Symols Usful hrmcoinic Equions = dos = dosing inrvl L = clrnc d = volum of disriuion = liion r consn = sorpion r consn F = frcion sord (iovililiy K = infusion r = durion of infusion = plsm concnrion Gnrl Eliion r consn L d 2 2 2 2 lf-lif. 693 d ( 2. 693 2 / L Inrvnous olus rough (mulipl dos Avrg concnrion (sdy s pss L Orl disrion lsm concnrion (singl dos F d im of mximum concnrion (singl dos mx lsm concnrion (mulipl dos F d Iniil concnrion d lsm concnrion (singl dos lsm concnrion (mulipl dos (mulipl dos mx im of mximum concnrion (mulipl dos mx Avrg concnrion (sdy s F L lrnc os F l AU l d Equions/Usful_phrmcoinic_qu_527
onsn r infusion lsm concnrion (during infusion L lsm concnrion (sdy s L lculd clrnc (hiou quion 2 2 d 2 L 2 2 2 Shor-rm infusion (singl dos mx( L rough (singl dos ( mx( (mulipl dos mx L rough (mulipl dos lculd p mx mx wih mx * = msurd p, msurd im * fr h nd of h infusion lculd rough wih * = msurd rough, msurd im * for h sr of h nx infusion lculd volum of disriuion d [ mx ( ] lculd rcommndd dosing inrvl mx( dsird ( dsird lculd rcommndd dos mx( dsird wo-omprmn-body Modl mx lculd liion r consn mx wih * mx = msurd p nd * = msurd rough, msurd ovr h im inrvl Equions/Usful_phrmcoinic_qu_527 2 AU / / d d c r rinin lrnc L L cr cr ss ( 4 g wigh ( ml 72 p cr ( 4 g wigh ( fml 85 p cr Wih wigh in g, g in yrs, crinin plsm conc. in mg/dl nd L cr in ml/
K for oglycosids K =.293(rL +.4 Molic nd Rnl lrnc E = lin fu Q l fu in l = E Q = Q lin fu Q l fu in F = Q Q l in fu l rn = RBFE = GFR in in ou l rn = l rn = l rn = r of xcrion plsm concnrion R of scrion - R of rsorpion fu GFR lsm concnrion Urin flow urin concnrion lsm concnrion Idl Body Wigh Ml IBW = 5 g + 2.3 g for ch inch ovr 5f in high Fml IBW = 45.5 g + 2.3 g for ch inch ovr 5f in high Os ABW = IBW +.4*(BW-IBW olum of isriuion lrnc l os AU l d K fu fu Equions/Usful_phrmcoinic_qu_527 3
For On omprmn Body Modl If h dosing involvs h us of I.. olus disrion: For singl I.. olus disrion: For mulipl I.. olus disrion: n n( p: = ; sdy s n rough: = mx ss ( ss mx ss If h dosing involvs h us of I.. infusion: For singl shor-rm I.. infusion: Sinc = for mx mx mx ( For mulipl shor-rm I.. infusion sdy s: mx mx ( Ls modifid 2 :\urrn \ph527_os_op_i\quions\527-28-quions.doc
Ls modifid 2 :\urrn \ph527_os_op_i\quions\527-28-quions.doc If h dosing involvs I.. infusion (mor quions: (mos gnrl q. during infusion = so, (during infusion sdy s, -, so, L pss (sdy s rmmring nd L If h dosing involvs orl disrion: For singl orl dos: F mx For mulipl orl doss: F mx