Development of Injectable Calcium Phosphate Bone Cement

Transcription

1 JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY Vol. 28 No. 1 Jan. 2006,,, (, ) :,,, : ; ; : R : A : (2006) Development of Injectable Calcium Phosphate Bone Cement DA I Hong2lian, CH EN Xiao2m i ng, HUA N G Fu2long, L I S hi2pu (Biomedical Materials and Engineering Research Center, Wuhan University of Technology, Wuhan , China) Abstract : The injectable calcium phosphate cement has many advantages : good biocompatibility, osteoconduction, biodegradation, easy2operability and plasticity. It was accepted by clinic in many fields such as bone restoration in non2load situs, drug or biofactor carri2 er, filling root canal, strengthening spongy bone screw and fixing fracture. The injectable calcium phosphate cement has wide application perspective in implantation, osteo2traumatology, radio2intervention, and so on. At present, the injectable calcium phosphate cement has become one main problem in the research of bone cement. The up2to2date research progress is summarized in this paper. Key words : calcium phosphate bone cement ; injectable ; recent developments 20 80,Brown (calcium phosphate cement,cpc), CPC,, CPC [1 ],,,,,,,,,, ( ),, CPC [2 ], CPC CPC, 1 CPC CPC, : : (2004AA303B03). : (19702),,. E2mail com. cn

2 28 1, : 31 (hydroxyapatite, HAP),, CPC 2 2, CPC Khairoun [3 ] CPC,, CPC,, ( ) Leroux [4 ] 4 %, p H,,,,CPC 0. 5 %,, 0. 5 %,, CPC,, Goncalves [5 ] CPC, 10 %, 47 % 55 % CPC,,5 % CPC, 52 % ; 5 %, 3 % CPC,,,, CPC,, 2 CPC Ooms [6 ] 2Ca 3 ( PO 4 ) 2 CaHPO 4 2H 2 O CaCO 3 HAP Na 2 HPO 4 CPC,8 5 15,, CPC Gauthier [7 ] CPC,,, CPC,,,,, CPC, CPC Wolke [8 ] CPC CPC [9 ] CPC, CPC,, Flautre [10 ] CPC( 2Ca 3 ( PO 4 ) 2 Ca ( H 2 PO 4 ) 2 NaH 2 PO 4 ), 3,12, %, 24, %, X, 2 Daculsi [11 ], CPC,,, :4 CPC,12, CPC,,,CPC, 2 Landuyt [12 ] ( ),,

3 CPC, CPC (0. 9 kn),, PMMA (1. 2 kn) / CPC Bai [1 ] CPC,,, PMMA [13 ], CPC, L,, 59 % 38 % CPC,, CPC, CPC Stankewich [14 ], 30 % 3,, CPC, N, N Gerhart [15 ] CPC,,12 CPC, CPC, PMMA Constantz [16 ] CPC, CPC,, Kopylov [17 ] CPC 40, 7 CPC X,2 Yetkinler [18 ], CPC 2, 3 CPC,,, CPC Otsuks [19 ], CPC CPC, CPC,,CPC, 2 :2 % 5 % 95 % 170 h 35 h ;0. 5 % 0. 2 % 500 h 50 % 30 % ;5 % 50 % h ;5 % (25 mg) 50 h 570 h 7 mg 17 mg CPC, CPC,, : 1) CPC ( ) ;2), ;3), CPC, Sasaki [20 ] CPC,,,, PBS, CPC,,, CPC + (BMP) + ( GF) (BMP) (rh TGF2 ) (bf GF) ( TNF) ( PD GF),,, CPC,,, [21 ], 20 ng 60 mg rh TGF2

4 28 1, : 33 CPC,CPC rh TGF2,24 h 20 % rh TGF2 CPC,10 d 10 ng rh TGF2 CPC AL P 3 20 ng rh TGF CPC AL P 5, AL P,rh TGF2 Kamegal [22 ] BMP CPC,14 d,21 d Meraw [23 ], 1. 5 mm, GF ( 2TGF bf GF PD GF) CPC, GF CPC 3 GF 1 mm, CPC GF, GF, GF CPC, CPC + GF, ( ),CPC,, CPC 4 CPC CT MRI,,, CPC,,,,,, /, CPC CPC,, CPC, CPC, CPC, CPC, ( ) CPC,, CPC, [1 ] Bai B, Jazrawi L M, Kummer F J, et al. The Use of an Injectable, Biodegradable Calcium Phosphate Bone Subsitute for the Prophylactic Augmentation of Osteroporotic Vertebral Compression [J ]. Spine, 1999, 24 : [2 ] Daculsi G, Rohanizadeh R, Weiss P, et al. Crystal Polymer Interaction with New Injectable Bone Substitute : SEM and Hr TEM Study [J ]. J Biomed Mater Res, 2000, 50 (1) :1 7. [3 ] Khairoun I, Boltong M G, Driessens F C M, et al. Some Factors Controlling the Injectability of Calcium Phosphate Bone Ce2 ments [J ]. J Mater Sci : Mater Medic, 1998,9 : [4 ] Leroux L, Hatim Z, Freche M, et al. Effects of Various Adjuvants(Lactic Acid, Glycerol and Chitosan) on the Injectability of a Calcium Phosphate Cement [J ]. Bone, 1999, 25 (2 Supplement) : 31S 34S. [ 5 ] Goncalves S, Brouchet A, Freche M, et al. Formulation of an Injectable Calcium Phosphate Cement [J ]. Bioceramics, 2001, 13 : [ 6 ] Ooms E M, Egglezos E A, Wolke J G C, et al. Soft2tissue Response to Injectable Calcium Phosphate Cements [J ]. Biomateri2 als, 2003, 24 : [7 ] Gauthier O, Khairoun I, Weiss P, et al. In vivo Comparison of Two Injectable Calcium Phosphate Biomaterials : Ionic Cement and Polymer2associated Particulate Ceramic [J ]. Key Engineering Materials, 2001, : [8 ] Wolke J G C, Ooms E M, Jansen J A. In vivo Resorption Behavior of High Strength Injectable Calcium2phosphate Cement

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