Point-of-Care devices Winnie E. Svendsen DTU Nanotech
Point of Care - Health http://www.continuaalliance. org/about-the-alliance
Point of Care Health http://health.rush.edu/healthinformation/care%20guides/28/000278.aspx
Point of Care Technology Ref: Center for Bio photonics Science and technology University of California
Point of Care Enviroment 2013 Vandforurening i Kalundborg Børnehave ramt af vandforurening på tredje uge Udgivet den 02.01.2013 21:18 2012 Stadig forbud mod brug af vand i centrum af Kalundborg Udgivet den 20.12.2012 21:09 af TV2 ØST's Redaktion 2011 Advarsel: Drik ikke vandet i KBH Fredag d. 19. aug. 2011 kl. 17:11
Point of Care Enviroment The Law : Lab test 30 test per year 72 hours response time
Nano Bio Integrated Systems (NaBIS ) Micro and Nano Sensor Platforms Microfluidic Sample handling and manipulation Bio Medical Applications 2012 Our vision is to incorporate our research in point of care (POC) technology for diagnostic and monitoring. This is achieved by application-driven research, adapting and refining methodologies to micro- and nanotechnology within bio-medical fields
Nano Bio Integrated Systems (NaBIS ) Micro and Nano Sensor Platforms Microfluidic Sample handling and manipulation Bio Medical Applications
Point of Care Sensors Micro and Nano Sensor Platforms Microfluidic Sample handling and manipulation Bio Medical Applications
Point of Care Sensors
Nano Bio sensors - Health A screenning system for The plasmacytosis virus in Mink Biomedical engineering for cancer and brain disease diagnosis and therapy development http://www.engcabra.eu
64 chips The Silicon Nano Wires Sensor SiNW h= 50 nm l = 200 µm w= 50 µm 300 nm 4 SiNW on one chip
SiNW h= 50 nm l = 200 µm w= 50 µm Azeem Zulfigar
Semiconducting Nanowire Sensor Know and can control charge carriers in the wire Acceptors Holes (mobile) + + + + + + + - - - Receptors binding a target molecule (negative) => Get a chage in conductance (DG/G)
Silicon Nanowire Biosensor Nanowire Add a functional layer Multiple functional layers
Silicon Nanowire Biosensor
SiNW sensor for Aleutian Disease Virus (ADV) Integration of Silicon Nanowires in Microfluidic Devices
SiNW sensor for Aleutian Disease Virus (ADV) Aleutian Disease or Mink Plasmacytosis is a highly contagious parvovirus affecting the animals, causing spontaneous abortion and death in minks and ferrets. ADV smallest virus existing d~7 nm Task : Screen blood samples for antibodies
Immobilization of whole virus APTES Goal : Attach the dead virus on the surface Detect antibodies in the animal sample
Test Functionalisation Scheme Immobilization results 12 hours without light 12 hours with light 3 hours with P H 3 CBF 4 Conclusion: 1.High selectivity 2.High Yield 3.The catalysts worked as planned
Screening for ADV virus in Minks sample Lars Andresen KU Sund 2010
Integration of Silicon Nanowires in Microfluidic Devices Michael Jørgensen Msc Martin H. Sørensen MSc
Fully automated system
POCT Screening of Cancer Biomedical engineering for cancer and brain disease diagnosis and therapy development CA9 NKG2D ligands
Functionalisation Scheme APTES Andrea DTU Lars KU Sund
Mouse Antibody Goat Antibody interaction
Sample Handling Andrea Pfreundt DTU Nanotech
System Engineering/ Embedded Systems Jan Madsen Francois Patou DTU Compute DTU NTCH
People NaBIS Acnowledgements Collaborators DTU Nanotecth Mads Brandbyge Kristian Mølhave Funds KU-life DTU Farma DPA isas Slovakia DTU Compute Søren Schou Lars Andresen Franziska, Phd student Åse Uttenthal Leif Bruun Rebekka Dam-Tuxen, Phd Stud. Prof. Silvia Patrokova Prof. Jan Madsen