Meso Scale Discovery. WINDOWS is a registered trademark of Microsoft Corporation

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1 Meso Scale Discovery M S D M S D Meso Scale Discovery, a division of Meso Scale Diagnostics, LLC. (MSD) 9238 Gaither Rd, Gaithersburg, MD Phone: Fax: sales@meso-scale.com Meso Scale Discovery, a division of Meso Scale Diagnostics, LLC. All Rights Reserved Meso Scale Discovery, Meso Scale Diagnostics, MSD, MSD(design), SECTOR, SECTOR PR, DISCOVERY WORKBENCH, MULTI-ARRAY and MULTI-SPOT are all trademarks of Meso Scale Diagnostics, LLC. MSD Technology.002 WINDOWS is a registered trademark of Microsoft Corporation

2 1 Contents 2. Vision 4. Technology 6. Power 8. Simplicity 10. Innovation 12. Convenience 14. Solutions 16. Time 18. Quality 20. Details

3 2 V i s i o n At Meso Scale Discovery we ve been quietly working for the last several years to build a company that can make a difference. A detection technology tailor-made for complex biology. Instruments built for the demands of modern discovery programs. Assays with simple formats that reduce workflow without compromising quality. Innovative platforms and informatics solutions for multiplexing and high information content screening. We re focused on the next generation of targets, and we want to be part of your discovery process. For us, our success will be measured by the success of our customers.

4 4 T e c h n o l o g y MSD s products are based on MULTI-ARRAY TM technology, a proprietary combination of electrochemiluminescence detection and patterned arrays. Electrochemiluminescence detection offers a unique combination of sensitivity, dynamic range and convenience. Arrays bring speed and high density of information to discovery through miniaturization, organization and parallel processing of biological assays. Electrochemiluminescence detection uses labels that emit light when electrochemically stimulated. Background signals are minimal because the stimulation mechanism (electricity) is decoupled from the signal (light). Labels are stable, non-radioactive and offer a choice of convenient coupling chemistries. They emit light at ~620 nm, eliminating problems with color quenching. Few compounds interfere with electrochemiluminescent labels so The detection process is initiated at electrodes located in the bottom of MSD s microplates. Only labels near the electrode are excited and detected, enabling non-washed assays with outstanding sensitivity. Multiple excitation cycles of each label amplify the signal to enhance light levels and improve sensitivity. you can use large, diverse libraries with confidence.

5 6 P o w e r SECTOR Imagers From their striking design to their innovative imaging systems, the SECTOR TM Imagers say performance. Whether you need their speed and reliability for the demands of ultra-high throughput screening or the vast information content of their MULTI-SPOT assays, the SECTOR Imagers are like no other instruments you ve seen before. TM Both Imagers are Multiplex Enabled! SECTOR Imager 6000 SECTOR Imager 2400 Both instruments use ultra-low A choice of plates: Our 96-, 384- Uncompromising speed: up to a Integrated conveniences, such as MSD DISCOVERY WORKBENCH Software noise charge-coupled device (CCD) and 1536-well MULTI-ARRAY plates plate per minute, for every plate onboard bar code readers, automatic offers Microsoft Windows 2000 user cameras with custom-designed or our MULTI-SPOT high-density on our SECTOR Imager 6000, motion control sensors and easy and file management protocols for telecentric lenses for rapid array plates offer the flexibility whether you re reading 96-, 384-, access plate stackers are standard operation in GLP laboratories. detection in all MULTI-ARRAY you need for complex assays well or MULTI-SPOT plates. on all SECTOR Imagers. or MULTI-SPOT plates.

6 8 S i m p l i c i t y SECTOR PR Readers One touch opens the door. One click of the mouse starts the assay. One look at the screen tells you the results. No filters, no fluidics, no parameters to set. Whether you re developing assays, processing clinical samples or running QC on your products, the SECTOR PR TM readers are so easy to use, you may never want to use another plate reader again. SECTOR PR 400 Multiplex Enabled! SECTOR PR 100 Both SECTOR PR readers process a Electrochemiluminescence detection Photodiode arrays make readouts fast One assay format from development MSD DISCOVERY WORKBENCH software Choose standalone or automated standard 96-well plate in two minutes. gives unmatched performance with and sensitive. Both SECTOR PR read- to screening: assays developed on offers one-click assays, enhanced data operation with robotic integration. The SECTOR PR 400 reader also runs simple, no-wash assays in both ers have attomole sensitivity, five logs the SECTOR PR readers are fully export tools, partial-plate reading The SECTOR PR readers can take multiplex assays, up to four assays per single and multiplex formats. of linear dynamic range and can read portable to the SECTOR Imagers. selection features, and is 21 CFR you from single plate assays to well in 96-well plates. a 96-well plate in two minutes. Part II compliant. screening.

7 10 I n n o v a t i o n MULTI-SPOT Plates The perfect marriage of form and function. MULTI-ARRAY microplate footprints for convenience. Integrated electrodes and arrays for performance. From our standard 384-well plates to our groundbreaking MULTI-SPOT technology, MSD is inventing new tools for discovery. 384-well MULTI-ARRAY plates MULTI-ARRAY plate formats include 96-, 384- and well plates. Dimensions and layout of all plates conform to SBS standards for straightforward integration with existing automation systems. 24-well MULTI-SPOT plates MULTI-SPOT plates, which offer arrays within the well for increased throughput and assay multiplexing, are available in 24-, 96-, and 384-well formats, with up to 100 spots per well. 96-well MULTI-SPOT 7 plate MSD s DISCOVERY WORKBENCH software provides real-time data visualization for multiplex assays and allows users to create custom data files for easy export.

8 12 C o n v e n i e n c e MSD provides a complete line of high quality products and services to help you succeed. Our microplates, assay buffers, labels, calibrators and blocking agents are available off-the-shelf and have been developed and tested with the highest standards of quality. Microplates are available plain, coated, and/or blocked, in your choice of standard or High-Bind formats. Custom coatings and blocking available upon request. Choose from a large menu of assay buffers and blocking reagents to optimize your assays. Many other assay reagents are available on a custom basis. MSD offers custom services such as assay development, labeling and custom reagent development. Services can be tailored to meet your specific needs.

9 14 S o l u t i o n s Meso Scale Discovery Kits You need information to make better, more timely decisions about compounds and targets. MSD's MULTI-SPOT Assay System can help. Our extensive menu of assays for biomarkers, cytokines and phosphoproteins for use in discovery, screening and pre-clinical/clinical applications are available as both single tests and multi-analyte panels and offer significant savings in time and cost when compared to traditional ELISAs. You can choose from our pre-configured kits or create your own custom panels. Either way, MSD will provide you with a complete and validated solution. MULTI-SPOT Assay kits provide Working with animal or Antibodies have been checked MSD thinks about the details. plates pre-coated with anti- clinical samples? Our assays for cross-reactivity against other Biomarker kits have diluents bodies immobilized onto spa- handle unpurified cell lysates, common targets and the speci- and other components opti- tially distinct electrodes in serum, plasma and tissue ficity of the assay has been mized for specific matrices the bottom of each well. homogenates with ease. validated using Western Blots. like serum or plasma. Assay kits are available in flexible sizes from a small demonstration kit to a full screen.

10 16 T i m e We know your time is valuable. In everything we do our products, our services, our commitment to customer support our goal is to make your time more productive. We offer experience and special expertise in assay development, custom labeling and high throughput screening. Whether you need reagents, instrumentation, fast turnaround on a custom service or a partner in your development process, MSD has the resources for you. Streamlined assay formats MSD s instruments and soft- Move quickly from assay Start screening now. Don t and rapid assay development ware are so easy to use, development to screening. let inferior technologies slow gets you up and running you ll spend your time on Assays developed on the you down or force you to quickly, so you spend your the assay, not the instru- SECTOR PR readers can be compromise on difficult time getting results that ment. No filters to screened on the SECTOR screens. MSD technology was matter. change, no complex proto- Imagers using the same designed for complex biology At MSD, we re here cols, no mysterious settings. protocols and reagents. and high-value targets. to help you get more time out of your day.

11 18 Q u a l i t y At MSD, quality is not an afterthought. It s part of everything we do and every product we sell. From our state-of-the-art manufacturing facilities to our rigorous QC standards, we are uncompromising in our commitment to making the best possible products. Borrowing from the microelectronics industry, we test every plate we make for 100% electrical integrity.

12 20 D e t a i l s SECTOR Imagers Dimensions Optics and Mechanics Performance Plate Formats Height 29.5 (74 cm) Cooled CCD camera (-35 C) Functional detection limit (binding assays): ~10 6 labels MULTI-ARRAY Plates for SECTOR Imager 6000 (96-, 384- and 1536-well plates) Depth 30.5 (77.5 cm) Custom telecentric lens Dynamic range: 10 5 MULTI-SPOT Plates for SECTOR Imager 6000 (24-, 96-, 384-well plates) Width 26.8 (68.1 cm) Integrated bar code readers Read time: 70 seconds per plate (SECTOR Imager 6000) MULTI-ARRAY Plates for SECTOR Imager 2400 (96- and 384-well plates) Weight 155 lbs. (70 kg) Two-dimensional motion control Read time: three minutes per plate (SECTOR Imager 2400) MULTI-SPOT Plates for SECTOR Imager 2400 (96- and 384-well plates) SECTOR PR readers Dimensions Optics and Mechanics Performance Plate Formats Height 8.8 (22.4 cm) Eight silicon photodiodes Functional detection limit (binding assays): ~5 x 10 6 labels 96-well MULTI-ARRAY plates Depth 16.2 (41.1 cm) Touch switch activation Dynamic range: well 4-spot plates (SECTOR PR 400) Width 8.6 (21.8 cm) Integrated plate carrier Read time: two minutes per plate Weight 18 lbs. (8 kg) Linear motion control Read time: five minutes per MULTI-SPOT plate (SECTOR PR 400) Integrated bar code readers Both Instruments Accessories Accessories cont. Software Software cont. Diagnostic test plates Tall stack tube (50-75 plates) MSD DISCOVERY WORKBENCH Software Real-time data visualization and processing tools Robotic integration software Short stack tube (20-30 plates) Microsoft Windows 2000 user and file security Custom data export for integration with external databases Robotic/manual adaptor (SECTOR Imager) On-board data storage in secure database Optional robotic integration tools