14th International Conference on Nuclear Reaction Mechanisms, Varenna 18th June 2015 Status and perspective of emission imaging techniques for ion beam therapy in Lyon on behalf of the CAS-PHABIO group of IPNL Lyon 1 University and CNRS/IN2P3, France
Rationale for ion therapy and range verification Present Reduced integral dose (factor ~3) Healthy Tissues Paganetti AAPM 2012 Tumor Target Tumor volume Organ at risk Future Reduction of safety margins (dose escalations; higher cure rate) Use of new irradiation fields (use of sharp distal penumbra of Braggpeaks) Tang et. al. Med.Phys. 2012 2
How do we reduce range uncertainties? In-vivo range verification PET Prompt gamma cameras Increasing accuracy in range prediction Ion CT 3
Prompt gamma 4
Prompt gamma based range verification Projectile Nucleons and clusters Projectile fragment Fireball Target Prompt gamma Target fragment 75, 95 MeV/u 12C ions on PMMA 160 MeV protons on PMMA TOF background discrimination BP position BP position BP position ENVISION collaboration: Dauvergne et al (IPNL Lyon), Prieels et al (IBA) 5
Collimated cameras in Lyon 6
Prompt gamma profiles: TOF influence 7
Multislit collimator in Lyon 8
Multislit collimator in Lyon 9
Compton camera in Lyon 10
Gamma cameras in Lyon: Hodoscope 11
Compton camera in Lyon: Scatter detector 12
Gamma cameras in Lyon: Absorber 13
IVI 14
Interaction vertex imaging (IVI) Projectile Projectile fragment Fireball Target Nucleons and clusters Target fragment Secondary charged particles (e.g, proton) Dauvergne et al 2009 AQUA Project: G4 simulations 07.05.2015 15
IVI in Lyon: Detectors 16
IVI in Lyon: Set-ups 17
IVI in Lyon: Measurements (GSI) 18
IVI in Lyon: Measurements (GSI) 19
IVI in Lyon: MC/Measurements (HIT) R. Rescigno et al, ICTR-PHE 2014 20
Summary Imaging range verification Hardware development Monte Carlo simulations 21
Thank you 07.05.2015 22
Backup 07.05.2015 23
Prompt gammas CAS-Phabio IPN-Lyon Multi-slit Prompt-gamma camera p 160 MeV on PMMA PG without TOF PG with TOF Diff with/without TOF Compton camera Roellinghoff et.al. Phys. Med. Biol. 59 (2014) Monte Carlo as a tool for feasibility and detector design studies Detection set-up characterization and optimization in clinical conditions Clinical validation of real time range verification 07.05.2015 24
Monte Carlo validation 3 p 160 MeV on MLFC p 160 MeV on PMMA 2 Smeets et al., PMB 57 (2012) 2 2 3 2 Rinaldi et al., PMB 56 (2011), 4001 07.05.2015 2 Ferrari, Rinaldi et al., in preparation 25
Range resolution with prompt gammas 1-sigma of a distributions of fall-off positions Roellinghoff et.al. Phys. Med. Biol. 59 (2014) - 1 mm precision with 2E+09 protons, TOF selection and small detector (4 cm high) for an homogeneous target - Increase of the solid angle by a factor 10: Millimetric precision on a pencil beam basis - For distal spots ~2x108 protons/spot 07.05.2015 26
IVI techniques Single-proton imaging (SP-IVI) Intersection of a secondary-proton trajectory with the incident-ion trajectory Double-proton imaging (DP-IVI) Intersection of 2 secondary-proton trajectories Detectors Tracker (CMOS) + beam hodoscope (in coincidence) 07.05.2015 Courtesy of E. Testa 27
IVI perspectives In-beam tests with CMOS detectors: GANIL (95 MeV/u) HIT (200-300 MeV/u) QAPIVI project (IPNL+IPHC) Courtesy of E. Testa 07.05.2015 28
IVI perspectives Henriquet et.al. PMB 2012 07.05.2015 Gwosch et.al. PMB 2013 29
How to measure prompt gamma Collimated camera single and multislit Common device: Hodoscope Ray (IPN Lyon) Hardware - array of scintillating fibres (1x1 mm2) - 2 prototypes: 2x32 and 2x128 fibres - time resolution 1 ns - goal: count rates up to 108 1/s Compton camera electronic collimation Ray (IPN Lyon) Electronics - development of ASIC - new version with DLL timing Krimmer and De Rydt (IPN Lyon) 07.05.2015 30