VI Brazilian Purine Club Meeting May 12 th to 14 th, Place of the Congress. Convention Center of the Solmar Hotel, João Pessoa - PB - Brazil.

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1 VI Brazilian Purine Club Meeting May 12 th to 14 th, 2016 Place of the Congress Convention Center of the Solmar Hotel, João Pessoa - PB - Brazil. Organizing Committee Prof. Dr. Henning Ulrich / USP Prof. Dr. Ana Maria Oliveira Battastini / UFRGS Prof. Dr. Ana Lucia Ventura / UFF Prof. Dr. Robson Coutinho-Silva / UFRJ Prof. Dr. Geanne Matos de Andrade / UFC Prof. Dr. Tatjana Keesen de Souza Lima / UFPB Prof. Dr. Lucianne Fragel Madeira / UFF Prof. Dr. Carla Inês Tasca / UFSC Prof. Dr. Lisiane Porciuncula / UFRGS Dr. Flávia Sarmento Vieira / USP Dr. Talita Glaser / USP

2 05/12/2016 Thursday 10:00-13:00 Registration 13:00-13:15 Opening Ceremony 13:15 14:00 Opening Conference Professor Mariusz Z. Ratajczak, University of Louisville's James Graham Brown Cancer Center, KY, USA Title: Purinergic signaling in lung cancer Chair: Henning Ulrich, University of São Paulo, Brazil 14:00 16:00 Symposium 1 (Room A) Purinergic signaling in stem and cancer cell mobilization and immune modulation Chair: Henning Ulrich - USP Purinergic signaling and melatonin production in the pineal gland in the presence of inflammatory agents Zulma Silva Ferreira-USP Papel do receptor P2X7 e da enzima CD39/NTPDASE1 na resposta à radioterapia em gliomas Fernanda Bueno Morrone-PUCRS Purinergic signaling against leukemia stem cells Edgar J. Paredes Gamero - UNIFESP Purinergic signaling in cancer stem cell mobilization to the bone marrow Claudiana Lameu - USP Purinergic signaling in mobilization of embryonic stem cells to neuronal differentiation Henning Ulrich - USP 16:00 18:00 Poster Presentation Odd numbers 18:00-20:00 Welcome Reception

3 05/13/2016 Friday 8:15 9:00 Coffee with the professors 9:00-11:00 Symposium 2 Ectonucleotidases as Regulators of Purinergic Signaling Chair: Ana Maria Battastini, UFRGS Ecto-5 -nucleotidase in bladder cancer models Ana Maria Battastini - UFRGS Modulation of adenosine levels in models of neurological disorders Carla Denise Bonan - PUCRS Changes in purinergic signaling in diabetes Maria Rosa Schetinger - UFSM Glioma - Astrocyte interactions modulate cancer progression involving increased ectonucleotidase and inos activities Elizandra Braganhol UFCSPA Adenine nucleotides hydrolysis in platelets and biomarkers of oxidative stress in Down syndrome individuals Rosélia Spanevello - UFPel 11:00 11:45 Guest Conference 1 Professor Robson Coutinho Silva, Federal University of Rio de Janeiro Title: New Findings about Purinergic signaling and Inflammatory Diseases Chair: Ana Maria Battastini, Federal University of Rio Grande do Sul 11:45 14:00 Lunch 14:00 16:00 Symposium 3 (Room A) (Oral communication selected from posters) Chair: Luiz Carlos Crocco Afonso UFOP Symposium 4 (Room B) Adenosine and regulatory functions Chair: Roberto Paes de Carvalho - UFF " Aspartate transporter activity and GABA are regulated by acute exposure to caffeine over development" Regina Kubrusly - UFF Purinergic and glutamatergic transmission cross-talk in the mechanism of neuroprotection Carla I. Tasca - UFSC Effect of caffeine in the retina during development and under ischemic conditions Karin da Costa Calaza UFF Novos mecanismos de regulação dos Transportadores Equilibrativos de Nucleosídeos do tipo 1 (ENT1) Alexandre Rodrigues UFF

4 Adenosine signaling and immunomodulation in ovarian cancer Fernando Guimarães - UNICAMP 16:00-17:50 Guest Conference 2 Rodrigo Cunha University of Coimbra - Portugal Title: Purinergic control of neurodegeneration triggered by convulsions Chair: Ana Ventura, Fluminense Federal University, Brazil 17:50 19:50 Poster Presentation Even Numbers 20:00-21:00 Annual Assembly of Brazilian Purine Club 21:00 23:00 Social Activity 05/14/2016 Saturday 8:15 9:00 Coffee with the professors 9:00 11:00 Symposium 5 (Room A) Signal Transduction mediated by P1 and P2 purinergic receptors Chair: Ana Lucia Marques Ventura - UFF Regulation of adenosine receptors expression and intracellular signaling pathways Mariana Rodrigues Pereira UFF The safety of cup of Joe during brain development Lisiane O. Porciúncula - UFRGS P2Y receptors and regulation of retinal progenitors proliferation in vivo Lucianne Fragel Madeira, UFF Adenosine Signaling in Embryonic Stem Cell Biology Talita Glaser - USP Signaling Pathways associated with Nucleotide-induced proliferation of retinal progenitors Ana Lucia Marques Ventura UFF 11:00 12:30 Symposium 6 (Room A) Purinergic Signaling during inflammation Chair: Lucianne Fragel Madeira, UFF Role of adenosine receptors in the Clostridium difficile infection Gerly Anne de Castro Brito, UFC The role of adenosinergic pathway in development of sepsis-induced immunosuppression José Carlos Alves Filho USP-Ribeirão Preto

5 Role of Brilliant Blue G antagonist on the myenteric neurons immunoreactive for the P2X7 receptor of the rats ileum following the intestinal ischemia/reperfusion Kelly Palombit, UFPI ATP-induced, P2X7-independent organic cation transport induced by 5-lipoxygenase inhibitors in macrophages Pedro Persechini UFRJ 12:30 14:00 Lunch 14:00 16:00 Symposium 7 Purinergic Signaling and Infectious Diseases Chair: Luís Carlos Crocco Afonso, UFOP " Leishmania NTPDase-2 and inhibition of macrophage activation " Luís Carlos Crocco Afonso, UFOP " Adenosine protects human vaginal epithelial cells from Trichomonas vaginalis cytotoxicity" Tiana Tasca, UFRGS Ecto-nucleotidases in protozoa parasites and other microorgasnisms José Roberto Meyer Fernandes, UFRJ " E-NTPDases from Trypanosoma cruzi and Leishmania: updates and review of biological roles Juliana Lopes Rangel Fietto, UFV " Natural and Peripheral regulatory T cells and CD39 and CD73 expression in infectious Diseases" Tatjana Keesen - UFPB 16:00 16:30 Coffee Break 16:30 17:15 Closing Conference Professor Roberto Paes de Carvalho Fluminense Federal University Title: Purinergic Modulation of Vitamin C Release in the Retina Chair: Carla I. Tasca, UFSC 17:30 Closing Session