ROOM C OPENING CEREMONY. Introduction. Professor Marek Droździk - President of the Polish Pharmacological Society.

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1 17 th September OPENING CEREMONY Introduction Professor Marek Droździk - President of the Polish Pharmacological Society Opening lecture Prof. Edmund Przegaliński (Honorary Member of Polish Pharmacological Society, Polish Academy of Sciences, Kraków, Poland) The origins of the Polish Pharmacological Society Honorary lecture Sponsored by the British Pharmacological Society Prof. Steve Alexander (School of Biomedical Sciences, University of Nottingham, UK) The endocannabinoid system as a nexus of signalling complexity Welcome Reception, D 18 th September 2015 ROOM E POSTER SESSION Plenary lecture Chairperson: Prof. Władysław Lasoń (Polish Academy of Sciences, Kraków, Poland) Prof. Stanisław J. Czuczwar (Department of Pathophysiology, Medical University, Lublin Department of Physiopathology, Institute of Rural Health, Lublin, Poland) Caffeine and other methylxantine derivatives are they dangerous to patients with epilepsy? 1

2 PROGRESS IN EPILEPSY AND ANTIEPILEPTIC DRUGS Chairpersons: Prof. Stanisław J. Czuczwar (Medical University in Lublin, Poland) Dr Roman Chwedorowicz (Institute of Rural Health, Lublin, Poland) 1. Ambiguous effects of neuroprotective treatment with free radical scavenger N-tert-butyl-alfa-phenylnitrone (PBN) on outcome of status epilepticus and their mechanisms Hana Kubová, Jaroslava Folbergrová, Pavel Mareš (Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic) 2. Drug - resistant epilepsy from the clinical point of view Barbara Błaszczyk (Department of Health Sciences at Economics, Law and Medical Sciences, Kielce) 3. mirna in models of acquired epilepsy Katarzyna Łukasiuk (The Nencki Institute of Experimental Biology, Warszawa, Poland) 4. Role of adenosinergic modulatory system in ictogenesis Pavel Mareš, Hana Kubová (Dept. Developmental Epileptology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic) Coffee break GLUTAMATE METABOTROPIC RECEPTORS AND CNS DISORDERS Chairpersons: Prof. Andrzej Pilc (Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland) Prof. Małgorzata Filip (Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland) 1. Chemical Biology at Lundbeck: enhancing CNS drug discovery research Dario Doller (Chemical Biology, Lundbeck Research, USA) 2. Group III mglurs in brain and periphery: implications for visceral pain Anna V. Golubeva, Rachel D. Moloney, Timothy G. Dinan, John F. Cryan (University College Cork, Ireland) 2

3 3. The mechanism of antipsychotic-like action of the mglu receptor activators: focus on GABAergic signaling Joanna M. Wierońska, Monika Woźniak, Francine Acher, Andrzej Pilc (Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland, Université Paris Descartes, Paris, France) 4. Alterations in brain mglur5 and D2 receptor density during MDMA abstinence in different living conditions in rats Małgorzata Frankowska, Lucyna Pomierny-Chamioło, Joanna Miszkiel, Bartosz Pomierny, Małgorzata Filip (Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland, Department of Toxicology, Jagiellonian University, Kraków, Poland) 5. Cocaine induced dysregulation in metabotropic glutamate receptors expression in rat brain areas Lucyna Pomierny-Chamiolo, Małgorzata Frankowska, Małgorzata Filip (Faculty of Pharmacy, Jagiellonian University, Medical College, Karaków, Poland, Institute of Pharmacology Polish Academy of Sciences, Kraków, Poland) Lunch time Plenary lecture Sponsored by Federation of European Pharmacological Societies (EPHAR) Chairperson: Prof. Marek Droździk (Pomeranian Medical University, Szczecin, Poland) Prof. Werner Siegmund (Department of Clinical Pharmacology, University Medicine of Greifswald, Greifswald, Germany) The route of drugs to their place of action - meaning and clinical implications of drug transporters ROOM A ORAL PRESENTATIONS Chairpersons: Prof. Andrzej Członkowski (Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, Warszawa, Poland) Assoc. Prof. Tomasz Kocki (Chair and Department of Experimental and Clinical Pharmacology, Medical University of Lublin, Poland) 3

4 1. The effects of metabotropic glutamate receptor 5 (mglur5) positive allosteric modulator (PAM), CDPPB, on learning and memory impaired by chronic ethanol treatment in rats Marta Marszalek-Grabska, Jolanta H. Kotlinska (Department of Pharmacology and Pharmacodynamics, Medical University, Lublin, Poland) 2. Novel gamma-aminobutyric acid reuptake inhibitor improves spatial learning and memory in Morris water maze and radial arm water maze tests Adrian Podkowa, Kinga Sałat, Anna Furgała, Szczepan Mogilski, Paula Zaręba, Katarzyna Kulig, Barbara Filipek (Department of Pharmacodynamics, Department of Physicochemical Drug Analysis, Faculty of Pharmacy, Jagiellonian University, Kraków, Poland) 3. From antiarrhythmics to anticonvulsants: ADD424042, a Disopyramide derivative, is a non-cardiotoxic ion channel blocker with broad-spectrum anticonvulsant activity. Marcin Ufnal, Marek Król, Piotr Podsadni, Bartłomiej Szulczyk, Jadwiga Turło, Adrian Drapala, Maciej Dawidowski (Department of Experimental Physiology and Pathophysiology, Laboratory of Centre for Preclinical Research, Department of Drug Technology and Pharmaceutical Biotechnology, Medical University of Warszawa, Poland) 4. Toxicity of the kynurenine pathwayelements to the early life stages of zebrafish (Daniorerio) Michał Majewski, Piotr Jakubowski, Piotr Podlasz, Natalia Kasica, Marta Pugaczewska (Department of Pharmacology and Toxicology, Department of Animal Anatomy, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland) 5. Impact of balance between protein kinase and phosphatase activities on state-dependent memory of psychoactive drugs in passive avoidance task in mice Agnieszka Michalak, Grażyna Biała (Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Lublin, Poland) 6. Extract from root of Pueraria lobata inhibits an acute alcohol tolerance in high-preferring (WHP) and low-preferring (WLP) alcohol-drinking rats Przemysław Ł. Mikołajczak, Michał Szulc, Ewa Kamińska, Wanda Dyr, Edyta Wyszogrodzka, Agnieszka Gryszczyńska, Teresa Bobkiewicz-Kozłowska (Department of Pharmacology, Poznań University of Medical Sciences, Poznań, Poland, Department of Pharmacology and Phytochemistry, Institute of Natural Fibres and Medicinal Plants, Poznań, Poland, Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Poland) 7. The Optimization of Local Application of Gentamicin for Treatment of Biofilm Related Osteomyelitis - Results of Microbiological Evaluation in vitro Adam Feliks Junka, Beata Mączyńska, Anna Secewicz, Danuta Smutnicka, Patrycja Szymczyk, Marzenna Bartoszewicz (Department of Pharmaceutical Microbiology, Medical University of Wroclaw, Wrocław, Poland, Centre for Advanced Manufacturing Technology, Wroclaw University of Technology, Wrocław, Poland) 4

5 8. Genetic polymorphism and the risk of drug dependence and methadone substitution therapy success Łukasz Łapiński, Jacek Gąsiorowski, Krystyna Głowacka (Department of Clinical Pharmacology, Department of Infectious Diseases, Hepatology and Acquired Immune Deficiencies, Wroclaw Medical University, Wrocław, Poland, Centre for Prophylaxis and Treatment of Infectious Diseases and Drug Addiction, Wroclaw Healthcare Centre, Wrocław, Poland) NEUROTOXICITY AND NEUROPROTECTION Chairpersons: Prof. Lucyna Antkiewicz-Michaluk (Polish Academy of Science, Kraków, Poland) Prof. Richard Kostrzewa (Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, USA) 1. Monoaminergic system interaction in neurotoxicicty Richard M. Kostrzewa, John P. Kostrzewa, Ryszard Brus (Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, USA, Department of Nurse, High School of Strategic Planning, Dąbrowa Górnicza, Poland) 2. Nerotoxicity of fluorine Dariusz Chlubek (Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland) 3. Mechanisms of calcium imbalance in tetrabromobisphenol A induced neurotoxicity Jerzy W. Łazarewicz, Dominik Diamandakis, Elżbieta Ziemińska, Elżbieta Salińska (Department of Neurochemistry, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warszawa, Poland) 4. New perspectives for therapeutic use of endogenous amines, 1MeTIQ: behavioral and biochemical studies Agnieszka Wąsik, Lucyna Antkiewicz-Michaluk (Department of Neurochemistry, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland) Banquet, D 5

6 19 th September 2015 ROOM E POSTER SESSION Plenary lecture Chairperson: Prof. Władysław Lasoń (Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland) Assoc. Prof. Małgorzata Kajta (Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland ) Pathomechanisms of xenobiotic action in the nervous system Coffee break ROOM A, B MOLECULAR MECHANISMS OF XENOBIOTIC INDUCED EFFECTS Chairpersons: Assoc. Prof. Małgorzata Kajta (Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland), Assoc. Prof. Anna K. Wójtowicz (University of Agriculture, Kraków, Poland) 1. Risks related to exposure to environmental pollutants Anna Wójtowicz (Department of Animal Biotechnology, University of Agriculture, Kraków, Poland) 2. Neurodevelopmental effects of nonylphenol Ewa Litwa, Joanna Rzemieniec, Agnieszka Wnuk, Władysław Lasoń, Małgorzata Kajta (Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland) 3. Impact of triclosan on apoptotic processes in neuronal cells Konrad A. Szychowski, Agnieszka M. Sitarz, Anna K. Wojtowicz (Department of Animal Biotechnology, University of Agriculture in Krakow, Kraków, Poland) 6

7 4. Mechanism of neurotoxic action of the pesticide DDT metabolite Agnieszka Wnuk, Joanna Rzemieniec, Ewa Litwa, Władysław Lasoń, Małgorzata Kajta (Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland) 5. Neuroprotective effects of phytoestrogens and selective modulators of nuclear receptors Joanna Rzemieniec, Ewa Litwa, Agnieszka Wnuk, Władysław Lasoń, Małgorzata Kajta (Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland) SAFETY AND OPIMIZATION OF PHARMACOTHERAPY in cooperation with the Polish Clinical Pharmacology and Therapy Society Chairpersons: Prof. Anna Jabłecka (Medical University in Poznan, Poland) Prof. Anna Wiela-Hojeńska (Medical University in Wrocław, Poland) 1. Optimization of antibiotic therapy Anna Wiela-Hojeńska, Magdalena Hurkacz, Krystyna Głowacka (Department of Clinical Pharmacology, Wrocław Medical University, Wrocław, Poland) 2. Pharmacogenetics in transplantation Mateusz Kurzawski (Department of Experimental and Clinical Pharmacology, Pomeranian Medical University, Szczecin, Poland) 3. Pharmacovigilance in Poland present and future Daria Schetz, Ivan Kocić (Department of Clinical Toxicology, Department of Pharmacology, Medical University of Gdansk, Gdańsk, Poland, Pomeranian Centre of Toxicology, Gdańsk, Poland) 4. Clinical significance of CYP450 polymorphism on the efficacy and safety of treatment of hypertension Anna Wojtczak, Mariola Rychlik-Sych, Małgorzata Barańska, Jadwiga Skrętkowicz (Department of Internal Medicine and Diabetology, Department of Pharmacogenetics, Medical University of Lodz, Łódź, Poland) 5. The safety of NSAIDs in geriatric population - analysis of Regional Centre for Monitoring Adverse Drug Reactions in Poznan (ROMDNL) Anna Jabłecka, Katarzyna Korzeniowska, Artur Cieślewicz, Agnieszka Gaczkowska, Olga Pustkowska, Adrianna Maria Borowicz, Mariola Pawlaczyk (Department of Clinical Pharmacology, Department of 7

8 Geriatric Medicine and Gerontology, University of Medical Sciences, Poznań, Poland) Lunch time CLOSING CEREMONY 8