20-21 May 2015, Lisbon, Portugal. Highlights. Speakers:

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Speakers: Dr Afshin Hosseiny Chair of the ECA Expert Working Group on GDP, Tabriz Consulting Comply with the new EU GDP Guideline Dr Martin Egger Pharmaserv Dr Daniel Müller GMP/GDP Inspector All participants receive a Roadmap to Good Distribution Practice containing: An overview of the designated Responsibilities for Senior Management, Responsible Person and Authority Checklist for the implementation of GDP principles in cooperation with 20-21 May 2015, Lisbon, Portugal Highlights The New EU GDP Guideline Role of the RP in Batch Release Roles and responsibilities of the Responsible Person GMP/GDP Inspections Control temperature distribution Track & Trace Case Study: Management of a GMP warehouse and distribution of medicinal products with a 3PL-Approach GDP Audits Roles and Responsibilities of a RP and a QP in a Warehouse and Distribution environment How to manage 3PL service providers This course is recognised for the ECA GMP Certification Programme Certified GDP Compliance Manager. Please find details at www.gmp-certification.eu

The Responsible Person for Good Distribution Practices (GDP) 20-21 May 2015, Lisbon, Portugal Objectives Good Manufacturing Practices (GMP) and Good Distribution Practices (GDP) are closely linked. A new GDP Guideline published by the European Commission will bring comprehensive changes for everyone involved in the distribution of Medicinal Products. The enhanced role of the Responsible Person for GDP will be highlighted at this event. The specific responsibilities and tasks of the Responsible Person will be discussed as well as the close link between QA and the QP of the Medicinal Product Manufacturer. Background In 2013, the European Commission s Directorate General for Health and Consumer Policy (DG SANCO) published the new Guideline on Good Distribution Practice of Medicinal Products for Human Use. Through its GMP/GDP Inspectors Working Group the European Medicine Agency worked on the revision of the guideline which was first published in 1994. The guideline was revised to take into account advancements of practices for an appropriate storage and distribution of medicinal products in the European Union. Moreover, it should take into account the amendments to the Community Code which have been introduced with Directive 2011/62/EU of the European Parliament and of the Council. It is amending Directive 2001/83/EC on the Community code relating to medicinal products for human use with regard to preventing falsified medicinal products to enter the legal supply chain. In Chapter 2 Personnel defines tasks and responsibilities of the Responsible Person are defined. This Responsible Person should be continuously contactable. General requirements like organisational chart, job descriptions and training requirements are new or outlined in much more detail. Target Group The Training Course is of particular interest to management and personnel from Pharmaceutical Companies as well as from Distributors and Service Providers involved in wholesale distribution of medicinal products for human use. Moderator This training course will be moderated by Dr Afshin Hosseiny Roadmap to Good Distribution Practice All participants receive a Roadmap to Good Distribution Practice containing: An overview of the designated Responsibilities for Senior Management, Responsible Person and Authority Checklist for the implementation of GDP principles

Programme The New EU GDP Guideline Role of the RP in batch release The counterfeit directive and pharma supply chain overview New/additional requirements Regulatory expectation for implementation Inspection approach View of a European GMP/GDP Inspector What does Batch Release mean to a Responsible Person? Responsible Person (RP) vs. Qualified Person (QP) role in batch release Basic requirements for the role of Responsible Person (RP) in batch release Roles and responsibilities of the Responsible Person GMP/GDP Inspections Qualifications requirements for RP Duties of a RP How to discharge your duties GDP Inspections Frequent Findings Expectations with regard to the Responsible Person View of a European GMP/GDP Inspector Track and Trace Control temperature distribution GDP Audits Recent developments How can track and trace support anti-counterfeiting requirements Current technologies How to manage cold chain products How to manage 15 25 C requirements Temperature monitoring or control what is the best option for the product? How to plan the audit Approach to GDP audits Reporting deficiencies Examples of recent audit findings Case Study: Management of a GMP warehouse and distribution of medicinal products with a 3PL-Approach Outsourcing in Pharma Logistics current trends & benefits Determining the scope of Outsourcing Processes, roles & responsibilities Monitoring of critical data Reporting of the performance & controlling of the 3PL The roles and responsibilities of wholesalers How wholesalers are organised Services offered How to manage different clients and their requirements Pick and pack best practices How to stay in compliance Roles and responsibilities of an RP and a QP in a warehouse and distribution environment where value added logistic activities, like re-labelling, etc. take place Responsible Person/Qualified Person Pharmaceutical versus Nutritional products Good Distribution/Manufacturing Practice Product Finishing activities Product Diversions Product Action, like QA holds Handling of Returned and Damaged goods Complaint Handling How to manage 3PL service providers Selection process Approval process Contracts and monitoring

Speakers Dr Afshin Hosseiny, GDP Working Group Afshin Hosseiny is Chair of the ECA Working Group who is currently preparing a guidance document on GDP. He is also Member of the ECA Advisory Group and Managing Director of Tabriz Consulting Ltd. Before working as a consultant, he was Director of Quality Assurance for the Global Supply Network of GlaxoSmithKline. Dr Martin Egger, Pharmaserv, Germany Martin Egger joined Pharmaserv in 2002 as the Head of Quality Management and was responsible until 2008. Since 2005, he additionally has been in charge of Logistics at Pharmaserv. Dr Daniel Müller, GMP/GDP Inspectorate Local Government, Germany Daniel Müller started working in the pharmaceutical industry in 1998. Among other positions he served as a Qualified Person of large volume parenterals. In 2001 he joined a German inspectorate in Tübingen. Social Event On the evening of the first day of the training course you are cordially invited to a social event. This is an excellent opportunity to share your experiences with colleagues from other companies in a relaxed atmosphere. About ECA The European Compliance Academy (ECA) was founded on the 1st of January 1999 as an independent membership association and is today the leading European association with regard to pharmaceutical Quality Assurance and GMP/GDP compliance. Close to 4.000 members from all over Europe and abroad represent more than 60 countries. The ECA has initiated several working groups. Among others the Good Distribution Practice Group which was founded in March 2013. The objective of the group is to support all stakeholders involved in Good Distribution Practice (GDP) by providing them information about the implementation of GDP. Membership is available at no costs at http://www.good-distribution-practice-group.org About the European QP Association The European Qualified Person (QP) Association was founded on 7 July 2006 by the European Compliance Academy s (ECA) Advisory Board Members. With this unique association the ECA wants to provide QPs in Europe with a platform allowing them to exchange their experience, discuss the latest regulatory requirements, to identify and address difficulties and challenges and to support a harmonised European approach. More information about the QP Association and a membership application form are available at www.qp-association.eu.

ECA Certified GDP Compliance Manager The European Commission has published the revised EU Good Distribution Practice (GDP) Guideline in March 2013. The completely revised document contains comprehensive requirements for all stakeholders involved such as logistic service providers, wholesalers, storage facilities and for the manufacturer of the medicinal products. Chapter 2 of the EU GDP Guideline defines that Personnel involved in GDP activities should receive initial and continuing training relevant to their role, based on written procedures and in accordance with a written training programme. Furthermore the GDP Guide states that a record of all training should be kept, and the effectiveness of training should be periodically assessed and documented. The certification programme of the ECA Academy aims to provide the necessary knowledge for personnel involved in GDP activities. Courses and Conferences acknowledged To receive the certificate, the applicant must attend two training courses. After attending the second course, the applicant can pass an exam. If the applicant passes the GDP exam he/she obtains the certificate ECA Certified GDP Manager The Responsible Person for GDP GMP meets GDP GDP how to get you there Further optional courses will be offered in future Please find the current dates for the above mentioned events at www.gmp-certification.org Special offer with Lufthansa up to 20% discounted travel for all ECA Events Attendees As an ECA course or conference attendee, you will receive up to 20% discounted travel fares (according to availability). And as Lufthansa German Airlines offers a comprehensive global route network linking major cities around the world you will most likely be able to benefit from these special prices and conditions. And this is how it works: Once you registered for a course or conference you will receive a link together with your registration confirmation. Opening that link will take you to the Mobility Partner Program website where you can enter a code in the Access to Event Booking area you will also receive. This will take you into an online booking platform that will automatically calculate the discount offered or provide you with an even better offer if another promotional fare is available. We look forward to welcoming you at one of our next events and we already wish you a pleasant flight! Conference Folder You cannot take part in this event? Just order the documentation at the price of 380.- + VAT+ postage and packing at www.gmp-comliance.org. Please note: In order to ensure that the documentation is complete, the conference folder will not be available until two weeks after the event. wa/vers1/18112014

Easy Registration Reservation Form: CONCEPT HEIDELBERG P.O. Box 10 17 64 69007 Heidelberg Germany Reservation Form: + 49 6221 84 44 34 @ e-mail: info@concept-heidelberg.de Internet: www.gmp-compliance.org Date Wednesday, 20 May 2015, 09:00 h 17:30h (Registration and coffee 08:30 h 09:00 h) Thursday, 21 May 2015, 09:00 h 16:00 h Venue Lisbon Marriott Hotel Avenida dos Combatentes 45 Lisbon, 1600-042 Portugal Phone +351 21 7235400 Fax +351 21 7264281 Accomodation CONCEPT HEIDELBERG has reserved a limited numger of rooms in the conference hotel. You will receive a room reservation form/pog when you have registered for the course. Reservation should be made directly with the hotel. Early reservation is recommended. Conference fees (per delegate plus VAT) ECA and European QP Association Members 1,590 APIC Members 1,690 Non-Members 1,790 EU GMP Inspectorates 895 The conference fee is payable in advance after receipt of invoice and includes conference documentation, dinner on the first day, lunch on both days and all refreshments. VAT is reclaimable. Registration Via attached reservation form, by e-mail or by fax message. Or you register online at www.gmp-compliance.org. Conference language The official conference language will be English. Organisation and Contact ECA has entrusted Concept Heidelberg with the organisation of this event. CONCEPT HEIDELBERG P.O. Box 10 17 64 69007 Heidelberg, Germany Phone +49 (0) 62 21/84 44-0 Fax +49 (0) 62 21/84 44 34 info@concept-heidelberg.de www.concept-heidelberg.de For questions regarding content: Mr Oliver Schmidt (Operations Director) at +49-62 21/84 44 23, or per e-mail at schmidt@concept-heidelberg.de. For questions regarding reservation, hotel, organisation etc.: Ms Nicole Bach (Organisation Manager) at +49-62 21/84 44 22, or per e-mail at bach@concept-heidelberg.de. If the bill-to-address deviates from the specification to the right, please fill out here: Registration form (please complete in full) The Responsible Person for Good Distribution Practices (GDP) 20-21 May 2015, Lisbon, Portugal +49 6221 84 44 34 0 Mr 0 Ms Title First name, surname Company Department Important: Please indicate your company s VAT ID Number CONCEPT HEIDELBERG P.O. Box 10 17 64 Fax +49 (0) 6221/84 44 34 69007 Heidelberg Germany Purchase Order No. (if applicable) Street / P.O. Box City Zip Code Country Phone / Fax E-mail (please fill in) General terms and conditions If you cannot attend the conference you have two options: 1. We are happy to welcome a substitute colleague at any time. 2. If you have to cancel entirely we must charge the following processing fees: Cancellation until 2 weeks prior to the conference 10 %, until 1 weeks prior to the conference 50 % within 1 week prior to the conference 100 %. CONCEPT HEIDELBERG reserves the right to change the materials, instructors, or speakers without notice or to cancel an event. If the event must be cancelled, registrants will be notified as soon as possible and will receive a full refund of fees paid. CONCEPT HEIDELBERGwill not be responsible for discount airfare penalties or other costs incurred due to a cancellation. Terms of payment: Payable without deductions within 10 days after receipt of invoice. Important: This is a binding registration and above fees are due in case of cancellation or non-appearance. If you cannot take part, you have to inform us in writing. The cancellation fee will then be calculated according to the point of time at which we receive your message. In case you do not appear at the event without having informed us, you will have to pay the full registration fee, even if you have not made the payment yet. Only after we have received your payment, you are entitled to participate in the conference (receipt of payment will not be confirmed)! (As of January 2012). Privacy Policy: By registering for this event, I accept the processing of my Personal Data. Concept Heidelberg will use my data for the processing of this order, for which I hereby declare to agree that my personal data is stored and processed. Concept Heidelberg will only send me information in relation with this order or similar ones. My personal data will not be disclosed to third parties (see also the privacy policy at http://www.gmp-compliance.org/ eca_privacy.html). I note that I can ask for the modification, correction or deletion of my data at any time via the contact form on this website.