Dipl. Phys. Michael George

Dipl. Phys. Michael George 25.05.1970 born in Bremerhaven 1989 Abitur 1989 1991 civil service, Werkstatt Pronova, Munich 1991 1998 studying physics and biophysics, Ludwig-Maximilians University Munich 1996 1998 diploma thesis, Institute for Biophysics, Ludwig-Maximilians University Munich Investigations for noninvasive membrane potential measurement with the Light addressable potentiometric sensor 1998 2002 Research associate, Center for Nanoscience CeNS, Ludwig-Maximilians University Munich since 2002 CTO, Nanion Technologies GmbH, Munich Honors/Awards: 2014 Nomination for the Federal German Future Prize The project Ion Channel Screening with High Throughput from University Bench to Global Player was nominated by the Federal Ministry for Education and Research. Publications: Obergrussberger A, Haarmann C, Rinke I, Becker N, Guinot D, Brueggemann A, Stoelzle-Feix S, George M, Fertig N Automated Patch Clamp Analysis of nachα7 and NaV 1.7 Channels Current protocols in pharmacology / editorial board, S.J. Enna (editor-in-chief)... [et al.]. 01/2014; 65:11.13.1-11.13.48. Becker N, Stoelzle S, Göpel S, Guinot D, Mumm P, Haarmann C, Malan D, Bohlen H, Kossolov E, Kettenhofen R, George M, Fertig N, Brüggemann A. Minimized cell usage for stem cell-derived and primary cells on an automated patch clamp system. J Pharmacol Toxicol Methods. 2013 Jul-Aug;68(1):82-7. doi: 10.1016/j.vascn.2013.03.009. Epub 2013 Apr 6. Haythornthwaite A, Stoelzle S, Hasler A, Kiss A, Mosbacher J, George M, Brüggemann A, Fertig N Characterizing human ion channels in induced pluripotent stem cell-derived neurons. J Biomol Screen. 2012 Oct;17(9):1264-72. Epub 2012 Aug 24 Stoelzle S, Obergrussberger A, Brüggemann A, Haarmann C, George M, Kettenhofen R, Fertig N. State-of-the-Art Automated Patch Clamp Devices: Heat Activation, Action Potentials, and High Throughput in Ion Channel Screening. Front Pharmacol. 2011;2:76. Epub 2011 Nov 24. Stoelzle S, Haythornthwaite A, Kettenhofen R, Kolossov E, Bohlen H, George M, Brüggemann A, Fertig N. Automated patch clamp on mesc-derived cardiomyocytes for cardiotoxicity prediction. J Biomol Screen. 2011 Sep;16(8):910-6. Epub 2011 Jul 20. Farre C, Haythornthwaite A, Haarmann C, Stoelzle S, Kreir M, George M, Brüggemann A, Fertig N. Port-a-patch and patchliner: high fidelity electrophysiology for secondary screening and safety pharmacology. Comb Chem High Throughput Screen. 2009 Jan;12(1):24-37. Review

Farre C., George M., Brüggemann A., Fertig N. 'Ion channel screening automated patch clamp on the rise' Drug Discovery Technology, 2009, Brüggemann A, Farre C, Haarmann C, Haythornthwaite A, Kreir M, Stoelzle S, George M, Fertig N. Planar patch clamp: advances in electrophysiology. Methods Mol Biol. 2008;491:165-76. Kreir M., Farre C., Beckler M., George M., Fertig N., 'Rapid screening of membrane protein activity: electrophysiological analysis of OmpF reconstituted in proteoliposomes' Lab-on-a-Chip, 2008, 8(4), 587-95. Pamir E., George M., Fertig N., Benoit M. 'Planar patch-clamp force microscopy on living cells', Ultramicroscopy, 2008, 108(6), 552-557. Farre C, Stoelzle S, Haarmann C, George M, Brüggemann A, Fertig N. Automated ion channel screening: patch clamping made easy. Expert Opin Ther Targets. 2007 Apr;11(4):557-65 M. Olapinski, S. Manus, M. George, A. Brüggemann, N. Fertig, F. C. Simmel, Detection of lipid bilayer and peptide pore formation at gigahertz frequencies, Applied Physics Letters 2006, art no. 013902. Brüggemann A, Stoelzle S, George M, Behrends JC, Fertig N. Microchip Technology for Automated and Parallel Patch Clamp Recording small 2006, 2, No. 7, 840 846 M. Sondermann, M. George, N. Fertig, J. C. Behrends, High-resolution electrophysiology on a chip: Transient dynamics of alamethicin channel formation Biochimica et Biophysica Acta 1758, 2006, 545 551. Brueggemann A, George M, Klau M, Beckler M, Steindl J, Behrends JC, Fertig N. Ion channel drug discovery and research: the automated Nano-Patch-Clamp technology. Curr Drug Discov Technol. 2004 Jan;1(1):91-6. Brüggemann A, George M, Klau M, Beckler M, Steindl J, Behrends JC, Fertig N. High quality ion channel analysis on a chip with the NPC technology. Assay Drug Dev Technol. 2003 Oct;1(5):665-73. B. Stein, M. George, H.E. Gaub, W.J. Parak. Extracellular measurements of averaged ionic currents with the light-addressable potentiometric sensor (LAPS) Sensors & Actuators B 2003

Fertig, N., C. Meyer, A. Tilke, M. George, M. Klau, C. Sobotta, R. H. Blick, and J.C. Behrends. 2003. Microstructured apertures in planar glass substrates for ion channel research. Channel and Receptors 9(1):29-40 B. Stein, M. George, H. E. Gaub, J. C. Behrends, W. J. Parak Spatially resolved monitoring of cellular metabolic activity with a semiconductor-based biosensor BIOSENSORS & BIOELECTRONICS 18 (1), pp 31-41, Jan 2003 T. Pap, A. Claus, S. Ohtsu, K. Hummel, P. Schwartz, S. Drynda, G. Pap, A. Machner, B. Stein, M. George, R. Gay, W. Neumann, S. Gay W. Aicher Osteoclast-independent bone resorption by fibroblast-like cells ARTHRITIS RESEARCH & THERAPY 5 (3), pp R163-R173, 2003 C. Kirchner, M. George, B. Stein, et al. Corrosion protection and long-term chemical functionalization of gallium arsenide in an aqueous environment ADV FUNCT MATER 12 (4), pp 266-276, APR 2002 M. Seitz, ; W. Parak; M. George; C. Kirchner; B. Stein, A. Lorke, J. Behrends: Ionenbindende Polymerbeschichtung zur Toxiditätsminderung von Halbleiter Substraten Deutsche Patentanmeldung 10104731 Anmelder: M. Seitz Anmeldedatum 02.02.2001, Veröffentlichungsdatum 14.08.2002 Fertig, N., M. Klau, M. George, R.H. Blick, and J.C. Behrends.. Activity of Single Ion Channel Proteins Detected with a Planar Microstructure. Appl. Phys. Lett. 81(25)2002: 4865-67 W. J. Parak, S. Dannöhl, M. George, M. K. Schuler, J. Schaumburger, H. E. Gaub, O. Müller and W. K. Aicher Metabolic Activation Stimulates Acid Production in Synovial Fibroblasts

Journal of Rheumatology 2000,27 (10): 2312-2322 W. J. Parak, M. George, J. Domke, M. Radmacher, H. E. Gaub, J. C. Behrends and M. C. Denyer Can the light-addressable potentiometric sensor (LAPS) detect extracellular potentials of cardiac myocytes? IEEE Transactions on Biomedical Engineering 2000, vol 47/8 pp 1106-1113 M. George, W. J. Parak, I. Gerhardt, W. Moritz, F. Kaesen, H. Geiger, I. Eisele and H. E. Gaub Investigation of the spatial resolution of the light-addressable potentiometric sensor (LAPS) Sensors and Actuators A 2000, 86/3, pp 187-196 M. George, W. J. Parak and H. E. Gaub Highly Integrated Surface Potential Sensors Sensors and Actuators B 2000, vol 69/3,pp 266-275 Z. Qintao, W. Ping, W. J. Parak, M. George and G. Zhang A novel design of multi-light LAPS based on digital compensation of frequency domain, Sensors and Actuators B 2000, vol 73/3,pp 152-156 W. Aicher, W. Parak, O. Müller; S. Gay; T. Pap; M. George, Verwendung von Protonenpumpen Hemmern zur Behandlung von Entzündungen, insbesondere von Erkrankungen des Bewegungsaparates Anmelder:Eberhard-Karls-Universität Tübingen Universitätsklinikum Deutsche Patentanmeldung 10040052 Anmeldedatum 11.08.2000, Veröffentlichungsdatum 07.03.2002 J. Behrends; M. George, C. Kirchner, Christian; W. Parak, M. Seitz, B.Stein, R. Metzger

Vorrichtung und Verfahren zum ortsaufgelösten Untersuchen vernetzter Zellen und/oder Zellsystemen und Verwendung für die Wirkstoffuntersuchung Anmelder: CellControl Biomedical Laboratories GmbH Deutsche Patentanmeldung 10041596 Anmeldedatum 24.08.2000 Veröffentlichungsdatum 21.03.2002 S. Böhm, W. J. Parak, M. George, H. E. Gaub and A. Lorke Characterization of the Field-Effect-Addressable Potentiometric Sensor (FAPS) Sensors and Actuators B 2000, vol 68/1-3 pp 266-273 W. J. Parak, M. George, M. Kudera, H. E. Gaub and J. C. Behrends Effects of Semiconductor Substrate and Glia-Free Culture on the Development of Voltage Dependent Currents in Rat Striatal Neurones European Biophysics Journal 2000 A. Lorke; S. Böhm; J. P. Kotthaus; W. Parak, M. George Ortsaufgelöster Potential-Sensor und Stimulator auf Halbleiterbasis Deutsches Patent 19840157 Anmelder:A. Lorke Anmeldedatum 03.09.1998 erteilt am 5.10.2000 W. J. Parak, J. Domke, M. George, A. Kardinal, M. Radmacher, H. E. Gaub, A. D. G. deroos, A. P. R. Theuvenet, G. Wiegand, E. Sackmann and J. C. Behrends Electrically Excitable NRK Fibroblasts - A New Model System For Cell-Semiconductor Hybrids Biophysical Journal 1999, vol 76, pp 1659-1667 J. Domke, W. J. Parak, M. George, H. E. Gaub and M. Radmacher Mapping the Mechanical Pulse of Single Cardiomyocytes with the Atomic Force Microscope Biophysical Journal 1999, vol 28, pp 179-186

W. J. Parak, M. George, H. E. Gaub, S. Böhm and A. Lorke The Field-Effect-Addressable Potentiometric Sensor / Stimulator (FAPS) - A new concept for a surface potential sensor and stimulator with spatial resolution Sensors and Actuators B 1999, vol 58, pp 497-504 Buchbeiträge und Übersichtsartikel: Brüggemann A., Farre C., Haarmann C., Haythornthwaite A., Kreir M., Stoelzle S., George M., Fertig N. 'Planar patch clamp Advances in electrophysiology', Methods in Molecular Biology, Potassium channels, Humana Press, 2008, 49, 165-176. N. Fertig, M. Klau, M. George, R. Blick und Jan C. Behrends, 2002. Biochip für die Analyse zellulärer Ionenkanäle. Laborwelt Nr. 3, 16-19. J. C. Behrends, R. Blick, N. Fertig, M. George und M. Klau 2003. Von der Pipette zum Chip. Einsichten: Forschung an der Ludwig-Maximilians-Universität München Nr1./2003.