Name (Youngsook Son) Education Major Activities

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1 CV Name (Youngsook Son) Affiliation: Dept of Genetic Engineering and Graduate School of Biotechnology, Kyung Hee University Address : 1 Seochun dong, Kiheung Gu, Yong In, Korea ysson@khu.ac.kr Education BA in Food Science and Nutrition, Seoul National University, Seoul, Korea MA in Microbiology, Seoul National University,Seoul, Korea Ph.D.in Pharmacology, University of California San Francisco (UCSF), San Francisco, USA Major Activities Post doctor (Elaine Fuchs Ph.D.'s Lab), University of Chicago, Howard Hughes Medical Institute, USA Special Research Fellow, Instructor, Seoul National University, School of Medicine Lab Chief, PI, Lab of Tissue Engineering, Korea Institute of Radiological and Medical Science (KIRAMS) 2006-present Professor, KHU Fellow, Department of Genetic Engineering, College of Life Science, Kyung Hee University 2013-present Dean, Graduate School of Biotechnology, Kyung Hee University 2009-present Vice president, Korean Tissue Engineering and Regenerative Medicine Society Editor in Chief, Tissue Engineering and Regenerative Medicine Member of Advisory Board of Basic Research Funds (Ministry of Education, Science and Technology, MOEST)

in Pharmacology, University of California San Francisco (UCSF), San Francisco, USA Major Activities 1989-1991 Post doctor (Elaine Fuchs Ph.D.

2 Honors and Awards 2006 Award of Excellence, Korea President Roe Moo Hyun 2010 Macrogen Woman Scientist Award, KSBMB 2010 Magnolia Award, Kyung Hee University 2011 Nomination for KHU fellow Research Interests Stem cell homing & trafficking, Tissue engineering of skin, cartilage & bone, Signal transduction Publications (Most representative 10 items) -Jiang MH, Chung, EK, Chi GF, Ahn W, Lim JE, Hong HS, Kim DW, Choi HW, Kim J, Son Y* (2012), Substance P induces anti-inflammatory M2 macrophages after spinal cord injury. Neuroreport Vol 23, Hong HS, Kim YH, Son Y* (2012), Perspectives on Mesenchymal Stem Cells: Tissue Repair, Immune Modulation, and Tumor Homing, Ach Pham Res, Vol.35, No.2, Hong HS, Kim DY, Yoon KJ, Son Y*(2011), A new paradigm for stem cell therapy: Substance-P as a stem cell-stimulating agent. Ach Pham Res, Vol.34, No.12, Woo CG, Shin H, Jeong CG, Jun KM, Lee JP, Lee JR, Lee HC, You SB, Son Y,Choi MS (2011), Selective Nanopatterning of Protein via Ion-Induced Focusing and its Application to Metal-Enhanced Fluorescence. Small, Vol. 7, No. 13, pp Guan Fan Chi, Kim DW, Mei Hua Jiang, Yoon KJ, Son Y* (2011), Schwann-like cells from human melanocytes and their fate in sciatic nerve injury. NeuroReport, Vol. 22, No. 12, pp An YS, Lee EA, Kang MH, Hong HS, Kim MR, Jang WS, SonY* YI JY (2011), SubstanceP Stimulates the recovery of bone marrow after their radiation, Journal of Cellular Physiology, Vol. 226, No. 5, pp Chi Guangfan, Kim MR, Kim DW, Jiang Meihua, Son Y* (2010), Schwann Cells

Hong HS, Kim DW, Choi HW, Kim J, Son Y* (2012), Substance P induces anti-inflammatory M2 macrophages after spinal cord injury.

3 Differentiated from Spheroid-Forming Cells of Rat Subcutaneous Fat Tissue Myelinate Axons in the Spinal Cord Injury, Experimental Neurology, Vol.222, No Lee EA, Yi JY, Chung EK, Son Y* (2010),Transforming growth factor beta1 transactivates EGFR via an H2O2-dependent mechanism in squamous carcinoma cell line. Cancer Letter. Vol.290, N.1, Hong HS, Lee JS, Lee EunAh, Kwon YS, Lee EK, Ahn WS, Jiang MH, Kim JC and Son Y* (2009), A new role of substancep as a injury-inducible messenger for mobilization of CD29 + stromal-like cells. Nature Medicine Vol.15, No.4, Kang MH, Kim DY, Yi JY, and Son Y* (2009), Substance P accelerates intestinal tissue regeneration after g-irradiation-induced damage. Wound Rep. Reg. Vol17, No2,

4 Stem Cell Mobilization and Microenvironment Control for Tissue Repair Hyun Sook Hong, Ph.D. & Youngsook Son, Ph.D, Professor, KHU fellow, Department of Genetic Engineering and Graduate School of Biotechnology, Kyung Hee University, South Korea.

D, Professor, KHU fellow, Department of Genetic Engineering and

5 Tissue injury may create a specific microenvironment, which brings up the systemic participation of reparative stem cells in the repair process. Previously, we identified a new role of substance-p (SP) as an injury-inducible messenger to mobilize bone marrow stromal cells, namely mesenchymal stem cells (BMSC or MSC) from the marrow to the blood, home to the injured tissue, and be engaged in the tissue repair in the alkali-burn corneal injury model (Nature Medicine, 2009 April). This elucidates endogenous healing mechanism recalling BMSC to the wound site. In addition to SP s BMSC mobilizer function, SP also mobilize endothelial precursor cells (EPC) from the bone marrow to the peripheral blood. When NK-1 receptor positive cells were isolated from the blood by MACS analysis after the SP injection, CD34+ Urex+ adherent cells were detected and also confirmed to be EPC by marker expressions, Matrigel endothelial tube formation, and in vivo vasculogenesis in the wound model. SP s EPC mobilization pattern was rather distinct from that of G-CSF previously reported. In contrast to the strong inflammatory response of G-CSF, its major unwanted effect for the use of tissue injury, SP did not accompany inflammatory response in the injury model but rather suppressed the injury-stimulated inflammation response. This inflammation-suppressive role of SP came earlier than its BMSC and EPC mobilization effect. We explored SP s dual positive roles in the orchestration of the tissue repair in a variety of the animal models such as the spinal cord injury, acute myocardiac infarction, radiation-induced BM injury and gastrointestinal injury. At the early stage of wound healing, anti-inflammatory effect of SP seems to play positive roles in the reduction of inflammationinduced secondary cell death and the creation of favorable microenvironment for the engraftment of incoming stem cells. At later stage, endogenous stem cells such as BMSC and EPC mobilized by SP finally participate in the tissue repair as reparative stem cells. Acknowledgements: This work was supported by Excellence Team of Stem Cell Research( ) and Biomedical Project ( ) from Ministry of Education and Science and Technology (MEST) given to Dr YSon. Keywords : MSC, EPC, stem cell mobilization, homing, tissue repair

blood, home to the injured tissue, and be engaged in the tissue repair in the alkali-burn corneal injury model (Nature Medicine, 2009 April).

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