Glucocorticoid Receptor Activity of a Wastewater Effluent-Dominated Stream
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1 Glucocorticoid Receptor Activity of a Wastewater Effluent-Dominated Stream Lower Santa Cruz River, Tucson AZ Darcy VanDervort Dr. Shane Snyder Research Group Department of Soil, Water, and Environmental Science College of Agriculture and Life Sciences University of Arizona Special Thanks to: Water Sustainability Graduate Student Fellowship Program Technology and Research Initiative Fund 2014/2015
2 Wastewater Treatment Plant Discharge 85% of municipal wastewater treatment plants discharge into surface waters in the United States
3 Glucocorticoid Hormones Human secreted and synthetic Anti-inflammatory properties that treat health problems such as asthma and rheumatic diseases Not filtered out by typical wastewater treatment systems Detected in the environment around the world including US, Netherlands, and China Disrupt biological endocrine systems
4 Santa Cruz River Sampling Sites
5 Glucocorticoid Receptor Bioassay Expose genetically modified cells to river extracts Agonists bind to glucocorticoid receptors Quantify by fluorescence
6 Glucocorticoid Chemical Analysis 28 Target Analytes Aldosterone Flumethasone Amcinonide Flunisolide Beclomethasone Fluocinolone Acetonide Beclomethasone Dipropionate Fluocinonide Betamethasone Fluorometholone Budesonide Fluticasone Propionate Clobetasol Propionate Hydrocortisone Clobetasone Butyrate 6-α-Methylprednisolone Corticosterone Mometasone Furoate Cortisone Prednisolone Deflazacort Prednisone Deoxycorticosterone Acetate Spironolactone Dexamethasone Triamcinolone Fludrocortisone Acetate Triamcinolone Acetonide 8 Surrogates Cortisone-d8 Fludrocortisone-d5 Cortisone-d8 Methylprednisolone-d2 Hydrocortisone-d4 Prednisolone-d6 Dexamethasone-d4 Prednisone-d4 Solid Phase Extraction Liquid Chromatography Tandem Mass Spectrometry
7 Dexamethasone Dose Response Effective Use Percent E-11 1.E-10 1.E-09 1.E-08 1.E Concentration (M) Plate1 Plate2 Plate3 Plate4 Plate5 Plate6 Plate7
8 GR Activity of the SCR 200 AN TR DEX-EQ (ng/l) Stream Distance (km) 12-May-14 6-Jun Sep-14 1-Dec Feb-15
9 Chemical Glucocorticoid Concentrations (ng/l) Sample Distance (km) Cort. Hydrocort. Prednsl. Beta. Triam. Acet. Fluoc. Acet. 12/1/2014 SCR SCR SCR SCR SCR SCR SCR SCR /12/2015 SCR SCR SCR SCR SCR SCR SCR <
10 Chemical vs Bioassay Data Dex-Eq (ng/l) 200 AN TR Stream Distance (km) February Chemical February Bioassay December Chemical December Bioassay
11 Conclusions Decrease in Glucocorticoid concentrations downstream from treatment plants Photolysis Biodegradation Deposition/Sediment sorption Chemical data can t predict GR response Unknown compounds causing response Synergy effects of mixtures
12 Acknowledgements Shane Snyder Lab Bioassay Team: Ai Jia, Kevin Daniels, Hao Vo Shimin Wu Fred Leusch, Griffith University School of Environment Jeff Bliznick, University of Arizona Soil Water and Environmental Science Matt Kaplan and the University of Arizona Functional Genomics Core Lab Team Kelly Reynolds and Jonathan Sexton, University of Arizona School of Public Health Thesis Committee: Shane Snyder, David Quanrud, and Jon Chorover Agilent Technologies
13 References Ammann, A.A., Macikova, P., Groh, K.J., Schirmer, K., Suter, M.J.F., LC- MS/MS determination of potential endocrine disruptors of cortico signalling in rivers and wastewaters. Anal. Bioanal. Chem. 406, Chang, H., Hu, J., Shao, B., Occurrence of natural and synthetic glucocorticoids in sewage treatment plants and receiving river waters. Environ. Sci. Technol. 41, Escher et al., Benchmarking organic micropollutants in wastewater, recycled water and drinking water with in vitro bioassays. Environ. Sci. Technol. 48, Stavreva, D. a, George, A. a, Klausmeyer, P., Varticovski, L., Sack, D., Voss, T.C., Schiltz, R.L., Blazer, V.S., Iwanowicz, L.R., Hager, G.L., Prevalent glucocorticoid and androgen activity in US water sources. Sci. Rep. 2, 937. USEPA, Clean Watersheds Needs Survey (CWNS) 2008: Report to Congress. Washington, DC. EPA-832-R Van der Linden, S.C., Heringa, M.B., Man, H.-Y., Sonneveld, E., Puijker, L.M., Brouwer, A., van der Burg, B., Detection of Multiple Hormonal Activities in Wastewater Effluents and Surface Water, Using a Panel of Steroid Receptor CALUX Bioassays. Environ. Sci. Technol. 42,
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