Charles AUFFRAY European Ins=tute for Systems Biology & Medicine - CNRS- ENS- UCBL Université de Lyon - France
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1 From Functional Genomics to Systems Medicine : Uniting Worldwide Efforts into a Joint Collaboration Biohealth Computing Roundtable on Big Data and Healthy Living European Scientific Institute, Archamps Technolope, France - August 28, 2015 Charles AUFFRAY cauffray@eisbm.org European Ins=tute for Systems Biology & Medicine - CNRS- ENS- UCBL Université de Lyon - France 1
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3 Charles AUFFRAY - CNRS- EISBM - Lyon - France High Performance CompuBng in Health Research Workshop Brussels - October 1, HPC is necessary and used already for processing large volumes of next- generabon sequencing and imaging data, and for mulb- scale integrabon and simulabon of models of complex biological systems - HPC is necessary and used currently to support translabonal research, such as the transmart/etriks platorm of the pre- compebbve public- private partnerships of the InnovaBve Medicines IniBaBve - The ethical and regulatory landscape needs consolidabon based e.g. on the Convergence IniBaBve and the Code on Secondary Use of PaBent Medical InformaBon in CollaboraBve ScienBfic Research - AdopBon of Open Consent, Open Standards and Open Data sharing policies is needed and essenbal to ensure the best use of HPC to support Personalized and Health and Care Research in Horizon 2020
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5 etriks Platform CollaboraBon PlaTorm CollaboraBon Research process IP capture and management Secure access AnalyBcs Environment Access to analybcs tools Open API for public and commercial sozware to plug- in Access Manag ement Study Book / Visual Research TR Knowledge Hub Cloud Infrastructure Load procedures Big Data storage Ontology management Study Management Ontology Management Scien=fic Data Architecture
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7 Bio-clinical clusters in U-BIOPRED Visualization of Data Structure Topology Data Analysis using Ayasdi Core
8 From Asthma to Allergy Dynamic Disease Maps Metacore - Static CNRS-EISBM-LCSB AsthmaMap Computerized and Dynamic
9 Participatory, Personalized, Predictive, Preventive Medicine Systems medicine: the future of medical genomics and healthcare Auffray C, Chen Z, Hood L (2009) Genome Medicine 1:2 Revolutionizing medicine in the 21st century through systems approaches Hood L, Balling R, Auffray C (2012) Biotechnol J 7: Systems biology and personalized medicine - the future is now Auffray C, Hood L (2012) Biotechnol J 7: Quantifying your body: A how-to guide from a systems biology perspective Smarr L (2012) Biotechnol J 7: Personal omics profiling reveals dynamic molecular and medical phenotypes Chen et al. (2012) Cell 148: The road from systems biology to systems medicine Wolkenhauer O, Auffray C, Jaster R, Steinhoff G, Dammann O (2013) NPG Pediatric Research, Epub Jan 11
10 Integrative Systems Biology & Medicine Participatory, Personalized, Predictive, Preventive Medicine Participatory medicine: a driving force for revolutionizing healthcare Hood L, Auffray C. (2013) Genome Med 5:110
11 11 Monitoring Wellness, Health and Disease Individual Dynamic Trajectories
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13 13 Monitoring Wellness, Health and Disease Big Data Analytics
14 Toward a Network of Systems BioMedicine Centers Introduction to Systems Biology Course Joseph Fourier University of Grenoble and Ecole Normale Supérieure de Lyon EISBM Annual Symposia and Workshops on Knowledge Management in Translational Research From Experimental Medicine to Systems Medicine Claude Bernard University of Lyon BIoHealth Computing Erasmus Mundus Summer Schools Grenoble-Alps University European Scientific Institute CERN Archamps Technopole Introduction to Systems Medicine Course Grenoble Alps University (in preparation)
15 Toward a Network of Systems BioMedicine Centers HCO-9 ERACoSysMed Systems Medicine to address clinical needs: Austria, Belgium, France, Germany, Ireland, Israel, Italy, Luxembourg, Norway, Slovakia, Slovenia, Spain, The Netherlands Perspectives in Environmental and Systems Biology, Grenoble, France April 13-15, CASyM Academic-Industry Interaction Workshop at Biovision, Lyon, France April 14, and CASyM Systems Medicine Summer School Stockholm KI Systems Medicine Web Hub online at
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