Goitre prevalence (%) Grade 1. Grade 2. TGP < >300 <100 Median Mean

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1 Vitamin and Mineral Nutrition Information System (VMNIS) WHO Global Database on Iodine Deficiency The database on iodine deficiency includes data by country on goitre prevalence and/or urinary iodine concentration Last Updated: Level Date Region and sample descriptor Sex Age (years) Sample size 1 Goitre prevalence (%) 2 Urinary iodine (µg/l) Distribution (%) Prevalence (%) TGP < >300 <100 Median Mean S 2000 North department: Infants/Pre-SAC: Total B Infants B Infants/Pre-SAC B Pre-SAC B N 1996 SU.VI.MAX Cohort: Women: Total F SU.VI.MAX Cohort: Men: Total M Women by region: Bourgogne F NS 78.0 Women by region: Bretagne F NS 84.0 Women by region: Ile de France F NS 84.0 Women by region: Rhone-Alpes F NS 71.0 Women by regions: Alsace/Lorraine/Frache-Comt F NS 75.0 Women by regions: Auvergne/Limousin F NS 67.0 Women by regions: Haute/Basse Normadie F NS 85.0 Women by regions: Nord-Pas-de-Calais/Picardie F NS 86.0 Women by regions: PACA/Languedoc-Roussillon F NS Women by regions: Poitou-Charentes/Aquitaine/M F NS 83.0 Men by region: Bourgogne M NS 85.0 Men by region: Bretagne M NS 96.0 Men by region: Ile de France M NS 88.0 Men by region: Rhone-Alpes M NS 74.0 Men by regions: Alsace/Lorraine/Frache-Comté/C M NS 75.0 Men by regions: Auvergne/Limousin M NS 76.0 Men by regions: Haute/Basse Normadie M NS 88.0 Men by regions: Nord-Pas-de-Calais/Picardie M NS 96.0 Men by regions: PACA/Languedoc-Roussillon M NS Men by regions: Poitou-Charentes/Aquitaine/Midi- M NS 89.0 SU.VI. MAX Cohort: Women F SU.VI. MAX Cohort: Men M R 1994 ThyroMobil study 4 regions: SAC: Total B SAC by region: Languedoc-Roussillon B SAC by region: Lorraine B SAC by region: Midi-Pyrénées B SAC by region: Rhone-Alpes B SAC by city: Albi B SAC by city: Artemare B SAC by city: Bagnols/ceze B SAC by city: Epinal B SAC by city: Foix B SAC by city: Gignac B SD Reference Notes General Line

2 Vitamin and Mineral Nutrition Information System (VMNIS) WHO Global Database on Iodine Deficiency The database on iodine deficiency includes data by country on goitre prevalence and/or urinary iodine concentration Last Updated: Level Date Region and sample descriptor Sex Age (years) Sample size 1 Goitre prevalence (%) 2 Urinary iodine (µg/l) Distribution (%) Prevalence (%) TGP < >300 <100 Median Mean R 1994 SAC by city: Ligny en Barrois B SAC by city: Lyon B SAC by city: Mende B SAC by city: Meyzieu B SAC by city: Nancy B SAC by city: Port Vendres B SAC by city: Rodez B SAC by city: Toulouse B SAC by city: Uckange B L 1994P Paris: Infants B Paris: Pre-SAC by age B Paris: Pre-SAC by age B L Southwest France: PW F Southwest France: PW F L Commune d'arsac-en-velay: Adults B NS a 22 Canton de Bess-en-Chandesse: Adults B NS Canton de Bess-en-Chandesse: Adults: Total B NS Commune d'arsac-en-velay: Adults: Total B NS Women by canton: Bess-en-Chandesse F NS Women by commune: Arsac-en-Velay F NS Men by canton: Bess-en-Chandesse M NS Men by commune: Arsac-en-Velay M NS R Auvergne Region: SAC: Total B b 24 SAC by department: Allier B SAC by department: Cantal B SAC by department: Haute-Loire B SAC by department: Puy-de-Dôme B Auvergne region: SAC: Total B SAC by department: Allier B SAC by department: Cantal B SAC by department: Haute-Loire B SAC by department: Puy-de-Dôme B SD Reference Notes General Line

3 NOTES Reference no 4755 General Notes: Facility based study (primary health care centres); sample selected from 5 health care centres in the Notrth department. Line note 1 Mean age: 17.7 months. Reference no 1269 General Notes: Cross-sectional survey of a sample of the SU.VI.MAX Cohort, reference No reports UI and thyroid volume (ultrasonography) in a subsample. Line note 2 PACA = Provence-Alpes-Cote-d'Azur Line note 3 PACA = Provence-Alpes-Cote-d'Azur Reference no 1329 General Notes: Sample comprised SAC from 4 regions (Rhone-Alpes, Lorraine, Midi-Pyrénées and Languedoc-Roussillon); data extracted from reference No. 1329, 1319 and Line note 4 UI median range: µg/l Line note 5 Midi-Pyrénées region. Line note 6 Rhone-Alpes region. Line note 7 Languedoc-Roussillon region. Line note 8 Lorraine region. Line note 9 Midi-Pyrénées region. Line note 10 Languedoc-Roussillon region. Line note 11 Lorraine region. Line note 12 Rhone-Alpes region. Line note 13 Languedoc-Roussillon region. Line note 14 Rhone-Alpes region. Line note 15 Lorraine region. Line note 16 Languedoc-Roussillon region. Line note 17 Midi-Pyrénées region. Line note 18 Midi-Pyrénées region. Line note 19 Lorraine region. Reference no 5140 General Notes: Facility based study (children's health examination centre); subjects randomly selected among children undergoing free medical check-up in the Paris area; same survey reported in reference No Reference no 3851 General Notes: Facility-based cohort study with a total of 347 consecutive pregnant women, enrolled between July 1993 and April 1994; subjects were seen in at the out patients department of hospitals or private clinics located in nine cities (Albi, Cahors, Castres, Foix, Lavaur, Motauban, Rodez, Saint Gaudens and Toulouse). Line note 20 PW during the first trimester. Line note 21 PW at ninth month of pregnancy. Reference no 1330a General Notes: Sample comprised subjects from the commune d'arsac-en-velay, Haute-Loire department and canton de Bess-en-Chandesse, Puy-de-Dome department, Auvergne region.

4 Line note 22 Line note 23 Reference no General Notes: Line note 24 Line note 25 Line note 26 Line note 27 Line note 28 UI mean (SD): (41.77) µg/g Cr UI mean (SD): (33.48) µg/g Cr 1330b Sample comprised SAC from the region of Auvergne (study related to the National French School Children Study); UI expressed in µg/g creatinine, values reported in the respective line notes. UI mean (SD): 62.9 (34.3) µg/g Cr UI mean (SD): 64 (44.3) µg/g Cr UI mean (SD): 73.3 (38.3) µg/g Cr UI mean (SD): 51.3 (15.5) µg/g Cr UI mean (SD): 64.4 (32.3) µg/g Cr

5 Reference 1269 Reference 1329 Reference 1330 Reference 3851 Reference 4755 Reference 5140 R E F E R E N C E S Valeix P, Zarebska M, Preziosi P, Galán P, Pelletier B, Hercberg S. Iodine deficiency in France. Lancet, 1999, 353 : Caron P, Jaffiol C, Leclere J, Orgiazzi J, Delange F. Apport iodé en France: résultats nationaux du projet thyromobile dans un population d'enfants scolarisés de 6 à 14 ans [Iodine consumption in France: national results of the Thyromobile project in a population of schoolchildren aged 6-14 years]. Annales d'endocrinologie, 1996, 57 : Thieblot P, Samrani J, Tauveron I. Epidémiologie du goitre en Auvergne [Epidemiology of goiter in Auvergne]. Annales d'endocrinologie, 1992, 53 : Caron P, Hoff M, Bazzi S, Dufor A, Faure G, Ghandour I, Lauzu P, Lucas Y, Maraval D, Mignot F, Ressigeac P, Vertongen F, Grange V. Urinary iodine excretion during normal pregnancy in healthy women living in the southwest of France: correlation with maternal thyroid parameters. Thyroid, 1997, 7 : Pouessel G, Bouarfa K, Soudan B, Sauvage J, Gottrand F, Turck D. Statut en iode et facteurs de risque e déficit en iode chez des enfants vus en consultation de protection maternelle et infantile dans le départment du Nord [Iodine nutritional status and risk factors for iodine deficiency in infants and children of the french North department]. Archives de Pédiatrie, 2003, 10 : Valeix P, Preziosi P, Rossignol C, Farnier MA, Hercberg S. Relationship between urinary iodine concentration and hearing capacity in children. European Journal of Clinical Nutrition, 1994, 48 :54-59.

6 ADDITIONAL REFERENCES Reference 228 Reference 536 Reference 545 Reference 1270 Reference 1271 Reference 2142 Reference 5141 Mornex R, Boucherat M, Lamand M, Tressol JC, Jaffiol C. Goitre prevalence and salt iodization in France. In: Delange F et al., eds. Iodine deficiency in Europe. A continuing concern. New York, Plenum Press, 1993 : Mornex R. Enquête sur la prévalence du goitre en France [Survey of goiter prevalence in France]. Bulletin de l'académie Nationale de Médecine, 1987, 171 : Blum CJ, Lafont C, Ducasse M, Hoff M, Labarre I, Bayard F, Albarede JL. Thyroid function tests in ageing and their relation to associated nonthyroidal disease. Journal of Endocrinological Investigation, 1989, 12 : Barrère X, Valeix P, Preziosi P, Bensimon M, Pelletier B, Galán P, Hercberg S. Determinants of thyroid volume in healthy French adults participating in the SU.VI.MAX cohort. Clinical Endocrinology, 2000, 52 : Jaffiol C, Gobert M, Cailhol A, Baylet R, Baldet L, Lachiver F, Chapate M, Mirouze J. Étude approfondie complémentaire d'une enquête épidémiologique réalisée en milieu scolaire sur la fréquence du goitre et la carence iodée en Languedoc-Roussillon [Supplemental in-depth study of an epidemiological survey performed in a school environment on the occurrence of goiter and iodine deficiency in Languedoc-Roussillon]. Bulletin de l'académie Nationale de Médecine, 1987, 171 : Valeix P, Preziosi P, Rossignol C, Farnier MA, Hercberg S. Iodine intakes assessed by urinary iodine concentrations in healthy children aged ten months, two years, and four years. Biological Trace Element Research, 1992, 32 : Agence Française de Securite Sanitaire des Aliments. Évaluation de l'mpact nutritionnel de l'introduction de composés iodés dans les produits agroalimemtaires. France, Agence Française de Securite Sanitaire des Aliments., 2005.