Chapter-21b: Hormones and Receptors
|
|
- Randell Gaines
- 8 years ago
- Views:
Transcription
1 1 hapter-21b: Hormones and Receptors Hormone classes Hormones are classified according to the distance over which they act. 1. Autocrine hormones --- act on the same cell that released them. Interleukin-2 on T-cells. 2. Paracrine hormones --- act only on cells close to the cell that released them. Prostaglandins and many polypeptide growth factors. 3. Endocrine hormones --- act on cells distant from the site of their release. Those are transported through bloodstream, etc. Endocrine hormones (insulin, epinephrine). Hormones act to: 1. maintain homeostasis (e.g., insulin vs. glucagon) 2. respond to stimuli (e.g., epinephrine) 3. control cyclic and developmental processes (e.g. sex hormones: steroids, peptides, and amino acid derivatives) 1
2 2 Responses are produced by second messengers, such as 3,5 -cyclic AMP (camp), inositol triphosphate (IP 3 ) and a 2+. H 2 A H 2 A P - camp H P - - H AMP H Four classes of receptors - Steroid receptors - Adrenoreceptors - Growth factor receptors - Acetylcholine receptors (Not discuss in this chapter) A. Steroid (hormone) receptors - are proteins in cytoplasm nucleus, but are not transmembrane proteins. - Steroid hormones are carried by serum binding protein in blood, and released near the target cells. The hormones diffuse into the target cells and bind the receptors in nucleus. - Hormones bound proteins bind to specific regulatory region of DNA and activated the DNA as transcription factors. B. Adrenoreceptors - are proteins on plasma membrane. - Polypeptides and amino acid derivatives bind to the plasma membrane receptors, and change concentration of a second messenger, camp, a 2+, etc. - Three examples are given: 1. β-adrenoreceptor system 2. α-adrenoreceptor system (Phosphoinositide system) 3. N system 2
3 3 Example-1: β-adrenoreceptor system - Human β-adrenoreceptor has 7 segments of membrane-spanning helices. - The N-terminal is on the extracellular surface where hormones bind, the -terminal is in the cytoplasmic side where G-proteins bind. R NH 2 H H 2 H R = H Norepinephrine (Noradrenalin) R = H 3 Epinephrine (Adrenalin) Receptor site H H G-protein binding site 3
4 4 G-proteins - are peripheral proteins, and are linked to membrane via a fatty acid on isoprenyl group. - receive the hormone (first messenger) message and transfer it to 2nd messenger. - G-protein has subunit structure, α, β, γ, or G α, G β, G γ. - GDP or GTP binds on G α. - The α-subunit (G α ) is separated from the βγ-subunits (G β and G γ ) when the bound GDP is replaced by GTP. The separated α-subunit (G α ) is the active form protein. - There are three kinds of G α proteins. G sα --- stimulating G α G iα --- inhibitory G α G qα --- phospholipid involved G α 4
5 5 Signal transduction process 1. Epinephrine binds to a specific receptor. 2. The occupied receptor causes replacement of the GDP bound to G s by GTP, activating G s. 3. G sα (α subunit) separates from G βγ subunits, and moves to adenylate cyclase (A) and activates it. 4. Activated A catalyzes the formation of 3,5 -cyclic AMP (camp) from ATP, i.e., [camp] is increased. 5. camp-dependent protein kinase (protein kinase A) is activated by camp. 6. Phosphorylation of cellular proteins by protein kinase A causes the cellular response to epinephrine. Epinephrine Norepinephrine Epinephrine Somatosteine pioids camp-dependent protein kinase (Protein kinase A) 5
6 6 Inhibitory mechanisms of signal transduction flow 1. GTP bound on activated G sα, G sα GTP is hydrolyzed to G sα GDP + P i. (step 3) 2. camp is degraded to AMP by phosphodiesterase. (step 5) 3. Phosphorylated proteins are dephosphorylated by phosphoprotein phosphatase. (step 6) 4. The binding of hormone to the inhibitory receptor, R i, triggers an almost identical chain of events except that the presence of G iα GTP complex inhibits A from synthesizing camp. Some inhibitors of the system (Note: These inhibitors increase the camp activity). 1. holera toxin - holera toxin (87 kd protein composed of A 1 B 5 ) inhibits the hydrolysis of G sα GTP G sα GDP + P i - AB 5 subunit structure of cholera toxin binds to receptor, and the A subunit takes into cell. - In the cell, A chain is divided to two chains, A 1 (195 AA) and A 2 (45 AA), by protease. Protease A A1 + A2 - A 1 catalyzes ADP ribosylation of an Arg residue in G sα. - This ADP-ribosylation prevents hydrolysis of GTP to GDP. Thus, G α GTP stays in active form. (Note: inactive form = G α GDP). - Therefore, camp is constantly produced. - - Epithelial cells of the small intestine secrete continuously digestive fluid (H 3 rich salt solution) in response to high [camp]. - onsequently, cholera patients have sever diarrhea and dehydration. - In this reaction, NAD + is a substrate rather than co-factor. 6
7 7 2. Pertussis toxin - ADP ribosylated G iα prevents exchange of GTP from GDP. Thus, G iα GDP stays in inactive form. - Thus, G iα cannot inhibit A activity, consequently, [camp] is increased. 3. affeine - affeine & theophylline inhibit the (camp AMP) reaction catalyzed by phosphodiesterase. - Thus, [camp] stays the same level, and constantly stimulate the camp-dependent protein kinase activity. 7
8 8 Example-2: α-adrenoreceptor system (Phosphoinositide pathway) - G-proteins also affect a 2+, phosphatidylinositol-4,5-bisphosphate (PIP 2 ), and sn-1,2- diacylglycerol (DG). Signal transduction processes 1. Hormone binds to a specific receptor. 2. The occupied receptor causes GDP-GTP exchange on G qα. 3. G qα, with bound GTP, moves to phospholipase (PL) and activate it. 4. Active PL cleaves phosphatidylinositol-4,5-bisphosphate to inositol-triphosphate (IP 3 ) and diacylglycerol (DG)* (see next page). 5. IP 3 binds to a specific receptor on the endoplasmic reticulum, releasing sequestered a 2+ to cytosol. 6. a 2+ stimulates a-calmodulin protein kinases, and/or a 2+, DG and PS (phosphatidylserine) activate protein kinase at the surface of the plasma membrane. 7. Phosphorylation of cellular proteins by a 2+ -am kinase and protein kinase produces the cellular response to the hormone. [a 2+ ] = 10-7 M a 2+ -almodulin Protein Kinase [a 2+ ] = 10-4 M 8
9 9 - IP 3 is degraded to IP 2 by inositol triphosphatase, and PIP 2 is regenerated. R 2 H 2 H 2 H P R 1-2- H P 3 H H P 3 2- Phosphatidyl-iositol-4,5-bisphosphate PL R 2 H 2 H 2 H + H 2- P 3 2- H P 3 H H P 3 2- R 1 Diacylglycerol (DG) Inositol - triphosphate (IP 3 ) Example-3: a 2+ activates Protein Kinase G via N as a biological messenger 1. N synthase is activated by a 2+ -calmodulin which is increased by external hormonal signal. 2. Nitric oxide (N) is produced from the Arg breakdown reaction catalyzed by N synthase. 3. The produced N activates guanylate cyclase. 4. Guanylate cyclase catalyzes the cgmp formation reaction from GTP. 5. cgmp activates cgmp-dependent protein kinase (protein kinase G). 6. Protein kinase G activates target proteins by phosphorylation, consequently, the smooth muscle cells are relaxed. a 2+ External hormonal signal NADPH Arg H 2 N 2 NADP + H N 2 a 2+ -am itrulline H 2 N 2 Nitroglycerin N synthase N Guanylate cyclase in smooth muscle cells cgmp cgmp - dependent protein kinase (Protein kinase G) Smooth muscle relaxation Phosphorylation of target proteins - Note: It is well-known that nitroglycerin works on angina pectoris (is a disease caused by insufficient blood flow to the heart muscle, leading to severe chest pain). Nitroglycerin produces N very quickly, and the N consequently relaxes the heart smooth muscle by stimulating the production of cgmp. 9
10 10. Receptors represented by growth factor receptors - are growth factor receptors - are transmembrane proteins consisted of α-subunit (receptor site) and β-subunit (transmembrane and tyrosine-specific protein kinase). - Binding growth factor such as insulin on the receptor triggers autophosphorylation of the Tyr residues in the -terminal domain of β-subunit. Protein H + ATP Protein P ADP - This phosphorylation allows the tyrosine kinase domain to catalyze phosphorylation of other target proteins. - Phosphorylated target proteins activate various enzymes. Tyrosine Kinase 10
11 11 Several different receptor tyrosine kinases 11
Mechanisms of Hormonal Action Bryant Miles
Mechanisms of ormonal Action Bryant Miles Multicellular organisms need to coordinate metabolic activities. Complex signaling systems have evolved using chemicals called hormones to regulate cellular activities.
More informationActions of Hormones on Target Cells Page 1. Actions of Hormones on Target Cells Page 2. Goals/ What You Need to Know Goals What You Need to Know
Actions of Hormones on Target Cells Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com) Page 1. Actions of Hormones on Target Cells Hormones
More informationCopyright 2000-2003 Mark Brandt, Ph.D. 93
Signal transduction In order to interact properly with their environment, cells need to allow information as well as molecules to cross their cell membranes. Information in many single-celled and all multicellular
More informationHormones & Chemical Signaling
Hormones & Chemical Signaling Part 2 modulation of signal pathways and hormone classification & function How are these pathways controlled? Receptors are proteins! Subject to Specificity of binding Competition
More information3) There are different types of extracellular signaling molecules. 4) most signaling molecules are secreted by exocytosis
XIV) Signaling. A) The need for Signaling in multicellular organisms B) yeast need to signal to respond to various factors C) Extracellular signaling molecules bind to receptors 1) most bind to receptors
More informationINTRODUCTION TO HORMONES
INTRODUCTION TO HORMONES UNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DISCIPLINE OF BIOCHEMISTRY & MOLECULAR BIOLOGY PBL MBBS II SEMINAR VJ Temple What are hormones? Cells in multi-cellular
More informationChapter 18. An Introduction to the Endocrine System. Hormone Chemistry
Chapter 18 An Introduction to the Endocrine System Hormone Chemistry Endocrine System Components endocrine system - glands, tissues, and cells that secrete hormones Copyright The McGraw-Hill Companies,
More informationDescribe how these hormones exert control quickly by changes in phosphorylation state of enzyme, and more slowly by changes of gene expression
Section VIII. Section VIII. Tissue metabolism Many tissues carry out specialized functions: Ch. 43 look at different hormones affect metabolism of fuels, especially counter-insulin Ch. 44 Proteins and
More informationMechanism of hormone action
Mechanism of hormone action ผศ.ดร.พญ.ส ว ฒณ ค ปต ว ฒ ภาคว ชาสร รว ทยา คณะแพทยศาสตร ศ ร ราชพยาบาล Aims What is hormone receptor Type of hormone receptors - cell surface receptor - intracellular receptor
More informationDiabetes and Insulin Signaling
Diabetes and Insulin Signaling NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE by Kristy J. Wilson School of Mathematics and Sciences Marian University, Indianapolis, IN Part I Research Orientation
More informationMolecular Cell Biology. Prof. D. Karunagaran. Department of Biotechnology. Indian Institute of Technology Madras. Module 7 Cell Signaling Mechanisms
Molecular Cell Biology Prof. D. Karunagaran Department of Biotechnology Indian Institute of Technology Madras Module 7 Cell Signaling Mechanisms Lecture 2 GPCR Signaling Receptors - G protein coupled receptors
More informationLecture 8. Protein Trafficking/Targeting. Protein targeting is necessary for proteins that are destined to work outside the cytoplasm.
Protein Trafficking/Targeting (8.1) Lecture 8 Protein Trafficking/Targeting Protein targeting is necessary for proteins that are destined to work outside the cytoplasm. Protein targeting is more complex
More informationStress & Catecholamines - Overview
Stress & Catecholamines - Overview UNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DISCIPLINE OF BIOCHEMISTRY AND MOLECULAR BIOLOGY PBL MBBS YEAR II SEMINAR VJ Temple Stress can due to: What is
More informationThe diagram below summarizes the effects of the compounds that cells use to regulate their own metabolism.
Regulation of carbohydrate metabolism Intracellular metabolic regulators Each of the control point steps in the carbohydrate metabolic pathways in effect regulates itself by responding to molecules that
More informationRegulation of enzyme activity
1 Regulation of enzyme activity Regulation of enzyme activity is important to coordinate the different metabolic processes. It is also important for homeostasis i.e. to maintain the internal environment
More informationLecture 6. Regulation of Protein Synthesis at the Translational Level
Regulation of Protein Synthesis (6.1) Lecture 6 Regulation of Protein Synthesis at the Translational Level Comparison of EF-Tu-GDP and EF-Tu-GTP conformations EF-Tu-GDP EF-Tu-GTP Next: Comparison of GDP
More information73 Cell Communication
73 Cell Communication and Multicellularity CHATEROUTLIE 7. What Are Signals, and How Do Cells Respond to Them? 7.2 How Do Signal Receptors Initiate a Cellular Response? 7.3 How Is the Response to a Signal
More information5 CELL SIGNALING. Introduction A. Types of Signaling B. Types of Receptors C. Other Conserved Functions
Signaling 1 5 CELL SIGNALING I II Introduction A. Types of Signaling B. Types of Receptors C. Other Conserved Functions G Protein-coupled Receptors A. Heterotrimeric G proteins B. G-protein coupled receptors
More informationHormones: Classification. Hormones: Classification. Peptide Hormone Synthesis, Packaging, and Release
Hormones: Classification Hormones: Classification Be able to give types and example. Compare synthesis, half-life and location of receptor 1. Peptide or protein hormones Insulin from amino acids 2. Steroid
More informationStudent name ID # 2. (4 pts) What is the terminal electron acceptor in respiration? In photosynthesis? O2, NADP+
1. Membrane transport. A. (4 pts) What ion couples primary and secondary active transport in animal cells? What ion serves the same function in plant cells? Na+, H+ 2. (4 pts) What is the terminal electron
More informationFight or Flight Response: Play-by-Play
One of the most remarkable examples of cell communication is the fight or flight response. When a threat occurs, cells communicate rapidly to elicit physiological responses that help the body handle extraordinary
More informationChapter 4. The Adrenal Medulla
Chapter 4 The Adrenal Medulla Introduction Induction of cortisol production requires several minutes, and full elaboration of cortisol action requires several hours. In contrast, the adrenal medullary
More informationDr. RAJENDRAN S INSTITUTE OF MEDICAL EDUCATION
Page 1 of 7 Dr. RAJENDRAN S INSTITUTE OF MEDICAL EDUCATION AIIMS NOVEMBER 2012 - QUESTIONS AND ANSWERS PHYSIOLOGY This contains only 3 out of 7 questions. For complete questions with explanatory answers,
More informationCopyright 2000-2003 Mark Brandt, Ph.D. 54
Pyruvate Oxidation Overview of pyruvate metabolism Pyruvate can be produced in a variety of ways. It is an end product of glycolysis, and can be derived from lactate taken up from the environment (or,
More informationKeystone Review Practice Test Module A Cells and Cell Processes. 1. Which characteristic is shared by all prokaryotes and eukaryotes?
Keystone Review Practice Test Module A Cells and Cell Processes 1. Which characteristic is shared by all prokaryotes and eukaryotes? a. Ability to store hereditary information b. Use of organelles to control
More information2007 7.013 Problem Set 1 KEY
2007 7.013 Problem Set 1 KEY Due before 5 PM on FRIDAY, February 16, 2007. Turn answers in to the box outside of 68-120. PLEASE WRITE YOUR ANSWERS ON THIS PRINTOUT. 1. Where in a eukaryotic cell do you
More informationWhat affects an enzyme s activity? General environmental factors, such as temperature and ph. Chemicals that specifically influence the enzyme.
CH s 8-9 Respiration & Metabolism Metabolism A catalyst is a chemical agent that speeds up a reaction without being consumed by the reaction. An enzyme is a catalytic protein. Hydrolysis of sucrose by
More information1. The diagram below represents a biological process
1. The diagram below represents a biological process 5. The chart below indicates the elements contained in four different molecules and the number of atoms of each element in those molecules. Which set
More informationRegulation of the Citric Acid Cycle
Regulation of the itric Acid ycle I. hanges in Free Energy February 17, 2003 Bryant Miles kj/mol 40 20 0 20 40 60 80 Reaction DGo' DG TA Free Energy hanges 1 2 3 4 5 6 7 8 9 1.) itrate Synthase 2.) Aconitase
More informationLecture 4 Enzymes Catalytic proteins. Enzymes. Enzymes 10/21/10. What enzymes do therefore is:
Lecture 4 Catalytic proteins Are a type of protein that acts as a catalyst-speeding up chemical reactions A catalyst is defined as a chemical agent that changes the rate of a reaction without being consumed
More informationChapter 14 Glycolysis. Glucose. 2 Pyruvate 2 Lactate (sent to liver to be converted back to glucose) TCA Cycle
Chapter 14 Glycolysis Requires mitochondria and O 2 Glucose glycolysis anaerobic respiration 2 Pyruvate 2 Lactate (sent to liver to be converted back to glucose) pyruvate dehydrogenase acetyl-coa TCA Cycle
More informationMetabolism Lecture 7 METABOLIC_REGULATION Restricted for students enrolled in MCB102, UC Berkeley, Spring 2008 ONLY
Bryan Krantz: University of California, Berkeley MCB 102, Spring 2008, Metabolism Lecture 7 Reading: Ch. 15 of Principles of Biochemistry, Principles of Metabolic Regulation, Illustrated with Glucose and
More informationCELL MEMBRANES, TRANSPORT, and COMMUNICATION. Teacher Packet
AP * BIOLOGY CELL MEMBRANES, TRANSPORT, and COMMUNICATION Teacher Packet AP* is a trademark of the College Entrance Examination Board. The College Entrance Examination Board was not involved in the production
More informationSmooth Muscle. Smooth Muscle Structure
Smooth Muscle Spindle-shaped Small (2-5 um wide, 50-300 um long) 1 centrally placed nucleus per cell Usually organized in small to moderate sized clusters of cells Lack sarcomeres No T-tubules or terminal
More informationIntegration of Metabolism
I. Central Themes of Metabolism 1. ATP is the universal energy carrier. Integration of Metabolism Bryant Miles 2. ATP is generated by the oxidation of metabolic fuels Glucose Fatty Acids Amino Acids 3.
More information7 Answers to end-of-chapter questions
7 Answers to end-of-chapter questions Multiple choice questions 1 B 2 B 3 A 4 B 5 A 6 D 7 C 8 C 9 B 10 B Structured questions 11 a i Maintenance of a constant internal environment within set limits i Concentration
More informationAP BIOLOGY 2008 SCORING GUIDELINES
AP BIOLOGY 2008 SCORING GUIDELINES Question 1 1. The physical structure of a protein often reflects and affects its function. (a) Describe THREE types of chemical bonds/interactions found in proteins.
More informationNO CALCULATORS OR CELL PHONES ALLOWED
Biol 205 Exam 1 TEST FORM A Spring 2008 NAME Fill out both sides of the Scantron Sheet. On Side 2 be sure to indicate that you have TEST FORM A The answers to Part I should be placed on the SCANTRON SHEET.
More informationMULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question.
Ch23_PT MULTIPLE CHOICE. Choose the one alternative that best completes the statement or answers the question. 1) All of the following statements concerning digestion are correct except A) The major physical
More informationCitric Acid Cycle. Cycle Overview. Metabolic Sources of Acetyl-Coenzyme A. Enzymes of the Citric Acid Cycle. Regulation of the Citric Acid Cycle
Citric Acid Cycle Cycle Overview Metabolic Sources of Acetyl-Coenzyme A Enzymes of the Citric Acid Cycle Regulation of the Citric Acid Cycle The Amphibolic Nature of the Citric Acid Cycle Cycle Overview
More informationIonization of amino acids
Amino Acids 20 common amino acids there are others found naturally but much less frequently Common structure for amino acid COOH, -NH 2, H and R functional groups all attached to the a carbon Ionization
More informationTransmembrane proteins span the bilayer. α-helix transmembrane domain. Multiple transmembrane helices in one polypeptide
Transmembrane proteins span the bilayer α-helix transmembrane domain Hydrophobic R groups of a.a. interact with fatty acid chains Multiple transmembrane helices in one polypeptide Polar a.a. Hydrophilic
More informationO ρόλος της ακετυλοχολίνης στη σύσπαση και τον πολλαπλασιασµό των ΛΜΚ (του αναπνευστικού) Απ. Χατζηευθυµίου 2015
O ρόλος της ακετυλοχολίνης στη σύσπαση και τον πολλαπλασιασµό των ΛΜΚ (του αναπνευστικού) Απ. Χατζηευθυµίου 2015 Σύσπαση ΛΜΙ An increase in free intracellular calcium can result from either increased flux
More informationMammalian Physiology. Cellular Membranes Membrane Transport UNLV. PHYSIOLOGY, Chapter 1 Berne, Levy, Koeppen, Stanton UNIVERSITY OF NEVADA LAS VEGAS
Mammalian Physiology Cellular Membranes Membrane Transport UNLV 1 UNIVERSITY OF NEVADA LAS VEGAS PHYSIOLOGY, Chapter 1 Berne, Levy, Koeppen, Stanton Objectives Describe the structure of the cell membrane
More informationregulation of ECF composition and volume regulation of metabolism thyroid hormones, epinephrine, growth hormone, insulin and glucagon
Hormonal Effects regulation of ECF composition and volume ADH, aldosterone, ANF regulation of metabolism thyroid hormones, epinephrine, growth hormone, insulin and glucagon regulation of muscle contraction
More information1. Enzymes. Biochemical Reactions. Chapter 5: Microbial Metabolism. 1. Enzymes. 2. ATP Production. 3. Autotrophic Processes
Chapter 5: Microbial Metabolism 1. Enzymes 2. ATP Production 3. Autotrophic Processes 1. Enzymes Biochemical Reactions All living cells depend on biochemical reactions to maintain homeostasis. All of the
More informationCopyright 2010 Pearson Education, Inc. Chapter Twenty Three 1
23.2 Glucose Metabolism: An Overview When glucose enters a cell from the bloodstream, it is immediately converted to glucose 6- phosphate. Once this phosphate is formed, glucose is trapped within the cell
More informationAP BIOLOGY CHAPTER 7 Cellular Respiration Outline
AP BIOLOGY CHAPTER 7 Cellular Respiration Outline I. How cells get energy. A. Cellular Respiration 1. Cellular respiration includes the various metabolic pathways that break down carbohydrates and other
More informationTEMA 10. REACCIONES INMUNITARIAS MEDIADAS POR CÉLULAS.
TEMA 10. REACCIONES INMUNITARIAS MEDIADAS POR CÉLULAS. The nomenclature of cytokines partly reflects their first-described function and also the order of their discovery. There is no single unified nomenclature,
More informationChapter 5. Endocrine Regulation of Glucose Metabolism
Chapter 5 Endocrine Regulation of Glucose Metabolism Overview of Glucose Homeostasis Glucose metabolism is critical to normal physiological functioning. Glucose acts both as a source of energy and as a
More informationCellular Respiration and Fermentation
LECTURE PRESENTATIONS For CAMPBELL BIOLOGY, NINTH EDITION Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson Chapter 9 Cellular Respiration and Fermentation
More informationWork and Energy in Muscles
Work and Energy in Muscles Why can't I sprint forever? I'll start this section with that silly question. What lies behind the undisputable observation that we must reduce speed if we want to run longer
More informationDigestive System Lecture 5 Winter 2014
Digestive System Lecture 5 Winter 2014 This lecture tells the story of the Flow of Matter from Food to Cells. The pictures are only there to help you visualize structures don t worry about names of structures
More informationSOME Important Points About Cellular Energetics by Dr. Ty C.M. Hoffman
SOME Important Points About Cellular Energetics by Dr. Ty C.M. Hoffman An Introduction to Metabolism Most biochemical processes occur as biochemical pathways, each individual reaction of which is catalyzed
More informationEndocrine Responses to Resistance Exercise
chapter 3 Endocrine Responses to Resistance Exercise Chapter Objectives Understand basic concepts of endocrinology. Explain the physiological roles of anabolic hormones. Describe hormonal responses to
More informationPRACTICE SET 6. A. Questions on Lipid Metabolism and Glyoxylate Cycle
PRATIE SET 6 A. Questions on Lipid Metabolism and Glyoxylate ycle 1. The hydroxy acid given below can be completely oxidized to acetyl-oa by betaoxidation. Write the series of individual reactions that
More informationISTEP+: Biology I End-of-Course Assessment Released Items and Scoring Notes
ISTEP+: Biology I End-of-Course Assessment Released Items and Scoring Notes Page 1 of 22 Introduction Indiana students enrolled in Biology I participated in the ISTEP+: Biology I Graduation Examination
More informationEnzymes and Metabolic Pathways
Enzymes and Metabolic Pathways Enzyme characteristics Made of protein Catalysts: reactions occur 1,000,000 times faster with enzymes Not part of reaction Not changed or affected by reaction Used over and
More informationLecture 6: Cholesterol (Ch. 9.1e, 9.2b, 19.7b,c) & Lipoproteins (Ch. 10.3*, 19.1, 19.7b,c)
Lecture 6: Cholesterol (Ch. 9.1e, 9.2b, 19.7b,c) & Lipoproteins (Ch. 10.3*, 19.1, 19.7b,c) Next lecture: Fatty Acid Oxidation (Ch. 19.2), Ketone Bodies (Ch. 19.3) and Fatty Acid Biosynthesis (Ch. 19.4)
More informationHow To Understand The Chemistry Of An Enzyme
Chapt. 8 Enzymes as catalysts Ch. 8 Enzymes as catalysts Student Learning Outcomes: Explain general features of enzymes as catalysts: Substrate -> Product Describe nature of catalytic sites general mechanisms
More informationThe correct answer is d C. Answer c is incorrect. Reliance on the energy produced by others is a characteristic of heterotrophs.
1. An autotroph is an organism that a. extracts energy from organic sources b. converts energy from sunlight into chemical energy c. relies on the energy produced by other organisms as an energy source
More information8/20/2012 H C OH H R. Proteins
Proteins Rubisco monomer = amino acids 20 different amino acids polymer = polypeptide protein can be one or more polypeptide chains folded & bonded together large & complex 3-D shape hemoglobin Amino acids
More informationPHC 313 The 7 th. Lecture. Adrenergic Agents
PHC 313 The 7 th. Lecture Adrenergic Agents Introduction Introduction Adrenergic agents are a broad class of agents employed in the treatment of many disorders. They are those chemical agents that exert
More informationChapter 16 The Citric Acid Cycle
Chapter 16 The Citric Acid Cycle Multiple Choice Questions 1. Which of the following is not true of the reaction catalyzed by the pyruvate dehydrogenase complex? A) Biotin participates in the decarboxylation.
More informationH H N - C - C 2 R. Three possible forms (not counting R group) depending on ph
Amino acids - 0 common amino acids there are others found naturally but much less frequently - Common structure for amino acid - C, -N, and functional groups all attached to the alpha carbon N - C - C
More informationBCH401G Lecture 39 Andres
BCH401G Lecture 39 Andres Lecture Summary: Ribosome: Understand its role in translation and differences between translation in prokaryotes and eukaryotes. Translation: Understand the chemistry of this
More informationEnergy Production In A Cell (Chapter 25 Metabolism)
Energy Production In A Cell (Chapter 25 Metabolism) Large food molecules contain a lot of potential energy in the form of chemical bonds but it requires a lot of work to liberate the energy. Cells need
More informationAnatomy and Physiology Placement Exam 2 Practice with Answers at End!
Anatomy and Physiology Placement Exam 2 Practice with Answers at End! General Chemical Principles 1. bonds are characterized by the sharing of electrons between the participating atoms. a. hydrogen b.
More informationT Cell Maturation,Activation and Differentiation
T Cell Maturation,Activation and Differentiation Positive Selection- In thymus, permits survival of only those T cells whose TCRs recognize self- MHC molecules (self-mhc restriction) Negative Selection-
More information12.4 G Protein Coupled Receptors and Second Messengers
8885d_c12_435 2/20/04 1:19 M age 435 mac76 mac76:385_reb: 12.4 G rotein Coupled eceptors and Second Messengers 435 tivated by cgm, phosphorylates Ser and Thr residues in target proteins. The catalytic
More informationName Date Period. 2. When a molecule of double-stranded DNA undergoes replication, it results in
DNA, RNA, Protein Synthesis Keystone 1. During the process shown above, the two strands of one DNA molecule are unwound. Then, DNA polymerases add complementary nucleotides to each strand which results
More informationThe tissues and organs of the vertebrate body cooperate
56 The Endocrine System Concept Outline 56.1 Regulation is often accomplished by chemical messengers. Types of Regulatory Molecules. Regulatory molecules may function as neurotransmitters, hormones, or
More informationParts of the Nerve Cell and Their Functions
Parts of the Nerve Cell and Their Functions Silvia Helena Cardoso, PhD [ 1. Cell body] [2. Neuronal membrane] [3. Dendrites] [4. Axon] [5. Nerve ending] 1. Cell body The cell body (soma) is the factory
More informationChemistry 20 Chapters 15 Enzymes
Chemistry 20 Chapters 15 Enzymes Enzymes: as a catalyst, an enzyme increases the rate of a reaction by changing the way a reaction takes place, but is itself not changed at the end of the reaction. An
More informationThe Lipid Bilayer Is a Two-Dimensional Fluid
The Lipid Bilayer Is a Two-Dimensional Fluid The aqueous environment inside and outside a cell prevents membrane lipids from escaping from bilayer, but nothing stops these molecules from moving about and
More informationChapter 25: Metabolism and Nutrition
Chapter 25: Metabolism and Nutrition Chapter Objectives INTRODUCTION 1. Generalize the way in which nutrients are processed through the three major metabolic fates in order to perform various energetic
More informationReview of the Cell and Its Organelles
Biology Learning Centre Review of the Cell and Its Organelles Tips for most effective learning of this material: Memorize the names and structures over several days. This will help you retain what you
More informationRegulation of cholesterol synthesis pathway. Cholesterol Synthesis. Cholesterol biosynthesis. Regulation of HMG CoA reductase activity
Cholesterol Synthesis Main function: ation of steroid nucleus Substrate: cytoplasmic acetyl CoA Endproduct: cholesterol Location: cytoplasm Regulation of cholesterol synthesis pathway HMG CoA reductase
More information1- Fatty acids are activated to acyl-coas and the acyl group is further transferred to carnitine because:
Section 10 Multiple Choice 1- Fatty acids are activated to acyl-coas and the acyl group is further transferred to carnitine because: A) acyl-carnitines readily cross the mitochondrial inner membrane, but
More informationProteins and Nucleic Acids
Proteins and Nucleic Acids Chapter 5 Macromolecules: Proteins Proteins Most structurally & functionally diverse group of biomolecules. : o Involved in almost everything o Enzymes o Structure (keratin,
More informationLecture 4: Peptides and Protein Primary Structure [PDF] Key Concepts. Objectives See also posted Peptide/pH/Ionization practice problems.
Lecture 4: Peptides and Protein Primary Structure [PDF] Reading: Berg, Tymoczko & Stryer, Chapter 2, pp. 34-37 Practice problems (peptide ionization) [PDF]; problems in textbook: chapter 2, pp. 63-64,
More informationAntibody Function & Structure
Antibody Function & Structure Specifically bind to antigens in both the recognition phase (cellular receptors) and during the effector phase (synthesis and secretion) of humoral immunity Serology: the
More informationSummary of Metabolism. Mechanism of Enzyme Action
Summary of Metabolism Mechanism of Enzyme Action 1. The substrate contacts the active site 2. The enzyme-substrate complex is formed. 3. The substrate molecule is altered (atoms are rearranged, or the
More informationPlasma Membrane hydrophilic polar heads
The Parts of the Cell 3 main parts in ALL cells: plasma membrane, cytoplasm, genetic material this is about the parts of a generic eukaryotic cell Plasma Membrane -is a fluid mosaic model membrane is fluid
More information1. What has a higher stored energy potential per gram, glycogen or triglycerides? Explain.
Lipid Metabolism 1. What has a higher stored energy potential per gram, glycogen or triglycerides? Explain. 2. How can excess acetyl CoA trapped in the mitochondria, be utilized as a substrate for fatty
More informationCarbon Hydrogen Oxygen Nitrogen
Concept 1 - Thinking Practice 1. If the following molecules were to undergo a dehydration synthesis reaction, what molecules would result? Circle the parts of each amino acid that will interact and draw
More informationBiochemistry of Cells
Biochemistry of Cells 1 Carbon-based Molecules Although a cell is mostly water, the rest of the cell consists mostly of carbon-based molecules Organic chemistry is the study of carbon compounds Carbon
More informationThe Endocrine System
Essentials of Human Anatomy & Physiology Elaine N. Marieb Seventh Edition Chapter 9 The Endocrine System Slides 9.1 9.48 Lecture Slides in PowerPoint by Jerry L. Cook The Endocrine System Second messenger
More informationPhosphogluconate pathway (pentose shunt) Classes of lipids. Phosphogluconate pathway (pentose shunt) Phosphogluconate pathway. G-6-P DHase.
Classes of lipids 1. fatty acids 2. triglycerides = glycerol + 3 f.a. 3. phosphoglycerides = gly. + 2 f.a. 4. steroids 5. sphingolipids=sphingosine+x+f.a. hosphogluconate pathway (pentose shunt) Main functions:
More informationThe Background for the Diabetes Detection Model
The Background for the Diabetes Detection Model James K. Peterson Department of Biological Sciences and Department of Mathematical Sciences Clemson University November 23, 2014 Outline The Background for
More informationTRANSDUCTION DU SIGNAL. Messagers intracellulaires Couplage aux protéines G Transmission via la voie des MAP kinases Transmission via la voie du NO
TRANSDUCTION DU SIGNAL Messagers intracellulaires Couplage aux protéines G Transmission via la voie des MAP kinases Transmission via la voie du NO TRANSDUCTION DU SIGNAL - MESSAGERS INTRACELULAIRES TRANSDUCTION
More informationSynaptic Processes. Chapter 5. 1. The Signaling Process in the Chemical Synapse
Biological Signal Processing Richard B. Wells Chapter 5 Synaptic Processes 1. The Signaling Process in the Chemical Synapse As the principal signaling junction in neural networks, the chemical synapse
More informationCardiac Muscle. Learning Objectives.
Cardiac Muscle. Learning Objectives. At the end of this course, you should be able to : 1. describe the structure of cardiac muscle 2. understand the concept of the functional syncytium 3. give a basic
More informationCells & Cell Organelles
Cells & Cell Organelles The Building Blocks of Life H Biology Types of cells bacteria cells Prokaryote - no organelles Eukaryotes - organelles animal cells plant cells Cell size comparison Animal cell
More informationhttp://faculty.sau.edu.sa/h.alshehri
http://faculty.sau.edu.sa/h.alshehri Definition: Proteins are macromolecules with a backbone formed by polymerization of amino acids. Proteins carry out a number of functions in living organisms: - They
More informationChapter 8: Energy and Metabolism
Chapter 8: Energy and Metabolism 1. Discuss energy conversions and the 1 st and 2 nd law of thermodynamics. Be sure to use the terms work, potential energy, kinetic energy, and entropy. 2. What are Joules
More informationCellular Calcium Dynamics. Jussi Koivumäki, Glenn Lines & Joakim Sundnes
Cellular Calcium Dynamics Jussi Koivumäki, Glenn Lines & Joakim Sundnes Cellular calcium dynamics A real cardiomyocyte is obviously not an empty cylinder, where Ca 2+ just diffuses freely......instead
More informationOverview of Glycolysis Under anaerobic conditions, the glycolytic pathway present in most species results in a balanced reaction:
Glycolysis Glucose is a valuable molecule. It can be used to generate energy (in red blood cells and in brain under normal conditions, glucose is the sole energy source), and it can be used to generate
More informationTodays Outline. Metabolism. Why do cells need energy? How do cells acquire energy? Metabolism. Concepts & Processes. The cells capacity to:
and Work Metabolic Pathways Enzymes Features Factors Affecting Enzyme Activity Membrane Transport Diffusion Osmosis Passive Transport Active Transport Bulk Transport Todays Outline -Releasing Pathways
More informationBIOLOGICAL MEMBRANES: FUNCTIONS, STRUCTURES & TRANSPORT
BIOLOGICAL MEMBRANES: FUNCTIONS, STRUCTURES & TRANSPORT UNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DISCIPLINE OF BIOCHEMISTRY AND MOLECULAR BIOLOGY BMLS II / B Pharm II / BDS II VJ Temple
More information