Curriculum Vitae Massimo M. Santoro, PhD

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1 Curriculum Vitae Massimo M. Santoro, PhD Current position Full Professor, KU Leuven, Belgium Group Leader, VIB-Vesalius Research Center, Leuven, Belgium Education 1994 BS in Biology summa cum laude and Special Award, University of Torino (Italy) 1996 Master in Biology and Biochemistry, University of Torino (Italy) 2001 Ph.D. in Cellular and Molecular Biology, Open University, London (UK) Professional experience Undergraduate student, Department of Biomedical Sciences and Oncology, University of Turin (Mentor: Paolo M. Comoglio) PhD student, Open University c/o Department of Biological and Technological Research (Dibit), University of Vita e Salute San Raffaele, HSR (Mentors: Julian Downward and Pier Carlo Marchisio) Assistant Professor, Department of Environmental and Life Science, Faculty of Science, University of Piemonte Orientale "A. Avogadro" Assistant Professor/Post-doc, Department of Medical Science, University of Piemonte Orientale A. Avogadro (Mentor: Giovanni Gaudino) Post-doc, Department of Biochemistry and Biophysics, University of California, San Francisco, UCSF (Mentor: Didier Y. Stainier) Principal Investigator at Molecular Biotechnology Center and Assistant Professor, University of Turin, Italy Group Leader, VIB-VRC, Full Professor, KU Leuven, Belgium Research Activities - Molecular and genetic basis of redox signaling during normal and pathological angiogenesis. - Cellular and molecular characterization of vascular and smooth muscle cells during development and differentiation in vertebrates. Awards and Honours 2015 ERC-Consolidator 2014 Odysseus FWO Awards 2010 Marie Curie Reintegration Award and Grant 2008 HFSP Career Developmental Award and Grant 2004 HFSP Long-term fellow 2004 EMBO Long-term fellow

2 1996 Open University/San Raffaele University merit-based fellow 1996 Italian Foundation of Cancer Research (AIRC) merit based fellow 1995 Award of First Class thesis, Faculty of Biological Sciences, University of Turin 1994 Medal for excellence as undergraduate student City Hall of Turin Invited speaker at National or International meeting 2015 Cell Symposia Multifaceted Mitochondria, Chicago, USA XVII Telethon Convention, Trento, Italy Gordon Conference on Endothelial Cell Behaviour, Maine, USA th international CoQ10 conference, Bologna, Italy rd EAS Congress, Glasgow, Scotland th International Kloster Seeon Meeting "Angiogenesis", Seeon, Germany th International Conference on Ophthalmology, Maryland, USA International Vascular Biology Meeting, Kyoto, Japan Keystone Symposia on Metabolism and Angiogenesis, USA NAVBO meeting, Vascular Biology, Hyannis, MA, USA th European Zebrafish meeting, Barcelona, Spain ABCD meeting, Ravenna, Italy Angiogenesis: Basi molecolari ed implicazioni terapeutiche V, Pontignano, Italy Vesalius Research Center, VIB, Leuven, Belgium ABCD meeting, Keynote lecture, Parma, Italy Fondazione Guido Bernardini, Milano, Italia 2009 Fondazione Guido Bernardini, Milano, Italia th European Zebrafish meeting, Cardiovascular workshop, Rome, Italy st Italian Zebrafish meeting, Brescia, Italy Angiogenesis: basi molecolari ed implicazioni terapeutiche III, Pontignano, Italy FISV meeting, Stem cell and regeneration workshop, Riva del Garda, Italy Gordon Conference on Endothelial Cell Behaviour, Maine, USA BaStaG meeting USCF retreat, San Francisco, USA FISV meeting, workshop on Signal Transduction of Cell Adhesion, Proliferation and Differentiation, Riva del Garda, Italy.

3 1997 FISV meeting, Workshop on Signal Transduction of Cell Adhesion, Proliferation and Differentiation, Riva del Garda, Italy Structures and Function of Interacting Protein Domains in Signal and Energy Transduction, NATO Conference, Napoli, Italy 1996 ABCD-AGI-SIBBM Conference, S. Giminiano, Italy Invited lectures at Institute or University 2014 Department of Biology, University of Milan, Italy Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany Institute of Molecular Life Sciences Universität Zürich UZH, Swiss NIH, Bethesda, Maryland, USA KU Leuven Medical School, Stem Cell Instituut, Leuven, Belgium IRIBHM- ULB, (Université Libre de Bruxelles), Brussels, Belgium Lecture, Stazione Zoologica A. Dohr, Napoli, Italy 2012 IFOM-IEO Campus, Milan, Italy VIB Vesalius Research Center, KU Leuven, Belgium Yale University, School of Medicine, Cardiovascular Department, USA 2011 University of Bordeaux, France 2011 PARCC retreat, Keynote Lecture, Paris, France University of Padova, Italy Cardiovascular Network, Molecular Biotechnology Center, University of Torino, Italy Seminar, UNITre, Torre Pellice, Italy TIGEM, Napoli, Italy Lecture, Stazione Zoologica A. Dohr, Napoli, Italy 2007 Faculty Candidate talk, Albert Einstein - Yoshiva University, New York, USA PASS-UCSF, San Francisco, USA DISCAFF, University of Piemonte Orientale, Novara, Italy 2005 Department of Biology, University of Torino, Italy Seminar, Regina Elena Cancer Institute, Rome, Italy 2000 PhD report, Cancer Research UK London Research Institute, London, UK

4 Service to Professional Organization 2011 Chairman, Molecular Basis of Cardiovascular diseases, 36th FEBS Congress, Turin, IT June Chairman, Cardiovascular session, 6 th European Zebrafish meeting, Rome, IT th July Organizing committee 6 th European Zebrafish meeting, Rome, IT th July Editorial Activities Editorial Board: Cardiovascular Research (Associate Editor), Frontiers in Cell and Developmental Biology (Associate Editor). Solicited reviewer for: EMBO Molecular Medicine, ATVB, Cardiovascular Research, Developmental Biology, Experimental Cell Research, Mechanism of Development, Neoplasia, British Journal of Pharmacology, Science Signaling, PLOS One, Scientific Reports. Solicited reviewer of grants for: MRC, HFSP, Cancer Research UK, EMBO, Wellcome Trust, AICR, Telethon, AIRC, FWO grant, Italian National Academy of Science, Australian National Grant Association. Professional memberships 2010-present 2005-present 2005-present 2002-present 2000-present European Vascular Biology Organization (EVBO) North American Vascular Biology Organization (NAVBO) American Society Cell Biology (ASCB) Italian Society of Biochemistry and Molecular Biology (SIBBM) Italian Association of Biological and Cellular Differentiation (ABCD) Patent 2011 Patent number PCT/EP2011/ UBIAD1 for cellular coenzyme Q10 synthesis and cardiovascular oxidative protection In vivo redox and metabolic endothelial biosensors. Patent under submission. Grants PRIN, Italian Research Council, Italy mio Ricerca Finalizzata Regione Piemonte, Italy mio Career Developmental Award HFSP, EU mio Marie Curie International Reintegration Grant, EU mio AIRC grant, Italy mio Telethon GGP101095, Italy mio

5 2013 FWO, Belgium, mio Odysseus Grant, Belgium mio VIB, Belgium 1.5 mio Italian Ministry of Health mio ERC Consolidator 2.0 mio

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