TRACKS GENETIC EPIDEMIOLOGY

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1 Dr. Priya Duggal, Director In the post-genomic era where larger amounts of genetic data are now readily available, it has become increasingly important to design studies and use analytical techniques that will accurately detect and describe the role genes play in human disease. Genes alone can cause some human diseases, and the public health impact of such Mendelian diseases must be considered. However, for most diseases with complex etiology, many genes and environmental factors contribute to risk. The field of genetic epidemiology is focused on designs and analytical techniques to identify how genetic variations contribute to the risk of disease. The academic program in genetic epidemiology provides background in human genetics and a comprehensive understanding of study designs and statistical approaches used in genetic epidemiology. These include assessment of heritability and familial aggregation, genetic linkage analysis, genetic association analyses in population-based and family-based studies, gene-gene and gene-environment interactions, structural variants and the analysis of high-throughput genomic data, including data from whole-genome microarray and next generation sequencing experiments. The sequence of genetic epidemiology courses taken during the first year offers a broad based introduction to techniques of disease variant identification and risk assessment. These courses complement the required epidemiology and biostatistics sequences and emphasize how specialized genetic and genomic techniques can be merged with conventional epidemiologic study designs. Other requirements of the genetic epidemiology concentration (e.g., Introduction to Molecular Biology) are designed to insure the student has a firm understanding of the molecular underpinnings of genetics or the necessary programming demands (e.g. Statistics for Genomics). In addition to the required courses, required journal clubs and research in progress are scheduled monthly, which offers an opportunity for informal discussions among students and faculty. The monthly Genetic Epidemiology Seminar Series, held jointly with the Institute for Genetic Medicine, serves as a forum for presentations of research by faculty within and outside of JHU (attendance required). In addition, a Genetic Research Day in collaboration with the Institute for Genetic Medicine occurs in the Fall/Winter and is an opportunity for students to present their work to the broader JHU research community. The genetic epidemiology program s faculty are actively engaged in a wide range of research projects, including investigations of: birth defects, infectious diseases, cancer, eye and vision disorders, renal and cardiovascular diseases, pulmonary disease, chronic kidney disease, diabetes and metabolic disorders, and developmental disorders. In addition our faculty are actively involved in methodologic research to develop and assess study designs and statistical methods for genetic epidemiology and genomics. Current and former students have conducted their thesis research on a variety of topics including genetic susceptibility to diabetes, AIDS, bipolar disorder, breast cancer, and asthma. Through collaborative research projects both within and outside the Department, students are offered the opportunity to develop their own ideas and implement and advance the analytical methods introduced in the required courses.

2 Required Core Courses in Genetic Epidemiology All students are required to take the courses below: Principles of Genetic Epidemiology 1 (4) Principles of Genetic Epidemiology 2 (3) Principles of Genetic Epidemiology 3 (3) Principles of Genetic Epidemiology 4 (2) Introduction to Molecular Biology (4) [pass/fail, suggested for 2 nd year] Statistics for Genomics (3) [suggested for 2 nd year] All students are required to take at least one of the courses listed below to meet the Departmental requirements of an epidemiologic survey course outside of their area of concentration (minimum 3 credits) Introduction to Cardiovascular Disease Epidemiology (4) Epidemiology of Aging (3) Etiology, Prevention & Control of Cancer (4) Epidemiology of Infectious Disease (4) Psychiatric Epidemiology (3) Reproductive and Perinatal Epidemiology (4) Recommended Courses Eye Disease: Epidemiology and Control (1) # Health Survey Research Methods (4) Genomics for Public Health (3) Introduction to SAS Statistical Package (4) PERL for Bioinformatics (4) Analysis of Biological Sequences (3) Survival Analysis (3) Statistical Machine Learning: Methods, Theory and Applications (4) Analysis of Longitudinal Data (4) Advanced Statistical Computing (3) Molecular Epidemiology and Biomarkers in Public Health (4) Principles of Immunology I (4) Principles of Immunology II (4) Analytic Strategies In The Genetics of Psychiatric, Behavioral And Other Complex Diseases (3) # required for Eye & Vision required for MD-GEM fellows

3 School of Medicine Courses (also recommended) *ME Evolution of Ideas in Human *ME Advanced Topics in Human (3 rd Q) *ME Molecular Mechanisms of Disease (4 th Q) * for more information, please call Dr. David Valle/Sandy Muscelli at 410 required for MD-GEM fellows With your advisor, each student should develop a tailored academic program that balances the students interests academically and for future career. Required Courses by Term First Term: Academic and Research Ethics (0) Epidemiologic Methods 1 (5) Statistical Methods in Public Health I (4) Methods in Biostatistics 1(4)* Principles of Genetic Epidemiology 1 (4) Responsible Conduct of Research (1) Research Ethics and Integrity: US and International Issues (3) (3 rd Term) Introduction to Molecular Biology (4)[Pass/Fail, Recommended 2 nd year] Doctoral Seminar in Epidemiology, Part 1 (3) [Doctoral Students only] Second Term: Epidemiologic Methods 2 (5) Statistical Methods in Public Health 2 (4) Methods in Biostatistics 2(4)*

4 Principles of Genetic Epidemiology 2 (3) Public Health Perspectives on Research (2) Doctoral Seminar in Epidemiology, part 2 (3) (Doctoral Students only) Third Term: Epidemiologic Methods 3 (5) Principles of Genetic Epidemiology 3 (3) Statistical Methods in Public Health III (4)* Methods in Biostatistics III (4)* Responsible Conduct of Research (1) Research Ethics and Integrity: US and International Issues (3) (3 rd Term) Doctoral Seminar in Epidemiology, part 3 (3) (Doctoral Students only) Fourth Term: Methodologic Challenges in Epidemiologic Research (5) Statistical Methods in Public Health IV (4) Methods in Biostatistics IV (4)* Principles of Genetic Epidemiology 4 (2)

5 Problems in the Design of Epidemiologic Studies (4) [Doctoral Students only] Statistics for Genomics (3) [recommended 2 nd year] * Doctoral students are encouraged to take the Methods in Biostatistics series ( , , , ). May be taken in the 2 nd year after taking the Statistical Methods in Public Health series ( , , , ) in the 1 st year. *This course has a separate lab Recommended coursework for the second year of the program is listed below. Masters' students should choose electives from available epidemiology and non-departmental courses in accordance with their own interests, after consulting with their advisor. All master's students should enroll for some credits of , Thesis Research credits, no later than the second term of the second year in order to complete their thesis within the two years allotted by the program. Recommended Courses by Term First term: PERL for Bioinformatics (4) Principles of Immunology I (4) Survival Analysis (3) Second Term: Principles of Immunology II (4) Health Survey Research Methods (4) (2 nd yr doctoral students) Etiology, Prevention & Control of Cancer (4) Third Term: Molecular Epidemiology and Biomarkers in Public Health (4) *ME Human Genetics Fourth Term: Genomics for Public Health (3) Reproductive and Perinatal Epidemiology (4) Analytic Strategies In The Genetics of Psychiatric, Behavioral And Other Complex Diseases (3) *ME Molecular Mechanisms of Disease

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