Paraneoplastic Antibodies in Clinical Practice. Mohammed El lahawi New Cross Hospital Wolverhampton

Size: px
Start display at page:

Download "Paraneoplastic Antibodies in Clinical Practice. Mohammed El lahawi New Cross Hospital Wolverhampton"

Transcription

1 Paraneoplastic Antibodies in Clinical Practice Mohammed El lahawi New Cross Hospital Wolverhampton 1

2 Effects of Neoplasm Direct mass ( pressure ) effect Metastasis effect Remote effect 2

3 The Nervous System 1- Central NS : - Brain - Cranial Nerves - Cerebellum - Spinal Cord 2- Peripheral NS : - Peripheral nerves - Neuromuscular junctions 3

4 The Nervous System 4

5 The Brain 5

6 The Brain 6

7 Tumours presentations Directly from the tumour Remote effect from the tumour 7

8 Tumours of the Nervous System Primary tumours Secondary tumours ( metastatic ) 8

9 Spinal cord tumour 9

10 Paraneoplastic Syndromes - Definition (.. Are a group of a rare degenerative disorders that are triggered by a person s immune system response to a neoplasm.. ) 10

11 PNS - Definition (...Clinical manifestations or remote effect produced by a tumour at a site different from the tumour itself or its metastasis. ) 11

12 Neurological - PNSs ( These occur when cancer fighting antibodies or white blood cells T cells mistakenly attack normal cells in the nervous system ) 12

13 PNS First paraneoplastic anti-neural antibody was reported in 1965 Typically affect middle-aged to elderly people Neurological symptoms develop over a period of days to weeks 13

14 PNS : when it happens? Many months or years before the appearance of the symptoms or signs of the underlying cancer At the same time of the cancer During the course of the cancer When the cancer relapse Rarely after treatment 14

15 PNS - pathophysiology ( The tumour produce antibodies that create an immune reaction or an immune response in certain parts of the nervous system, leading to tissue damage and hence the clinical manifestation ) 15

16 PNS Which Tumours?? All tumours Commonest tumours are : ~ lung ~ Ovarian ~ Lymphatic ~ Breast 16

17 PNS Which parts of NS # The brain # The Cerebellum # The peripheral nerves # The Neuromuscular junction # The eyes 17

18 Neurological paraneoplastic diseases Cerebellar ataxia and C degeneration Lambert-Eaton myasthenic syndrome Stiff person syndrome Encephalomyelitis Myasthenia gravis Opsoclonus Sensory neuropathy 18

19 The Cerebellum 19

20 The Cerebellum 20

21 The Cerebellum Forms about 10% of the brain weight Responsible for co-ordination of almost all fine and sophisticated movements 21

22 The Cerebellum The cerebellum form about 10% of the brain volume and occupied the posterior fossa The main function is co-ordination of all fine movements Main symptoms : ataxia, lack of coordination and difficulty in speech 22

23 Cerebellar ataxia The cerebellum is commonly involved in the paraneoplastic process The commonest tumours are : lung, breast, genital and lympho- proliferative The symptoms and / or signs may precede the cancer by months or even years The cerebellum may appear normal in the scan May be isolated or with involvement of other parts of the nervous system 23

24 Cerebellar Ataxia Before neoplasm Gait disorder Rapid progression over weeks to months,then stabilization Small ca of the lung : Hu or Calcium channel antibodies Ovarian :Yo antibody Breast : Yo or Ri antibody Hodgkins lymphoma 24

25 Cerebellar ataxia May be from structural causes like : # tumours : primary or secondary # haemorrhage # infarction # multiple sclerosis # inflammation 25

26 Cerebellar ataxia 26

27 Cerebellar ataxia ( In any patient with cerebellar ataxia, specially elderly patients, when no obvious cause like : tumour, haematoma, infarction, genetic etc had been found paraneoplastic syndrome should be considered as the cause until proved otherwise.. ) 27

28 Neuromuscular junction disorders Myasthenia Gravis : - Neoplasm : Thymoma - Patients : > 25 years - Antibodies : * Antiacetylcholine receptors antibodies * Anti skeletal muscles antibodies 28

29 LEMS (Lambert( Lambert-Eaton)syndrome Very similar to MG Usually associated with small cell carcinoma of the lung Symptoms may precede the cancer by weeks or months Prognosis is not good 29

30 Stiffman Syndrome Tumour : usually breast Other tumours : lung and thymoma Antibodies : Amphiphysin 30

31 Encephalopathies Limbic and Brain stem encephaloparhy Male = Female Tumour : small cell lung Antibodies : Hu Progressive over days to weeks Memory loss, seizures, hallucinations lethargy, dysarthria and ataxia Onset : 3 years before to 1 year after Prognosis : poor 31

32 Opsoclonus/Myoclonus syndrome Tumour : breast and lung Onset age : May be associated with ataxia,myopathy and peripheral neuropathy In 15% of cases the tumour was discovered before the syndrome Good response to steroids 32

L E A D I N G C N S A N T I B O D Y T E S T I N G S E R V I C E S

L E A D I N G C N S A N T I B O D Y T E S T I N G S E R V I C E S L E A D I N G C N S A N T I B O D Y T E S T I N G S E R V I C E S Paraneoplastic Autoimmune Neurological Disorder Testing Services New Tests Now Available. Why Athena Diagnostics? Faster, More Relevant

More information

Management in the pre-hospital setting

Management in the pre-hospital setting Management in the pre-hospital setting Inflammation of the joints Two main types: Osteoarthritis - cartilage loss from wear and tear Rheumatoid arthritis - autoimmune disorder Affects all age groups,

More information

Thymus Cancer. This reference summary will help you better understand what thymus cancer is and what treatment options are available.

Thymus Cancer. This reference summary will help you better understand what thymus cancer is and what treatment options are available. Thymus Cancer Introduction Thymus cancer is a rare cancer. It starts in the small organ that lies in the upper chest under the breastbone. The thymus makes white blood cells that protect the body against

More information

By Dr Sarosh R Irani, Dr Camilla Buckley and Prof Angela Vincent

By Dr Sarosh R Irani, Dr Camilla Buckley and Prof Angela Vincent Limbic Encephalitis By Dr Sarosh R Irani, Dr Camilla Buckley and Prof Angela Vincent This factsheet aims to provide people affected by Encephalitis, their families, friends and carers with a better undertstanding

More information

2.1 Who first described NMO?

2.1 Who first described NMO? History & Discovery 54 2 History & Discovery 2.1 Who first described NMO? 2.2 What is the difference between NMO and Multiple Sclerosis? 2.3 How common is NMO? 2.4 Who is affected by NMO? 2.1 Who first

More information

This is the written version of our Hot Topic video presentation available at: MayoMedicalLaboratories.com/hot-topics

This is the written version of our Hot Topic video presentation available at: MayoMedicalLaboratories.com/hot-topics This is the written version of our Hot Topic video presentation available at: MayoMedicalLaboratories.com/hot-topics Welcome to Mayo Medical Laboratories Hot Topics. These presentations provide short discussion

More information

Teriflunomide (Aubagio) 14mg once daily tablet

Teriflunomide (Aubagio) 14mg once daily tablet Teriflunomide (Aubagio) 14mg once daily tablet Exceptional healthcare, personally delivered Your Consultant Neurologist has suggested that you may benefit from treatment with Teriflunomide. The decision

More information

F r e q u e n t l y A s k e d Q u e s t i o n s

F r e q u e n t l y A s k e d Q u e s t i o n s Myasthenia Gravis Q: What is myasthenia gravis (MG)? A: Myasthenia gravis (meye-uhss- THEEN-ee-uh GRAV uhss) (MG) is an autoimmune disease that weakens the muscles. The name comes from Greek and Latin

More information

Alcohol related ataxia. Information for patients Neurology

Alcohol related ataxia. Information for patients Neurology Alcohol related ataxia Information for patients Neurology page 2 of 8 What is ataxia? Ataxia means lack of co-ordination, and is the result of damage to a part of the brain called the cerebellum which

More information

Understanding. Brain Tumors. Jana, diagnosed in 1999, with her husband, Paul.

Understanding. Brain Tumors. Jana, diagnosed in 1999, with her husband, Paul. Understanding Brain Tumors Jana, diagnosed in 1999, with her husband, Paul. What Is a Brain Tumor? A brain tumor, like other tumors, is a collection of cells that multiply at a rapid rate. The tumor may

More information

Metastatic Cancer: Questions and Answers. Key Points

Metastatic Cancer: Questions and Answers. Key Points CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Metastatic Cancer: Questions

More information

Optic Neuritis. The optic nerve fibers are coated with myelin to help them conduct the electrical signals back to your brain.

Optic Neuritis. The optic nerve fibers are coated with myelin to help them conduct the electrical signals back to your brain. Optic Neuritis Your doctor thinks that you have had an episode of optic neuritis. This is the most common cause of sudden visual loss in a young patient. It is often associated with discomfort in or around

More information

Report series: General cancer information

Report series: General cancer information Fighting cancer with information Report series: General cancer information Eastern Cancer Registration and Information Centre ECRIC report series: General cancer information Cancer is a general term for

More information

A Definition of Multiple Sclerosis

A Definition of Multiple Sclerosis English 182 READING PRACTICE by Alyx Meltzer, Spring 2009 Vocabulary Preview (see bolded, underlined words) gait: (n) a particular way of walking transient: (adj) temporary; synonym = transitory remission:

More information

Doctor I can t walk properly - a guided walk around some gait problems

Doctor I can t walk properly - a guided walk around some gait problems Doctor I can t walk properly - a guided walk around some gait problems Dr Jeremy Rees Consultant Neurologist National Hospital for Neurology and Neurosurgery, Queen Square www.london-neurology.co.uk Walking

More information

Trauma Insurance Claims Seminar Invitation

Trauma Insurance Claims Seminar Invitation Trauma Insurance Claims Seminar Invitation Introduction Since the development of Trauma Insurance in Australia in the 1980s, the product has evolved at a great pace. Some of the challenges faced by claims

More information

Case Study: John Woodbury

Case Study: John Woodbury Case Presentation John is 44 years old. He is sitting in the chair in the examination room. As he moves to the table, he stumbles on the carpet, laughs at himself and says that happens all the time. John

More information

AUBMC Multiple Sclerosis Center

AUBMC Multiple Sclerosis Center AUBMC Multiple Sclerosis Center 1 AUBMC Multiple Sclerosis Center The vision of the American University of Beirut Medical Center (AUBMC) is to be the leading academic medical center in Lebanon and the

More information

Neurology Clerkship Learning Objectives

Neurology Clerkship Learning Objectives Neurology Clerkship Learning Objectives Clinical skills Perform a neurological screening examination of the cranial nerves, motor system, reflexes, and sensory system under the observation and guidance

More information

FastTest. You ve read the book... ... now test yourself

FastTest. You ve read the book... ... now test yourself FastTest You ve read the book...... now test yourself To ensure you have learned the key points that will improve your patient care, read the authors questions below. The answers will refer you back to

More information

This reference summary explains platelet disorders. It covers symptoms of these disorders as well as treatment options.

This reference summary explains platelet disorders. It covers symptoms of these disorders as well as treatment options. Platelet Disorders Introduction Platelets are little pieces of blood cells that help wounds heal. They prevent severe bleeding by forming blood clots. Having too few platelets, too many platelets or platelets

More information

Aggressive lymphomas. Michael Crump Princess Margaret Hospital

Aggressive lymphomas. Michael Crump Princess Margaret Hospital Aggressive lymphomas Michael Crump Princess Margaret Hospital What are the aggressive lymphomas? Diffuse large B cell Mediastinal large B cell Anaplastic large cell Burkitt lymphoma (transformed lymphoma:

More information

Estimated New Cases of Leukemia, Lymphoma, Myeloma 2014

Estimated New Cases of Leukemia, Lymphoma, Myeloma 2014 ABOUT BLOOD CANCERS Leukemia, Hodgkin lymphoma (HL), non-hodgkin lymphoma (NHL), myeloma, myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPNs) are types of cancer that can affect the

More information

Brain Cancer. This reference summary will help you understand how brain tumors are diagnosed and what options are available to treat them.

Brain Cancer. This reference summary will help you understand how brain tumors are diagnosed and what options are available to treat them. Brain Cancer Introduction Brain tumors are not rare. Thousands of people are diagnosed every year with tumors of the brain and the rest of the nervous system. The diagnosis and treatment of brain tumors

More information

ICD-10-CM Codes for Neurology

ICD-10-CM Codes for Neurology Diagnostic Services -CM s for Neurology Behavioral/Cognitive Syndromes F04 F09 F90.9 Amnestic Disorder Due To Known Physiological Condition Mental Disorder Due To Known Physiological Condition Attention-Deficit

More information

Understanding How Existing and Emerging MS Therapies Work

Understanding How Existing and Emerging MS Therapies Work Understanding How Existing and Emerging MS Therapies Work This is a promising and hopeful time in the field of multiple sclerosis (MS). Many new and different therapies are nearing the final stages of

More information

Stroke diagnosis and misdiagnosis. Dr. Peter Enevoldson Consultant Neurologist Walton Centre for Neurology & Neurosurgery Liverpool

Stroke diagnosis and misdiagnosis. Dr. Peter Enevoldson Consultant Neurologist Walton Centre for Neurology & Neurosurgery Liverpool Stroke diagnosis and misdiagnosis Dr. Peter Enevoldson Consultant Neurologist Walton Centre for Neurology & Neurosurgery Liverpool Stroke A clinical syndrome characterised by rapidly developing clinical

More information

Myositis and Your Lungs

Myositis and Your Lungs Myositis and Your Lungs 2011 TMA Annual Meeting Las Vegas, Nevada Chester V. Oddis, MD University of Pittsburgh Myositis Heterogeneous group of autoimmune syndromes characterized by chronic muscle weakness

More information

It s not something you want to think about, but it s something you want to prepare for.

It s not something you want to think about, but it s something you want to prepare for. It s not something you want to think about, but it s something you want to prepare for. StemCyte cord blood banking offers your family a new lifesaving treatment alternative Why Bank Take the once-in-alifetime

More information

Entry-level Educational Curriculum Content Guidelines for Electrophysiological Examination and Evaluation

Entry-level Educational Curriculum Content Guidelines for Electrophysiological Examination and Evaluation Entry-level Educational Curriculum Content Guidelines for Electrophysiological Examination and Evaluation Introduction: Section on Clinical Electrophysiology and Wound Management American Physical Therapy

More information

Guideline for the Management of Acute Peripheral Facial nerve palsy. Bells Palsy in Children

Guideline for the Management of Acute Peripheral Facial nerve palsy. Bells Palsy in Children Guideline for the Management of Acute Peripheral Facial nerve palsy Definition Bells Palsy in Children Bell palsy is an acute, idiopathic unilateral lower motor neurone facial nerve palsy that is not associated

More information

guides BIOLOGY OF AGING STEM CELLS An introduction to aging science brought to you by the American Federation for Aging Research

guides BIOLOGY OF AGING STEM CELLS An introduction to aging science brought to you by the American Federation for Aging Research infoaging guides BIOLOGY OF AGING STEM CELLS An introduction to aging science brought to you by the American Federation for Aging Research WHAT ARE STEM CELLS? Stem cells are cells that, in cell cultures

More information

Guide to Critical Illness Definitions For guidance purposes only

Guide to Critical Illness Definitions For guidance purposes only LIFE PROTECTION Guide to Critical Illness Definitions For guidance purposes only Lift art drawn by LoBianco Studios 5/99 About this booklet This booklet has been produced for guidance purposes only. Please

More information

GENENTECH S OCRELIZUMAB FIRST INVESTIGATIONAL MEDICINE TO SHOW EFFICACY IN PEOPLE WITH PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS IN LARGE PHASE III STUDY

GENENTECH S OCRELIZUMAB FIRST INVESTIGATIONAL MEDICINE TO SHOW EFFICACY IN PEOPLE WITH PRIMARY PROGRESSIVE MULTIPLE SCLEROSIS IN LARGE PHASE III STUDY NEWS RELEASE Media Contact: Tara Iannuccillo (650) 467-6800 Investor Contacts: Stefan Foser Karl Mahler (650) 467-2016 011 41 61 687 8503 GENENTECH S OCRELIZUMAB FIRST INVESTIGATIONAL MEDICINE TO SHOW

More information

The NeurOmics team at a recent project meeting

The NeurOmics team at a recent project meeting Introduction Welcome to the NeurOmics project newsletter. This is the second edition and comes after the project has been underway for just over a year. This means that whilst we still have lots of work

More information

Disease Modifying Therapies for MS

Disease Modifying Therapies for MS Disease Modifying Therapies for MS The term disease-modifying therapy means a drug that can modify or change the course of a disease. In other words a DMT should be able to reduce the number of attacks

More information

Tumour Markers. What are Tumour Markers? How Are Tumour Markers Used?

Tumour Markers. What are Tumour Markers? How Are Tumour Markers Used? Dr. Anthony C.H. YING What are? Tumour markers are substances that can be found in the body when cancer is present. They are usually found in the blood or urine. They can be products of cancer cells or

More information

LUPUS. and the Brain LUPUSUK 2015

LUPUS. and the Brain LUPUSUK 2015 12 LUPUS and the Brain LUPUSUK 2015 LUPUS and the Brain This factsheet endeavours to answer some of the many questions asked regarding lupus and the brain. Doctors throughout the world are now recognising

More information

NEUROLOCALIZATION MADE EASY

NEUROLOCALIZATION MADE EASY NEUROLOCALIZATION MADE EASY Jared B. Galle, DVM, Diplomate ACVIM (Neurology) Dogwood Veterinary Referral Center 4920 Ann Arbor-Saline Road Ann Arbor, MI 48103 Localizing a neurologic problem to an anatomical

More information

Primary -Benign - Malignant Secondary

Primary -Benign - Malignant Secondary TUMOURS OF THE LUNG Primary -Benign - Malignant Secondary The incidence of lung cancer has been increasing almost logarithmically and is now reaching epidemic levels. The overall cure rate is very low

More information

Autoimmune Diseases More common than you think Randall Stevens, MD

Autoimmune Diseases More common than you think Randall Stevens, MD Autoimmune Diseases More common than you think Randall Stevens, MD picture placeholder Autoimmune Diseases More than 60 different disorders Autoimmune disorders (AID) diseases caused by the immune system

More information

The Nuts and Bolts of Multiple Sclerosis. Rebecca Milholland, M.D., Ph.D. Center for Neurosciences

The Nuts and Bolts of Multiple Sclerosis. Rebecca Milholland, M.D., Ph.D. Center for Neurosciences The Nuts and Bolts of Multiple Sclerosis Rebecca Milholland, M.D., Ph.D. Center for Neurosciences Objectives Discuss which patients are at risk for Multiple Sclerosis Discuss the diagnostic criteria for

More information

Use of oral steroids in Multiple Sclerosis

Use of oral steroids in Multiple Sclerosis Use of oral steroids in Multiple Sclerosis Information for patients and carers Neurology Department Aberdeen Royal Infirmary What are steroids? The steroids used to treat Multiple Sclerosis (MS) relapses

More information

Vision Health: Conditions, Disorders & Treatments NEUROOPTHALMOLOGY

Vision Health: Conditions, Disorders & Treatments NEUROOPTHALMOLOGY Vision Health: Conditions, Disorders & Treatments NEUROOPTHALMOLOGY Neuroophthalmology focuses on conditions caused by brain or systemic abnormalities that result in visual disturbances, among other symptoms.

More information

End of life care: What problems will we meet in neurological patients? Dr Eli Silber Consultant Neurologist Kings College Hospital

End of life care: What problems will we meet in neurological patients? Dr Eli Silber Consultant Neurologist Kings College Hospital End of life care: What problems will we meet in neurological patients? Dr Eli Silber Consultant Neurologist Kings College Hospital Outline How do neurologists work? Which neurological conditions may require

More information

Oxford University Hospitals. NHS Trust. Department of Neurology Natalizumab (Tysabri) for Multiple Sclerosis. Information for patients

Oxford University Hospitals. NHS Trust. Department of Neurology Natalizumab (Tysabri) for Multiple Sclerosis. Information for patients Oxford University Hospitals NHS Trust Department of Neurology Natalizumab (Tysabri) for Multiple Sclerosis Information for patients page 2 What is Natalizumab and what is it used for? Natalizumab is an

More information

The Types of stem cells: Totipotent Pluripotent Multipotent

The Types of stem cells: Totipotent Pluripotent Multipotent Stem Cells is the main material for building and regeneration of the body Stem cells are not differentiated and can transform to any cell of organism Stem cells are capable of indefinite renewal through

More information

3nd Biennial Contemporary Clinical Neurophysiological Symposium October 12, 2013 Fundamentals of NCS and NMJ Testing

3nd Biennial Contemporary Clinical Neurophysiological Symposium October 12, 2013 Fundamentals of NCS and NMJ Testing 3nd Biennial Contemporary Clinical Neurophysiological Symposium October 12, 2013 Fundamentals of NCS and NMJ Testing Peter D. Donofrio, M.D. Professor of Neurology Vanderbilt University Medical Center

More information

EMG and the Electrodiagnostic Consultation for the Family Physician

EMG and the Electrodiagnostic Consultation for the Family Physician EMG and the Electrodiagnostic Consultation for the Family Physician Stephanie Kopey, D.O., P.T. 9/27/15 The American Association of Neuromuscular & Electrodiagnostic Medicine (AANEM) Marketing Committee

More information

Oncology. Objectives. Cancer Nomenclature. Cancer is a disease of the cell Cancer develops when certain cells begin to grow out of control

Oncology. Objectives. Cancer Nomenclature. Cancer is a disease of the cell Cancer develops when certain cells begin to grow out of control Oncology Objectives Describe the etiology and pathophysiological mechanisms of cancer Discuss medical and family history findings relevant to cancer Identify general signs and symptoms associated with

More information

EUROPEAN BOARD OF PHYSICAL AND REHABILITATION MEDICINE LOGBOOK EUROPEAN UNION OF MEDICAL SPECIALISTS UEMS

EUROPEAN BOARD OF PHYSICAL AND REHABILITATION MEDICINE LOGBOOK EUROPEAN UNION OF MEDICAL SPECIALISTS UEMS EUROPEAN BOARD OF PHYSICAL AND REHABILITATION MEDICINE LOGBOOK EUROPEAN UNION OF MEDICAL SPECIALISTS UEMS IDENTIFICATION... 2 INSTRUCTIONS FOR USE... 3 THE TRAINING COURSE... 3 TRAINING PROGRAMME... 4

More information

MULTIPLE SCLEROSIS. Mary Beth Rensberger, RN, BSN, MPH Author

MULTIPLE SCLEROSIS. Mary Beth Rensberger, RN, BSN, MPH Author MULTIPLE SCLEROSIS Mary Beth Rensberger, RN, BSN, MPH Author All rights reserved. Purchasers of this module are permitted to reproduce the forms contained herein for their individual internal use only.

More information

Understanding. Multiple Sclerosis. Tim, diagnosed in 2004.

Understanding. Multiple Sclerosis. Tim, diagnosed in 2004. Understanding Multiple Sclerosis Tim, diagnosed in 2004. What Is Multiple Sclerosis? Multiple sclerosis (MS) is a neurologic disorder that affects the central nervous system (CNS). The CNS includes the

More information

Acute Disseminated Encephalomyelitis (ADEM)

Acute Disseminated Encephalomyelitis (ADEM) Acute Disseminated Encephalomyelitis (ADEM) By Professor Clive Hawkins, Professor of Clinical Neurology, Consultant Neurologist, University Hospital of North Staffordshire and reviewed by Dr Sarosh Irani,

More information

Module 1: The Somato-Motor System: Tendon Tap reflex

Module 1: The Somato-Motor System: Tendon Tap reflex Module 1: The Somato-Motor System: Tendon Tap reflex Module Objectives: 1. Describe the anatomic pathway of a tendon tap reflex. 2. Explain how a tendon tap reflex assessment assists in diagnosis of a

More information

Disease Modifying Therapies for MS

Disease Modifying Therapies for MS Disease Modifying Therapies for MS The term disease-modifying therapy (DMT) means a drug that can modify or change the course of a disease. In other words a DMT should be able to reduce the number of attacks

More information

The Central Nervous System

The Central Nervous System A fact sheet for patients and carers Spinal strokes This fact sheet provides information on spinal strokes. Our fact sheets are designed as general introductions to each subject and are intended to be

More information

Anatomy and Physiology (ANPY) CTY Course Syllabus

Anatomy and Physiology (ANPY) CTY Course Syllabus Anatomy and Physiology (ANPY) CTY Course Syllabus When Key Points / Objectives Content Day 1 INTRODUCTION HOMEOSTASIS LEVELS OF ORGANIZATION Day 2 CELLULAR AND MOLECULAR BIOLOGY GENETICS Day 3 INTEGUMENTARY

More information

Muscular Dystrophy and Multiple Sclerosis. ultimately lead to the crippling of the muscular system, there are many differences between these

Muscular Dystrophy and Multiple Sclerosis. ultimately lead to the crippling of the muscular system, there are many differences between these Battles 1 Becky Battles Instructor s Name English 1013 21 November 2006 Muscular Dystrophy and Multiple Sclerosis Although muscular dystrophy and multiple sclerosis are both progressive diseases that ultimately

More information

Understanding Metastatic Disease

Understanding Metastatic Disease Supported by an unrestricted educational grant from Pfizer Understanding Metastatic Disease Metastatic disease or metastases are phrases that mean the same as Secondary cancer. This means that the cancer

More information

Aetna Nerve Conduction Study Policy

Aetna Nerve Conduction Study Policy Aetna Nerve Conduction Study Policy Policy Aetna considers nerve conduction velocity (NCV) studies medically necessary when both of the following criteria are met: 1. Member has any of the following indications:

More information

Disorders Considered. A Brief Synopsis of Select Neurological Disorders. Neurological and Psychiatric Symptoms. Neurological Basis

Disorders Considered. A Brief Synopsis of Select Neurological Disorders. Neurological and Psychiatric Symptoms. Neurological Basis Disorders Considered A Brief Synopsis of Select Neurological Disorders Four neurological disorders are examined to illustrate pathological conditions that can develop related to course material Myasthenia

More information

CEREBELLAR ATAXIA: A GUIDE FOR THE MEDICAL PROFESSION

CEREBELLAR ATAXIA: A GUIDE FOR THE MEDICAL PROFESSION CEREBELLAR ATAXIA: A GUIDE FOR THE MEDICAL PROFESSION Cerebellar ataxia can be thought of as a syndrome which has many different causes, the commonest in the UK being multiple sclerosis and alcoholic cerebellar

More information

Management of spinal cord compression

Management of spinal cord compression Management of spinal cord compression (SUMMARY) Main points a) On diagnosis, all patients should receive dexamethasone 10mg IV one dose, then 4mg every 6h. then switched to oral dose and tapered as tolerated

More information

When it s time to apply for Social Security Disability Insurance: Making a stressful and complicated process easier for you and your family!

When it s time to apply for Social Security Disability Insurance: Making a stressful and complicated process easier for you and your family! When it s time to apply for Social Security Disability Insurance: Making a stressful and complicated process easier for you and your family! Presenter Disclosures Art Spencer The following personal financial

More information

Radiotherapy in locally advanced & metastatic NSC lung cancer

Radiotherapy in locally advanced & metastatic NSC lung cancer Radiotherapy in locally advanced & metastatic NSC lung cancer Dr Raj Hegde. MD. FRANZCR Consultant Radiation Oncologist. William Buckland Radiotherapy Centre. Latrobe Regional Hospital. Locally advanced

More information

Unit 1 Lesson 5 The Nervous and Endocrine Systems Essential Question: How do the nervous and endocrine system work?

Unit 1 Lesson 5 The Nervous and Endocrine Systems Essential Question: How do the nervous and endocrine system work? Unit 1 Lesson 5 The Nervous and Endocrine Systems Essential Question: How do the nervous and endocrine system work? Copyright Houghton Mifflin Harcourt Publishing Company P60 What is the function of the

More information

Stem Cell Research: Adult or Somatic Stem Cells

Stem Cell Research: Adult or Somatic Stem Cells Chiang 1 Stem Cell Research: Adult or Somatic Stem Cells Abstract Kelly Chiang Cluster 7 Dr. LeFebvre 07/26/10 Over the past few decades, stem cells have been a controversial topic in the scientific field.

More information

Childhood Cancer in the Primary Care Setting

Childhood Cancer in the Primary Care Setting Childhood Cancer in the Primary Care Setting Mohamed Radhi, M.D. Associate Professor, UMKC Pediatric Hematology/Oncology/BMT Children s Mercy Hospital I will discuss: Overview of childhood cancer Presentation

More information

Multiple Sclerosis: An imaging review and update on new treatments.

Multiple Sclerosis: An imaging review and update on new treatments. Multiple Sclerosis: An imaging review and update on new treatments. Dr Marcus Likeman Consultant Neuroradiologist North Bristol NHS Trust Bristol Royal Hospital for Children MRI appearances - White Matter

More information

Perceived fatigue and muscle fatigability in persons with multiple sclerosis Wolkorte, Ria

Perceived fatigue and muscle fatigability in persons with multiple sclerosis Wolkorte, Ria Perceived fatigue and muscle fatigability in persons with multiple sclerosis Wolkorte, Ria IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from

More information

Chapter 2 End of Life Care in Neurological Disease

Chapter 2 End of Life Care in Neurological Disease Chapter 2 End of Life Care in Neurological Disease David Oliver and Eli Silber Abstract Neurological disease may present and progress in many different ways, according to the disease and the individual,

More information

Anatomy and Physiology (ANPY) CTY: Academic Explorations Grades 7 and 8

Anatomy and Physiology (ANPY) CTY: Academic Explorations Grades 7 and 8 Anatomy and Physiology (ANPY) CTY: Academic Explorations Grades 7 and 8 Text: Mader s Understanding Human Anatomy & Physiology; 7 th Edition. TOPIC/OBJECTIVES HOW 1 Welcome and Introduction Ice Breaker

More information

UAMS / CAVHS Adult Neurology Neuro-Ophthalmology Curriculum 6/13/08

UAMS / CAVHS Adult Neurology Neuro-Ophthalmology Curriculum 6/13/08 UAMS / CAVHS Adult Neurology Neuro-Ophthalmology Curriculum 6/13/08 Summary Description of Rotation The adult neurology neuro-ophthalmology rotation is an extremely important rotation for 1 month during

More information

Chiari malformations

Chiari malformations A fact sheet for patients and carers Chiari malformations This fact sheet provides information on Chiari malformations. It focuses on Chiari malformations in adults. Our fact sheets are designed as general

More information

CHAPTER 2. Neoplasms (C00-D49) March 2014. 2014 MVP Health Care, Inc.

CHAPTER 2. Neoplasms (C00-D49) March 2014. 2014 MVP Health Care, Inc. Neoplasms (C00-D49) March 2014 2014 MVP Health Care, Inc. CHAPTER SPECIFIC CATEGORY CODE BLOCKS C00-C14 Malignant neoplasms of lip, oral cavity and pharynx C15-C26 Malignant neoplasms of digestive organs

More information

acquired chronic immune-mediated inflammatory condition of CNS. MS in children: 10% +secondary progressive MS: rare +primary progressive MS: rare

acquired chronic immune-mediated inflammatory condition of CNS. MS in children: 10% +secondary progressive MS: rare +primary progressive MS: rare Immunomodulatory Therapies in Pediatric MS Vuong Chinh Quyen Neurology Department Medscape Mar 8, 2013 Multiple Sclerosis in Children. Iran J Child Neurol. 2013 Spring Introduction acquired chronic immune-mediated

More information

Myasthenia Gravis: A Nursing Perspective and Clinical Guidelines Online CE Program. Post Test

Myasthenia Gravis: A Nursing Perspective and Clinical Guidelines Online CE Program. Post Test Myasthenia Gravis: A Nursing Perspective and Clinical Guidelines Online CE Program Post Test QUESTION 1 Myasthenia Gravis is characterized by: A) Unilateral ocular muscle weakness B) Chronic, hereditary

More information

IF YOU ARE RECEIVING TREATMENT WITH TYSABRI FOR RELAPSING-REMITTING MS (NATALIZUMAB)

IF YOU ARE RECEIVING TREATMENT WITH TYSABRI FOR RELAPSING-REMITTING MS (NATALIZUMAB) IF YOU ARE RECEIVING (NATALIZUMAB) TREATMENT WITH TYSABRI FOR RELAPSING-REMITTING MS Read the patient information leaflet that accompanies the medicine carefully. 1 This brochure is a supplement to the

More information

Eye movement problems in adults

Eye movement problems in adults Eye movement problems in adults 07/12/2015 A. Dahlmann-Noor Dr med PhD FRCOphth FRCS(Ed) DipMedEd Consultant Ophthalmologist Clinical Trials Lead Paediatric Ophthalmology Horizontal misalignment (Cyclo)vertical

More information

CNS DEMYLINATING DISORDERS

CNS DEMYLINATING DISORDERS CNS DEMYLINATING DISORDERS Multiple sclerosis A Dutch saint named Lidwina, who died in 1433, may have been one of the first known MS patients. After she fell while ice skating, she developed symptoms such

More information

Transverse Myelitis ISBN 978-1-901893-57-1. A guide for patients and carers

Transverse Myelitis ISBN 978-1-901893-57-1. A guide for patients and carers Transverse Myelitis ISBN 978-1-901893-57-1 A guide for patients and carers The Brain and Spine Foundation provides support and information on all aspects of neurological conditions. Our publications are

More information

Advanced Practice Provider Academy

Advanced Practice Provider Academy (+)Dean T. Harrison, MPAS,PA C,DFAAPA Director of Mid Level Practitioners; Assistant Medical Director Clinical Evaluation Unit, Division of Emergency Medicine, Department of Surgery, Duke University Medical

More information

NEW DIRECTION IN THE IMPROVEMENT OF CLINICAL CONDITIONS IN MULTIPLE SCLEROSIS PATIENTS By F. De Silvestri, E. Romani, A. Grasso

NEW DIRECTION IN THE IMPROVEMENT OF CLINICAL CONDITIONS IN MULTIPLE SCLEROSIS PATIENTS By F. De Silvestri, E. Romani, A. Grasso NEW DIRECTION IN THE IMPROVEMENT OF CLINICAL CONDITIONS IN MULTIPLE SCLEROSIS PATIENTS By F. De Silvestri, E. Romani, A. Grasso Introduction Multiple sclerosis (MS), in its many and varied clinical forms,

More information

CBT IN THE CITY. adjusted to the news of being with MS? April 2013. Experts at your fingertips call now. Check out our new services in you local area

CBT IN THE CITY. adjusted to the news of being with MS? April 2013. Experts at your fingertips call now. Check out our new services in you local area April 2013 Experts at your fingertips call now CBT IN THE CITY Check out our new services in you local area contents. A message from Susie, Information Multiple Sclerosis CBT can make a difference on the

More information

BOTOX Treatment. for Chronic Migraine. Information for patients and their families. Botulinum Toxin Type A

BOTOX Treatment. for Chronic Migraine. Information for patients and their families. Botulinum Toxin Type A BOTOX Treatment Botulinum Toxin Type A for Chronic Migraine Information for patients and their families. Is Chronic Migraine the same as Migraine? Chronic Migraine is similar to migraine as sufferers experience

More information

Critical Illness Benefit BP/FFS/CI/06 Page 1 of 5

Critical Illness Benefit BP/FFS/CI/06 Page 1 of 5 Critical Illness Benefit BP/FFS/CI/06 Page 1 of 5 The following Benefits are payable in respect of the Benefit Participants shown in the Policy Schedule as entitled to Critical Illness Benefits. No Benefit

More information

Diagram 2(i): Structure of the Neuron

Diagram 2(i): Structure of the Neuron Diagram 2(i): Structure of the Neuron Generally speaking, we can divide the nervous system into different parts, according to location and function. So far we have mentioned the central nervous system

More information

Neuromuscular Medicine Fellowship Curriculum

Neuromuscular Medicine Fellowship Curriculum Neuromuscular Medicine Fellowship Curriculum General Review Goals and Objectives Attend weekly EMG sessions as assigned Take a Directed History and Exam of each EMG patient Attend every other week Muscle

More information

Understanding your Tecfidera treatment

Understanding your Tecfidera treatment Understanding your Tecfidera treatment Information for patients who have been prescribed treatment with Tecfidera. (dimethyl fumarate) Contents About Multiple Sclerosis (MS) What is MS? Symptoms of MS

More information

Understanding your Tecfidera treatment

Understanding your Tecfidera treatment Understanding your Tecfidera treatment Information for patients who have been prescribed treatment with Tecfidera. (dimethyl fumarate) Contents About Multiple Sclerosis (MS) What is MS? Symptoms of MS

More information

Understanding cancer talk

Understanding cancer talk Understanding cancer talk Doctors may use words you don t understand. It s okay to ask them to explain something again. Understanding cancer advanced disease benign Disease that has spread outside the

More information

the progressive decline in function and performance which accompanies advancing years

the progressive decline in function and performance which accompanies advancing years Ageing: the progressive decline in function and performance which accompanies advancing years The survival rate against age can be shown in the following graph: Percentage Survival verses Age Percentage

More information

Group Benefits Evidence of Insurability for Comprehensive Optional Critical Illness Insurance

Group Benefits Evidence of Insurability for Comprehensive Optional Critical Illness Insurance Group Benefits Evidence of Insurability for Comprehensive Optional Critical Illness Insurance INSTRUCTIONS - Please print all answers If required, retain a photocopy for your files. 1a) Plan contract number(s)

More information

Desert Institute for Spine Disorders, PC

Desert Institute for Spine Disorders, PC Desert Institute for Spine Disorders, PC PATIENT INFORMED CONSENT FOR SPINE SURGERY Surgical treatment has been agreed upon and selected by you and Duane Pitt M.D. to address your symptoms or condition.

More information

A Guide to Neuropathy

A Guide to Neuropathy Neuropathy Action Foundation Awareness Education Empowerment A Guide to Neuropathy Jonathan Katz, MD Michelle Greer, RN The Neuropathy Action Foundation (NAF), a 501(c)(3) non profit, is dedicated to ensuring

More information

Neurological Disorders

Neurological Disorders Neurological Disorders Grades 9-12 Driving Question: In what ways do neurological impairments affect brain function? Objectives: Students will be able to Describe how migraines, Alzheimer s disease, and

More information

CAMBRIDGE UNIVERSITY CENTRE FOR BRAIN REPAIR A layman's account of our scientific objectives What is Brain Damage? Many forms of trauma and disease affect the nervous system to produce permanent neurological

More information

ICD-10 Physician Education. Neuropsychology

ICD-10 Physician Education. Neuropsychology ICD-10 Physician Education Neuropsychology 1 Training Objectives ICD-9 to ICD-10 Comparison Documentation Tips Additional Educational Opportunities Questions ICD-9 to ICD-10 Comparison Code Structure Diagnosis

More information

Chapter 6 Musculoskeletal System Diseases and Disorders

Chapter 6 Musculoskeletal System Diseases and Disorders Chapter 6 Musculoskeletal System Diseases and Disorders Anatomy and Physiology Bones and Joints Bones provide framework and support; classified by shape and composition Joints: where two or more bones

More information