Europass Curriculum Vitae

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1 Europass Curriculum Vitae Personal information First name(s) / Surname(s) Address(es) Department of Molecular Immunology, Viale Regina Elena Rome Italy Telephone(s) / Fax(es) [email protected] Nationality Italian Date of birth 16/06/1970 Gender Male Occupational field IMMUNOLOGY Dates 2002-present Occupation or position held RESEARCHER Page 1/5 - Curriculum vitae of

2 Main activities and responsibilities Scientific activity: He is mainly interested in the molecular mechanisms regulating mouse NK cell trafficking and differentiation in the bone marrow. Using an in vivo mouse model, he previously analyzed changes in NK cell distribution following stimuli that affect chemokine receptor function. The results of this study suggest that the combined action of chemokines selectively regulates localization of NK cell subsets in the BM and direct their maturation and migration to the periphery. He was also responsible of a project aimed at analyze the role of chemokines in human glioma cell invasiveness. His recent results indicate that endogenous expression of CX3CL1 is controlled by TGF-beta1 and negatively regulates glioma invasion likely by promoting tumor cell aggregation. Teaching Experience: Teaching and student training in the Immunology course (Biotechnology Inter-Faculty course). Faculty of Medicine University of Rome La Sapienza Lecturer in the immunology course. Faculty of Medicine University of Rome La Sapienza Name and address of employer University of Rome La Sapienza Sector General Pathology/Immunology Dates Occupation or position held Post-doctoral fellow Main activities and responsibilities Scientific activity: Visiting scholar in the Laboratory directed by Prof. Eugene C. Butcher at Stanford University. In that period and in a subsequent period in Rome he was interested in the analysis of signal transduction pathway acrtivated by chemokines leading to integrin activation. His results have shown that chemoattractant-induced LFA-1 dependent migration is regulated by PI 3K activation and that a Fyn-PI 3K-LFA-1 complex has to be formed to promote migration. Name and address of employer Stanford University School of Medicine Stanford, California Sector Immunological Sciences Dates Occupation or position held PhD student in Immunology Page 2/5 - Curriculum vitae of

3 Main activities and responsibilities Scientific activities: Involved in cloning of the human chemokine receptor CCR8 ORF and in the identification of its human and viral ligands. In collaboration with the laboratories of Prof. Ziche in Firenze e of Prof. Ribatti in Bari he demonstrated that I- 309 stimulates chemotaxis and invasion of endothelial cells, enhances HUVEC differentiation and induces angiogenesis in vivo. In addition, he contributed to the cloning of the ORF of other GPCRs and to their genetic and functional characterization. Name and address of employer Sector Sapienza University of Rome/ Istituto Dermopatico dell Immacolata, Rome Immunological Sciences Education and training Dates Title of qualification awarded Post-doctoral fellow Dates 2000 Laboratory of Immunology and Vascular Biology Stanford University Medical School Director: Prof. Eugene C. Butcher Founded by: Italian Federation for Cancer Research Fellowship and The Foundation Blanceflor Boncompagni-Ludovisi of Sweden Title of qualification awarded PhD in Immunological Science University of Rome La Sapienza. Dates 1996 Title of qualification awarded National Board for Biologists Dates 1994 Title of qualification awarded Graduated with honors in Biology University of Rome La Sapienza. Page 3/5 - Curriculum vitae of

4 Personal skills and competences Dr. Bernardini has a high competence and experience in several techniques in cellular and molecular biology, as well as in immunology. Since 2003, he has been teaching Immunology at the Sapienza Università di Roma. He has experience in supervising students, postdocs and in leading small research groups as well as in writing grants. Dr. Bernardini has a long lasting experience in the study of the role of chemotactic molecules of the chemokine family in several aspects of physiological and pathological processes. His results have been published in highly qualified international journals, such as FASEB journal, Blood, Journal of Immunology, etc. and presented in international congress.. Mother tongue(s) ITALIAN Other language(s) Self-assessment Understanding Speaking Writing European level (*) Listening Reading Spoken interaction Spoken production English B2 B2 B2 B2 B2 Freanch A2 A2 A2 A1 A1 (*) Common European Framework of Reference for Languages Additional information Prof Angela Santoni, Sapienza University Viale Regina Elena Rome Phone: Annexes. Scientific Publication 16 Dr. Monica Napolitano, Istituto Dermopatico dell Immacolata Via dei Monti di Creta 104 Roma Phone: O [email protected] Prof. Eugene C Butcher, Stanford University School of Medicine Department of Pathology Lane Building, Mailcode 5324 Stanford, CA [email protected] Textbooks (Chapters, etc.) 2 Page 4/5 - Curriculum vitae of

5 Scientific Publications 1. Napolitano, M., Zingoni, A., Bernardini, G., Spinetti, G., Nista, A., Storlazzi, C.T., Rocchi, M. and Santoni A. Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues. J. Immunol. (1996), 157: I.F Nista, A., Leonetti, C., Bernardini, G., Mattioni, M., Santoni A. Functional role of alpha4beta1 and alpha5beta1 integrin fibronectin receptors expressed on adriamycin-resistant MCF-7 human mammary carcinoma cells. Int J Cancer (1997), 72: I.F Zingoni, A., Rocchi M., Storlazzi, T.C., Bernardini, G., Santoni A. and Napolitano M. Isolation and chromosomal localization of GPR31 a human gene encoding a putative G protein coupled receptor. Genomics (1997), 42: I.F Bernardini G, Hedrick J, Sozzani S, Luini W, Spinetti G, Weiss M, Menon S, Zlotnik A, Mantovani A, Santoni A, Napolitano M. Identification of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. Eur J Immunol (1998) 28:582-8 I.F Sozzani S, Luini W, Bianchi G, Allavena P, Wells TN, Napolitano M, Bernardini G, Vecchi A, D'Ambrosio D, Mazzeo D, Sinigaglia F, Santoni A, Maggi E, Romagnani S, Mantovani A. The viral chemokine macrophage inflammatory protein-ii is a selective Th2 chemoattractant. Blood (1998), 92: I.F Camarda G., Spinetti G. Bernardini G., Farrell H.E., Davis-Poynter N., Capogrossi M.C. and Napolitano M. The EHV-2 E1 open reading frame encodes for a functional chemokine receptor. J. Virol (1999), 73: I.F Bernardini G., Spinetti G., Ribatti D., Camarda G., Ziche M., Morbidelli L., Santoni A., Capogrossi M.C., and Napolitano M. I-309 binds to and modulates endothelial cell functions and acts as an angiogenic molecule in vivo. Blood. (2000) 15;96: I.F Spinetti G, Camarda G, Bernardini G, Romano Di Peppe S, Capogrossi MC, Napolitano M.The chemokine CXCL13 (BCA-1) inhibits FGF-2 effects on endothelial cells. Biochem Biophys Res Commun (2001); 289: I.F Bernardini G., Ribatti D., Spinetti G., Morbidelli L., Ziche M., Santoni A., Capogrossi M.C., and Napolitano M. Analysis of the role of chemokines in angiogenesis. Journal of Immunological Methods (2002); 9233:1-19. I.F Spinetti G., Bernardini G., Camarda G., Santoni A., Capogrossi MC e Napolitano M. The chemokine receptor CCR8 mediates rescue from dexamethasone-induced apoptosis via an ERK1/2-dependent pathway. J Leukoc Biol. 2003;73:201-7 I.F Bernardini G., Kim JY, Gismondi A., Butcher EC, Santoni A. Chemoattractant induces LFA-1 associated PI 3K activity and cell migration that are dependent on Fyn signaling. FASEB J. 2005;19: I.F Bernardini G, Sciume G, Bosisio D, Morrone S, Sozzani S, Santoni A. CCL3 and CXCL12 regulate trafficking of mouse bone marrow NK cell subsets. Blood. 2008; 111: I.F Sciumè G, Soriani A, Piccoli M, Frati L, Santoni A*, Bernardini G*. CX3CR1/CX3CL1 axis negatively controls glioma cell invasion and is modulated by transforming growth factor-beta1. NEURO-ONCOLOGY, 2010 vol. 12; p doi: /neuonc/nop076 I.F Sciumè G, Santoni A*, Bernardini G*. (2010). Chemokines and glioma: Invasion and more. JOURNAL OF NEUROIMMUNOLOGY, 224: 8-12 doi: /j.jneuroim I.F Sciumè G, De Angelis G, Benigni G, Morrone S, Santoni A*, Bernardini G*. CX3CR1 expression defines two KLRG1+ mouse NK cell subsets with distinct functional properties and positioning in the Bone Marrow. Blood. 2011; 117: I.F Bernardini G, Gismondi A, Santoni A. Chemokines and NK cells: regulators of development, trafficking and functions. Immunol Lett. under revision *Equal Contribution Text Books 1. Bernardini G, Ribatti D, Spinetti G, Morbidelli L, Ziche M, Santoni A, Capogrossi MC, Napolitano M. In vitro and in vivo models to study chemokine regulation of angiogenesis. Methods Mol Biol. 2004;239: Gismondi A*, Bernardini G* and Santoni A. NK cells and Chemokines. Edited in: Natural Killer Cells Chapter 15: Editors: MICHAEL T. LOTZE & ANGUS W. THOMSON Elsevier *Equal Contribution Page 5/5 - Curriculum vitae of