biodegradable Magnesium

Size: px
Start display at page:

Download "biodegradable Magnesium"

Transcription

1 In vivo Micro CT Evaluation of From Bioresorbable Material to Sensor Applications biodegradable Magnesium in Medical Technology Annelie-Martina Weinberg, Mathias-Spital Rheine Germany / TU Graz - Austria Implants BRIC - Bioresorbable Implants for Children 1

2 Medicine sensor technology Contact leses - Blood glucose 2

3 Medicine sensor technology Chronical disease acute disease/injury Online monitoring Patient individulized medicine Reducing resources Faster reintegration in normal life 3

4 For example: Fracture treatment Healing dynamic process Implants are to rigid Changes in healing are not defined Biomechanical changes during healing unclear Total hip arthroplasty no knowledge about patient individual biomechnical properties 4

5 For example: brain damage Healing dynamic process Online information in the area of injured brain Stimulation during healing Observing the function of new cells 5

6 For example: miniaturism brain damage Miniaturism perfect body with no artificial parts 6

7 Conventional materials Stain Titanium and its alloys Cobald-chrome alloys 7

8 Biodegradable materials Appropriate materials: Metals: Mg, Fe Ceramics Polymers: Polylactide acide (PLA), Poly(3hydroxybutyrate) (PHB) Prerequisite for biocompatibility: bone cell adhesion to implant surface 8

9 Drawbacks of conventional materials Through abrasion released toxic components can lead to inflammatory reactions (Allen, 1997) Rigidity of metal implants reduces micromovements essential for fracture healing ( stress shielding ) Long time application can lead to implant loosening (Jacobs, 1998) Current metallic implants need a second operation for implant removal 9

10 10

11 Bioresorbable materials - a new approach No second operation for implant/sensor removal is necessary reduced morbidity reduced patient stress cost reduction for health care system by modulating for example the healing process 11

12 Collaboration partners Heraeus Technical University Vienna University of Natural Resources and Life Sciences Vienna Wien Leoben ETH Zürich Innsbruck Graz AT&S Leoben Medical University Innsbruck Technical University Graz Medical University Graz 12

13 Development of biodegradable Materials ETH Zurich Development of biodegradable metals Magnesium Iron Technical University Graz Development of biodegradable polymers Polyhydroxyalkanoats (PHA) 13

14 In vitro material testing Technical University Graz in vitro degradation testing Medical University Graz Cyto-viability tests 14

15 Material characterization Technical University Vienna Testing of mechanical properties AT&S Leoben Surface characterization Perthometer REM 15

16 In vivo studies Medical University Graz Continuous µct monitoring Blood examinations 16

17 Medical University Innsbruck Histomorphological analysis PHA, 17

18 In vivo studies University of Natural Resources and Life Sciences Vienna Screening of degradation products (LA-ICP-MS) 18

19 In vivo testing Technical University Vienna Push-out tests 19

20 PHB Poly(3-hydroxybutyrat) same mechanical properties as PLAs less environmental ph changes than PLAs produced by procaryontes (e.g. Bacillus megaterium) high purification methods reduce amount of endotoxin

21 Material 6 groups (n=6) of cylindrical pins (length: 8mm, diameter: 1,6mm) PHB PHB + 3% ZrO 2 (added to improve visualization in µct) PHB + 3% ZrO % Herafill (alternative bone material) Coatings of Mg-Alloys: PHB PHB with TBA connected PLDLA (Heraeus )

22 Methods µct Scans Histological slices

23 Micro CT BRIC - Bioresorbable Implants for Children

24 PHB Zr BRIC - Bioresorbable Implants for Children

25 PHB Zr sagittal 1m 6m 3m 9m

26 PHB Zr + 30% Herafill sagittal 1m 6m 3m 9m

27 Calculation Degradation PHB + Zr PHB + Zr + 10%H PHB + Zr + 30%H % Decrease per month bis 2,48 1,55 3,37 1,77 3,17

28 µct Implant Visualisation & 3D bone formation (6m) PHB PHB + Zr PHB+ Zr+ Herafill

29 Results µct Significant decrease of bone volume with ZrO2 in month 1 and 6 PHB + ZrO 2 (p=0,013)

30 Histological Slices Percentage of bone adherence on the implant length Zoom PHB + Zr + Herafill (6m)

31 Results Histological Slices Tendency of increasing bone adherence in samples with ZrO2 + Herafill in month 6 (p=0,012) Significant decrease of bone adherence with ZrO2 in month 6 (p=0,024)

32 Coatings of Mg-Alloy PHB (1w) PHB/TBA (1w) PLDLA (1w) PHB (4w) PHB/TBA (4w) PLDLA (4w)

33 Summary Addendums enable µct visualisation of PHB implants ZrO 2 decreases osteoconductive properties of PHB significantly Bone tissue formation can be improved by adding Herafill Coating not appropiate enough after 1w degradation and gas formation of alloy visible No differences between coatings

34 On-going fields of work Material improvement (crosslinking of PHAs, new metal alloy compositions) Implant surface modification (Micro-arc oxidation, coatings) Combination with additives to improve bone tissue reaction (Heraeus) In vivo models (rats, sheep and trauma models on brain and bone) 34

35 Thanks for your kind attention Techniker: Leopold Berger, Masterstudent, TU Wien Dipl.-Ing. Anna Celarek,PhD Studentin, TU Wien Dipl.-Ing. Dr. techn. Martin Koller, TU Graz Dipl.Ing. Martin Meischel, BoKu Wien Univ.Prof. Dipl.-Ing. Dr.techn. Franz Stelzer, TU Graz Ao.Univ.Prof. Dipl.-Ing. Dr.techn. Elmar Tschegg, TU Wien Univ.-Prof. i.r. Dr.phil. Stefanie Tschegg; BoKu Wien Ass.Prof. Dr.rer.nat. Frank Wiesbrock, TU Graz Forschung: Dipl.Biol, Dr.rer.nat. Heidi Schmitt Materialwissenschaftler: Dr Anja Hänzi, ETH Zürich Prof. Dr Peter Uggowitzer, ETH Zürich, Prof. Dr. Jörg Löffler, ETH Zürich Industriepartner: Dr. Andre Kobelt, Heraeus Dr. Klaus-Dieter Kühn, Heraeus Dr. Mario Krassnitzer, ATS Dr. Hannes Voraberger, ATS Chemikerin: Mag. Lisa Martinelli, PhD-Student, Med Uni Graz Mediziner: PD Dr Christoph Castellani, Ass.-Arzt, Meduni Graz Dr Peter Ferlic, Ass.Arzt, Med Uni Graz Dr Michael Fiedler, Ass. Arzt UKH Graz Dr Stefan Fischerauer, PhD-Student, Med Uni Graz Dr Tanja Kraus, OÄ, Meduni GrazDr.med.univ. Dr Karin Pichler, PhD-Student, Med Uni Graz Gustav Schmöller, Medizinstudent, Med Uni Graz Dr Eva Widni, Ass Ärztin, Med Uni Graz Dr Silvia Zötsch, Med Uni Graz Prof. Dr. Annelie Weinberg

TECHNOLOGICAL INNOVATION FOR CORONARY STENTS Francesco Migliavacca

TECHNOLOGICAL INNOVATION FOR CORONARY STENTS Francesco Migliavacca LABORATORY OF BIOLOGICAL STRUCTURE MECHANICS www.labsmech.polimi.it TECHNOLOGICAL INNOVATION FOR CORONARY STENTS Francesco Migliavacca Erice, 1 maggio 2015 International School of Cardiac Surgery Introduction

More information

Technology Breakthrough in Spinal Implants (Technical Insights)

Technology Breakthrough in Spinal Implants (Technical Insights) Technology Breakthrough in Spinal Implants (Technical Insights) Biomaterial innovations is a growth factor for spinal implant market June 2014 Table of Contents Section Page Number Executive Summary 4

More information

Implant materials. Learning outcomes. Implant materials in trauma. How to use this handout? Functions of implants. Types of materials

Implant materials. Learning outcomes. Implant materials in trauma. How to use this handout? Functions of implants. Types of materials Implant materials How to use this handout? The left column is the information as given during the lecture. The column at the right gives you space to make personal notes. Learning outcomes At the end of

More information

Titanium versus Zirconium Implants

Titanium versus Zirconium Implants Titanium versus Zirconium Implants A dental materials comparison Dr. Gerald Regni, DMD!!" Christian St. Phila. PA 1213" T: (""") %&'-!"#" E: Dr.Gerald_Regni@yahoo.com Titanium versus Zirconium Implants

More information

VERILAST Technology for Hip Replacement Implants

VERILAST Technology for Hip Replacement Implants VERILAST Technology for Hip Replacement Implants Surgeon Name Clinic Name Clinic Address Clinic i Address Phone Number Web Address Total Hip Replacement What Is VERILAST Hip Technology? OXINIUM Oxidized

More information

Biomaterials in tissue engineering

Biomaterials in tissue engineering Biomaterials in tissue engineering S. Swaminathan Director Centre for Nanotechnology & Advanced Biomaterials School of Chemical & Biotechnology SASTRA University Thanjavur 613 401 Tamil Nadu Page 1 of

More information

Implants of high-performance ceramic. vk-lange 12.03.2007 14:44 Uhr Seite 1. One-piece precision implant. Made in Germany

Implants of high-performance ceramic. vk-lange 12.03.2007 14:44 Uhr Seite 1. One-piece precision implant. Made in Germany OMNIS Implants of high-performance ceramic vk-lange 12.03.2007 14:44 Uhr Seite 1 One-piece precision implant C M Y CM MY CY CMY K Dieter Lange Verkaufsleiter Labor Made in Germany creamed nge 12.03.2007

More information

chronos BOne VOid Filler Beta-Tricalcium Phosphate (b-tcp) bone graft substitute

chronos BOne VOid Filler Beta-Tricalcium Phosphate (b-tcp) bone graft substitute chronos BOne VOid Filler Beta-Tricalcium Phosphate (b-tcp) bone graft substitute chronos Bone Void Filler Osteoconductive Resorbable Synthetic chronos Granules and Preforms are synthetic, porous, osteoconductive,

More information

Classification of dental cements

Classification of dental cements Classification of dental cements Type I: Luting agents* that include temporary cements Class 1: powder-liquid -> harden Class 2: paste-paste -> remain soft Type II: Luting agents for permanent applications

More information

TOTAL HIP REPLACEMENT FOR A LIFETIME: THE CEMENTLESS METAL ON METAL RECONSTRUCTION

TOTAL HIP REPLACEMENT FOR A LIFETIME: THE CEMENTLESS METAL ON METAL RECONSTRUCTION Richard A. Sweet, M.D. Louisville Orthopaedic Clinic Louisville, KY TOTAL HIP REPLACEMENT FOR A LIFETIME: THE CEMENTLESS METAL ON METAL RECONSTRUCTION INTRODUCTION Total hip replacement surgery (THR) has

More information

Testing and characterization of anti-reflection coatings on glass

Testing and characterization of anti-reflection coatings on glass Testing and characterization of anti-reflection coatings on glass Diagnostic approaches at CSP M.Turek, M. Dyrba, S. Großer, V. Naumann, Ch. Hagendorf contact: marko.turek@csp.fraunhofer.de Tests and methods

More information

Thomas J. Webster, Weldon School of Biomedical Engineering and School of Materials Engineering, Purdue University, West Lafayette, IN 47907

Thomas J. Webster, Weldon School of Biomedical Engineering and School of Materials Engineering, Purdue University, West Lafayette, IN 47907 Nanotechnology to Benefit Tissue Engineering Thomas J. Webster, Weldon School of Biomedical Engineering and School of Materials Engineering, Purdue University, West Lafayette, IN 47907 Introduction Nanobiotechnology

More information

Bildgebende Verfahren als. Control 2011 Alexander Nolte CADFEM GmbH

Bildgebende Verfahren als. Control 2011 Alexander Nolte CADFEM GmbH Bildgebende Verfahren als Basis für die FEM-Simulation Control 2011 Alexander Nolte CADFEM GmbH CADFEM: FEM Software and Services CADFEM FEM Software & Services 25+ years experience 140+ employees 40 Mio.

More information

Restoration of a screw retained single tooth restoration in the upper jaw with Thommen Titanium base abutment.

Restoration of a screw retained single tooth restoration in the upper jaw with Thommen Titanium base abutment. Restoration of a screw retained single tooth restoration in the upper jaw with Thommen Titanium base abutment. Dr. med. dent. David McFadden, Dallas County, USA Initial situation (single X-ray) Tooth 16

More information

Key Material Technologies for Next Generation Implants

Key Material Technologies for Next Generation Implants Brochure More information from http://www.researchandmarkets.com/reports/3147651/ Key Material Technologies for Next Generation Implants Description: With the rise of lifestyle diseases and aging population,

More information

Dental implants and Astra Tech

Dental implants and Astra Tech Background Dental implants and Astra Tech March 2009 1/6 CONTENTS Tooth loss: A common problem... 3 Traditional solutions... 3 Dental implants... 4 Astra Tech Implant System..... 4 Atlantis - patient-specific

More information

Abutment Solutions For customized implant restorations fabricated with CEREC and inlab. Digital all around.

Abutment Solutions For customized implant restorations fabricated with CEREC and inlab. Digital all around. Abutment Solutions For customized implant restorations fabricated with CEREC and inlab Digital all around. The digital treatment workflow Digital impression taking Coordinated digital workflows in CAD/CAM

More information

Biomaterials: Production, Processing and Application

Biomaterials: Production, Processing and Application AITEX infoday - New Textiles. Research and Innovation in the Textile-Clothing- Technical Textiles Industry Brussels, 31st March 2009 Silk-Based Biomaterials: Production, Processing and Application Dr.

More information

Hybrid bio-active medical implant coatings

Hybrid bio-active medical implant coatings Hybrid bio-active medical implant coatings Riga, 2014 TECHNOLOGY 3 SPHERES OF MEDICAL USAGE Dental surgery Orthopaedic surgery Cardio surgery Reconstructive surgery Plastic Surgery Oncology 4 USUAL REHAB

More information

CHAPTER 1 INTRODUCTION

CHAPTER 1 INTRODUCTION CHAPTER 1 INTRODUCTION 1.1 Research Background Diabetes mellitus is a disease in which the body cannot produce sufficient insulin in their pancreas to adequately control the level of glucose in their blood

More information

Wear-contact analysis of hip implant coated with functionally graded material

Wear-contact analysis of hip implant coated with functionally graded material 2014; 1(7): 439-443 IJMRD 2014; 1(7): 439-443 www.allsubjectjournal.com Received: 13-12-2014 Accepted: 30-12-2014 e-issn: 2349-4182 p-issn: 2349-5979 Impact Factor: 3.762 Vinod Pallapu M. Tech Student

More information

Materials Sciences. Dr.-Ing. Norbert Hort norbert.hort@gkss.de. International Masters Programme in Biomedical Engineering

Materials Sciences. Dr.-Ing. Norbert Hort norbert.hort@gkss.de. International Masters Programme in Biomedical Engineering Materials Sciences International Masters Programme in Biomedical Engineering Magnesium Innovations Center (MagIC) GKSS Forschungszentrum Geesthacht GmbH Dr.-Ing. Norbert Hort norbert.hort@gkss.de Contents

More information

Photofunctionalization

Photofunctionalization Photofunctionalization One and only technology to overcome the biological aging of titanium Scientific brochure of photofunctionalization Volume 1, Issue 1, 2013 published by Global Network for Photofunctionalized

More information

Pulsed laser deposition of organic materials

Pulsed laser deposition of organic materials Pulsed laser deposition of organic materials PhD theses Gabriella Kecskeméti Department of Optics and Quantum Electronics University of Szeged Supervisor: Dr. Béla Hopp senior research fellow Department

More information

Information on the product

Information on the product Information on the product Information on the product -Implantat.doc Page 1 of 15 This document composes of the following items 1. Name of the product 2. Raw materials 3. Structure and dimensions 3.1.

More information

Welcome to the World of High Performance Ceramics

Welcome to the World of High Performance Ceramics Welcome to the World of High Performance Ceramics Agenda Company Introduction BIOLOX BIOLOX Inteligent Ceramic Material Future Material Hot Topics New Applications for Ceramics - Medical Engineering Division

More information

Orsiro Hybrid Drug Eluting Stent Industry's first hybrid DES

Orsiro Hybrid Drug Eluting Stent Industry's first hybrid DES Vascular Intervention Drug Eluting Stents Orsiro Orsiro Hybrid Drug Eluting Stent Industry's first hybrid DES Orsiro An ideal combination of passive and active components The Orsiro Hybrid Drug Eluting

More information

TRI Product NewsFlash. December 2015

TRI Product NewsFlash. December 2015 TRI Product NewsFlash December 2015 Study Overview 2015 Dear Partners Year in, year out, we are screening all major scientific journals to ensure that our TRI Performance Concept still reflects the latest

More information

Implant Systems MAX LOGIC MONO. Today s name in tomorrow s implant technology

Implant Systems MAX LOGIC MONO. Today s name in tomorrow s implant technology Implant Systems MAX LOGIC MONO Today s name in tomorrow s implant technology Implant Systems Etgar Medical Implant Systems brings to the market an entire spectrum of dental implant products based on its

More information

SAST II - Novel Electrochemical Scaffolding Technique for SAST

SAST II - Novel Electrochemical Scaffolding Technique for SAST SAST II - Novel Electrochemical Scaffolding Technique for SAST Luigi De Nardo luigi.denardo@polimi.it Dipartimento di Chimica, Materiali e Ingegneria Chimica G. Natta Outline 1. Why scaffolding in medicine?

More information

Forming the Interface Between Doctor and Designing Engineer

Forming the Interface Between Doctor and Designing Engineer Forming the Interface Between Doctor and Designing Engineer Christine Schoene (&), Philipp Sembdner, Stefan Holzhausen, and Ralph Stelzer Faculty of Mechanical Science and Engineering, Technische Universitaet

More information

IMPLANT CONSENT FORM WHAT ARE DENTAL IMPLANTS?

IMPLANT CONSENT FORM WHAT ARE DENTAL IMPLANTS? IMPLANT CONSENT FORM WHAT ARE DENTAL IMPLANTS? Dental implants are a very successful and accepted treatment option to replace lost or missing teeth. A dental implant is essentially an artificial tooth

More information

Wrist and Hand. Patient Information Guide to Bone Fracture, Bone Reconstruction and Bone Fusion: Fractures of the Wrist and Hand: Carpal bones

Wrist and Hand. Patient Information Guide to Bone Fracture, Bone Reconstruction and Bone Fusion: Fractures of the Wrist and Hand: Carpal bones Patient Information Guide to Bone Fracture, Bone Reconstruction and Bone Fusion: Wrist and Hand Fractures of the Wrist and Hand: Fractures of the wrist The wrist joint is made up of the two bones in your

More information

Y O U R S U R G E O N S. choice of. implants F O R Y O U R S U R G E R Y

Y O U R S U R G E O N S. choice of. implants F O R Y O U R S U R G E R Y Y O U R S U R G E O N S choice of implants F O R Y O U R S U R G E R Y Y O U R S U R G E O N S choice of implants F O R Y O U R S U R G E R Y Your Surgeon Has Chosen the C 2 a-taper Acetabular System The

More information

ZIRCONIA INFORMATION FOR DENTISTS. FAQ S from the dental practice ENGLISH

ZIRCONIA INFORMATION FOR DENTISTS. FAQ S from the dental practice ENGLISH ZIRCONIA INFORMATION FOR DENTISTS FAQ S from the dental practice ENGLISH Zr Facts and Answers 2 Facts and Answers What is Zirconia? Zirconium (ZrSiO ) belongs to the mineral group of silicates and 4 was

More information

Titanized Mesh Implants Hernia Surgery

Titanized Mesh Implants Hernia Surgery Quality and Experience Titanized Mesh Implants Hernia Surgery The titanized mesh implants from pfm medical distinguish themselves with a minimum in inflammation rates and a minimum in shrinkage as they

More information

ICD-10-CM Official Guidelines for Coding and Reporting

ICD-10-CM Official Guidelines for Coding and Reporting 2013 Narrative changes appear in bold text Items underlined have been moved within the guidelines since the 2012 version Italics are used to indicate revisions to heading changes The Centers for Medicare

More information

Titanium Foam Implant

Titanium Foam Implant Titanium Foam Implant The Innovator 2 Move Implants is a Research & Development company which focuses on creating innovating products, not only to improve a product, but also the way of doing business.

More information

Patient Labeling Information System Description

Patient Labeling Information System Description Patient Labeling Information System Description The Trident Ceramic Acetabular System is an artificial hip replacement device that features a new, state-of-the-art ceramic-on-ceramic bearing couple. The

More information

TEPZZ 69 _ZA T EP 2 692 310 A2 (19) (11) EP 2 692 310 A2. (12) EUROPEAN PATENT APPLICATION published in accordance with Art.

TEPZZ 69 _ZA T EP 2 692 310 A2 (19) (11) EP 2 692 310 A2. (12) EUROPEAN PATENT APPLICATION published in accordance with Art. (19) TEPZZ 69 _ZA T (11) EP 2 692 3 A2 (12) EUROPEAN PATENT APPLICATION published in accordance with Art. 13(4) EPC (43) Date of publication: 0.02.14 Bulletin 14/06 (21) Application number: 1276632.0 (22)

More information

Contact: Steve Hurson VP, R & D Nobel Biocare 22715 Savi Ranch Pkwy Yorba Linda, CA 92887 (714) 282-5072 steve.hurson@nobelbiocare.

Contact: Steve Hurson VP, R & D Nobel Biocare 22715 Savi Ranch Pkwy Yorba Linda, CA 92887 (714) 282-5072 steve.hurson@nobelbiocare. Use of CP Titanium and Titanium alloys for Dental Implants Steve Hurson, Nobel Biocare U.S.A. Yorba Linda CA Abstract Professor Per Ingvar Branemark of Sweden published his results on 15 years of research

More information

THE RESORBABLE MATRIX. Relax. Remaix. The membrane of choice for reliable bone and tissue regeneration

THE RESORBABLE MATRIX. Relax. Remaix. The membrane of choice for reliable bone and tissue regeneration THE RESORBABLE MATRIX Relax. Remaix. The membrane of choice for reliable bone and tissue regeneration Remaix properties Remaix is a resorbable barrier membrane for use in guided bone regeneration (GBR)

More information

Zimmer Trabecular Metal Dental Implant

Zimmer Trabecular Metal Dental Implant Zimmer Trabecular Metal Dental Implant TRABECULAR METAL MATERIAL: Designed to Enhance Secondary Stability Through Bone Ingrowth. Artistic Rendering osseoincorporation TRABECULAR METAL MATERIAL Designed

More information

Micro-CT for SEM Non-destructive Measurement and Volume Visualization of Specimens Internal Microstructure in SEM Micro-CT Innovation with Integrity

Micro-CT for SEM Non-destructive Measurement and Volume Visualization of Specimens Internal Microstructure in SEM Micro-CT Innovation with Integrity Micro-CT for SEM Non-destructive Measurement and Volume Visualization of Specimens Internal Microstructure in SEM Innovation with Integrity Micro-CT 3D Microscopy Using Micro-CT for SEM Micro-CT for SEM

More information

Answers to commonly asked questions from patients with metal-on-metal hip replacements / resurfacings. Contents

Answers to commonly asked questions from patients with metal-on-metal hip replacements / resurfacings. Contents Answers to commonly asked questions from patients with metal-on-metal hip replacements / resurfacings John Skinner 1 and Alister Hart 2, Consultant Orthopaedic Surgeons and Directors of the London Implant

More information

Computer Aided Engineering (CAE) Techniques Applied To Hip Implant

Computer Aided Engineering (CAE) Techniques Applied To Hip Implant International Journal Of Computational Engineering Research (ijceronline.com) Vol. 3 Issue. 3 Computer Aided Engineering (CAE) Techniques Applied To Hip Implant 1, M. S. Abo_Elkhair, 2, M. E. Abo-Elnor,

More information

Cell Culture Days 2015

Cell Culture Days 2015 Cell Culture Days 2015 Thursday, 07.05.2015 9:00 11:00 Tissue and 3D Cell Culture Giving cancer a shape: 3-dimensional in vitro and ex vivo lung carcinoma Katharina Leithner Organotypic cultures: Methods

More information

POST-OCCUPANCY-EVALUATION, ENERGY MONITORING AND COST ANALYSIS OF PASSIVE AND LOW ENERGY HOUSING ESTATES

POST-OCCUPANCY-EVALUATION, ENERGY MONITORING AND COST ANALYSIS OF PASSIVE AND LOW ENERGY HOUSING ESTATES IKI AG-RB IKI AG-RB SUSTAINABILITY MONITORING OF VIENNESE HOUSING ESTATES. POST-OCCUPANCY-EVALUATION, ENERGY MONITORING AND COST ANALYSIS OF PASSIVE AND LOW ENERGY HOUSING ESTATES Supported by Viennese

More information

Safe Nano Design Molecule Manufacturing Market

Safe Nano Design Molecule Manufacturing Market August 14 16, 212 College of Nanoscale Science & Engineering (CNSE) of the University at Albany National Institute for Occupational Safety and Health (NIOSH) Prevention through Design Program Safe Nano

More information

Concept Laser Industry Specific Solutions

Concept Laser Industry Specific Solutions Concept Laser Industry Specific Solutions Medical Advantages of the LaserCUSING process Front End Software/ - interfaces Machine solutions Materials QM system Post treatment Case studies Seite 1 Hofmann

More information

Information for Our Patients Regarding Metal-on-Metal (MoM) Hip Replacements

Information for Our Patients Regarding Metal-on-Metal (MoM) Hip Replacements Information for Our Patients Regarding Metal-on-Metal (MoM) Hip Replacements The American Association of Hip and Knee Surgeons, The Hip Society and the American Academy of Orthopaedic Surgeons Concerns

More information

The early history of research on the Metabolic Syndrome

The early history of research on the Metabolic Syndrome Lund 3 rd November 2006 The early history of research on the Metabolic Syndrome Peter Nilsson, MD, PhD Department of Clinical Sciences Medicine University Hospital MAS, Malmö Department for History of

More information

Whether plastic, rubber, wood, metal or ceramic,

Whether plastic, rubber, wood, metal or ceramic, Material Guide A practical overview on 3D printing materials Whether plastic, rubber, wood, metal or ceramic, 3D printers can process a wide range of materials. In the following is a brief overview of

More information

Metal-on-Metal Hip Systems

Metal-on-Metal Hip Systems Meeting of the Orthopaedic and Rehabilitation Devices Advisory Panel June 27-28, 2012 Metal-on-Metal Hip Systems Center for Devices and Radiological Health U.S. Food and Drug Administration Meeting of

More information

AUSTRIAN KNEE SYMPOSIUM Sports Medicine Traumatology Prostheses Level: Advanced

AUSTRIAN KNEE SYMPOSIUM Sports Medicine Traumatology Prostheses Level: Advanced AUSTRIAN KNEE SYMPOSIUM Sports Medicine Traumatology Prostheses Level: Advanced June 11 12, 2015 Vienna, Orthopaedic Hospital Speising Chair: Prim. Univ.-Prof. Dr. Martin Dominkus AGENDA 2 DePuy Synthes

More information

Dr Marcin Adamiak marcin.adamiak. www.imiib.polsl.pl/

Dr Marcin Adamiak marcin.adamiak. www.imiib.polsl.pl/ FP7 NMP/INCO Brokerage Event Warsaw, 17-18 September 2009 Dr Marcin Adamiak marcin.adamiak adamiak@polsl.pl http://www.imiib.polsl.pl www.imiib.polsl.pl/ Institute of Engineering Materials and Biomaterials

More information

V Congresso Brasileiro de Engenharia de Fabricação, 14 a 17 de abril de 2009, Belo Horizonte MG

V Congresso Brasileiro de Engenharia de Fabricação, 14 a 17 de abril de 2009, Belo Horizonte MG 5 V CONGRESSO BRASILEIRO DE ENGENHARIA DE FABRICAÇÃO 14 a 17 de abril de 2009 - Belo Horizonte - Minas Gerais - Brasil MANUFACTURING OF DRUG DELIVERY DEVICE BY SELECTIVE LASER SINTERING USING OF POLYCAPROLACTONE

More information

OCCUPATIONAL LUNG CANCER

OCCUPATIONAL LUNG CANCER OCCUPATIONAL LUNG CANCER Anwar Jusuf, Agus Dwi Susanto Department of Pulmonology & Respiratory Medicine, Faculty of Medicine University Of Indonesia - Persahabatan Hospital-Jakarta INTRODUCTION Occupational

More information

Tailored bioabsorbable implants and scaffolds for biomedical and tissue engineering applications

Tailored bioabsorbable implants and scaffolds for biomedical and tissue engineering applications Tailored bioabsorbable implants and scaffolds for biomedical and tissue engineering applications Minna Kellomäki Professor, Dr Tech, FBSE BioMediTech and Department of Electronics and Communications Engineering

More information

Metal Injection Molding (MIM) of components made of Titanium and its alloys

Metal Injection Molding (MIM) of components made of Titanium and its alloys Metal Injection Molding (MIM) of components made of Titanium and its alloys 1 Presentation content Introduction to Metal Injection Molding (MIM) Technology - explaination Products - examples Company brief

More information

MINI FRAGMENT SYSTEM. Instruments and implants for 1.5 mm, 2.0 mm, and 2.4 mm plate fixation PRODUCT OVERVIEW

MINI FRAGMENT SYSTEM. Instruments and implants for 1.5 mm, 2.0 mm, and 2.4 mm plate fixation PRODUCT OVERVIEW MINI FRAGMENT SYSTEM Instruments and implants for 1.5 mm, 2.0 mm, and 2.4 mm plate fixation PRODUCT OVERVIEW TABLE OF CONTENTS INTRODUCTION Mini Fragment System 2 PRODUCT INFORMATION Plates 4 Screws 6

More information

Considerations on Dental Implants Fixation

Considerations on Dental Implants Fixation MECAHITECH 1 Bucharest, 23-24 September 21 Considerations on Dental Implants Fixation Conf. Sorin Kostrakievici *, As. Mircea Iulian Nistor *, S.l. Doina Bucur *, Medic Cristian Dobreci **, *Politehnica

More information

BNG 331 Cell-Tissue Material Interactions. Biomaterial Surfaces

BNG 331 Cell-Tissue Material Interactions. Biomaterial Surfaces BNG 331 Cell-Tissue Material Interactions Biomaterial Surfaces Course update Updated syllabus Homework 4 due today LBL 5 Friday Schedule for today: Chapter 8 Biomaterial surface characterization Surface

More information

The National Centre for Biomedical Engineering Science

The National Centre for Biomedical Engineering Science The How this Integrated Technology Platform has impacted the development of R&D Clusters in Galway Jacinta Thornton, PhD Executive Manager, NCBES National Centre for Biomedical Engineering g Science Mission

More information

SURFACE MODIFICATION OF METAL IMPLANTS WITH PLASMA SPRAYED LAYERS

SURFACE MODIFICATION OF METAL IMPLANTS WITH PLASMA SPRAYED LAYERS SURFACE MODIFICATION OF METAL IMPLANTS WITH PLASMA SPRAYED LAYERS Prof. János Takács Budapest University of Technology and Economics (BME) Ozsváth Péter MSc Budapest University of Technology and Economics

More information

Methods for analysis and visualization of industrial XCT data of fibre reinforced composites

Methods for analysis and visualization of industrial XCT data of fibre reinforced composites Methods for analysis and visualization of industrial XCT data of fibre reinforced composites Christoph Heinzl Team DI(FH) Michael Reiter Software development, simulation, dimensional measurement Andreas

More information

International Construction Project Management

International Construction Project Management icpm.tuwien.ac.at International Construction Project Management Vienna University of Technology Postgraduate MEng Program Master of Engineering (MEng) 4 semesters, part time Competitive Edge STEERING Construction

More information

.org. Arthritis of the Hand. Description

.org. Arthritis of the Hand. Description Arthritis of the Hand Page ( 1 ) The hand and wrist have multiple small joints that work together to produce motion, including the fine motion needed to thread a needle or tie a shoelace. When the joints

More information

September 13-16, 2009

September 13-16, 2009 September 13-16, 2009 Waikoloa, HI September 13-16, 2009, Waokoloa, Waikoloa, HI Biomimetic i Tooth Implants by Electron Beam Melting Mari Koike, DDS, PhD 1 ; Gilbert Chahine 2 ; Radovan Kovacevic, PhD

More information

Scuffing Measurement Methodology and Improved Film Coating Systems

Scuffing Measurement Methodology and Improved Film Coating Systems OPADRY II Application Data High Performance Film Coating System Scuffing Measurement Methodology and Improved Film Coating Systems PURPOSE Scuffing is a term used to describe coated tablet defects consisting

More information

ABOUT US. The Complete and Comprehensive solution for implants! Edison Medical. Edison Medical s Quality Strategy:

ABOUT US. The Complete and Comprehensive solution for implants! Edison Medical. Edison Medical s Quality Strategy: IMPLANTS CATALOG ABOUT US Edison Medical The Complete and Comprehensive solution for implants! Edison Medical Ltd. is engaged in the import, export, marketing and distribution of dental Implants and other

More information

BG Trauma Hospital Hamburg Germany Information Brochure for Patients & Medical Doctors

BG Trauma Hospital Hamburg Germany Information Brochure for Patients & Medical Doctors BG Trauma Hospital Hamburg Germany Information Brochure for Patients & Medical Doctors CEO: Dr. Hubert Erhard Medical Director: Prof. Dr. med. C. Jürgens Design and editorial staff: J. Jarmer, Layout and

More information

Lecture 3: Biodegradable Polymers

Lecture 3: Biodegradable Polymers 4A3 Advanced Polymer Synthesis Lecture 3: Biodegradable Polymers 4A3 - Slide 40 Learning outcomes By the end of todays lecture you should be able to: (i) discuss what biodegradability means, and why it

More information

TriLock 1.5 Implants for the Phalanges

TriLock 1.5 Implants for the Phalanges P R O D U C T IN F O RM AT I O N TriLock 1.5 Implants for the Phalanges APTUS Hand 2 TriLock 1.5 Implants for the Phalanges TriLock 1.5 The Smallest Locking System Small, slender, strong Low profile and

More information

4. Cell Separation - Clinical Research Products

4. Cell Separation - Clinical Research Products 4. Cell Separation - Clinical Research Products Introduction of Dynabeads ClinExVivo 53 Dynabeads ClinExVivo Epoxy 54 Dynabeads ClinExVivo Sheep anti-mouse IgG 55 Visit for the latest product up-dates

More information

Trabecular Metal Technology. The Best Thing Next to Bone

Trabecular Metal Technology. The Best Thing Next to Bone Trabecular Metal Technology The Best Thing Next to Bone Trabecular Metal Technology The Best Thing Next to Bone When you need a hip, knee, shoulder or spine implant, you want assurance that your implant

More information

Hip pain in the active patient. Jason Cochran D.O. Michigan Orthopedic Center Sparrow Health System Lansing, MI 517-267-0200

Hip pain in the active patient. Jason Cochran D.O. Michigan Orthopedic Center Sparrow Health System Lansing, MI 517-267-0200 Hip pain in the active patient Jason Cochran D.O. Michigan Orthopedic Center Sparrow Health System Lansing, MI 517-267-0200 Who is the active patient? Why do you hurt? Goals Causes of hip pain Nonsurgical

More information

MEDICAL TECHNOLOGY IN IMPRESSIVE 3D

MEDICAL TECHNOLOGY IN IMPRESSIVE 3D MEDICAL TECHNOLOGY IN IMPRESSIVE 3D ABOUT 3D MEDICAL PRINT As a master dental technician with my own dental lab, I have always been looking for further education and innovative techniques in the medical

More information

Who we are and what we do - FHNW. Untersuchungen und Oberflächenmodifikationen. von SLM Strukturen. M. de Wild. Location: area of Basel

Who we are and what we do - FHNW. Untersuchungen und Oberflächenmodifikationen. von SLM Strukturen. M. de Wild. Location: area of Basel Untersuchungen und Oberflächenmodifikationen von SLM Strukturen M. de Wild University of Applied Sciences Northwestern Switzerland, Institute for Medical Technologies IMA, CH 4132 Muttenz, Switzerland

More information

ARTHRITIS INTRODUCTION

ARTHRITIS INTRODUCTION ARTHRITIS INTRODUCTION Arthritis is the most common disease affecting the joints. There are various forms of arthritis but the two that are the most common are osteoarthritis (OA), and rheumatoid arthritis

More information

Nickel Free Room Temperature Seal: an innovative and ecological process

Nickel Free Room Temperature Seal: an innovative and ecological process Nickel Free Room Temperature Seal: an innovative and ecological process 2015 ANODIZING CONFERENCE San Diego, California Prepared by: Marcello Rossi Italtecno Srl Italy NICKEL FREE ROOM TEMPERATURE SEAL:

More information

frequently asked questions Knee and Hip Joint Replacement Technology

frequently asked questions Knee and Hip Joint Replacement Technology frequently asked questions Knee and Hip Joint Replacement Technology frequently asked questions Knee and Hip Joint Replacement Technology Recently, you may have seen advertisements from legal companies

More information

How cryo will solve your problems

How cryo will solve your problems How cryo will solve your problems Nadejda B. Matsko FELMI, TU Graz, and ZFE Graz What for do we need cryo microscopy? Cryo fixation Conventional fixation (rapid rapid dehydration) High resolution microscopy

More information

.URGENT DEVICE CORRECTION

.URGENT DEVICE CORRECTION zimmer.urgent DEVICE CORRECTION Zimmer, Inc. P.O. Box 706 Warsaw, IN 46561-0706 574.267.6131 www.zimmer.com July 22, 2008 Dear Surgeon: Since we last wrote to you in May 2008 regarding the Durom Acetabular

More information

November 21 22, 2008 Siófok, Hotel Residence Hungary. Seminar on Geriatric Fractures

November 21 22, 2008 Siófok, Hotel Residence Hungary. Seminar on Geriatric Fractures November 21 22, 2008 Siófok, Hotel Residence Hungary 2008 Seminar on Geriatric Fractures Course Faculty Course language: English Dear Colleagues! It is a great honor for me to invite you on behalf of the

More information

Information for the Patient About Surgical

Information for the Patient About Surgical Information for the Patient About Surgical Decompression and Stabilization of the Spine Aging and the Spine Daily wear and tear, along with disc degeneration due to aging and injury, are common causes

More information

Competitive Edge STEERING Construction Projects securely and successfully. International Construction Project Management. icpm.tuwien.ac.

Competitive Edge STEERING Construction Projects securely and successfully. International Construction Project Management. icpm.tuwien.ac. icpm.tuwien.ac.at CONTINUING EDUCATION CENTER Competitive Edge STEERING Construction Projects securely and successfully Within the framework of our involvement in the postgraduate program International

More information

Like natural teeth. Treatment with dental implants is a safe, reliable and well-proven solution for permanently replacing one or more missing teeth.

Like natural teeth. Treatment with dental implants is a safe, reliable and well-proven solution for permanently replacing one or more missing teeth. Implants for life 2 IMPLANTS FOR LIFE Like natural teeth Treatment with dental implants is a safe, reliable and well-proven solution for permanently replacing one or more missing teeth. Millions of people

More information

Summer School 2011 Berlin SFB Transregio 19

Summer School 2011 Berlin SFB Transregio 19 Summer School 2011 Berlin SFB Transregio 19 27th October 29th October 2011 Molecular Mechanisms and Consequences of Inflammatory Cardiomyopathy: State of the Art and Future Challenges Welcome Address

More information

Fuel Cell Activities at TU Graz

Fuel Cell Activities at TU Graz Fuel Cell Activities at TU Graz Viktor Hacker Institute of Chemical Engineering and Environmental Technology Graz University of Technology IEA Workshop TU Graz September 1 st, 2010 Content Lifetime and

More information

USE OF SIMULATION TO IMPROVE CARDIOVASCULAR STENT DEVELOPMENT

USE OF SIMULATION TO IMPROVE CARDIOVASCULAR STENT DEVELOPMENT USE OF SIMULATION TO IMPROVE CARDIOVASCULAR STENT DEVELOPMENT V. Astier, S. Bidal, V. Garitey, F. Mouret Abstract : A stent is a wire metal mesh tube placed into an artery or blood vessel to hold the structure

More information

Humoral response to therapeutic low-intensity pulsed ultrasound (LIPUS) treatment of rat maxillary socket after the removal of a molar tooth

Humoral response to therapeutic low-intensity pulsed ultrasound (LIPUS) treatment of rat maxillary socket after the removal of a molar tooth Humoral response to therapeutic low-intensity pulsed ultrasound (LIPUS) treatment of rat maxillary socket after the removal of a molar tooth Kouki Hidaka *1, Chihiro Miyamoto *2, Satoko Wada-Takahashi

More information

Fracture bone healing and biodegradation of AZ31 implant in rats. Department of Plastic Surgery. Hospital Universitario La Paz, Madrid, 28046,

Fracture bone healing and biodegradation of AZ31 implant in rats. Department of Plastic Surgery. Hospital Universitario La Paz, Madrid, 28046, Fracture bone healing and biodegradation of AZ31 implant in rats C Iglesias a, OG Bodelón b, R Montoya b,1, C Clemente c, MC Garcia-Alonso b, JC Rubio d and ML Escudero b* a Spain. Department of Plastic

More information

The Surface and Material of Dental Implants

The Surface and Material of Dental Implants The Surface and Material of Dental Implants Conrado Aparicio, PhD Minnesota Dental Research Center for Biomaterials and Biomechanics Dpt. of Restorative Sciences. School of Dentistry University of Minnesota

More information

Subproject 4: Specification and Documentation of Metabolic and Neoplastic Diseases

Subproject 4: Specification and Documentation of Metabolic and Neoplastic Diseases Subproject 4: Specification and Documentation of Metabolic and Neoplastic Diseases M. Trauner, Division of Gastroenterology and Hepatology, Department of Internal Medicine, MUG Co- Investigator: H. Samonigg,

More information

Sinterstation. Pro Direct Metal SLM System

Sinterstation. Pro Direct Metal SLM System Sinterstation Pro Direct Metal SLM System Jim Dier SLS and SLM Systems, Upper Midwest 3D Systems, Inc. 18 July 2008 Introduction Product overview Systems Sinterstation Pro DM100 SLM System Sinterstation

More information

Jacket crown. Advantage : Crown and Bridge

Jacket crown. Advantage : Crown and Bridge Crown and Bridge Lecture 1 Dr.Nibras AL-Kuraine Jacket crown It is a type of crown that is formed by a tooth colored material. It is mainly used as a single unit in the anterior quadrant of the mouth.

More information

Osteoarthritis progresses slowly and the pain and stiffness it causes worsens over time.

Osteoarthritis progresses slowly and the pain and stiffness it causes worsens over time. Arthritis of the Foot and Ankle Arthritis is the leading cause of disability in the United States. It can occur at any age, and literally means "pain within a joint." As a result, arthritis is a term used

More information

Total Shoulder Arthroplasty

Total Shoulder Arthroplasty Specialists in Joint Replacement, Spinal Surgery, Orthopaedics and Sport Injuries Total Shoulder Arthroplasty Ms. Ruth Delaney Consultant Orthopaedic Surgeon www.sportssurgeryclinic.com Introduction Arthritis

More information