Personal Invitation New Methods in Process Chemistry. 3rd Symposium and Siegfried Medal Award. 4 September 2008 Kongresshaus Zurich, Switzerland

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1 Personal Invitation New Methods in Process Chemistry 3rd Symposium and Siegfried Medal Award 4 September 2008 Kongresshaus Zurich, Switzerland

2 Dear visitors, Dear colleagues, Siegfried Ltd and the University of Zurich (UZH), the Organic Chemistry Institute and the Laboratorium für Prozessforschung (LPF) invite you to join them for the 3rd Siegfried Symposium. During the Symposium the internationally recognized Siegfried Medal will be awarded jointly by the UZH and Siegfried for outstanding research in the field of chemical process development. This year s Siegfried Symposium offers a wide range of outstanding speakers who will delve into the world of process development as practiced by leading companies. The speakers will offer real life scenarios and acquaint the participants with current research at various universities. The demand for close cooperation between academia and industry is being heard repeatedly as is the call for breakthroughs in chemical process development attained at universities to be made available to industry as quickly as possible. Siegfried enjoys a longstanding cooperation with the University of Zurich s Laboratorium für Prozessforschung (LPF), which has provided significant benefits for both organizations. We consider the Siegfried Symposium an expression of this cooperation and an important step toward strengthening interest in process research. We look forward to seeing you all soon in Zurich. Prof. Jay Siegel Director LPF, University Zurich Douglas C. Günthardt CEO Siegfried Group

3 Representatives of the leading pharma companies of the world will present various case studies of important methods in process development Prof. Matthias Beller, Rostock Institute for Catalysis «Molecular-defined Catalysis - A Key Technology for Organic Synthesis» Prof. Anthony GM Barrett, Imperial College London «Recent Advances in the Synthesis of Bioactive Aromatic Compounds» Dr. Michael Lipton, Schering Plough «Pharmaceutical Process Development, So Many Problems, So Little Time» Dr. Thomas Bader, LPF Zurich Dr. Hans-Rudolf Marti, Siegfried Ltd «Practical API Development: Fun, Challenging or Routine and Tedious?» Dr. Michael K. Levis, Siegfried Ltd «SQE 2, a Principle in Process Design. Synergies of an Integrated Approach in API Development»

4 Active in Life Science markets, the Siegfried Group is a global manufacturer of pharmaceutical products. With production facilities located in Switzerland, Germany, Malta and the USA, Siegfried currently has approximately 950 employees and achieved annual sales of approx. CHF 300 million in Siegfried integrates two pharmaceutical Divisions. Siegfried Actives develops and produces both exclusive active pharmaceutical ingredients (API) and cgmp and non cgmp intermediates for the pharma industry as well as standard APIs. Siegfried Generics produces demanding generic products. Siegfried Holding AG is listed on the Swiss Stock Exchange in Zurich (SWX: SFZN).

5 New Methods in Process Chemistry 3rd Symposium and Siegfried Medal Award 4 September 2008 Kongresshaus Zurich, Gotthardstrasse 5, 8022 Zurich Gartensaal 08:45 10:45 a.m. Exhibition and Poster Session Registration Morning Coffee 10:45 11:00 a.m. Morning Opening Douglas C. Günthardt Chief Executive Officer, Siegfried Group Prof. Jay Siegel Director LPF, Institute of Organic Chemistry, University Zurich 11:00 12:00 a.m. Hans-Rudolf Marti, Ph.D. «Practical API Development: Siegfried Ltd Fun, Challenging or Routine and Tedious?» and Thomas Bader, Ph.D. LPF Zurich 12:00 13:00 p.m. Lunch Break (standing only) 13:00 13:45 p.m. Prof. Matthias Beller, Ph.D. «Molecular-defined Catalysis: Rostock Institute for Catalysis A Key Technology for Organic Synthesis» 13:45 14:30 p.m. Michael Levis, Ph.D. «SQE 2, a Principle in Process Design Siegfried Ltd Synergies of an Integrated Approach in API Development» 14:30 15:00 p.m. Coffee Break 15:00 15:45 p.m. Michael Lipton, Ph.D. «Pharmaceutical Process Development: Schering Plough So Many Problems, So Little Time» 15:45 16:30 p.m. Prof. Anthony GM Barret, Ph.D. «Recent Advances in the Synthesis Imperial College London of Bioactive Aromatic Compounds» 16:30 16:45 p.m. Award of Siegfried Medal The jury will announce the Winner of the Award in May 16:45 17:30 p.m. Lecture of the Medalist 17:30 17:45 p.m. Closing Remarks Prof. Jay Siegel 17:45 18:45 p.m. Cocktails

6 GERMANY FRANCE Basel A2 Olten Zürich A1 Lucerne A1 A12 Berne A2 Geneva Lugano FRANCE ITALY Kongresshaus Zürich Gotthardstrasse Zürich Phone Fax Hotel Central Plaza Central Zürich Phone Kongresshaus Zurich - within quick and easy reach Arrival from the Airport Unique in Zurich Kloten: Train SBB to Zurich main station Arrival from Zurich main station: By tram to Stockerstrasse -Tram Nr. 6 (direction station Enge) -Tram Nr. 7 (direction Zurich Wollishofen) -Tram Nr. 13 (direction Albisgüetli) Then a 5 minute walk along the Beethovenstrasse OR Arrival from Zurich main station: By tram to Bürkliplatz -Tram Nr. 11 (direction Rehalp) Then a 5 minute walk along General Guisan-Quai Parking at the Park Hotel Hyatt, Beethovenstrasse 21

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