Kick-Off Lecture by Nobel Laureate in Physiology or Medicine -Prof. Bruce A. Beutler



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The 1 st International Symposium on Mucosal Immunity and Vaccine Development 2014 Kick-Off Lecture by Nobel Laureate in Physiology or Medicine -Prof. Bruce A. Beutler Date: October 17 (Fri), 2014 Place: First Building Auditorium, Institute of Medical Science, The University of Tokyo Organizer: International Research and Development Center for Mucosal Vaccines, Institute of Medical Science, The University of Tokyo (IMSUT) Chair: Hiroshi Kiyono (IMSUT) Committee members: Satoshi Uematsu (IMSUT), Koji Hase (IMSUT), Shintaro Sato (IMSUT) Sponsor: MEDICAL & BIOLOGICAL LABORATORIES CO.,LTD. (MBL) Program: October 17 (Fri) 13:30-13:35 Welcome remarks Hiroshi Kiyono (Dean, IMSUT) 13:35-13:40 Opening remarks Naoki Kimura (Director, Scientific Research Institutes Division, Research Promotion, Bureau, Ministry of Education, Culture, Sports, Science and Technology) 13:45-13:50 Sponsor announcement Jun Sasaki (CEO, MBL) 13:50-15:20 Lecture Bruce A. Beutler 15:20-15:35 Coffee Break 15:35-16:05 Q&A Session 16:05-16:10 Closing Remarks 1

Bruce A. Beutler, M.D. Regental Professor and Director Center for the Genetics of Host Defense, Univerity of Texas Southwestern PAST POSITIONS Chairman Department of Genetics (2007-2011), The Scripps Research Institute, La Jolla, CA Professor Department of Immunology and Microbial Sciences (2000-2011), The Scripps Research Institute, La Jolla, CA Professor Department of Internal Medicine (1996-2000) UT Southwestern Medical Center, Dallas, TX Associate The Howard Hughes Medical Institute (1991-2000) Investigator Dallas, TX Associate Department of Internal Medicine (1990-1996) Professor UT Southwestern Medical Center, Dallas, TX Assistant Department of Internal Medicine (1986-1990) Professor UT Southwestern Medical Center, Dallas, TX Assistant The Howard Hughes Medical Institute (1991-2000) Investigator Dallas, TX Investigator The Howard Hughes Medical Institute (1986-1991) Dallas, TX Assistant Associate Physician The Rockefeller University (1985-1986) Professor New York, NY Associate The Rockefeller University Hospital (1984-1986) Physician New York, NY Fellow The Rockefeller University (1983-1985) New York, NY Resident Department of Neurology (1982-1983) UT Southwestern Medical Center, Dallas, TX Intern Department of Medicine (1981-1982) UT Southwestern Medical Center, Dallas, TX 2

EDUCATION Medical School: University of Chicago, M.D., 1981 Undergraduate: University of California, San Diego (Revelle College), B.A., 1976 AWARDS 2013 Rabbi Shai Shacknai Memorial Prize in Immunology and Cancer Research 2013 Korsmeyer Award 2012 Drexel Medicine Prize in Immunology 2011 Nobel Prize in Physiology or Medicine 2011 Shaw Prize, PRC 2010 University of Chicago, Professional Achievement Citation 2009 Will Rogers Institute Annual Prize for Scientific Research 2009 Albany Medical Center Prize in Medicine and Biomedical Research 2008 Frederik B. Bang Award (The Stanley Watson Foundation, USA) 2007 Balzan Prize (International Balzan Foundation, Italy and Switzerland) 2006 Gran Prix Charles-Léopold Mayer (Académie des Sciences, France) 2006 William B. Coley Award (Cancer Research Institute, USA) 2004 Robert Koch Prize (Robert Koch Stiftung, Germany) 1994 Young Investigator Award (American Federation for Clinical Research, USA) 1993 Alexander von Humboldt Prize, Germany 3

Ito International Research Center (IIRC) Symposium, The University of Tokyo The 1 st International Symposium on Mucosal Immunity and Vaccine Development 2014 Date: October 20 (Mon) -21 (Tue), 2014 Place: Lecture: Ito Hall, Ito International Research Center, The University of Tokyo Organizer: International Research and Development Center for Mucosal Vaccines, Institute of Medical Science, The University of Tokyo (IMSUT) Chair: Hiroshi Kiyono (IMSUT) Committee members: Satoshi Uematsu (IMSUT) Koji Hase (IMSUT) Shintaro Sato (IMSUT) Program: Day 1: October 20 (Mon) 13:00 Opening remarks: Hiroshi Kiyono Session I: Immune Responses and Barrier Functions at Mucosal Surface Chairs: Hiroshi Ohno (RIKEN IMS) Satoshi Uematsu (IMSUT) 13:10-17:30 1. Sidonia Fagarasan RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Kanagawa, 2. Gregory Sonnenberg Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA 3. Kiyoshi Takeda Laboratory of Immune Regulation, Department of Microbiology and Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, 4

4. Naoko Satoh-Takayama (Short talk * ) Innate Immunity Unit, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, France (15:00-15:20 Coffee brake) 5. Ken Cadwell Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY, USA 6. Won-Jae Lee School of Biological Science, Seoul National University, Seoul, Korea 7. Satoshi Uematsu Division of Innate immune regulation, International Research and Development Center for Mucosal Vaccine, IMSUT, Minato-ku, Tokyo, 8. Tomokazu Ohta (Short talk) WPI Immunology Fontier Research Center, Osaka University, Suita, Osaka, 9. Yosuke Kurashima (Short talk) Division of Mucosal Immunology, Department of Microbiology and Immunology, IMSUT, Minato-ku, Tokyo, Day 2: October 21 (Tue) Session II: Host-Microbe Interaction on Health and Diseases 9:00-12:00 Chairs: Toshinori Nakayama (Chiba Univ.) Masahira Hattori (Univ. of Tokyo) 1. Julie K. Pfeiffer Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA 2. Kenya Honda RIKEN IMS, Yokohama, Kanagawa, 3. Naoko Ohtani Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Noda, Chiba, JAPAN (10:30-10:50 Coffee brake) 5

4. Takuji Yamada Department of Biological Information, Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology, Meguro-ku, Tokyo, 5. Koji Hase Division of Mucosal Barriology, International Research and Development Center for Mucosal Vaccine, IMSUT, Minato-ku, Tokyo, 6. Lena Takayasu (Short talk) Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, 7. Mitsuharu Matsumoto (Short talk) Dairy Science and Technology Institute, Kyodo Milk Industry Co. Ltd. Tokyo, Nishitama, Tokyo, 12:30 Lunch Break Session III: New Strategy for Mucosal Vaccine Development 13:30-17:30 6 Chairs: Kiyoshi Takatsu (Toyama Univ.) Tetsuro Matano (IMSUT) 1. Mi-Na Kweon Department of Convergence Medicine, University of Ulsan College of Medicine/Asan Medical Center, Seoul, Korea 2. Ken Ishii Laboratory of Adjuvant Innovation, National Institute of Biomedical Innovation, Ibaraki, Osaka, 3. Akiko Yonekawa (Short Talk) Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, 4. Shinichiro Sawa (Short Talk) Department of Immunology Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, (15:10-15:30 Coffee Brake) 1. Rafick-Pierre Sekaly VGTI Florida, Port Saint Lucie, FL, USA 2. Hiroshi Kiyono Division of Mucosal Immunology, IMSUT, Tokyo,

3. David W. Pascual Department of Infectious Diseases and Pathology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA 4. Jun Kunisawa Laboratory of Vaccine Materials, National Institute of Biomedical Innovation, Ibaraki, Osaka, 17:30 Nature Immunology Award ** ceremony 17:45 Closing remarks * Short talk (20 min) speakers were selected from submitted abstracts. ** Nature Immunology Award will be awarded by courtesy of Nature Immunology. The winner will be selected from the short talk speakers. 7