Thermo Scientific ISQ Single Quadrupole GC-MS

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1 c h r o m a t o g r a p h y Thermo Scientific ISQ Single Quadrupole GC-MS Unstoppable productivity Part of Thermo Fisher Scientific

2 Thermo Scientific ISQ Single Quadrupole GC-MS The Ideal Solution for Truly Unstoppable GC-MS Productivity Let s face it. The reality of using GC-MS systems for analysis of samples clean, dirty, complex, or routine means that your system will get dirty. Stopping to clean the instrument means lost time, lost money, and lost resources. Even scheduled maintenance means rearranging priorities and shifting of work to take care of the cleaning. It s a day of work, gone. Not anymore. Re-think the way your lab operates with the Thermo Scientific ISQ single quadrupole GC-MS system. The ISQ GC-MS incorporates a new source design that lets your system stay cleaner, longer. With heat throughout the ion optics, the ISQ can analyze more dirty samples per day, with maximum uptime. Better yet, when the instrument finally requires cleaning, the new source design can be fully removed including all of the lenses and the repeller through the front vacuum interlock, without venting the system. This lets you clean your source, swap it, or change ionization type, and be ready to run samples within minutes, not hours or days. Why break your workflow when you can have unstoppable productivity? Innovation with a Purpose Your Lab s Success Today s technology is changing fast, and your lab is changing too. The ISQ represents a new design, not an incremental improvement, and it includes the latest in today s technology and knowhow. With the ISQ, there is no need to buy different GC-MS systems from different vendors to perform different tasks. The ISQ delivers excellent performance for routine GC-MS analyses, while incorporating innovative advances that allow you to easily expand your lab s test ranges or incorporate new sample analysis techniques. This innovation lies in the new ExtractaBrite source, the heart of the ISQ mass spectrometer. The Heart of the ISQ The ISQ is designed to stay cleaner, longer, to maximize your instrument s uptime and improve your lab s productivity. The need to break vacuum, cool off your system, and spend hours cleaning, reassembling, and restoring the system is gone. The heated ion volume, lens stack, and ion optics path in the ISQ ensure that the system stays cleaner longer, but when the system no longer meets your analytical needs, restoring performance is quick and easy. The ExtractaBrite source incorporates a cartridge that contains the repeller, source lenses, and RF lens, all of which can be removed from the instrument while still under vacuum. What once took hours, or even an entire day, is now accomplished in minutes. ISQ Feature Benefits Extend instrument uptime with unique Full Source Removal for continuous day-in, day-out operation Improve sample throughput using the industry's fastest scan rate across a usable mass range for use with today s high-performance gas chromatographs Extended mass range for analytical versatility Sequential Full Scan/SIM for confirmation and screening in the same analysis

3 QUICK LINKS Advanced Technology, Routine Applications The ISQ single quadrupole mass spectrometer consists of the ExtractaBrite source, S-shaped ion guide, solid metal quadrupole rods, and the Thermo Scientific DynaMax XR detection system. This powerful combination provides a system that gives you unmatched analytical performance with the benefit of extending the time between instrument maintenance cycles. Heat Right Where it Belongs The entire ion source and lens stack is heated, not just the ion volume. More heat equals more robustness. Plus, the S-Shaped ion guide protects the analyzer rods from contamination. There is no need to worry about cleaning, heating, or replacing the rod set it is not subject to contamination. Performance without Compromise Excellent sensitivity in all modes of analysis Page 4 ExtractaBrite Source Inert, high-temperature source for excellent transmission and robustness Page 6 Extended Mass Range u with unit mass resolution throughout the range Page 7 DynaMax XR Detection System Broadest electronic dynamic range in the industry Page 7 Time to Clean? No Time Lost! The ExtractaBrite source features a hightemperature source and independently heated lenses. The cartridge source includes the repeller, ion volume, lenses and RF lens. This entire cartridge can be removed from the front of the ISQ without breaking the system vacuum. Fully restore instrument performance in minutes. Software that Works for You Software solutions to streamline workflows Page 8 GC and Autosampler Options Flexible, efficient and powerful sample introduction and separation Page 10 Analytical Flexibility and Versatility Options for applications from research to routine Page 11 GC-MS Columns and Supplies High-quality Thermo Scientific and certified supplies for optimal analytical results Page 13

4 Thermo Scientific ISQ Single Quadrupole GC-MS The Right GC-MS System for Today s Challenges, Tomorrow s Opportunities Ease of Use Built Right In The ISQ GC-MS system is designed to easily fit into your laboratory s workflows. Easy to learn, easy to use, and easy to maintain the ISQ was developed to meet the needs of the modern analytical laboratory. Whether you re upgrading from GC detectors to GC-MS, adding a new system to your lab, or just getting started with GC-MS, the ISQ offers the right mix of power and simplicity. Rugged enough for demanding 24/7 operations, the ISQ also provides for future growth and expansion by being easily upgradeable. This flexibility means that your investment is protected, and your lab s ability to change to meet changing environments is assured. Extended Mass Range More Compounds to Cover The ISQ offers an extended mass range, from 1.2 to 1100 u. This wide mass range means that your lab can perform analyses across the broadest range of compounds. Because the ISQ is compatible with direct sample introduction, you are not limited to the mass range of compounds that are GC-able, allowing you to further exploit this mass range. Decabromobiphenyl Enhanced Transferline Design The ISQ features an optimized GC-MS interface. This transferline evenly distributes heat across the length of the analytical column, ensuring that there are no hot or cold spots, which in turn delivers Gaussian peak shapes, even for high-boiling compounds. Decabromobiphenyl ether Decabromobiphenyl and decabromobiphenyl ether, demonstrating excellent peak shape

5 Meet Demanding Performance Requirements, Day In and Day Out What do you give up when you move to unstoppable productivity? With the ISQ you don t have to compromise performance for productivity. Today s GC-MS assays demand ultimate sensitivity for meeting strict regulatory guidance, so the ISQ offers unbeatable performance in all modes of analysis. No Noise is Good Noise Achieving lower detection limits using a single quadrupole GC-MS requires breaking boundaries of noise chemical noise, electronic noise, and neutral noise. Chemical noise and neutral noise contribute to higher backgrounds and affect detectability the ability to distinguish a low-concentration target from noise. The ISQ design reduces chemical and neutral noise, allowing for lower detection limits and improved sensitivity. Excellent Sensitivity Unparalleled Robustness Easily meet your required detection limits, and consistently meet them even as you continue to run samples. It s not only about how sensitive your system is when it first arrives, but how long you can continue to achieve your required performance levels that is the true measure of productivity. Heated ion optic zones in the ISQ help ensure that the system stays cleaner for a longer period of time. ISQ Features Mass range from u Vacuum interlock for Full-Source Removal without venting S-Shaped Ion Guide for noise reduction ExtractaBrite source for analytical robustness and flexibility Fast acquisition rates compatible with high-speed gas chromatography Removable cartridge source design for quick maintenance or to easily change ionization modes Sequential full scan/sim for qualitative and quantitative analysis in a single injection Dual filament with fine-tuned control for reliable operation QuanLab Forms layered application software for easy acquisition, review and reporting of GC-MS data Analytical Flexibility EI mode for unknown analysis the standard for GC-MS acquisitions Chemical ionization, including PCI for molecular weight confirmation, NCI for enhanced selectivity and sensitivity, with PPINICI standard for alternating PCI and NCI scans in a single injection Expanded Capabilities Liquid and headspace autosampler options DEP/DIP direct sample probes Range of injection port options, all with large volume injection capabilities EnviroLab Forms and ToxLab Forms for workflow-oriented data acquisition, review and reporting according to specific market needs Choice of gas chromatographs to match GC performance to the analytical needs of your lab Compatible with additional sample introduction techniques, such as thermal desorption, purge and trap and solid phase microextraction (SPME)

6 Thermo Scientific ISQ Single Quadrupole GC-MS Design Innovations that Work for You Tapping into advanced technology to streamline day-to-day operations The ISQ GC-single quadrupole MS has been designed to be at its heart a true workhorse for your laboratory. Rugged components, simplified access, and streamlined tool requirements are all incorporated into the ISQ to make the system easy to use, simple to maintain, and ideal for your GC-MS analysis needs from research to routine. Full Source Removal for Easy Maintenance The ExtractaBrite source incorporates a source cartridge that contains the repeller, lens stack, and RF lens, all of which can be removed from the instrument while still under vacuum. What once took hours, or even an entire day, is now accomplished in minutes. The cartridge source allows you to change ionization modes from electron ionization (EI) to chemical ionization (CI) and back again without shutting off your system. Why compromise EI or CI performance using a source that isn t optimized for your ionization mode when you can simply change sources in minutes? Unique Dual-Filament Design The ISQ offers a dual filament for extended operation and lifetime. The unique design of the filament in the ISQ ensures that both filaments offer similar analytical performance. The filaments are oriented in the same direction for improved performance and are protected by an electron lens. Your analyses do not pay a price for switching from one filament to the next. In addition, filament current at lower settings is more tightly regulated, for better accuracy and increased dynamic range. Go Wireless The cartridge source eliminates the hassle of connecting and disconnecting wires when maintaining your ion source. Secure electrical connections with the ion optics offer consistent connections, wirelessly. There is no need to inspect the source to confirm that the wires are in the correct location, or to remember which lead goes where just insert the cartridge and go. On-Axis (in-line) Optics noise reduced to ~2 ions/sec Noise reduction due to off-axis ion optics S-shaped Ion Guide Reduces Excited Helium Noise Off-axis optics combined with a unique s-shaped ion guide (SSIG) dramatically reduce the effects of excited helium neutrals reaching the detector by creating a path that the neutrals cannot navigate. The ISQ offers improved detectivity without reducing the available dynamic range of the instrument and without affecting the spectral data generated. Off-Axis Optics

7 Scan Fast, Across a Useful Mass Range Fast scan rates on a GC-MS system sound good, until you run into analytical limits on the utility of these faster scan rates. The ISQ features fast electronics that write data to disc nearly as fast as it can be acquired, so your applications are limited more by the physics of ion flight time, not the instrument s electronics. Mass spectra generated at high scan rates are comparable to those created at slower scan rates, meaning that you ll be able to confidently identify compounds using standard library searching. Unsurpassed Detector Dynamic Range The ISQ detection system was designed to provide a broad dynamic range to cover concentrations that could vary widely from sample to sample. Within a day s batch, unknown concentrations can be either very low, approaching the detection limits, or very high, pushing the capability of both the analytical column and the mass spectrometer. The detection system is modular to facilitate quick, easy, and cost effective replacement of the multiplier element over the life of the instrument. The conversion dynode and associated ion optics remain a permanent part of the instrument. Only the multiplier module is replaced. The mounting is designed to insure proper alignment for maximum performance. The multiplier itself is a discretedynode device which enables maximum dynamic range while reducing noise. High scan rates for quantitative precision and fast throughput Excellent analytical linearity reduces re-analysis needs Wide mass range covers broad application needs

8 Thermo Scientific ISQ Single Quadrupole GC-MS Maximize Productivity with Workflow-Oriented Software Options Designed for routine GC-MS analyses, to improve efficiency and productivity Lab Forms Software Packages The ISQ GC-MS system offers reliable, robust performance, ideally suited for GC-MS applications from research to routine. Thermo Scientific Lab Forms applications QuanLab Forms, EnviroLab Forms and ToxLab Forms complement routine GC-MS applications and streamline your workflows. Lab Forms Core Capabilities The Lab Forms packages offer common user tools that simplify workflows and make getting from sample to result easier and more efficient. Easy Navigation A dashboard guides users to their activities to move quickly to the desired mode. Configure and customize the application, develop and create methods, or focus on daily production to program batches, review data, and generate reports. User Role Capabilities Optional user roles allow you to control access to program settings and functions based on the user s job types. This allows simplified routine workflows and protects methods and data from inadvertent changes. Active Reporting Where the Lab Forms software packages truly redefine workflows is with a revolutionary approach to data review and reporting. Through powerful Smart Reporting, data review and data reporting are dynamically linked in Active View, allowing for real-time changes to the reports based on changes to the data. Any changes to data are immediately reflected in the report no reprocessing, no reanalyzing the data. Manual integrations are flagged for auditing purposes, so a record is kept of the changes made to the batch. Custom Reports Lab Forms software offers the ability to use custom reporting by creating special Microsoft Excel reports. These custom reports can be automated at a batch or sample level, using the same processes as the integrated standard reports. Simplified workflows for efficient navigation Dynamically linked data review and reporting Optimized Data Review The Lab Forms Data Review environment is designed to simplify reviewing complex data sets by incorporating easy-to-interpret flags. These flags can highlight data that falls outside of your lab s criteria, allowing you to easily spot and correct any issues, simply and easily.

9 QuanLab Forms QuanLab Forms comes with your ISQ GC-MS system, providing you with a simple tool for routine GC-MS data acquisition, analysis and reporting. A wide selection of standard, preconfigured reports allows you to easily report data in a style that suits your lab s needs, plus customizable reports allow you to tailor reports for your specific applications. Generate reports in real time during sample acquisition, or review and report data through the intuitive Data Review screen. EnviroLab Forms For today s environmental labs, balancing high productivity and sample throughput with stringent quality controls means that the data review process is typically a bottleneck in moving from sample to report. EnviroLab Forms follows environmental laboratory workflows, with report options tailored to the needs of environmental laboratories. Because reviewing environmental data can be very time-consuming, Smart Reporting streamlines this task. Simply double-click out of range or questionable results, review and fix if possible, and you re done. Manual integrations are flagged for auditing purposes, and reports are ready to approve and print. Enhanced tools for tentatively identified compounds are included in EnviroLab Forms. ToxLab Forms ToxLab Forms is designed for the clinical research or forensic toxicology laboratory. ToxLab Forms streamlines the path from unknown sample to known result in a manner that is secure, defensible, and aligned with your lab s specific needs. Enhancements customized for routine toxicology analysis are built into the system. ToxLab Forms provides automated spectral library searching for nontarget peaks and reports semi-quantitative results for these unknown compounds. ToxLab Forms Method View EnviroLab Forms Data review Xcalibur Data System The Xcalibur data system provides confident control from method development to reporting using the ISQ GC-MS system. Xcalibur is also used to provide tools for generating and maintaining your own spectral libraries. It is compatible with commercial libraries such as NIST, Wiley, Maurer-Pfleger-Weber and others. Xcalibur provides complete control of the TRACE GC Ultra and FOCUS GC, the ISQ mass spectrometer and optional liquid or headspace autosamplers. Easy Interpretation of Mass Spectral Data Mass Frontier software provides a suite of options that allows the MS operator to interpret mass spectral data. This optional software package assists the operator in structural identification, isotope pattern determination, and spectral classifications.

10 Thermo Scientific ISQ Single Quadrupole GC-MS Excellence in GC-MS Begins with the GC Match GC and Autosampler Options to Your Lab s Needs The ISQ GC-MS system can be configured with either the FOCUS GC, a single-channel gas chromatograph with a split/splitless injection port or the TRACE GC Ultra gas chromatograph, with a full range of versatile injector and detector options. Thermo Scientific TRACE GC Ultra The Ideal ISQ Partner The TRACE GC Ultra gas chromatograph is a full-performance, full-featured instrument ideal for routine or advanced GC techniques. The TRACE GC Ultra offers an unparalleled range of injection port options, designed to meet your sample requirements: Standard split/splitless for routine sample analysis, plus perform large volume splitless injections with only minor modifications Advanced multi-mode programmable temperature vaporizing inlet (PTV) with PTV mode, constant temperature and available large-volume and backflush options True cold-on-column inlet for ultimate in non-discriminating injections, with full automation possible using the Thermo Scientific TriPlus Autosampler The TRACE GC Ultra also offers the ability to add a complement of GC detectors: FID, ECD, PID, FPD, NPD, and PDD. Data for up to two detectors plus the ISQ can be automatically acquired and processed through the Thermo Scientific Xcalibur data system. Thermo Scientific FOCUS GC Small in Stature, Big on Performance The FOCUS GC is equipped with a full-sized GC oven, compatible with standard GC column cages, yet it takes up a fraction of the bench space of the full-sized GCs. This GC offers full-sized GC performance, too, with a standard split/splitless injection port. Combined with the ISQ, this creates a powerful GC-MS system ideal for routine applications in environmental, petrochemical, forensic and QA/QC laboratories ISQ with FOCUS GC ISQ with TRACE GC Ultra Fast analysis of volatile organics in drinking water

11 AS 3000 II Autosampler Thermo Scientific Autosampler Options Precise sample introductions are required for best reproducibility and accuracy. The Thermo Scientific AI/AS 3000 II autosampler and TriPlus autosampler offer ideal solutions for automated injections. TriPlus Autosampler Flexible Sampling Solutions With advanced robotic technology and independent three-dimensional movement of the syringe holder, the TriPlus Autosampler provides flexibility in sample capacity and handling for high lab productivity. TriPlus AS for liquid samples Excellent precision for reproducible results Capacity for mL autosampler vials Use 50 mm or 80 mm needle lengths Compatible with large volume injections Anticipated injection cycles for faster sample-to-sample times TriPlus DUO includes both headspace and liquid sampling turrets Interchangeable turrets provide flexible configuration depending on analytical needs TriPlus SPME* Option for automated solid phase microextraction Automates sample preparation and analysis Excellent for pesticide residue analysis to minimize initial sample preparation AI/AS 3000 II Sampler The AI 3000 II offers a basic configuration for up to 8 vials at a time, while the AS 3000 II holds 105 standard liquid autosampler vials. Excellent precision and tool-free alignment make this sampler a perfect choice for routine liquid sample injections. TriPlus HS for headspace analysis Excellent for use in volatiles analysis and solvent detection Heated syringe-based system minimizes sample loss Simplified method development TriPlus AS Liquid Autosampler * Sold under license from Supelco

12 Thermo Scientific Chromatography Columns and Consumables The perfect partner for optimal analytical performance Thermo Scientific chromatography columns and consumables are designed to complement our innovative range of GC and GC-MS systems. Get the most out of the ISQ GC-MS system by pairing it with advanced, high-performance Thermo Scientific products. The wide range of consumables and accessories offer customers applications-focused solutions in the environmental, food analysis, forensics/toxicology, petrochemical, pharmaceutical and general analytical industries. Sample Handling Comprehensive range of vials and closures Mass Spec Certified vials, the only pre-cleaned chromatography vial available Sample Preparation Thermo Scientific HyperSep Retain polymeric solid phase extraction products QuEChERS solutions for efficient sample preparation and clean-up GC derivatization reagents Reacti-Therm sample derivatization system GC Columns and Accessories TraceGOLD GC columns TracePLOT columns for permanent gas and light hydrocarbon GC Consumables Essential tools and equipment, including the following: GLD-Pro Leak Detector GFM-Pro Electronic Flowmeter Columns and Consumables

13 Easy to Use for Routine Applications, with Advanced Options for Research Break detection limit barriers Chemical Ionization for Routine Use Chemical ionization using reagent gases is one tool for increasing the selectivity of single quadrupole GC-MS analyses. However, this technique is not often applied to routine applications due to its apparent complexity. The ISQ allows you to tap into the utility of chemical ionization, easily, to incorporate it into routine analytical applications. Plumb two reagent gases into the system, with software selection of the reagent gas inside your instrument method. Optimize methods for two different reagent gases, and switch easily between them without any manual modifications to the system. Change from chemical ionization to electron ionization and back without venting your mass spectrometer using the standard vacuum interlock feature. Acquire positive and negative ion chemical ionization results in a single injection using Thermo Scientific proprietary Pulsed Positive Ion Negative Ion Chemical Ionization (PPINICI ) capability, standard with chemical ionization on the ISQ system. Oil-Free Pump for Clean Environments An available oil-free pump preferable for clean environments is available for the ISQ system. Eliminate oil changes and costly disposal of used pump oil with the systems's dry pump option, also suitable for use with ammonia reagent gas. Direct Sample Probe for Analysis without the Gas Chromatograph Perform quick characterizations of liquid or solid samples without using the gas chromatograph by employing a Direct Sample Probe. The Direct Sample Probe allows you to use either a micro-crucible approach to more slowly volatilize your sample (Direct Insertion Probe), or use a filament to rapidly heat the sample for a quicker volatilization (Direct Exposure Probe). Both are easily performed on the ISQ, all without venting the system. Plus, the GC remains in place, allowing you the flexibility to switch between traditional gas chromatography and the direct sample probe approach.

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