Ministero della Salute Direzione Generale Ricerca Scientifica e Tecnologica

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1 Ministero della Salute Direzione Generale Ricerca Scientifica e Tecnologica BANDO 2009 RICERCA FINALIZZATA e GIOVANI RICERCATORI Graduatoria 1 RF Development of Alzheimer disease therapeutics based on a natural variant of amyloid beta that hinders amyloidogenesis 5 biomedica Brain Disorders and ,00 2 RF Micro RNA Regulated Gene Transfer for Treatment of Autoimmune Diseases 5 biomedica Immunology 3 RF BLOOD PRESSURE CONTROL AND CARDIOVASCULAR RISK MANAGEMENT IN HIGH RISK HYPERTENSIVE PATIENTS. CLINICAL EFFICACY AND FEASIBILITY OF HOME TELEMONITORING. 5,5 clinico assistenziale Healthcare Delivery and Methodologies ,00 4 RF Development of osteoinductive micro and nano structured polymer surfaces for bone replacement 5,5 biomedica Bioengineering Sciences and Technologies ,00 5 RF Cognitive, imaging and genetic predictors of behavioral disturbances in Parkinson s disease 5,75 clinico assistenziale Brain Disorders and ,00 6 RF Role of alpha6 nicotinic receptor subunit in tobacco dependence 6 biomedica Brain Disorders and ,00 7 RF Role of autophagy in neuromuscular diseases 6 biomedica Cell Biology ,00 8 GR Allergic components in experimental multiple sclerosis: novel targets for immune intervention 6 biomedica Immunology ,00 9 RF ITALIAN MULTICENTRE RANDOMIZED CLINICAL TRIAL ON SUBLICNICAL ACUTE REJECTION IN KNEY TRASNPLANT RECIPIENTS 6 clinico assistenziale Immunology ,00 10 RF Analysis and manipulation of LXR signaling to induce successful antitumor responses 6 biomedica Immunology ,00 Pagina 1 di 244

2 11 RF Epigenetic control of breast cancer progression: animal and clinical studies 6 biomedica Biobehavioral and Behavioral Processes ,00 12 RF Induced pluripotent stem cells (ipsc) in the treatment of TCIRG1 dependent osteopetrosis: a step by step reproduction of the entire therapeutic process in the mouse 6 biomedica Genes, Genomes and ,00 13 GR Self Extinction of Stem Cells and the Spontaneous Regression/Dormancy of Breast Cancer 6,17 biomedica Oncology 1 Basic ,00 14 RF Role of delta16her2 splice variant in tumor progression and in response to biodrugs targeting HER2 receptor 6,25 biomedica Oncology 1 Basic ,00 15 GR Positron Emission Tomography (PET)/Computerized Tomography (CT) and Magnetic Resonance Imaging (MRI) fusion for the in vivo characterization of atherosclerotic plaques at risk 6,3 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering 16 RF INTERACTION FRAMEWORK BETWEEN PATIENT ADVOCACY GROUPS AND CANCER CENTERS ON SARCOMAS, AS A MODEL FOR RARE CANCERS 6,5 clinico assistenziale Healthcare Delivery and Methodologies ,00 17 RF SILS Study (Single Incision Laparoscopic Surgery Study) 6,5 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering ,00 18 RF Uncovering the genetic footprint of T cells residing in the pancreatic draining lymph nodes of patients with type 1 diabetes 6,5 biomedica Immunology ,00 19 GR ENVIROMENTAL, GENETIC AND EPIGENETIC COMPONENTS IN DRUG ABUSE AND RELAPSE TO DRUG SEEKING 6,5 biomedica Brain Disorders and 20 RF SNAP25 heterozygous mice as models to identify a safer pharmacological treatment for ADHD 6,5 biomedica Brain Disorders and ,00 21 RF Treatment optimization of HER2 positive breast cancer 6,5 clinico assistenziale Oncology 2 Clinical ,00 22 RF Investigation of the specific role for mglu2 and mglu3 metabotropic glutamate receptors in chronic pain. 6,5 biomedica Integrative, Functional, and Cognitive Neuroscience ,00 Pagina 2 di 244

3 23 RF Study of coagulation and tumor associated neutrophils in intestinal cancer development. 6,75 biomedica Immunology ,00 24 GR Definition of magnetic resonance imaging (MRI) biomarkers of cognitive impairment in multiple sclerosis patients with different disease phenotypes, from childhood to adulthood: application and integration of structural and functional MR based techniques 6,75 clinico assistenziale Brain Disorders and 25 GR Novel approaches to imaging and treatment of epilepsy: virus like striped nanoparticles. 7 biomedica Bioengineering Sciences and Technologies ,00 26 RF Analysis of the inkt cell DCs crosstalk for tolerance induction and prevention of autoimmune Type 1 Diabetes 7 biomedica Immunology , GR Ruvbl 1 in the pathogenesis of Hepatocellular Carcinoma. 7 biomedica Oncology 1 Basic RF Parameter invariant TCP NTCP Radiotherapy Plan Ranking 7 biomedica Oncology 2 Clinical GR Potential involvement of the atypical amino acid D aspartate in schizophrenia 7 biomedica Brain Disorders and RF HMGB1 blockade as a therapeutic tool in Systemic Lupus Erythematosus 7 biomedica Musculoskeletal, Oral and Skin Sciences , , , ,00 31 RF NEXT GENERATION DNA SEQUENCING IN DEEP VEIN THROMBOSIS 7 biomedica Vascular and Hematology ,00 32 RF Development of innovative methods for the detection of pathogenic bacteria in fresh vegetables and in irrigation and washing water of crops 7 biomedica Veterinary Food Safety FOSA 33 RF Toll like receptors at the intersection between infection and seizures: role in epileptogenesis and in developmental epilepsy 7 biomedica Brain Disorders and ,00 34 GR Exploring Opa1 dependent mitochondrial cristae remodelling as a therapeutic target in cancer 7 biomedica Cell Biology Pagina 3 di 244

4 35 GR Modelling and treatment of cystic fibrosis through an integrated Systems Biology approach 7 biomedica Cardiovascular and ,00 36 GR In pursuit of novel neuroprotective strategies for Parkinson s disease: understanding the role of PINK1 in regulating autophagy and apoptosis 7 biomedica Molecular, Cellular, and Developmental Neuroscience ,00 37 GR GENETIC VARIANTS AND SUSCEPTIBILITY TO SEVERE AND/OR RECURRENT LOWER RESPIRATORY TRACT INFECTIONS WITH WHEEZING IN CHILDREN 7 clinico assistenziale Infectious Diseases and Microbiology 38 RF Role of p53/p63/p73 family in breast cancer stem cells 7 biomedica Oncology 1 Basic ,00 39 RF Mechanisms of de regulation of self renewal and differentiation in cancer stem cells 7 biomedica Oncology 1 Basic 40 RF The novel emergence of atypical animal and human TSEs. A clinical, pathological, molecular, and experimental approach to define interspecies similarities and strain connections 7 biomedica Veterinary Animal Health ANHE 41 RF Mechanism of action and in vivo efficacy of old and new glucocorticoids and new combination treatments for an improved outcome of spinal cord injury 7,25 biomedica Brain Disorders and 42 GR Development of innovative preclinical mouse models to define the molecular mechanisms of trasformation of Anaplastic Large T cell Lymphoma 7,25 biomedica Oncology 2 Clinical ,00 43 GR Study of Radiobiological and Radiotherapic Effects of a Novel Laser Driven Electron Accelerator 7,25 biomedica Oncology 2 Clinical 44 RF Health technology assessment of needlestick prevention devices to enhance safety of health care workers 7,25 clinico assistenziale Healthcare Delivery and Methodologies , RF The zoonotic potential of Transmisible Spongiform Encephalopathies 7,25 biomedica Brain Disorders and RF Targeting HMGB1 in inflammation associated tumors 7,34 biomedica Oncology 1 Basic , ,00 Pagina 4 di 244

5 47 GR Novel nanostructured coating for dental implants and prostheses with high osseointegration efficiency 7,5 biomedica Musculoskeletal, Oral and Skin Sciences ,00 48 RF Molecular bases and pathogenic mechanisms of hereditary spinocerebellar degenerations caused by defects of mitochondrial protein quality control 7,5 biomedica Brain Disorders and ,00 49 GR Design, development and pilot clinical application of innovative biofeedback systems for multidisciplinary motor rehabilitation in Parkinson s Disease 7,5 biomedica Musculoskeletal, Oral and Skin Sciences ,00 50 RF Allotransplantation of mesoangioblasts for Duchenne Muscular Dystrophy: a phase I/II clinical trial. 7,5 clinico assistenziale Musculoskeletal, Oral and Skin Sciences ,00 51 GR Investigation of novel predictors of response to antiangiogenic treatments in hepatocellular carcinoma: Contrast Enhanced Ultrasonography (CEUS), VEGFR2 targeted CEUS and elastosonography 7,5 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering ,00 52 GR Effect on professional practice and health care outcomes of computerized evidence based information system and clinical decision support: a randomized controlled trial in orthopedics 7,5 clinico assistenziale Healthcare Delivery and Methodologies ,00 53 RF Metabolic defects in stem cells as major causes of age related diseases 7,5 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences ,00 54 GR Functional and genetic dissection of Pseudomonas aeruginosa and host response to respiratory infection 7,5 biomedica Infectious Diseases and Microbiology ,00 55 GR Promote self other merging in Autism Spectrum Conditions by combined behavioural manipulation and Noninvasive Brain Stimulation. 7,5 clinico assistenziale Brain Disorders and ,00 56 RF A multicenter randomised trial of contrast enhanced MR imaging as a breast cancer screening tool in addition to mammography and ultrasonography in women at intermediate risk. Feasibility, and short term results. 7,5 biomedica Healthcare Delivery and Methodologies ,00 57 RF Metabotropic glutamate receptors: new targets for the treatment of autoimmune disorders of the Central Nervous System 7,5 biomedica Immunology ,00 Pagina 5 di 244

6 58 RF TRANSCRANIAL STIMULATION FOR INDUCING SLEEP: Effectiveness of tdcs and TMS techniques 7,5 biomedica Integrative, Functional, and Cognitive Neuroscience ,00 59 RF Mechanisms of immune surveillance of prostate cancer by CD1d restricted invariant NKT cells 7,5 biomedica Immunology ,00 60 RF Impact of engineered nanoparticles on reproductive health and embryonic development 7,5 biomedica Bioengineering Sciences and Technologies ,00 61 RF Randomized, multi center, open label, study of monotherapy with darunavir/ritonavir or lopinavir/ritonavir vs. standard of care in virologically suppressed HIV infected patients. 7,5 clinico assistenziale AS and Related Research 62 RF DESIGN OF A CLINICAL TRIAL USING CD133 LV(U7) 7,5 clinico assistenziale Genes, Genomes and ,00 63 RF Motor neuron death in Spinal Muscular Atrophy (SMA): new animal models and innovative therapeutic strategies 7,5 biomedica Brain Disorders and ,00 64 RF Lentiviral vectors and cell permeable peptides against Ras GRF and ERK signalling to treat L DOPA induced Dyskinesia 7,5 biomedica Molecular, Cellular, and Developmental Neuroscience 65 RF BONE MARROW AS AN ALTERNATIVE SITE FOR ISLET TRANSPLANTATION IN PATIENTS WITH TYPE 1 DIABETES 7,5 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences 66 RF DISEASE MODIFIERS AND NOVEL THERAPEUTIC TARGETS FOR ALTERED TISSUE REPAIR IN DYSTROPHIC EPERMOLYSIS BULLOSA 7,67 biomedica Musculoskeletal, Oral and Skin Sciences ,00 67 RF Chronic rejection in kidney transplantation: identification of new diagnostics targets 7,67 biomedica Immunology ,00 68 GR Beyond the use of autologous graft for urethral stricture repair: a novel application of stem cell in urethral tissue reconstruction. 7,75 clinico assistenziale Bioengineering Sciences and Technologies ,00 Pagina 6 di 244

7 69 GR Innovative approaches for diagnosis and treatment of B cell Chronic Lymphocytic Leukemia 7,75 clinico assistenziale Oncology 2 Clinical ,00 70 RF A novel 3D bioreactor for in vitro platelet production: a translational research strategy to support platelet supply problems in patients undergoing chemotherapy and/or receiving autologous stem cells. 7,75 biomedica Oncology 2 Clinical ,00 71 RF Combined Gene and Cell Therapy Approaches for the Treatment of Primary Immunodeficiencies 7,75 biomedica Genes, Genomes and ,00 72 RF Induction of long term synaptic plasticity in the human cerebellum by repetitive TMS: cellular mechanisms and implications for rehabilitation in ataxia 7,75 biomedica Integrative, Functional, and Cognitive Neuroscience ,00 73 RF Role of protein misfolding in the pathogenesis of Niemann Pick type C disease: a possible therapeutic target 7,84 biomedica Brain Disorders and ,00 74 RF Impact of Modified Intention to Treat Reporting on Treatment Effect in Metaanalyses: A Meta Epidemiological Study 8 clinico assistenziale Healthcare Delivery and Methodologies ,00 75 GR Dosimetric and methodological evaluation of the novel PET amyloid tracer 18F FDDNP 8 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering ,00 76 RF Use of nanoparticles overcoming the blood brain barrier in the treatment of the mouse model of the Krabbe Disease severe form. 8 biomedica Molecular, Cellular, and Developmental Neuroscience ,00 77 RF Isolated Hemihyperplasia, a pediatric cancer risk disease: search for genetic/epigenetic mechanisms involved in its pathogenesis 8 biomedica Genes, Genomes and ,00 78 RF Population based comparisons of cancer burden indicators 8 clinico assistenziale Population Sciences and Epidemiology ,00 79 RF Study of the molecular, biochemical and metabolic mechanisms involved in the cardioprotective effect of T3 8 biomedica Cardiovascular and ,00 80 GR Functional characterization of the circulating B cell compartment in rheumatoid arthritis: relationship with clinical remission and sub clinical disease activity 8 biomedica Musculoskeletal, Oral and Skin Sciences ,00 Pagina 7 di 244

8 81 GR The relationship among food, mycotoxins, gastrointestinal disorders and autism: a multidisciplinary approach for the molecular investigation. 8 biomedica Brain Disorders and ,00 82 RF Resistance to kinase Inhibitors in cancer therapy and in target validation 8 biomedica Oncology 1 Basic 83 RF Role of mitochondrial dynamics in myogenesis and in the therapeutic action of Nitric Oxide in muscular dystrophy 8 biomedica Musculoskeletal, Oral and Skin Sciences ,00 84 RF Phospholipid homeostasis and endosomal dynamics in neurodegenerative disorders of the central and peripheral nervous system 8 biomedica Molecular, Cellular, and Developmental Neuroscience ,00 85 RF Modeling glioma progression and oncogene addiction in vivo to identify and challenge new therapeutic targets 8 biomedica Oncology 1 Basic ,00 86 RF Gene therapy for beta thalassemia: studies of efficacy and safety 8 biomedica Genes, Genomes and ,00 87 RF Enhanced cell therapy of peripheral artery disease: improving survival and engraftment of transplanted endothelial cells by cell protection from oxidative stress. 8 biomedica Vascular and Hematology ,00 88 RF Platelet Rich Plasma, from clinical application to research and back: a new nonsurgical bioactive treatment for knee cartilage degeneration and osteoarthritis. 8 clinico assistenziale Musculoskeletal, Oral and Skin Sciences 89 RF models of atlastin function and dysfunction 8 biomedica Cell Biology ,00 90 RF The Role of Adipose Triglyceride Lipase (ATGL) in the Intracellular Muscle and Adipocyte Lipid Metabolism: the Model of Neutral Lipid Storage Disease with Myopathy (NLSDM) 8 biomedica Musculoskeletal, Oral and Skin Sciences ,00 91 RF LONG TERM PROGNOSIS OF OLDER PATIENTS AFTER HOSPITAL ADMISSION: ROLE OF PHYSICAL PERFORMANCE MEASURES, INFLAMMATORY MARKERS AND ADMINISTRATIVE DATA 8 clinico assistenziale Biology of Development and Aging ,00 92 RF Mitochondrial Carrier Diseases: Clinical prevalence, study of mechanisms, and possible therapies 8 biomedica Brain Disorders and ,00 Pagina 8 di 244

9 93 GR Quantitative proteomics to decipher the molecular code of protein methylation: the dynamic methylome dissected by MS and its role in cancer 8,17 biomedica Biological Chemistry and Macromolecular Biophysics ,00 94 RF A POTENTIAL IRON LIP METABOLISM CONNECTION REVEALED BY STUDIES OF HEPCIN REGULATION: RELEVANCE TO IRON DISORDERS AND METABOLIC SYNDROME 8,17 biomedica Vascular and Hematology , RF Dissecting the Role of Autophagy in HCV induced Steatosis 8,17 biomedica Infectious Diseases and Microbiology GR Folate metabolism, epigenetics, and Alzheimer s disease 8,25 biomedica Brain Disorders and , ,00 97 RF The role of alloreactive natural killer (NK) cells in children with hematological malignancies given a T cell depleted haematopoietic stem cell transplantation (HSCT) from an HLA disparate relative. 8,25 biomedica Oncology 2 Clinical ,00 98 RF New and emerging vector borne infectious diseases in Italy: epidemiology, surveillance, diagnosis and impact on the safety of blood and organ donations. 8,25 clinico assistenziale Infectious Diseases and Microbiology ,00 99 RF Cortical stimulation in the study of time processing and anosognosia in brain damaged patients 8,25 clinico assistenziale Brain Disorders and , GR Gene therapy for inborn errors of metabolism 8,25 biomedica Genes, Genomes and GR NEurocontrolled MEchatronic prosthesis (NEMESIS) 8,25 biomedica Emerging Technologies and Training in Neurosciences GR Subthalamic Nucleus Deep Brain Stimulation in Tourette s Syndrome 8,25 clinico assistenziale Brain Disorders and , , , RF Objective diagnosis of the hearing functionality and of the hearing loss susceptibility in workers exposed to noise and/or ototoxic agents, by development of advanced techniques for the acquisition and analysis of otoacoustic emissions. Evaluation of the 8,25 biomedica Bioengineering Sciences and Technologies ,00 Pagina 9 di 244

10 104 RF Ita MNGIE: An Italian network for MNGIE epidemiology, molecular mechanisms and enzyme replacement therapy by stem cell transplant 8,25 clinico assistenziale Genes, Genomes and , RF Sensori motor Integration. Physiology and Pathophysiology. 8,34 biomedica Integrative, Functional, and Cognitive Neuroscience RF Prevention of anthracycline induced cardiotoxicity: a multicentre randomized trial 8,5 clinico assistenziale Cardiovascular and , , RF Borrelia infection and mantle cell lymphoma: a pathogenic association of clinicotherapeutic relevance 8,5 biomedica Oncology 1 Basic , RF A sequencing based genome wide association scan for autoimmunity in Sardinia 8,5 biomedica Genes, Genomes and , RF Right ventricular adaptiation in pulmonary arterial hypertension: the interplay between shape and myocardial injury 8,5 clinico assistenziale Cardiovascular and , RF Pharmacological enhancement of tumor cell death by soluble or membrane TRAIL and SMAC mimetics 8,5 biomedica Oncology 2 Clinical , RF SEARCHING NEW THERAPEUTIC TARGETS IN CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) BY DISSECTING TUMOR CELL/ MICROENVIRONMENT INTERACTIONS 8,5 biomedica Oncology 1 Basic , RF Italian Network of Genetic Isolates (INGI): identification of genetic and environmental risk factors for cardiovascular disorders 8,5 biomedica Genes, Genomes and 113 RF DRUG TRANSPORTERS AND RESISTANCE TO TREATMENT OF OVARIAN CARCINOMA 8,5 biomedica Oncology 1 Basic , GR B cell reconstitution upon gene therapy in WAS patients from the first clinical trial with lentiviral vectors 8,5 biomedica Immunology , RF Towards a functional classification of human melanoma: dissecting the altered intracellular signaling profile by phosphoproteomics approaches. 8,5 biomedica Oncology 1 Basic ,00 Pagina 10 di 244

11 116 GR The Role of Endothelial Mineralocorticoid Receptors in Vascular Inflammation and Atherosclerosis 8,5 biomedica Vascular and Hematology , GR MULTISCIPLINARY TRANSLATIONAL BIOMEDICS APPROACH TO BICUSP AORTIC VALVE RELATED AORTOPATHY FOR THE DEVELOPMENT OF NEW CLINICAL DIAGNOSTIC AND PROGNOSTIC TOOLS 8,5 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering , GR Theta band oscillations and resonance in the cerebellum: implications for cerebellar ataxia 8,5 biomedica Integrative, Functional, and Cognitive Neuroscience , RF Studies on the functional role and regulation of a restricted signature of micrornas in acute myeloid leukemia 8,5 biomedica Oncology 1 Basic , RF Growing Old with Less Disease Enhancing Neurofunctions (GOLDEN) study. A cohort study over young and old adults from general population 8,5 clinico assistenziale Biology of Development and Aging , RF Development of novel drugs counteracting amyloid driven organ damage in systemic amyloidosis 8,5 biomedica Biological Chemistry and Macromolecular Biophysics , RF Context specific response to proteotoxicity and its role in degenerative diseases 8,5 biomedica Cell Biology 123 GR Tripartite Motif (TRIM) 22 Mediated Restriction Of HIV 1 And Other Pathogenic Human Retroviruses: Investigation Of The Molecular Interactions For Novel Therapeutic Approaches 8,5 biomedica AS and Related Research , RF Cognitive reserve, brain reserve, and neuroplasticity in Alzheimer's disease 8,5 clinico assistenziale Brain Disorders and 125 GR GENETIC AND FUNCTIONAL ANALYSIS OF COPY NUMBER VARIATIONS (CNVs) AFFECTING ION CHANNEL GENES IN FAMILIAL IOPATHIC GENERALIZED EPILEPSY 8,5 biomedica Genes, Genomes and , RF Biomaterials to promote nerve regeneration: towards clinical trials. 8,5 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering ,00 Pagina 11 di 244

12 127 RF DEVELOPMENT OF DRUGS SELECTIVELY ACTIVATING Na+/Ca2+ EXCHANGER ISOFORMS TO TREAT CEREBRAL ISCHEMIA 8,5 biomedica Molecular, Cellular, and Developmental Neuroscience , RF Development of guidelines, management systems and new methodologies for GMOs traceability, own checks procedures and official control in the food and feed supply chain with respect to EU legal requirements 8,67 biomedica Veterinary Food Safety FOSA , RF Gene expression profiling in juvenile idiopathic arthritis: integrated analysis of clinical, imaging and molecular features 8,67 biomedica Musculoskeletal, Oral and Skin Sciences 130 RF A renal transplant model designed to identify non invasive kidney injury biomarkers and urinary exosomes of acute rejection and nephrotoxicity. A study in a swine lymphocyte antigens (SLA) defined strain of pigs 8,75 biomedica Immunology , GR Advanced diagnostics and innovative procedures for diagnosis and therapy in striated muscle channelopathies 8,75 biomedica Musculoskeletal, Oral and Skin Sciences , RF Contribution of Urokinase Plasminogen Activator to HIV and Tumor Derived Stroma Driving Polarization of Macrophages 8,75 biomedica AS and Related Research , GR Sudden cardiac death during myocardial ischemia: unmasking genetic factors contributing to ventricular fibrillation 8,75 biomedica Genes, Genomes and , RF DEVELOPMENT OF BIOMARKERS BY LOW INVASIVE METHODS AND THEIR VALATION IN DUCHENNE MUSCULAR DYSTROPHY AND COLLAGEN 6 MYOPATHIES TO EVALUATE MECHANISM BASED PHARMACOLOGICAL THERAPY 8,84 biomedica Musculoskeletal, Oral and Skin Sciences , RF Potentiating clinical and immunological effects of chemotherapy by neutralizing acidic ph at tumor site: a phase II randomized study in melanoma patients 8,84 clinico assistenziale Oncology 2 Clinical , RF STUDIES ON THE INVOLVEMENT OF GENETIC, EPIGENETIC AND ENVRINOMENTAL FACTORS IN THE PATHOGENESIS OF CONGENITAL HYPOTHYROISM. NOVEL PERSPECTIVES FOR THE MANAGEMENT OF A LARGELY UNEXPLAINED DISORDER 8,84 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences ,00 Pagina 12 di 244

13 137 GR MECHANISMS AND EFFECTS OF THE DNA DAMAGE RESPONSE IN THE HEART AND NOVEL MOLECULAR APPROACHES TO ENHANCE CARDIOMYOCYTE REPAIR 9 biomedica Cardiovascular and , GR Elaboration and pre clinical validation of a combinatorial immunotherapeutic strategy for the dual targeting of tumour vessels and cancer initiating cells 9 biomedica Oncology 1 Basic , RF On demand release of antimicrobial agents on biofilm colonized urinary catheters by drug functionalized polymer nanoparticles and liposomes 9 biomedica Infectious Diseases and Microbiology 140 GR Innovative screening tool for allergic diseases in children: impact on clinical outcome, quality of life and socio economic burden. 9 clinico assistenziale Healthcare Delivery and Methodologies 141 GR THE PREDICTOMIC STUDY: METABOLOMIC APPROACH IN PHENOTYPING AND DRUG RESPONSE PREDICTION IN PEDIATRIC RESPIRATORY DISESASES 9 biomedica Cardiovascular and , GR Mouse and human induced pluripotent stem cells for myocardial diseases. 9 biomedica Cardiovascular and 143 RF The role of B Cell Receptor stimulation in the pathogenesis of Chronic Lymphocytic Leukemia 9 biomedica Oncology 1 Basic , GR Mesenchymal Stem Cells and Inflammatory Bowel Disease 9 biomedica Digestive, Kidney and Urological Systems , RF Role of natural killer cells in the pathogenesis and progression of multiple sclerosis 9 biomedica Immunology , RF RIFF Project Risk and Incidence of Fragility Fractures (RIFF) in Italy for the updating and validation of the Italian version of FRAX and supporting the Nation Registry of Fragility Fractures 9 clinico assistenziale Population Sciences and Epidemiology 147 GR Reorganization of the macrophage epigenome during sustained inflammation and its functional implications. 9 biomedica Immunology , GR "My Mind" Project: the effects of cognitive training for elderly 9 clinico assistenziale Healthcare Delivery and Methodologies Pagina 13 di 244

14 149 RF Ultra deep pyrosequencing as a tool to evaluate the genetic variability of viruses, and to define markers of clinical relevance: from applied research to routine diagnosis 9 clinico assistenziale Infectious Diseases and Microbiology , RF Role of kinases and phosphatases in controlling progression through mitosis 9 biomedica Cell Biology , RF Endothelial injury and repair in diabetes. The development of a non invasive multimarker index for "vascular competence". 9 biomedica Vascular and Hematology , GR Modulation of ER stress as a therapeutic approach in hereditary neuropathies 9 biomedica Molecular, Cellular, and Developmental Neuroscience 153 GR Exploring the role of mitochondrial dynamics in the regulation of T cell homeostasis associated with MS 9 biomedica Cell Biology , GR Role of kidney, breast and lung cancer stem cells in bone metastases 9 biomedica Oncology 1 Basic , RF MicroRNAs as molecular markers of susceptibility to Mycobacterium tuberculosis infection and responsiveness to vaccination in IRF 8 deficient mouse model. 9 biomedica Infectious Diseases and Microbiology , GR Regenerative potential of the proinflammatory cytokine interleukin 22: towards new therapeutic approaches for diabetic ulcer treatment 9 biomedica Musculoskeletal, Oral and Skin Sciences , GR UNRAVELING THE PATHOGENESIS OF FAMILIAL MYELOPROLIFERATIVE NEOPLASMS: ENTIFICATION OF THE INHERITED PREDISPOSITION THROUGH GENOME WE LINKAGE ANALYSIS, GENOME WE ASSOCIATION STUDIES AND NEXT GENERATION SEQUENCING 9 biomedica Vascular and Hematology , GR Renal Committed Embryonic Stem Cells to Promote Kidney Regeneration 9 biomedica Digestive, Kidney and Urological Systems , RF Poly(ADPribosyl)ation as a member of the regulators of mitochondrial function, implication in mitochondrial disorders 9 biomedica Brain Disorders and , GR Therapeutic Inhibition of Classical and Lectin Pathways of Complement to Prevent Local and Systemic effects of Renal Ischemia Reperfusion Injury. 9 biomedica Digestive, Kidney and Urological Systems ,00 Pagina 14 di 244

15 161 GR Memory Enhancement by Advanced Non Invasive Brain Stimulation: A project on Neuro Rehabilitation of patients with memory diseases. 9 biomedica Brain Disorders and , RF Proteomic analysis of newborn's saliva. 9 biomedica Biological Chemistry and Macromolecular Biophysics , GR PATHOGENESIS OF COENZYME Q10 DEFICIENCY 9 biomedica Genes, Genomes and , RF Validation of the micronucleus assay in buccal exfoliated cells as a tool for biomonitoring DNA damage in human populations and predicting cancer in healthy subjects. 9 biomedica Population Sciences and Epidemiology , RF VRehab Virtual Reality in the Assessment and TeleRehabilitation of Parkinson s Disease and Post Stroke Disabilities 9 clinico assistenziale Emerging Technologies and Training in Neurosciences , GR ips derived neural stem cells for Spinal Muscular Atrophy Therapy (SMAThera) 9 biomedica Brain Disorders and , RF Functional relevance of Natural Killer cells in the pathogenesis of primary sclerosing cholangitis 9 biomedica Immunology , RF Converting the kinetochore spindle contact into an anticancer drug target 9 biomedica Cell Biology , RF Neuromodulation of synaptic plasticity in the cerebellum and its implications for cerebro cerebellar dysfunction in autism 9 biomedica Integrative, Functional, and Cognitive Neuroscience , RF Cell permeable JNK3 inhibitor peptides as drug delivery system to prevent neurodegeneration in Alzheimer disease 9 biomedica Brain Disorders and , GR Mucosal Dendritic Cells Anti inflammatory Phenotype Induction by Polyphenols Oral Administration: Effects on IBD Therapies. 9 biomedica Digestive, Kidney and Urological Systems , GR Modulation of MicroRNA expression by microenvironmental stimuli in Chronic Lymphocytic Leukemia: implication for therapy 9 biomedica Oncology 1 Basic ,00 Pagina 15 di 244

16 173 RF Optimization of ex vivo generation of human erythroid cells for transfusion 9 biomedica Vascular and Hematology , RF Multimodality approach in epilepsy 9 biomedica Surgical Sciences, Biomedical Imaging, and Bioengineering , RF Host cell interactions with replicating or non replicating Mycobacterium tuberculosis as a preclinical model to disclose new targets of immunointervention for tuberculosis 9 biomedica Cardiovascular and , RF Inflammation and neuroretinal injury in Diabetic Retinopathy: possible role of Pigment Epithelium Derived Factor as therapeutic agent 9 biomedica Cell Biology , RF Coupling Soluble and Cellular Diagnostics with Advanced Therapeutics for Bone Metastasis 9,17 biomedica Oncology 2 Clinical 178 GR The role of leukaemia specific mutant of NPM1 in activation of Wnt signalling, retinoic acid sensitivity in NPMc+AML 9,25 biomedica Vascular and Hematology , GR A new Cardiopulmonary By Pass system that minimizes haemodilution, haemolysis and systemic inflammation. Effects on organ damage and surgical outcome 9,25 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering , RF GONARTHRITIS TREATMENT WITH PLATELET RICH PLASM (PRP): ANALYSIS OF JOINT MICROENVIRONMENT AND PRP GROWTH FACTORS TO PREDICT THE CLINICAL OUTCOME 9,25 biomedica Musculoskeletal, Oral and Skin Sciences , RF Identification of immunosuppressive biomarkers in peripheral blood and tissues of patients with melanoma 9,25 biomedica Oncology 2 Clinical , GR Relationship between sleep disordered breathing and clinical phenotype in PD: paroxysmal motor behavioural manifestations, sleepiness and cognition. Uncover the effect by treating sleep apnoea. 9,25 clinico assistenziale Brain Disorders and , GR Safety, traceability and reliability of collection, processing and transplantation of haematopoietic stem cells (HSCs) and therapeutic cells (TCs): integrated procedures and tools to support operations, clinical care and banking 9,25 clinico assistenziale Vascular and Hematology ,00 Pagina 16 di 244

17 184 GR CO TRANSPLANTATION OF MESENCHYMAL STEM CELLS AND PANCREATIC ISLETS: A PRECLINICAL STUDY TO EVALUATE THE EFFECT ON ENGRAFTMENT AND IMMUNORESPONSE AFTER CO LOCALIZATION IN THE BONE MARROW 9,25 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences , GR CLASSICAL AND INNOVATIVE STRATEGIES FOR THE ENTIFICATION OF GENETIC DEFECTS AT THE BASIS OF RARE FORMS OF PARTIAL EPILEPSY 9,25 biomedica Genes, Genomes and , GR Straight and curved walking in Parkinson s disease: basic mechanisms, pathophysiology and rehabilitation interventions 9,25 biomedica Musculoskeletal, Oral and Skin Sciences , GR DEVELOPMENT OF NON INVASIVE STRATEGIES FOR PRENATAL DIAGNOSIS OF RARE DISEASES BASED ON SURFACE PLASMON RESONANCE (SPR) IMAGING, PEPTE NUCLEIC ACS PROBES AND PCR FREE HYBRIZATION 9,5 biomedica Genes, Genomes and , RF Novel mutated oncogenes in multiple myeloma 9,5 biomedica Oncology 1 Basic GR Identification of functional role of potassium channels in primary aldosteronism 9,5 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences , , RF Endothelial cell cell junctions:targets for vascular normalization and therapeutic intervention in tumors 9,5 biomedica Oncology 1 Basic RF Food and environmental safety: the problem of the endocrine disruptors 9,5 biomedica Veterinary Food Safety FOSA GR Promoting and imaging restoration of brain function in Multiple Sclerosis 9,5 biomedica Brain Disorders and , RF Functional analysis of NCAM in acute myeloid leukemia 9,5 biomedica Vascular and Hematology , RF Role of the RNA binding protein Sam68 in the regulation of SMN2 splicing: implications for novel therapeutic approaches to Spinal Muscular Atrophy 9,5 biomedica Genes, Genomes and , GR Post translational modifications induced by reactive species in tumor microenvironment: a new pathway to tumor immune escape 9,5 biomedica Immunology ,00 Pagina 17 di 244

18 196 RF THE ROLE OF GENDER IN PARKINSON'S DISEASE: SEX SPECIFIC THERAPEUTIC APPROACH BASED ON NEUROACTIVE STEROS 9,5 biomedica Brain Disorders and , RF Group I metabotropic glutamate receptors as possible targets for innovative pharmacological treatment of amyotrophic lateral sclerosis 9,5 biomedica Brain Disorders and , RF Role of nutrients involved in one carbon metabolism in the development of different molecular subtypes of breast cancer in the ORDET cohort 9,5 clinico assistenziale Population Sciences and Epidemiology , GR An open label, single arm, phase II, prospective, pilot study of tocilizumab in patients with Erdheim Chester disease 9,5 clinico assistenziale Immunology , RF Immunesurveillance of leukaemia by CD1 restricted T cells specific for self lipid antigens 9,5 biomedica Immunology , GR Exploiting oncogene addiction and premature senescence to design novel therapeutic strategies for the treatment of cancer 9,5 biomedica Cell Biology , RF A novel endoscopic surveillance protocol in patients with Barrett s esophagus to predict the progression to esophageal adenocarcinoma 9,5 biomedica Oncology 2 Clinical , RF Risk evaluation of human exposure to Mycobacterium avium subsp. paratuberculosis (Map) and comparative analysis of strains of human and animal origin 9,5 biomedica Veterinary Food Safety FOSA , GR Improving dementia care using early counseling and support for caregivers. 9,5 clinico assistenziale Risk, Prevention and Health Behavior , RF Cell therapy with different types of IL 10 producing regulatory T cells: pre clinical comparative validation of efficacy 9,5 biomedica Oncology 2 Clinical 206 RF Identification of new prognostic factors for disease outcome in a regional cohort of patients with B cell chronic lymphocytic leukemia (B CLL) 9,5 biomedica Vascular and Hematology , RF Role of the regulatory pathways in the pathogenesis of T cell dysfunction in chronic HBV and HCV infections: diagnostic and therapeutic implications 9,5 biomedica Infectious Diseases and Microbiology Pagina 18 di 244

19 208 RF Rehabilitation of Acalculia 9,5 clinico assistenziale Brain Disorders and , RF Physiopathology studies on the increased thyroid cancer incidence in the volcanic areas of Sicily 9,5 biomedica Oncology 1 Basic , RF Biomacromolecular characterization and multi resolution modeling in structural genomics/proteomics. Development of a comprehensive facility, and application to the fibrin(ogen) integrins cell extracellular matrix interactions model system. 9,5 biomedica Biological Chemistry and Macromolecular Biophysics , RF Effects of Hp(2 20) peptide on cutaneous, corneal, conjunctival and gastric wound healing 9,5 biomedica Veterinary Animal Health ANHE , RF Protection against influenza infection: define persistence and cross reactivity of protective immune status induced by the natural infection and vaccination; analysis of the immunological milieu in human ex vivo models. 9,5 biomedica Infectious Diseases and Microbiology , RF Development of a cerebellar connectivity EEG index to evaluate cerebro cerebellar interactions. 9,5 biomedica Brain Disorders and , RF TOTAL PANCREATECTOMY WITH ISLET AUTOTRANSPLANTATION AS A SUPERIOR ALTERNATIVE TO PANCREATODUODENECTOMY IN PATIENTS AT VERY HIGH RISK OF COMPLICATIONS OF THE PANCREATIC ANASTOMOSIS: A SINGLE CENTER PROSPECTIC RANDOMISED CLINICAL TRIAL 9,5 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering 215 RF Role of the immune system in bone resorption: the mineralized matrix as an osteoclast activating danger signal 9,5 biomedica Musculoskeletal, Oral and Skin Sciences , RF Understanding the interactions between retroviral vectors and the genome of human somatic stem cells 9,5 biomedica Genes, Genomes and , RF Dynamic interplay between innate and acquired immune response and pandemic influenza A H1N virus evolution 9,67 biomedica Infectious Diseases and Microbiology 218 GR Towards an innovative therapy of Ectrodactyly Ectodermal dysplasia Clefting (EEC) syndrome using allele specific RNA silencing 9,67 biomedica Genes, Genomes and ,00 Pagina 19 di 244

20 219 GR New insights on the role of purinergic P2Y12 receptor in Multiple Sclerosis 9,75 biomedica Brain Disorders and , RF Monitoring of chimerism on sorted peripheral CD34+ cells in patients with acute leukemia receiving allogeneic bone marrow transplantation 9,75 clinico assistenziale Oncology 2 Clinical , RF ASSESSING BEST STRATEGIES FOR ADAPTIVE IMAGE GUED TOMOTHERAPY 9,75 biomedica Oncology 2 Clinical , GR Adenoviral gene transfer of donor specific MHC class II on Aire expressing mtec to induce allograft tolerance 9,75 biomedica Immunology , GR Multi site RCT comparing regional and general anaesthesia for effects on neurodevelopmental outcome in infants The GAS study 9,75 clinico assistenziale Brain Disorders and , GR Hunt for new disease genes in hereditary spastic paraplegia 9,75 biomedica Brain Disorders and 225 GR A PROSPECTIVE COMPARATIVE STUDY BETWEEN OPEN AND ROBOTIC ASSISTED LAPAROSCOPIC RADICAL PROSTATECTOMY FOR PATIENTS WITH ORGAN CONFINED PROSTATE CANCER. IMPACT OF SURGICAL APPROACH ON ONCOLOGICAL AND FUNCTIONAL RESULTS, PERI OPERATIVE PARAMETERS AND COSTS. 9,84 clinico assistenziale Surgical Sciences, Biomedical Imaging, and Bioengineering , GR Role of Chromatin Remodeling in Germ Stem Cell Identity 10 biomedica Genes, Genomes and , GR A NEW MULTISCIPLINARY STRATEGY FOR DRUG DISCOVERY IN NEURODEGENERATIVE DISEASES 10 biomedica Molecular, Cellular, and Developmental Neuroscience , GR Standardized Brain Imaging Database for the Evaluation of Semantic Memory Disorders and Cognitive Reserve in Mild Cognitive Impairment and Alzheimer's Disease (SBSMCR) 10 biomedica Brain Disorders and , GR Psychological consequences of cancer in elderly patients and their family 10 clinico assistenziale Oncology 2 Clinical ,00 Pagina 20 di 244

21 230 GR Investigating the molecular mechanisms leading to genome instability in tumours: analysis of role of the replication stress response and its potential for early diagnosis and target therapy of cancer 10 biomedica Oncology 1 Basic , RF Preclinical characterization and sequence optimization of a potent antimicrobial peptide for the development of a new drug for Cystic Fibrosis 10 biomedica Infectious Diseases and Microbiology , RF Role of HIV 1 infection on colorectal carcinoma onset and progression and development of novel therapeutic strategies 10 biomedica AS and Related Research , GR The molecular signature of liver autoimmunity: genome wide differences in epigenetics and copy number variations between monozygotic twins discordant for primary biliary cirrhosis 10 biomedica Digestive, Kidney and Urological Systems , GR Mechanism driven exploration of hormonal interventions for menopause and aging related cardiovascular diseases 10 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences , RF "Tailored" Accreditation Model for Comprehensive Cancer Centers: validation through the applicability of the experimental OECI based model to the Network of Cancer IRCCS of Alleanza contro il Cancro 10 clinico assistenziale Healthcare Delivery and Methodologies 236 GR Service for detection of Pre psychoses: from genomics to phenomenology in a human/animal perspective 10 biomedica Brain Disorders and 237 RF IGF I isoforms and Breast Cancer 10 clinico assistenziale Endocrinology, Metabolism, Nutrition and Reproductive Sciences , GR Evaluation of cytochrome p450 2D6 and 2C19, ABCG1, ABCG2 polymorphisms in patients affected by chronic myeloid leukemia and their therapeutic implications 10 clinico assistenziale Oncology 2 Clinical , GR Role of Che 1 in DNA damage response 10 biomedica Oncology 1 Basic 240 GR Identification of immunological molecular patterns in atherosclerosis. 10 biomedica Vascular and Hematology ,00 Pagina 21 di 244

22 241 RF ANTIPLATELET TREATMENT FOR PREVENTION OF VASCULAR OUTCOMES IN PAD PATIENTS UNDERGOING PERIPHERAL REVASCULARIZATION. 10 clinico assistenziale Vascular and Hematology , GR Investigation of novel indicators of sleepiness in healthy subjects and in sleep disorders by simultaneous polysomnographic fmri techniques 10 biomedica Emerging Technologies and Training in Neurosciences , GR Development of a multifunction platform for telerehabilitation. 10 biomedica Healthcare Delivery and Methodologies , RF Study of the healthy benefits of anthocyanin dietary supplementation on obesity and cancer 10 biomedica Endocrinology, Metabolism, Nutrition and Reproductive Sciences , RF Development of a novel mouse model of B CLL: validation of p66shc as a prognostic marker and therapeutic target 10 biomedica Oncology 2 Clinical , GR Management of severe health care associated infections in high risk departments based on on line Infectious Diseases Specialists consulting: evaluation of efficacy and efficiency 10 clinico assistenziale Healthcare Delivery and Methodologies , GR The non oncotic properties of human serum albumin in liver cirrhosis: functional characterization, clinical application and therapeutic perspectives. 10 biomedica Digestive, Kidney and Urological Systems , RF Role of IL 2 family cytokines in the regulation of cell survival and gene expression of neoplastic B cells 10 biomedica Vascular and Hematology , GR The role of Gas6/RTK receptors in Rheumatoid Arthritis and Multiple Sclerosis: a patient and biological study 10 biomedica Immunology , RF Identification of a Polycystin 1/Nephrocystin 1 Complex: functional and biochemical studies in vitro and in vivo 10 biomedica Digestive, Kidney and Urological Systems 251 RF Identification of new biomarkers for metabolic syndrome associated with antipsychotic treatment 10 biomedica Biobehavioral and Behavioral Processes 252 RF From BioEngineering new tools for identification of early markers of respiratory and cardiac impairment in Duchenne Muscular Dystrophy 10 clinico assistenziale Musculoskeletal, Oral and Skin Sciences ,00 Pagina 22 di 244

23 253 RF Exome sequencing of familial Parkinson disease: fishing for new genes trough next generation sequencing 10 biomedica Genes, Genomes and 254 RF MOLECULAR AND PHARMACOLOGICAL CHARACTERIZATION OF TMEM16A (ANOCTAMIN 1) AS A NOVEL CHLORE CHANNEL 10 biomedica Cell Biology , RF The mevalonate pathway as a target of immune intervention in lymphoproliferative diseases and solid cancers 10 biomedica Oncology 2 Clinical , GR From hyperphenylalaninemia to mental retardation: the key role of serotonin. 10 biomedica Brain Disorders and , GR Proteins and genes in Frontotemporal lobar degeneration: old and novel players in neurodegeneration 10 biomedica Genes, Genomes and , RF A multidisciplinary approach to unravel the role of uromodulin in chronic diseases of the kidney 10 biomedica Digestive, Kidney and Urological Systems 259 RF MECHANISMS OF HCV PERSISTENCE IN THE HOST AND INDUCTION OF THE LYMPHOMAGENETIC PROCESS 10 biomedica Oncology 1 Basic , GR GENERATION AND TRANSPLANTATION OF GENETICALLY ENGINEERED NEURAL STEM CELLS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS 10 biomedica Brain Disorders and , RF Integrated approaches for the classification of variants of uncertain significance in BRCA genes. 10 biomedica Oncology 1 Basic , RF Combating Mitochondrial Disorders in cells, animal models and patients 10 biomedica Molecular, Cellular, and Developmental Neuroscience , RF A metagenomic approach to evaluate the influence of antimicrobial therapy on the selection of multi drug resistant clones responsible for health care associated infections in the Intensive Care Unit setting 10 biomedica Infectious Diseases and Microbiology , RF The role of necdin in the self renewal and activation of endogenous stem cells for the repair of dystrophic muscle 10 biomedica Musculoskeletal, Oral and Skin Sciences ,00 Pagina 23 di 244