5 th Molecular Cell and Immune Biology Winter Symposium
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1 5 th Molecular Cell and Immune Biology Winter Symposium organized by the Molecular, Cellular and Immune Biology Doctoral School and Molecular Medicine Program University of Debrecen Galyatető 4-7 January,
2 5 th Molecular Cell and Immune Biology Winter School, 2012 Program: 4 January 16:00 pm Opening: László Fésüs 16:10-18:25 pm Section 1: Chair: Bálint Bálint 16:10-16:40 Éva Rajnavölgyi: Nobel Prize 2011: Toll-like receptors 16:40-17:00 Debrecen Award for Molecular Medicine (video lecture from 2006) 17:00-17:20 László Nagy Trends in dendritic cell research: reflections and perspectives 17:20-17:40 István Szatmári: Modulation of dendritic cell development by transcription factor mediated programming 17:40-17:55 Zsófia Agod: The role of SLAM receptors in the regulation of dendritic cell functions 17:55-18:10 Adrienn Gyöngyösi: The role of PPARg receptor in the retinoid pathway of human dendritic cells 18:10-18:25 Ildikó Bacskai: Monocyte-derived dendritic cell subpopulations express different pattern of matrix metalloproteinases 2
3 18:25-20:00 pm Dinner 20:00-21:55 pm Section 2: Chair: Goran Petrovski 20:00-20:20 Attila Bácsi: Sirtuins in inflammation: friends or foes? 20:20-20:40 Szilvia Benkő: Nod-like receptors and the different types of human macrophages Regular Talks 20:40-20:55 Aliz Varga: Ragweed pollen extract generated ROS enhance LPS-induced IL-1b secretion via NLRP3 inflammasome in human macrophages 20:55-21:10 Krisztina Köröskényi: Adenosine inhibits proinflammatory cytokine production of LPS-induced macrophages 21:10-21:25 Ákos Tisza: The role of the 8-oxoguanine in the inflammatory processes 21:25-21:40 Marietta Budai: Immunomodulatory effect of Aloe Vera extract on human macrophages 21:40-21:55 Zsolt Czimmerer: Is Mir-210 a human macrophage activation state specific microrna? 3
4 5 January 7:00 am Breakfast 8:00-10:25 am Section 3 Chair: Attila Bácsi Goran Petrovski: Induction of Autophagy and Cell Death in Cultured ARPE-19 Cells and Related Clearance Mechanisms :40 Zsolt Sarang: Investigation of the role of LXR receptor activation on apoptotic cell uptake of mouse macrophages Endre Kristóf: Role of ICAM3 and its interacting partners in the phagocytosis of apoptotic neutrophil granulocytes by human macrophages 8:55-9:10 Éva Garabuczi: Dexamethasone might promote phagocytosis of apoptotic cells by macrophages via activating the LXR pathway 9:10-9:25 Gizem Ayna: Upstream mechanisms of NALP3 inflammasome activation with dying autophagic cells in mouse macrophages' 9:25-9:40 Edina Keresztesi: Role of adenosine A3 receptors in the regulation of proinflammatory cytokine production in macrophages engulfing apoptotic cells 9:40-9:55 Anitta Sárvári: Adipocyte cell death and clearance 4
5 9:55-10:10 Bea Kiss: Retinoids induce apoptosis in thymocytes via activating Nur77 10:10-10:25 Anna Pallai: GluLys dipeptide produced by transglutaminase inhibits the proinflammatory cytokine production of LPS stimulated macrophages 10:25 am-16:00 pm Skiing, swimming, and excursion 16:00-18:25 pm Section 4: Chair: Zsolt Bacsó 16:00-16:20 András Mádi: Lasker Award 2011: Molecular mechanism of protein folding in the cell 16:20-16:50 Mónika Fuxreiter: Towards therapeutic applications of protein disorders 16:50-17:05 János Aradi: Redox regulation by thiol disulfide exchange processes; cell membrane as redox barrier 17:05-17:25 Kajal Kanchan: Biochemical characterization of htg2 and investigation of its interacting partners 17:25-17:40 Zsófia Simon-Vecsei: Structural analysis and clinical significance of celiac disease antibody epitopes on transglutaminase 2 17:40-17:55 Ferenc Tóth: Exploration of HIV-1 capsid mutants 5
6 17:55-18:10 Beáta Bozóki: Studies on the substrate specificity of alphavirus proteases 18: Minh Doan: Immunophenotyping by imaging cytometry in atopic dermatitis 18:25-20:00 pm Dinner 20:00-21:55 pm Section 5: Chair: Endre Barta 20: Zsolt Bacsó: Raftology update : Katalin Goda: Catalytic mechanism of drug transporting ABC proteins 20:40-20:55 Zsuzsa Gutayné Tóth: Cholesterol dependent trafficking of Pgp conformational states 20:55-21:10 Gábor Szalóki: Plasmamembrane drug sequestration in ATPase deficient MDR1 mutants :25 Orsolya Bársony: Elucidation of the catalytic intermediates of P-glycoprotein 21:25-21:40 Melinda Paholcsek: Aspergillus diagnostics in Debrecen 6
7 21:40-21:55 Krisztina Matúz: Studies on the inhibition of the gammaretrovirus XMRV protease 6 January 7:00 am Breakfast 8:00-10:25 am Section 6: Chair: István Szatmári 8:00-8:20 Gábor Szabó: To be or not to be impartial in chromatin research 8: Lóránt Székvölgyi: Global mapping of chromosomal R-loops and single-strand nicks" 8:40-8:55 Tamás Varga: Macrophage PPARgamma is a regulator of tissue regeneration 8:55-9:10 László Imre: Global epigenetic and structural changes in chromatin accompanying embryonic stem cell differentiation 9:10-9:25 Réka Albert: Role of Human Corneal Stroma-Derived Mesenchymal-Like Stem Cells in Immunity, Wound Healing and Angiogenesis 9:25-9:40 Ixchelt Cuaranta: Gene expression analysis during Adipocyte differentiation from PPARg knock out ips cells 7
8 9:40-9:55 Attila Pap: PPARgamma null mouse line, new approaches to study the function of this receptor 9:55-10:10 Boglárka Tóth: Primary cellular defects in coeliac-risk cells 10:10-10:25 Beáta Tóth: Immortalization of primary Human Umbilical Vein Endothelial Cells (HUVECs) 10:25 am-16:00 pm Skiing, swimming, and excursion 16:00-17:40 pm Section 7: Chair: Szilvia Benkő 16:00-16:20 Ralph Ruehl: Update about the lipidomic profile and application for inflammatory diseases 16:20-16:40 Bálint Bálint: Deep sequencing pipeline for everyone 16:40-17:00 Zsolt Keresztessy: Protein Expression and Cell Engineering developments and services at Debrecen Clinical Genomic Center 17:00-17:20 Éva Csősz: Body fluid proteomics. Annual report: Proteomics Core Facility in :20-17:40 Attila Pap: Laboratory Animal Core Facility, an overview of 2011 year 8
9 17:40-18:10 pm Section 8: Poster viewing Renáta Bencsik: Generation and characterization of GFP expressing inducible embryonic stem cell lines Krisztián Bene: Human monocyte-derived dendritic cell responses to commensal bacteria Tímea Beregi: Exporing of SMRT/NCoR core complex expression during the neuronal differentiation Pál Botó: Modulation of embryonic stem cell-derived dendritic cell development by Hoxa4 and Hoxb4 Gyöngyi Buchan: Detection of tissue transglutaminase in human mesenchymal stem cells Lívia Gazda: Studies on retrotransposone Ty1 and Ty3 proteases Gergely Joós: Effect of retinoic acid on the phagocytosis of apoptotic cells Gergely Kalló: Brain tumor protein quantitation by targeted proteomic approach Erika Takács: Comparison the gene expression profile of embryonic stem cell- versus bone marrow-derived dendritic cells Szabolcs Tarapcsák: Interaction of retinoids with ABCG2 18:10-20:00 pm Dinner 9
10 20:00-21:40 pm Section 9: Chair: István Balogh 20: Ralph Ruehl: Identification of novel endogenous and nutritional relevant ligands for RAR and RXR receptors 20: Zsuzsanna Nagy: Identification of novel putative co-factors for PPARg and IL-4 induced STAT6 20: Péter Brázda: Nuclear receptors on the run 20:55-21:10 Zoltán Simándi: The nuclear receptor coactivator PRMT1 is a context-dependent repressor Educational issues 21:10-21:40 Beáta Scholtz: New Molecular Biologist Master Program 7 January 7:00 am Breakfast 8:00-10:05 am Section 10: Chair: Katalin Goda 8:00-8:20 István Balogh: Mutation testing in monogenic diseases 10
11 8:20-8:50 Endre Barta: The newest functional genomics results reveal interesting details of genome-wide transcriptional landscape 8:50-9:05 Gergely Nagy: High correlation between GRO-seq enhancer transcripts and ChIP-seq peaks 9:05-9:20 György Fenyőfalvi "Come on, let's twist again, like we did last year" - Quantifying DNA superhelicity in eukaryotic cell nuclei 9:20-9:35 János Mótyán: Probing the inhibitor complexes of Xenotropic Murine Leukemia Virus (XMRV) protease by molecular modeling :50 Mohamed Mahdi: HIV-2 Protease as a chemotherapeutic target 9:50-10:05 Bertalan Meskó: Pharmacogenomics of autoimmune diseases General discussion 10:15pm Concluding remarks: László Nagy Éva Rajnavölgyi József Tőzsér Gábor Szabó László Fésüs 11
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