Broad Selection of Antibodies & Antigens. for the Diagnostics Industry in North America

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1 Broad Selection of Antibodies & Antigens for the Diagnostics Industry in North America

2 Antibodies and Antigens for Diagnostics Diagnostics manufacturers require antibodies and antigens of proven quality specifically produced for use in diagnostic kits. Roche Custom Biotech offers a broad spectrum of high quality products for use in clinical chemistry and immunological applications. Roche antibodies and antigens: Excellent state-of-the-art performance for raw materials High lot-to-lot consistency Guaranteed specifications and stability Manufactured from milligrams to kilograms, providing supply security Benefit from Roche Diagnostics as a well-established manufacturer of raw materials: Over 25 years of expertise in development and manufacturing of monoclonal and polyclonal antibodies Preferred supplier for leading IVD manufacturers Certified according to ISO 13485:2012 Worldwide distribution and support network through Custom Biotech key account teams and Roche affiliates From cell clone to purified antibodies Products are for further processing only. Trademarks Other brands or product names are trademarks of their respective holders.

3 Antibodies for Clinical Chemistry CRP Testing C-Reactive Protein (CRP) is a member of the globulin family of human plasma proteins. Increased levels of CRP are involved in a variety of inflammatory diseases. Elevated CRP serum levels indicate tissue injury, transplant rejection, carcinogenesis, and acute myocardial infarction. In turbidimetric/nephelometric assays, PAB<CRP>S IgG is coupled onto latex surfaces. These aggregates can be detected at 340/700 nm. Test Components Catalog Number PAB<CRP>S IgG Tris buffer N-Methylisothiazolone (MIT) Pancreatic -Amylase Testing In human serum and urine, the two major iso enzymes of human- -amylase, salivary (s) and pancreatic (p) amylase, are present. For selective measurement of acute pancreatitis, blocking of salivation, -amylase is necessary. The combi nation of MAB<H-S-AMY>Tu88E8 IgG and MAB<H-S-AMY>Tu66C7 IgG inhibits the human salivary -amylase 97%, while maintaining the activity of the pancreatic -amylase. Test Components Catalog Number MAB<H-S-AMY>Tu88E8 lgg MAB<H-S-AMY>Tu66C7 lgg Glucosidase ,6-Ethylidene-G7PNP (EPS) Polidocanol N-Methylisothiazolone (MIT) Hepes buffer Creatine Kinase MB Testing Creatine Kinase MB (CK-MB) measurement is a key parameter for the diagnosis of acute myocardial infarction. The MAB<CK-MM>Mix inhibits the CK-M subunit by 99.7%, allowing accurate measurement of the CK-MB subunit. Four highly specific mono clonal mouse antibodies enable the same inhibition of CK-MM as a polyclonal antibody. The MAB<CK-MM>Mix inhibits faster than the polyclonal precursor, and can be added to both assay reagents. Test Components Catalog Number MAB<CK-MM>Mix Hexokinase (HK) G-6-PDH AMP, di-na Diadenosine pentaphosphate, Tri-Li NADP, mono-k ADP, mono-k Creatine phosphate, di-na Imidazole buffer N-Acetylcysteine Due to the absence of proteases, the preparation of stable liquid reagents is possible.

4 Antibodies and Antigens for Immunological Assays (HetIAs) The well-established portfolio of target-specific antibodies and antigens comprises key indication areas such as infectious diseases testing, fertility/thyroid diagnostics, oncology, cardiac, and hormone assays. Assay Target Product Name Catalog Number Oncology AFP MAB<AFP>M-TU11 IgG MAB<AFP>M-LJ738 IgG Assay Target Product Name Catalog Number Hormones Insulin MAB<INSULIN>M-BM1 IgG MAB<INSULIN>M-ST3 IgG CEA MAB<CEA>M-TU3 IgG MAB<CEA>M-TU2 IgG Ferritin MAB<Ferr>M IgG MAB<Ferr>M IgG Miscellaneous D-Dimer MAB<DD>M IgG MAB<DD>M IgG IgE MAB<IGE>M-323 IgG Cardiac MAB<IGE>M-7H8 IGG CK-MB MAB<CK-MB>M IgG MAB<CK-MB>M IgG Digoxin MAB<Dig>M IgG Fertility/Thyroid Estradiol PAB<E2>K IgG FSH MAB<FSH>M-W3 IgG MAB<FSH>M IgG HCG MAB<HCG>M-INN2 IgG MAB<HCG>M-INN22 IgG LH MAB<LH>M IgG MAB<LH>M IgG TSH MAB<TSH>M-ROC136T IgG MAB<TSH>M-TU1.20 IgG T3 PAB<T3>S IgG T4 PAB<T4>S-IgG Products are for further processing only.

5 Matching Pairs for Immunological Assays (HetIA) Save IVD kit development time and effort by using the the following matching pairs in sandwich assay formats. Assay Target Capture Detection Oncology AFP Assay Target Capture Detection Hormones Insulin CEA Ferritin Miscellaneous D-Dimer Cardiac IgE CK-MB Fertility/Thyroid TG TSH FSH HCG LH

6 Published by Roche Diagnostics GmbH Sandhofer Straße Mannheim Germany 2014 Roche Diagnostics. All rights reserved Your Roche Custom Biotech Customer Service United States Roche Diagnostics Corporation Roche Custom Biotech 9115 Hague Road P.O. Box Indianapolis, IN , USA Phone , ext (toll-free) Fax Canada Roche Diagnostics 201, Boulevard Armand-Frappier HV 4A2 Laval, Québec, Canada Phone Fax custombiotech.roche.com

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