The gross mortality rate increases to deaths per 100,000 inhabitants in 2012, that is, 3.8% more as compared with the previous year

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31 January 2014 Deaths according to Cause of Death. Year 2012 The gross mortality rate increases to 861.6 deaths per 100,000 inhabitants in 2012, that is, 3.8% more as compared with the previous year Deaths due to respiratory diseases increase 53.6% in February and March Deaths in traffic accidents decrease 9.5%, whereas suicides increase 11.3% 402,950 deaths were recorded in Spain in 2012, that is, 15,039 more than those registered in 2011 (3.9% more). This increase was concentrated in the months of February and March, a period that registered 21.0% more deaths, as compared with the same period of the previous year. By sex, 197,030 women (4.8% more) and 205,920 men (3.0% more) died. The gross mortality rate reached 861.6 deaths per 100,000 inhabitants, (3.8% more than in 2011) 1, standing at its highest value since 2005. The female rate stood at 831.0 deaths per 100,000 women, whereas the male rate was 893.1 deaths per 100,000 men. Causes of death, by groups of illnesses 2 The group of diseases of the circulatory tract remained the first cause of death (responsible for 30.3 out of every 100 deaths) followed by tumours (27.5) and respiratory diseases (11.7). The group of diseases of the nervous system, which includes Alzheimer, was the fourth cause of deaths. By sex, tumours were the first cause of death in males (with a rate of 296.3 deaths per 100,000) and the second in females (180.0). In turn, diseases of the circulatory tract were the first cause of death in females (282.2 deaths per 100,000 inhabitants) and the second in males (239.4). 1 Gross mortality rates in 2011 have been recalculated with the 2001-2011 intercensal population revised by the INE in 2013. Therefore, they differ from the rates published until now, in which the population data previous to the review was used. 2 Chapters of the International Classification of Diseases (ICD-10), tenth revision of the WHO. 1

Number of deaths by most frequent causes of death Year 2012 Total Men Women Total deaths 402,950 205,920 197,030 Ischaemic heart diseases 34,751 19,973 14,778 Cerebrovascular diseases 29,520 12,436 17,084 Bronchial and lung cancer 21,487 17,661 3,826 Cardiac failure 18,453 6,412 12,041 Chronic diseases of the lower respiratory tracts 16,964 12,557 4,407 Dementia 16,361 5,314 11,047 Alzheimer's disease 13,015 3,830 9,185 Colon cancer 11,768 6,937 4,831 Hypertensive diseases 10,273 3,354 6,919 Diabetes mellitus 9,987 4,207 5,780 Pneumonia 9,289 4,699 4,590 Renal failure 7,067 3,282 3,785 Breast cancer 6,375 93 6,282 Prostate cancer 6,045 6,045 - Pancreatic cancer 5,976 3,121 2,855 (1) Causes whose relative weight is greater than 1.5% Gross rates per 100,000 inhabitants by cause of death by chapters of the ICD and sex. Year 2012 Tumours Disease of the circulatory tract Disease of the respiratory tract Disease of the digestive tract External causes Diseases of the nervous system and sense organs Mental and behaviour disorders Endocrine diseases Diseases of genitourinary system Infectious disease Diseases of the osteomuscular system 45.7 39.1 39.5 20.6 36.5 57.6 25.3 47.8 22.8 31.9 23.0 27.6 14.3 13.6 5.3 10.8 87.3 115.5 180.0 239.4 Men Woman 282.2 296.3 2

By age, the main cause of death in persons aged 1 to 14 and 40 to 79 years old were tumours (with rates of 3.2 and 314.8 per 100,000 persons of these age groups, respectively). Among the persons aged 15 to 39 years the main cause of death was the external causes group (15.4 per 100,000 persons) and for the group of persons older than 79 years old the main cause was the group of diseases of the circulatory tract (3,391.2 deaths per 100,000 persons). The main cause of death among children aged less than one year were affections originating in the perinatal period, with a rate of 176.4 per 100,000 children born alive. 100% Main causes of death by age Pecentage over the total deaths. Year 2012 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% Less than From 1 to 1 year old 14 From 15 to 24 From 25 to 34 From 35 to 44 From 45 to 54 From 55 to 64 From 65 to 74 From 75 to 84 85 years old and over Tumorurs Perinatal and congenital malformations Circulatory system External causes Mortality increase in 2012 In 2012, the number of deaths increased in almost every chapter of diseases. The two groups that registered a greatest increase were mental and behavioural disorders, with an increase of 12.2% as compared with 2011 (within this group vascular and senile dementia, as well as other types of dementia other than Alzheimer are included), and respiratory diseases, with an increase of 12.1%. It is worth mentioning the upturn in mortality caused by those two groups in the months of February and March, as compared with the same period of the previous year: 53.6% more in the case of respiratory diseases and 41.2% in mental and behavioural disorders. 3

Interannual variation in the number of deaths by groups of diseases of the ICD. Years 2012-2011 Mental and behavioural disorders Diseases of the respiratory tract Diseases of the osteomuscular system 11.2% 12.2% 12.1% Diseases of the nervous system and sensory organs 9.1% Diseases of the genitourinary system 7.5% TOTAL DISEASES Diseases of the circulatory tract 3.2% 3.9% Infectious diseases Tumours Diseases of the digestive tract Endocrine diseases External causes 1.9% 1.5% 1.1% 0.3% 1.6% Among the causes that explain the increase in deaths at the beginning of the year, it is worth noting the flu epidemic, which began later during the 2011-12 season, as compared with the previous seasonal epidemics of this disease. The peak of maximum flu incidence was registered in February 2012. Deaths caused by the flu had a greater impact in the age group of 75 years old and over, up to double the number of deaths, as compared with the previous year (175 cases). Interannual variation in the number of deaths by months. Years 2012-2011 62.1% 44.4% 28.7% 12.1% 10.4% 3.9% 4.7% 13.4% 18.1% 9.8% 6.2% 3.8% 0.2% -0.6% -1.4% -2.5% -1.5% -0.3% -3.1% -1.7% -4.1% -3.6% -4.0% -4.4% -8.1% -4.1% ALL THE YEAR Jan Feb Mar Apr May Jun Jul Agu Sep Oct Nov Dec Total causes Respiratory diseases 4

Although the flu is not the direct cause of a large number of deaths, it can contribute to the aggravation of other diseases. In that sense, in February and March a great increase in mortality due to almost all respiratory diseases was registered. Thus, deaths due to pneumonia increased by 59.1%, as compared with the same period of the previous year, whereas those due to chronic lower respiratory diseases (bronchitis, emphysema ) increased by 38.7%. In those two months, mortality due to diseases of the circulatory tract, such as heart failure (29.6% more) also registered an increase. In turn, the number of deaths due to diseases of the nervous system (including Alzheimer) increased 36.5% in February and March. Throughout the year, the increase in the number of deaths due to these diseases was 9.1%. It is also worth mentioning the increase in deaths due to dementias in the months of February and March (42.8% more than in the same period of the previous year). Increase in mortality in the months of February and March 2012 as compared with 2011 by diseases Diabetes mellitus Cerebrovascular diseases ALL CAUSES Hypertensive diseases Asthma Cardiac failure Respiratory failure Chronic diseases of the lower respiratory tracts Alzheimer's disease Dementia Flu Pneumonia Other respiratory diseases 15.7% 17.9% 21.0% 21.7% 26.0% 29.6% 33.7% 38.7% 40.4% 42.8% 55.6% 59.1% 70.9% Most common diseases causing deaths On a more detailed level, within the group of circulatory diseases, ischaemic heart diseases (heart attack, angina pectoris etc.) occupied the first place in the number of deaths, although they registered a decrease of 0.2% as compared with the previous year. Followed by cerebrovascular diseases, which registered an increase of 2.3%. By sex, ischaemic heart diseases were the leading cause of death in men and cerebrovascular diseases were the main cause in women. Among tumours, those causing the greatest mortality were bronchial and lung cancer and colon cancer (which increased by 2.0% and 0.7%, respectively). The first was the cancer causing the largest number of deaths among men. In women it was breast cancer (although the total number of deaths decreased 0.4% as compared with 2011). 5

Dementias 3 caused 16,361 deaths and occupied the seventh place in terms of most frequent causes of death in Spain. The increase in mortality due to this disease (12.2%) was the second highest among the main diseases, after pneumonia (13.7%). Alzheimer caused 13,015 deaths, that is, 9.3% more than in 2011 (and 40.4% more in the period between February and March). In both dementias and Alzheimer, worth noting is the excess mortality registered among women. In fact, out of 10 deaths due to these two causes, seven were women. Number of deaths by most frequent causes of death Year 2012 Total Men Women Total deaths 402,950 205,920 197,030 Ischaemic heart diseases 34,751 19,973 14,778 Cerebrovascular diseases 29,520 12,436 17,084 Bronchial and lung cancer 21,487 17,661 3,826 Cardiac failure 18,453 6,412 12,041 Chronic diseases of the lower respiratory tracts 16,964 12,557 4,407 Dementia 16,361 5,314 11,047 Alzheimer's disease 13,015 3,830 9,185 Colon cancer 11,768 6,937 4,831 Hypertensive diseases 10,273 3,354 6,919 Diabetes mellitus 9,987 4,207 5,780 Pneumonia 9,289 4,699 4,590 Renal failure 7,067 3,282 3,785 Breast cancer 6,375 93 6,282 Prostate cancer 6,045 6,045 - Pancreatic cancer 5,976 3,121 2,855 (1) Causes whose relative weight is greater than 1.5% External causes Deaths due to external causes registered a 1.6% decrease in 2012, as compared with the overall increase of the rest of the causes. Deaths due to traffic accidents continued their downward trend. Specifically, there were 1,915 deaths, 9.5% less as compared with 2011. Suicide was, once again, the main external cause of mortality. In 2012, 3,539 persons died (2,724 men and 815 women), that is, 11.3% more than in the previous year. The suicide rate 3 It includes vascular dementia and others, such as senile dementia. However, it does not include Alzheimer dementia, which is considered within the group of diseases of the nervous system. 6

stood at 7.6 per 100,000 inhabitants (11.8 in men and 3.4 in women). This was the highest rate registered since 2005. Among the persons aged 25 to 34 years old, suicide was the second cause of death, being the first one tumours, with 15.0% of the total deaths. Among men of said age group, suicide was the main cause of death (17.8% of the total). Percentage of deaths due to suicide and traffic accidents over the total deaths by age. Year 2012 17.5% 13.6% 15.0% 10.9% 9.8% 0.2% 2.7% 4.9% 3.9% 1.5% 1.7% 0.7% 0.3% 0.2% Under 15 years old From 15 to 24 From 25 to 34 From 35 to 44 From 45 to 54 From 55 to 64 65 years old and over Suicides Traffic Accidents Mortality rates by Autonomous Community The highest gross death rates per 100,000 inhabitants in 2012 corresponded to Principado de Asturias, Castilla y León and Galicia. In turn, the lowest mortality rates were recorded in the Autonomous Cities of Melilla and Ceuta and in the Autonomous Communities of Canarias and Comunidad de Madrid. Gross death rates were higher in ageing territories, as there were more deaths due to the age structure. In order to adjust the results, standardised rates representing mortality in Autonomous Communities if all of them had the same age composition are calculated. After conducting this adjustment, the regions with the highest standardised rates were the Autonomous Cities of Melilla and Ceuta, and the Autonomous Communities of Andalucía and Extremadura. 7

Mortality rates by AACC(*). Year 2012 719.6 615.0 670.1 748.7 662.5 666.4 655.7 Asturias, Principado de Castilla y León Galicia Extremadura Aragón Cantabria Rioja, La 1228.3 1118.3 1116.2 1029.7 1023.6 983.3 944.4 647.8 País Vasco 930.3 668.4 Castilla-La Mancha 907.4 687.2 717.9 608.1 667.7 788.9 740.5 715.4 730.9 583.1 819.4 824.6 standardized rates TOTAL NATIONAL Comunitat Valenciana Navarra, C. Foral de Cataluña Andalucía Murcia, Región de Balears, Illes Canarias Madrid, Comunidad de Ceuta Melilla Gross rates 861.6 846.2 840.8 840.1 815.5 730.9 730.6 672.8 666.0 578.4 569.9 (*) Autonomous community of residence The main cause of death in all Autonomous Communities were diseases of the circulatory tract, except for Canarias, Cantabria, Comunidad de Madrid, Comunidad Foral de Navarra and País Vasco, where the main cause of death were tumours. 8

Gross motality rates per 100,000 inhabitants of the two leading causes of death(*). Year 2012 Melilla Canarias Madrid, Comunidad de Ceuta Balears, Illes Murcia, Región de Cataluña Navarra, Comunidad Foral de TOTAL NATIONAL País Vasco Castilla-La Mancha Andalucía Comunitat Valenciana Cantabria Rioja, La Extremadura Aragón Castilla y León Galicia Asturias, Principado de 150.0 153.7 204.8 165.7 197.9 170.1 135.4 191.2 197.3 221.6 181.9 233.2 230.1 240.6 243.5 243.4 237.3 261.1 282.0 263.1 232.9 268.7 210.9 271.3 228.5 272.2 291.7 286.9 277.1 297.4 290.1 317.6 278.6 318.1 319.2 337.6 305.2 371.9 349.3 391.0 Diseases in the circulatory tract Tumours 9

The evolution in mortality between 2011 and 2012 was marked in all Autonomous Communities to a greater or a lesser extent by an increase in deaths in the months of February and March, especially due to respiratory diseases. Evolution of the gross death rate by AACC(*) Year-on-year variation 2012-2011 Melilla -4.2% -5.2% Ceuta -6.9% Aragón País Vasco Madrid, Comunidad de Canarias Galicia Andalucía Cantabria Comunitat Valenciana TOTAL NATIONAL Navarra, Comunidad Foral de Asturias, Principado de Balears, Illes Murcia, Región de Cataluña Castilla y León Rioja, La Castilla - La Mancha Extremadura 15.7% 1.5% 13.4% 2.4% 9.0% 2.6% 8.6% 2.9% 12.6% 3.5% 8.7% 3.7% 11.3% 3.8% 8.2% 3.8% 7.8% 3.8% 12.0% 4.1% 10.6% 4.2% 18.6% 4.4% 18.6% 4.7% 17.6% 4.7% 12.2% 5.0% 15.2% 5.1% 10.9% 5.7% 20.4% 7.4% 23.9% All causes Respiratory diseases (*) Autonomous Community of residence 10

Evolution of the number of deaths by month of death and AACC (*). Year-on-year variation 2012-2011 Melilla Ceuta Madrid, Comunidad de Canarias Galicia Aragón Asturias, Principado de País Vasco Murcia, Región de TOTAL NATIONAL Cantabria Castilla y León Andalucía Comunitat Valenciana Castilla - La Mancha Balears, Illes Navarra, Comunidad Foral de Extremadura Cataluña Rioja, La -18.8% -5.2% -2.2% -2.1% -1.3% -0.1% 0.0% -0.4% -0.6% -1.3% 1.1% 2.1% 0.5% 0.8% 1.2% 0.2% 0.7% 1.8% 1.0% 0.3% 3.0% 20.0% 11.1% 11.5% 16.4% 17.3% 18.4% 19.3% 19.9% 21.0% 21.3% 21.8% 21.9% 22.8% 23.4% 23.6% 23.9% 26.8% 29.2% 36.6% February - March Rest of the year (*) Autonomous Community of residence 11

International data: standardized rates by chapters of illnesses for some countries of the OECD The OECD published the data of Death by Cause of Death according to how it links the chapters of the ICD-10. Among the data it provided, the standardized rates are included. These allow the comparison of mortality data between countries with different population structure 4. The following table shows the standardized rates for some of the countries and the most significant causes of death. Standardized rates per 100,000 inhabitants by cause of death 5. Year 2011 5 Countries All causes Circulatory tract Tumours Respiratory tract Nervous system Transport accident Suicides Germany 786.8 310.2 211.1 54.3 21.1 5.1 10.8 Australia 673.3 208.2 202.5 57.7 31.1 6.8 10.1 Spain 687.1 204.9 200.1 72.7 35.1 4.9 6.2 United States 822.8 261.2 198.7 80.2 47.0 12.4 12.5 Italy 699.2 256.0 216.4 44.6 26.5 7.3 5.8 Korea 753.9 182.2 188.2 68.9 21.6 13.8 33.3 Japan 632.8 170.7 189.3 93.5 11.2 4.5 20.9 Mexico 1.019.5 292.1 128.4 103.4 15.5 17.5 4.8 The Netherlands 768.8 217.2 244.3 76.0 29.0 4.3 9.5 Poland 1.020.3 476.2 248.8 55.1 14.2 12.2 15.1 Portugal 778.4 233.2 199.3 87.7 23.2 8.7 8.5 United Kingdom 790.6 248.7 231.4 104.9 29.4 3.6 6.7 4 The gross mortality rates are highly affected by the population structure of the country. In order to compare the data between countries or in time intervals in which there are significant changes in the population structures by age, it is required to calculate the standardized rates from a certain population group. The interpretation of the data obtained this way is the mortality rate that would be obtained if all countries had the same population. These rates are calculated with the standard population recommended by the World Heath Organisation. 5 The rates of the United States, Italy, Mexico and the United Kingdom correspond to the year 2010 12

Methodological note The Death Statistics according to Cause of Death provides annual information on deaths which have occurred in the country dealing, by basic cause of death, in accordance with the International Classification of Diseases (ICD) of the World Health Organisation (WHO). The 10th revision of this classification has been used since 1999. This harmonised European Statistics is conducted in accordance with the Commission Regulation (EU) No 328/2011 of 5 April 2011 on Statistics according to Cause of Death. In accordance with the recommendations of the WHO, the classification of causes of death is investigated and tabulated depending of the basic cause of death. This is defined as the illness or injury which started the chain of pathological events which directly led to death. When the cause is a traumatic injury, the basic cause is considered to be the circumstances of the accident or violence which produced the fatal injury. To be exact, this set or chain of illnesses is what the doctor certifying the death must provide in the statistical bulletin. Starting with these causes, named by the WHO as immediate, intermediate, initial or fundamental and other processes, and in accordance with the international regulations established in the ICD for selecting the basic cause, the latter is reached. Data on causes of death is collected in three statistical questionnaire models: Medical Death Certificate/Statistical Death Register (CMD/BED), Judicial Statistical Death Register (BEDJ) and the Statistical Bulletin of Infants who died within 24 hours (BEP). The first one collects data on deaths due to natural causes, without requiring the intervention of a judge, whereas the second is directed at obtaining information on deaths due to causes requiring judicial intervention, since there are signs of a possible accidental or violent cause; both contain data on deaths among those who have lived more than 24 hours. Deaths occurring within 24 hours of life are collected in the BEP. The sections in the bulletins containing the causes of death are different in both models. In the CMD/BED, 4 causes are described, which form the chain of illnesses which led to death, in the BEP only two are shown, one relating to the mother and another to the foetus, and in the BEDJ the external circumstances that caused the death are shown. These statistics provide information on mortality by dealing with the basic cause of death, its distribution by sex, age, residence and month of death. It also offers indicators that enable the drawing of comparisons on an Autonomous Community level and large groups of causes of death. For further information see INEbase-www.ine.es/en/ All press releases at: www.ine.es/en/prensa/prensa_en.htm Press Office: Telephone numbers: 91 583 93 63 / 94 08 Fax: 91 583 90 87 - gprensa@ine.es Information Area: Telephone number: 91 583 91 00 Fax: 91 583 91 58 www.ine.es/infoine/?l=1 13