Dr. med Matthias Frank Institute of Tropical Medicine Eberhard Karls Universität Tübingen Wilhelmstr 27, R Tübingen

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1 CURRICULUM VITAE Dr. med. Matthias Frank Institute of Tropical Medicine Eberhard Karls Universität Tübingen Wilhelmstr 27, R Tübingen Matthias.Frank@uni-tuebingen.de Date of Birth: April 7, 1966 Place of Birth: Bad Oldesloe, Germany Education: 1984 Bolivian High School Diploma 1985 Abitur Deutsche Schule, La Paz, Bolivia 1994 M.D., Medizinische Fakultät, Freie Universität Berlin 1996 Dissertation (magna cum laude) Medizinische Fakultät, Freie Universität Berlin Dissertation: "Spread and Diagnosis of Chagas' Disease in nonendemic areas, with a particular focus on the use of kdna PCR for the diagnosis of congenital infections" Advisor: Prof. Dr. Thomas Weinke Professional Experience: 7/1996-5/1999 Postdoctoral Fellow Harvard University, School of Public Health, Department of Immunolgy and Infectious Diseases Boston, USA

2 2 Laboratory: Professor Dr. Dyann Wirth Research project: Analyzing the Plasmodium falciparum multi drug resistance gene in E. coli and Saccharomycees cerevisiae 6/1999-6/2002 Resident in Internal Medicine University of Washington, School of Medicine, Department of Internal Medicine Seattle, USA Fellowship Director: Professor Dr. Findlay Wallace 7/2002-6/2006 Fellow in Infectious Diseases Weill Medical College of Cornell University, New York Presbyterian Hospital, Department of Internal Medicine, Division of International Medicine and Infectious Diseases New York City, USA Fellowship Director: Professor Dr. Warren Johnson Jr. Laboratory: Assistant Professor Dr. Kirk Deitsch Research project: molecular mechanisms of antigenic variation in Plasmodiun falciparum malaria 7/2006-5/2009 Research Group Leader and staff physician Institute for Tropical Medicine (ITM) Division of Human Parasitology Tübingen, Germany Division Head: Professor Dr. med. Peter G. Kremsner 6/2009- present Appointmnet as Head of the Diagnostic Laboratory of the Institute of Tropical Medicine 10/2009- present Appointment as assistant medical director of the Institute of Tropical Medicine Medical Examinations and Certifiaction: American Medical Examinations and Certification: 1991 Foreign Medical Graduate Examination (FMGEMS) Step I 1993 Foreign Medical Graduate Examination (FMGEMS) Step II 1998 Clincal Skills Assessment Test 1998 ECFMG Certificate 2002 Board certified in Internal Medicine American Board of Internal Medicine 2006 Board certified in Infectious Diseases American Board of Internal Medicine

3 3 German Medical Examinations and Certification: 1988 Physikum Staatsexamen Staatsexamen Staatsexamen 2000 Approbation als Arzt 2008 Facharzt für Innere Medizin 2008 Zusatzweiterbildung Infektiologie Research interests: Antigenic variation in Plasmodium falciparum malaria Drug resistance of Plasmodium falciparum Development and evaluation of new diagnostic tools for TB and malaria HIV-TB coinfection Awards: Scholarship Medizinische Fakultät der Eberhard Karl Universität Tübingen, to study at Brown University Medical School, Providence, RI, USA Postdoctoral fellowship German Academic Exchange Service (Program: Epidemiology and Public Health) 2004 Award for best presentation XV Molecular Parasitology Meeting Woods Hole, USA 2005 Award for best presentation XVI Molecular Parasitology Meeting Woods Hole, USA 2006 Award for best presentation XVII Molecular Parasitology Meeting Woods Hole, USA Awards to Trainees 2012 Award for best presentation 25. annual meeting of the German Society for Tropical Medicine: Dr. Corinna Enderes: Transgenic Plasmodium falciparum parasites from a chronically infected African individual suggest that Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is not the main antigen on the surface of infected red blood cells Posteraward 25. annual meeting Dr. Ellen Bruske: Characterization of PfEMP1 immunogenicity through quantification of the variant surface antigen signal and var

4 4 gene transcription in field isolates from a natural infection in Lambaréné, Gabon 2013 Helmut-Wolf award for best presentation Emmanuel Mouafo Tekwu: Decreased levels of tuberculosis drug resistance 15 years after the implementation of national DOTs policy in the central region of Cameroon. 31. annual meeting of the German Working group for tropical pediatrics 2014 Award for best presentation 26. annual meeting of the German Society for Tropical Medicine Dr.Ellen Bruske: Analysis of M.tuberculosis isolates from Lambaréné reveals clonal expansion of an MDR tuberculosis strain in rural Gabon Certificates and Courses: credits in Epidemiology courses Harvard School of Public Health Boston, USA 2008 Clinical Trial Principal Investigator Certificate Centrial, University of Tübingen Academic and Research Activities: During Internal Medicine Residency 2001, Feb./Mar. Cloning of lanosterol synthase gene of Leishmania mayor Laboratory of Dr.Wesley van Voorhis, Department of Medicine Division of Infectious Diseases, University of Washington, Seattle, USA 2002, Sept./Nov. Analysis of var gene expression during malaria in pregnancy in women from Burkina Faso Laboratory: Professor Dr. Michael Lanzer Medizinische Fakultät Abteilung für Parasitologie Ruprecht Karls Universität Heidelberg, Germany During Medical School: Second year of Medical School Brown University Medical School in Providence, RI, USA Clinical Clerkships University of New Mexico Medical School, University of New Mexico Hospital, Albuquerque, NM, USA 1994 Clinical Clerkships

5 5 Harvard Medical School, Beth Israel Hospital, Brigham and Women's Hospital, Massachusetts General Hospital, Boston, MA, USA Languages: German Spanish English Society Memberships: 2005-present Member of American Society for Tropical Medicine and Hygiene Member of Infectious Disease Society of America 1996-present Member of the German Society for Infectious Diseases 1996-present Member of the German Society for Tropical Medicine and International Health Grant support Principal Investigator for German Center for Infection Research/Deutsches Zentrum für Infektionsforschung (DZIF) TTU Tuberculosis Principal Investigator of the DAAD-Ärzteprogramm: Clinical capacity building in malaria and tuberculosis. Principal Investigator German Israeli Foundation (Research Grant agreement No /2008) Ron Dzikowksi, Hebrew University, Jerusalem Matthias Frank, Universität Tübingen Principal Investigator of the DAAD-Ärzteprogramm, Excellence in clinical trials against Malaria and HIV Funding organization: DAAD (German academic exchange service) Principal Investigator for University of Tübingen in PROMPT trial (Prevention of early mortality by presumptive tuberculosis treatment in HIV infetcted patients initiating antiretroviral therapy) a multicenter trial conducted by a consortium of 4 African Institutions (Infectious Diseases Institute, Markere University, Kampala, University of Limpopo, Pretoria, South Africa, Medical Research Unit of the Albert Schweitzer Hospital, Lambaréné, Gabon, Catholic University of Mozambique, Beira, Mozambique) and 3 European Institutions (Academic Medical Center at the University of Amsterdam, Netherlands, Institute of Tropical Medicine Antwerp, Belgium, Instiute of Tropcial Medicine, University of Tübingen, Germany) Funding organization: EDCTP

6 6 Principal Investgator of Bundesministerium für Bildung und Forschung (BMBF): Prävention der frühen Mortalität bei HIV-infizierten Patienten durch die gleichzeitige Behandlung von Tuberkulose und AIDS Funding organization: BMBF Principal Investigator for Universtiy of Tübingen in TBfastest network. A EU sponsored network to evaluate rapid point of care tests for the diagnosis of mycobacterium tuberculosis infection Funding organization: EU Principal Investigator Educational Grant for continuing education of african physician ( ) Funding organization: German academic exchange services (DAAD-Ärzteprogramm) Principal Investigator for University of Tübingen in CANTAM network (Central African Network for TB, AIDS and Malaria) ( ) Funding organizatin: EDCTP Publications: Kamgue Sidze, L., Mouafo Tekwu, E., Kuaban, C., Assam Assam, J.P., Tedom, J.C., Eyangoh, S., Fouda, Nolna D., F.-X., Ntoumi, F., Frank, M*., Penlap Beng, V.N Strong Decrease in Streptomycin-Resistance and Absence of XDR 12 Years after the Reorganization of the National Tuberculosis Control Program in the Central Region of Cameroon. PLoS One.;9(6):e *corresponding author Mouafo Tekwu, E., Kamgue Sidze, L., Assam Assam,J.P., Tedom,J.C., Tchatchouang, S., Guiewi Makafe, G., Tchokote Wetewale,A.L., Kuaban, C.,Eyangoh,S., Ntoumi,F., Penlap Beng,V.N., Frank, M Sequence analysis for detection of drug resistance in Mycobacterium tuberculosis complex isolates from the Central Region of Cameroon. BMC Microbiology 14(1):113. Ehrhardt, J.,Richter, J., Frank, M Plasmodium knowlesi: Fallberichte der ersten nach Deutschland importierten Infektionen. Epidemiologisches Bulletin (Robert Koch Institut) 14: Slesak, G., Tappe, D., Keller, C., Cramer. J, Güthoff, W., Zanger,P., Frank, M., Ernestus, K., Rauthe, S., Stich,A., Schäfer, J Suspected Sarcocystis infection after travel to Malaysia: a series of 26 German patients. Deutsche Medizinische Wochenschrift 139(19):990-5.

7 7 Ehrhardt,J.,Trein, A.P., Kremsner, P., Frank, M Plasmodium knowlesi and HIV co-infection in a German traveller to Thailand. Malaria Journal 12:283 Kamgue Sidze, L., Mouafo Tekwu, E., Kuaban, C., Assam Assam, J.P., Tedom, J.C., Niemann, S., Frank, M., Penlap Beng, V.N Estimates of Genetic Variability of Mycobacterium tuberculosis Complex and Its Association with Drug Resistance in Cameroon. Advances in Infectious Diseases, 3, Ehrhardt J, Tintelnot K, Kremsner P, Frank M Progressive malaise and joint pain after travel to Costa Rica. Deutsche Medizinische Wochenschrift 137(44). Enderes,C., D.Kombila, M.Dal-Bianco, R.Dzikowski, P.Kremsner, and M.Frank Var Gene Promoter Activation in Clonal Plasmodium falciparum Isolates Follows a Hierarchy and Suggests a Conserved Switching Program that Is Independent of Genetic Background. Journal of Infectious Diseases 204: Frank,M., N.Lehners, P.I.Mayengue, J.Gabor, M.Dal-Bianco, D.U.Kombila, G.M.Ngoma, C.Supan, B.Lell, F.Ntoumi, M.P.Grobusch, K.Dietz, and P.G.Kremsner A thirteen-year analysis of Plasmodium falciparum populations reveals high conservation of the mutant pfcrt haplotype despite the withdrawal of chloroquine from national treatment guidelines in Gabon. Malaria Journal 10. Rupp,I., L.Sologub, K.C.Williamson, M.Scheuermayer, L.Reininger, C.Doerig, S.Eksi, D.U.Kombila, M.Frank, and G.Pradel Malaria parasites form filamentous cell-tocell connections during reproduction in the mosquito midgut. Cell Research 21: Frank,M. and C.Enderes Antigenic variation in Plasmodium falciparum: moving beyond the laboratory strains. Wiener Klinische Wochenschrift 122:7-10. Frank,M., L.Kirkman, D.Costantini, S.Sanyal, C.Lavazec, T.J.Templeton, and K.W.Deitsch Frequent recombination events generate diversity within the multicopy variant antigen gene families of Plasmodium falciparum. International Journal for Parasitology 38: Dzikowski,R., F.Li, B.Amulic, A.Eisberg, M.Frank, S.Patel, T.E.Wellems, and K.W.Deitsch Mechanisms underlying mutually exclusive expression of virulence genes by malaria parasites. Embo Reports 8: Frank,M., R.Dzikowski, B.Amulic, and K.Deitsch Variable switching rates of malaria virulence genes are associated with chromosomal position. Molecular Microbiology 64: Chookajorn,T., R.Dzikowski, M.Frank, F.Li, A.Z.Jiwani, D.L.Hartl, and K.W.Deitsch Epigenetic memory at malaria virulence genes. Proc.Natl.Acad.Sci.U.S A 104:

8 8 Frank,M. and K.Deitsch Activation, silencing and mutually exclusive expression within the var gene family of Plasmodium falciparum. Int.J.Parasitol. 36: Frank,M., R.Dzikowski, D.Costantini, B.Amulic, E.Berdougo, and K.Deitsch Strict pairing of var promoters and introns is required for var gene silencing in the malaria parasite Plasmodium falciparum. J.Biol.Chem. 281: Dzikowski,R., M.Frank, and K.Deitsch Mutually exclusive expression of virulence genes by malaria parasites is regulated independently of antigen production. Plos Pathogens 2: Frank,M., B.Hegenscheid, K.Janitschke, and T.Weinke Prevalence and epidemiological significance of Trypanosoma cruzi infection among Latin American immigrants in Berlin, Germany. Infection 25: Achnowleged contributions to other authors work Books Sepkowitz K. How contagious is vaccinia? New England Journal of Medicine 2003, 348: Frank M, Spread and Diagnosis of Chagas' disease in nonendemic areas, with a particular focus on the use of kdna PCR for the diagnosis of congenital infections, Doctoral thesis (1996) (in German), Free University of Berlin, Verlag für Wissenschaft und Forschung. Chair of international and national meeting DAAD Expert seminar Analysis and publication strategy of emerging drug resistance data for Mycobacterium tuberculosis from Central Africa, Tübingen January 28-February 1, 2013 Chair of Meeting 10. Annual Meeting of Working Group Malaria of the Paul Ehrlich Society for Chemotherapy, German Society for Tropical Medicine, German Society for Parsitology, Marburg November 9-10, 2012 Chair of Session: Drug resistance CANTAM/DAAD Expert Semiar: Drug resistance in Malaria and Tuberculosis in Central Africa, Brazzaville, Republic of Congo

9 9 October 15-19, 2012 Co-chair of Meeting together with Prof. Francine Ntoumi Tropical Medicine and Parasitology 25 th Annual Meeting of German Society for Tropical Medicine, 102 sd Annual Meeting of the German Society for Parsitology, Heidelberg March 15-16, 2012 Chair of Session: Translational Research in Malaria KIT Kongress für Infektionskrankheiten und Tropenmedizin, Köln April 25-28, 2012 Chair of Session: Molekulare Resistenzepidemiologie bei Tuberkulose und Malaria DAAD workshop: Clinical capacity building in tuberculosis and malaria, Tübingen April 23-24, 2012 Chair of Workshop DAAD Malaria and TB drug resistance meeting Tübingen 2011 Multilateral Initiative on Malaria (MIM) meeting Nov. 1-5, 2009 Nairobi, Kenia Session: Genomics La prise en charge clinic due VIH, de la Tuberculose et du Paludisme. 19 Mai-23 May 2008, Lambaréné, Gabon 6. Annual Meeting of Working Group Malaria of the Paul Ehrlich Society for Chemotherapy. Nov 7-8, 2008 Tübingen, Germany 54 th annual meeting of the American Society for Tropical Medicine and Hygiene Session: Malaria- Biology and Pathogenesis I