng on column) demonstrates >4 orders of linear mass correction dynamic range with DRE enabled. Sensitivity: High duty cycle compared to scanning instruments providing low- and sub-picogram sensitivity with full spectra Dynamic Range: Enhanced up to four orders for both exact measurement and quantitative analysis High Spectral Sampling Rate: Ion beam sampled up to 25,000 times per second eliminating spectral skew associated with Figure 1. Proven oa-tof technology in a compact bench top traditional scanning instruments GC/MS system. High Spectral Acquisition Rate: Up to 20 spectra per second can be acquired to disk, enabling narrow chromatographic peaks to be accommodated and enhancing the performance of spectral deconvolution routines Versatile Range of Sources and Probes: A full range of source and probe options are available, including Electron Impact (EI), Chemical Ionization (CI), Desorption Chemical Ionization (DCI), Field Ionization (FI), Field Desorption (FD) and Direct Insertion Probe (DIP) Compound 1 thujopsene GC and AutoSampler Control: Integrated control of Agilent 6890N GC and Agilent 7683, and CTC-GCPal and CTCCombiPal autosamplers ChromaLynx Application Manager: Facilitates the rapid detection, identification and semi-quantitative determination of components Figure 2. Exact mass MS measurement enables compounds in complex mixtures while enabling the comparison of sample to be more easily identified. Confirming a measured m/z to and control extracts within 5 ppm significantly increases confidence in assigning MarkerLynx db Application Manager: Dynamic statistical elemental composition. processing and visualization of complex data sets for metabolomic and metabonomic applications TargetLynx Application Manager: Dedicated target compound quantitation software allowing easy method setup and a full range of regulatory QC checks OpenLynx Compound 2 fruitate Compound 3 cyclamen aldehyde Application Manager: Automated exact mass processing for batch confirmation of synthetics Figure 4. Example of spectral deconvolution of overlapping peaks in a complex chromatogram. This processing was performed Figure 5. Illustration of the absence of spectral skew from the GCT Premier Mass using ChromaLynx Application Manager. Spectrometer as chromatographic intensity changes.

4 Enhance Your Lab s GC/MS Capabilities with the GCT Premier Technology Platform Increase Productivity with Rapid Spectral Sampling and Acquisition Rate The GCT Premier is a powerful orthogonal acceleration time-of-flight (oa-tof) GC/MS that offers fast acquisition of full spectrum data Maximize Detection Capabilities with Dynamic Range Enhancement (DRE) with high sensitivity, extended dynamic range and elevated resolution. The GCT Premier s elevated resolution minimizes the likelihood The advantage of the full mass range spectra produced by the spectral skew associated with scanning instruments, which means that accurate spectra and quantitative of mass interference. Exact mass capability, which leads to elemental composition determination, offers another dimension over GCT Premier enables a wide range of components, both known data can be obtained with fewer scans over the chromatographic peak. In addition, the high spectral acquisition rate traditional GC/MS. and unknown, to be detected with high sensitivity. Full mass range (up to 20 spectra per second) enables narrow chromatographic peaks to be processed. In combination with Waters spectra are beneficial when trying to characterize samples in terms deconvolution algorithm, pure spectra can be obtained from partially co-eluting components in complex chromatograms. With the GCT Premier, your lab will benefit from: of identity and quantity. Compact Size: Powerful oa-tof with reflectron technology The extended dynamic range of the GCT Premier delivers up to four The GCT Premier samples the source ion beam at 25,000 times per second. This eliminates the orders of magnitude for exact mass measurement and quantitative minimizing linear bench space without sacrificing performance studies allowing you to maximize information produced from a Elevated Resolution: 7000 FWHM single analysis. Exact Mass Measurement: Sub-5 ppm RMS with internal lock Figure 3. This example of hexachlorobenzene (500 fg to 8 ng on column) demonstrates >4 orders of linear mass correction dynamic range with DRE enabled. Sensitivity: High duty cycle compared to scanning instruments providing low- and sub-picogram sensitivity with full spectra Dynamic Range: Enhanced up to four orders for both exact measurement and quantitative analysis High Spectral Sampling Rate: Ion beam sampled up to 25,000 times per second eliminating spectral skew associated with Figure 1. Proven oa-tof technology in a compact bench top traditional scanning instruments GC/MS system. High Spectral Acquisition Rate: Up to 20 spectra per second can be acquired to disk, enabling narrow chromatographic peaks to be accommodated and enhancing the performance of spectral deconvolution routines Versatile Range of Sources and Probes: A full range of source and probe options are available, including Electron Impact (EI), Chemical Ionization (CI), Desorption Chemical Ionization (DCI), Field Ionization (FI), Field Desorption (FD) and Direct Insertion Probe (DIP) Compound 1 thujopsene GC and AutoSampler Control: Integrated control of Agilent 6890N GC and Agilent 7683, and CTC-GCPal and CTCCombiPal autosamplers ChromaLynx Application Manager: Facilitates the rapid detection, identification and semi-quantitative determination of components Figure 2. Exact mass MS measurement enables compounds in complex mixtures while enabling the comparison of sample to be more easily identified. Confirming a measured m/z to and control extracts within 5 ppm significantly increases confidence in assigning MarkerLynx db Application Manager: Dynamic statistical elemental composition. processing and visualization of complex data sets for metabolomic and metabonomic applications TargetLynx Application Manager: Dedicated target compound quantitation software allowing easy method setup and a full range of regulatory QC checks OpenLynx Compound 2 fruitate Compound 3 cyclamen aldehyde Application Manager: Automated exact mass processing for batch confirmation of synthetics Figure 4. Example of spectral deconvolution of overlapping peaks in a complex chromatogram. This processing was performed Figure 5. Illustration of the absence of spectral skew from the GCT Premier Mass using ChromaLynx Application Manager. Spectrometer as chromatographic intensity changes.

5 Additional Techniques Provide Enhanced Versatility The variety of ionization and probe techniques available on the GCT Premier Mass Spectrometer maximizes the amount of information that can be obtained across a wide range of sample types. Figure 6. EI and CI are complementary techniques, providing structural and molecular weight information. Figure 7. FI is the softest ionization technique for generating molecular weight information on most compound types. Figure 8. DCI is a softer alternative to solids probe CI for thermally labile compounds. The molecular ion can be seen at m/z 380.

6 Waters: For Complete Confidence Waters Corporation is the world's leading provider of instruments, chemistries, software, and support services for chromatography, mass spectrometry, thermal analysis and laboratory informatics. For more than 45 years, Waters has been supplying scientists with the analytical tools that allow them to better understand the secrets of chemistry and of life itself. Around the globe, Waters systems and solutions are used by pharmaceutical, life science, proteomics, food and beverage, environmental, clinical, industrial, and biotechnology researchers to push the boundaries of analytical science. To learn more visit Sales Offices: Austria Australia Belgium and Luxembourg Brazil Canada X2205 Czech Republic Denmark Finland France Germany Hong Kong Hungary India Ireland Italy Japan Korea Mexico The Netherlands Norway People s Republic of China Poland Puerto Rico Russia/CIS Singapore Spain Sweden Switzerland Taiwan UK US WATERS CORPORATION 34 Maple St. Milford, MA U.S.A. T: F: Waters, GCT, GCT Premier, ChromaLynx, MarkerLynx, TargetLynx, OpenLynx and Connections are trademarks of Waters Corporation. All other trademarks are property of their respective owners Waters Corporation Printed in the U.S.A. June EN AG&LW-CV