Integrating Bioinformatics, Medical Sciences and Drug Discovery

Save this PDF as:
 WORD  PNG  TXT  JPG

Size: px
Start display at page:

Download "Integrating Bioinformatics, Medical Sciences and Drug Discovery"

Transcription

1 Integrating Bioinformatics, Medical Sciences and Drug Discovery M. Madan Babu Centre for Biotechnology, Anna University, Chennai phone: :: Bioinformatics Bioinformatics, a term coined for the applications of computer science in biology is now emerging as a major element in contemporary biology and biomedical research. There is a paradigm shift in biological research to use the computers, software tools and computational models in a large scale. Walter Gilbert, a renowned scientist, described this shift in biology as follows: "The new paradigm, now emerging, is that all of the genes will be known (in the sense of being resident in databases available electronically), and that the starting point of a biological investigation will be theoretical. An individual scientist will begin with a theoretical conjecture only then turning to experiment to follow or test that hypothesis." Bioinformatics deals with the exponential growth in biological data has led to the development of primary and secondary databases of nucleic acid sequences, protein sequences and structures. Some of the well-known databases include GenBank, SWISS-PROT, PDB, PIR, SCOP, CATH, etc., These databases are available as public domain information and hosted on various Internet servers across the world. Basic research and modelling is done using these databases with the help sequence analysis tools like BLAST, FASTA, CLUSTALW, etc., and the modelled structures are visualized using visualization tools such as WebLab, MOLMOL, Rasmol, etc., Bioinformatics plays an important role for the integration of broad disciplines of Biology to understand the complex mechanisms of the cell. Bioinformatics also aids the way in which biomedical investigators use the information in their testing. The complete process of data collection to analysis of the results of such tests may be categorized under a separate area named " Clinical Informatics". Informatics and Medical Sciences It is a known fact that most of the doctors are averse to computers. To overcome this problem, one of the solutions proposed, after an intensive research contacting 1500 doctors from different cities, is to introduce Palmtops specially tailored for physicians. These palmtops are of the size that easily fits in to the pocket of a lab coat. This helps the doctor to feed in the medical data in a sequential manner that he has collected when moving from ward to ward. This addresses the basic need of any medical analysis - data capture and creating Electronic Medical Records (EMR) which eventually develops in to a database for reference and analysis. The major advantage with the introduction of the concept of Electronic Medical Records (EMR) is that, the information can be easily accessed and shared in comparison to traditional medical records. EMR also drastically reduces the possibilities of introduction of errors due to frustration and other psychological disturbances during the manual data entry process after collecting the necessary information on paper. It also helps to eliminate the manual task of extracting data from charts or filling out specialized data sheets. The data required for a study can be obtained directly from the electronic record, thus making research data collection for analysis, a byproduct of routine clinical record keeping. The record environment can help to assure compliance with a research protocol, pointing out to a clinician when a patient is eligible for a study, or when the protocol for a study calls for a specific management plan given the currently available data about that patient (Fig. 1). In the near future one can see a situation where the complete information on the patient can be accessed from the EMR. These informations can be of any type, ranging from drug trial data to the various tests performed on that patient and the outcome of such experiments. The challenge in such cases will be to organize and integrate the heterogeneity of the information in to a comprehensive, knowledge based database from which an individual can access the necessary portion of the record for any research analysis.

2 Bioinformatics and Medical Sciences Bioinformatics has a profound impact in medical sciences. The biological databases are helping physicians to diagnose the disease and develop strategies for its therapy. Consider a situation where a patient with a genetic form of hemophilia meets a physician. The physician is not sure with the symptoms of the disease but has the only clue that the patient s family has suffered from hemophilia earlier. The physician could (Fig. 2) surf the web to get the information on the disease by checking out the OMIM (Online Mendelian Inheritance of Man) resources available at which provides detailed information on genetic disorders. A focussed search for diabetes would reveal multiple disorders including Von Willerbrand Disease and also provides the information that the primary defect is due to the low antihemophilic globulin (AHG; factor VIII) in this disorder. Further, the search on Factor VIII in the protein sequence database would result in the match encoding the human Factor VIII with the complete cdna and corresponding protein sequence. The gene is linked to its DNA sequence, protein sequence and a set of references in the MEDLINE literature database. Following this MEDLINE literature database, the original research article (where the association of factor VIII with hemophilia is discussed) is obtained. By following the link to the protein sequence, the detailed information is obtained from the SWISS-PROT database and Protein Information Resource (PIR). The information on the crystal structure can be obtained by following the link to Protein Data Bank (PDB) provided in the SWISS- PROT database. Following the link to the DNA sequence in the genetic database, GENBANK, the nucleotide sequence of the gene is obtained along with records of gene irregularities. Thus the physician uses a number of databases to collect information about the disease which aids him to diagnose and device strategies for therapy. Bioinformatics and Drug Discovery Infectious diseases are now the world's biggest killers of children and young adults. "They account for more than 13 million deaths a year - one in two deaths in developing countries" as stated by the WHO. Most deaths from infectious diseases occur in developing countries. The cause for this has been attributed to the unavailability of efficient drugs and if at all available, the high cost associated with those drugs. Development of cheap and efficient drugs for a disease is one of the major problems faced by mankind. The solution to this problem could be from rational drug design using Bioinformatics. The focus of the pharmaceutical industry has shifted from the trial and error process of drug discovery to a rational, structure based drug design. A successful and reliable drug design process could reduce the time and cost of developing useful pharmacological agents. Computational methods are used for the prediction of drug-likeness which is nothing but the identification and elimination of candidate molecules that are unlikely to survive the later stages of discovery and development. Drug-likeness could be predicted by genetic algorithm and neural network based approaches. People have been working on constructing efficient algorithms and better energy functions to predict protein structures and interaction of small molecules with them. The technical barrier to these approaches is that they are computation intensive and we do not have the computational power to handle such massive requirement. Fig. 3 highlights the magnitude of computation involved for the various kinds of interactions that can be considered in biomolecules. The most naïve and simple approach to problems involving interactions between rigid ligand and rigid receptors requires a computer performance of 0.5 Gflop. The more sophisticated approach considering parameters to simulate real conditions like flexible receptor-ligand interactions in the presence of solvent molecules require a computer performance of approximately 1 Tflop, which is quite expensive in the present day scenario though has been achieved. Realizing the amount of raw computational power needed in such problems, IBM had recently announced a new $100 million exploratory research initiative to build a supercomputer which is 500 times more powerful than the worlds fastest existing computer and 2 million times faster than the today s fastest desktop PC. This new computer nicknamed "Blue Gene" by IBM researchers will be capable of performing close to one Petaflop (10 15 operations per second).

3 As stated earlier, from the pharmaceutical industry point of view, Bioinformatics is the key to rational drug design. It reduces the number of trials in the screening of drug compounds and in identifying potential drug targets for a particular disease using high power computing workstations and software like Insight. This profound application of Bioinformatics in genome sequence has led to a new area in pharmacology Pharmacogenomics, which is the study of genetic basis for the differences between individuals in response to drugs. This is mainly due to Single Nucleotide Polymorphisms (SNPs). In order to develop innovative and safe drugs, Pharmacogenomics needs to be integrated in the drug development process. Knowing the importance of SNPs, an international consortium to produce a map of human SNPs (which could aid Phramacogenomics) has been formed by major pharmaceutical companies in which IBM, is also a member. In future, drug design is going to rely on the variation in SNPs. In fact SNPs with combinatorial chemistry can speed up the process of drug discovery and may also result in identifying a new set of target proteins that cross-react with drugs in the preliminary clinical trials. Taking in to account all the above mentioned factors that has to go in for developing effective drugs, there has been a strong urge to start the Human Proteomics Initiative. This initiative aims at identifying the functions and polymorphism of all the proteins coded in the human genome and predict their structure, or solve the structure of these proteins if possible so that these could be used as potential targets for developing drugs. Need for Integration Rapid advances in the field of computers coupled with increasing computer literacy among professionals favor the implementation of computer applications in medical practice. Further, the availability of numerous databases on the Internet has revolutionized the way by which a physician devices a strategy for treatment. Projects like the Human Proteomics Initiative is a classic example to show the necessity of integrating Bioinformatics - to predict structures and functions of proteins, Medical Sciences - to identify proteins that are important in metabolic or other disorders and Pharmacology (drug discovery) - to identify novel drugs against the predicted targets. Thus it is apt to conclude that all the three areas must work in concert to achieve the ultimate goal of understanding the basis of life process and apply it for the betterment of human lives. References 1. Computational methods for the prediction of 'drug-likeness' D.E. Clark and S.D. Pickett. Drug Discovery Today (2): Bioinformatics in support of molecular medicine. R.B. Altman. Author's site at 3. New advances in Pharmacogenomics. B. Destenaves and F. Thomas. Current Opinion in Chemical Biology : Proteomics Factories. E. Russo. The Scientist (3):1. 5. Trends in Computational Biology: A Summary based on a RECOMB Plenary lecture. J.C. Wooley. Journal of Computational Biology (3/4): The Computer Meets Medicine and Biology: Emergence of a Discipline. (Chapter. 1 of the course material). E.H. Shortliffe and M.S. Blois.

4 Information on prescribed drugs and their effects Information on patients health Evaluation of a drug Electronic Medical Records (EMR) Easy retrieval of data for analysis Information on the tests conducted Provides status on the patients compliance with a particular treatment procedure Suggests the outcome of a treatment procedure and thus helps in altering the procedure Fig. 1: Heterogeneity of Information in EMR and its advantages in designing better treatment procedures

5 Search for Hemophilia in OMIM produces the following result Following a link Links to Protein, DNA, Medline and other databases Following the link to Medline to get the original reference Fig. 2: The steps a physician needs to follow to get information on the disease and device strategies for diagnosis and cure

6 C O M P L E X I T Y of A P P R O A C H Search database for lead Lead Optimization Improved drug Characteristics Flexible Ligand Rigid Receptor Rigid Ligand Rigid Receptor De novo Drug design Discovery of targets Design of resistance evading drugs Multiple flexible Ligands Flexible Receptors Flexible Ligand Flexible Receptor Protein- Protein Docking Ligands, Receptors and Solvent Design of Biomaterials Prediction of large assemblies 0.2 GFlop 1 GFlop 10 GFlop 100 GFlop 1 TFlop 10 TFlop 100 TFlop Computer Performance Fig. 3: Requirement of Computational Power for studying various interactions

Biological Databases and Protein Sequence Analysis

Biological Databases and Protein Sequence Analysis Biological Databases and Protein Sequence Analysis Introduction M. Madan Babu, Center for Biotechnology, Anna University, Chennai 25, India Bioinformatics is the application of Information technology to

More information

Human Mendelian Disorders. Genetic Technology. What is Genetics? Genes are DNA 9/3/2008. Multifactorial Disorders

Human Mendelian Disorders. Genetic Technology. What is Genetics? Genes are DNA 9/3/2008. Multifactorial Disorders Human genetics: Why? Human Genetics Introduction Determine genotypic basis of variant phenotypes to facilitate: Understanding biological basis of human genetic diversity Prenatal diagnosis Predictive testing

More information

Vad är bioinformatik och varför behöver vi det i vården? a bioinformatician's perspectives

Vad är bioinformatik och varför behöver vi det i vården? a bioinformatician's perspectives Vad är bioinformatik och varför behöver vi det i vården? a bioinformatician's perspectives Dirk.Repsilber@oru.se 2015-05-21 Functional Bioinformatics, Örebro University Vad är bioinformatik och varför

More information

Genetic testing. The difference diagnostics can make. The British In Vitro Diagnostics Association

Genetic testing. The difference diagnostics can make. The British In Vitro Diagnostics Association 6 Genetic testing The difference diagnostics can make The British In Vitro Diagnostics Association Genetic INTRODUCTION testing The Department of Health published Our Inheritance, Our Future - Realising

More information

BIO 3350: ELEMENTS OF BIOINFORMATICS PARTIALLY ONLINE SYLLABUS

BIO 3350: ELEMENTS OF BIOINFORMATICS PARTIALLY ONLINE SYLLABUS BIO 3350: ELEMENTS OF BIOINFORMATICS PARTIALLY ONLINE SYLLABUS NEW YORK CITY COLLEGE OF TECHNOLOGY The City University Of New York School of Arts and Sciences Biological Sciences Department Course title:

More information

RETRIEVING SEQUENCE INFORMATION. Nucleotide sequence databases. Database search. Sequence alignment and comparison

RETRIEVING SEQUENCE INFORMATION. Nucleotide sequence databases. Database search. Sequence alignment and comparison RETRIEVING SEQUENCE INFORMATION Nucleotide sequence databases Database search Sequence alignment and comparison Biological sequence databases Originally just a storage place for sequences. Currently the

More information

A leader in the development and application of information technology to prevent and treat disease.

A leader in the development and application of information technology to prevent and treat disease. A leader in the development and application of information technology to prevent and treat disease. About MOLECULAR HEALTH Molecular Health was founded in 2004 with the vision of changing healthcare. Today

More information

Pharmacology skills for drug discovery. Why is pharmacology important?

Pharmacology skills for drug discovery. Why is pharmacology important? skills for drug discovery Why is pharmacology important?, the science underlying the interaction between chemicals and living systems, emerged as a distinct discipline allied to medicine in the mid-19th

More information

1. WHY ARE ELECTRONIC MEDICAL RECORDS IMPORTANT FOR PERSONALIZED MEDICINE?

1. WHY ARE ELECTRONIC MEDICAL RECORDS IMPORTANT FOR PERSONALIZED MEDICINE? THE ELECTRONIC MEDICAL RECORD: A CRITICAL ISSUE IN PERSONALIZED MEDICINE 1. WHY ARE ELECTRONIC MEDICAL RECORDS IMPORTANT FOR PERSONALIZED MEDICINE? As initially configured, electronic medical records (EMRs)

More information

Just the Facts: A Basic Introduction to the Science Underlying NCBI Resources

Just the Facts: A Basic Introduction to the Science Underlying NCBI Resources 1 of 8 11/7/2004 11:00 AM National Center for Biotechnology Information About NCBI NCBI at a Glance A Science Primer Human Genome Resources Model Organisms Guide Outreach and Education Databases and Tools

More information

P4 Medicine: Personalized, Predictive, Preventive, Participatory A Change of View that Changes Everything

P4 Medicine: Personalized, Predictive, Preventive, Participatory A Change of View that Changes Everything P4 Medicine: Personalized, Predictive, Preventive, Participatory A Change of View that Changes Everything Leroy E. Hood Institute for Systems Biology David J. Galas Battelle Memorial Institute Version

More information

The National Institute of Genomic Medicine (INMEGEN) was

The National Institute of Genomic Medicine (INMEGEN) was Genome is...... the complete set of genetic information contained within all of the chromosomes of an organism. It defines the particular phenotype of an individual. What is Genomics? The study of the

More information

REGULATIONS FOR THE DEGREE OF BACHELOR OF SCIENCE IN BIOINFORMATICS (BSc[BioInf])

REGULATIONS FOR THE DEGREE OF BACHELOR OF SCIENCE IN BIOINFORMATICS (BSc[BioInf]) 820 REGULATIONS FOR THE DEGREE OF BACHELOR OF SCIENCE IN BIOINFORMATICS (BSc[BioInf]) (See also General Regulations) BMS1 Admission to the Degree To be eligible for admission to the degree of Bachelor

More information

Integration of Genetic and Familial Data into. Electronic Medical Records and Healthcare Processes

Integration of Genetic and Familial Data into. Electronic Medical Records and Healthcare Processes Integration of Genetic and Familial Data into Electronic Medical Records and Healthcare Processes By Thomas Kmiecik and Dale Sanders February 2, 2009 Introduction Although our health is certainly impacted

More information

BIOINF 525 Winter 2016 Foundations of Bioinformatics and Systems Biology http://tinyurl.com/bioinf525-w16

BIOINF 525 Winter 2016 Foundations of Bioinformatics and Systems Biology http://tinyurl.com/bioinf525-w16 Course Director: Dr. Barry Grant (DCM&B, bjgrant@med.umich.edu) Description: This is a three module course covering (1) Foundations of Bioinformatics, (2) Statistics in Bioinformatics, and (3) Systems

More information

Teaching Bioinformatics to Undergraduates

Teaching Bioinformatics to Undergraduates Teaching Bioinformatics to Undergraduates http://www.med.nyu.edu/rcr/asm Stuart M. Brown Research Computing, NYU School of Medicine I. What is Bioinformatics? II. Challenges of teaching bioinformatics

More information

Genetic Testing in Research & Healthcare

Genetic Testing in Research & Healthcare We Innovate Healthcare Genetic Testing in Research & Healthcare We Innovate Healthcare Genetic Testing in Research and Healthcare Human genetic testing is a growing science. It is used to study genes

More information

Dr Alexander Henzing

Dr Alexander Henzing Horizon 2020 Health, Demographic Change & Wellbeing EU funding, research and collaboration opportunities for 2016/17 Innovate UK funding opportunities in omics, bridging health and life sciences Dr Alexander

More information

Cancer Genomics: What Does It Mean for You?

Cancer Genomics: What Does It Mean for You? Cancer Genomics: What Does It Mean for You? The Connection Between Cancer and DNA One person dies from cancer each minute in the United States. That s 1,500 deaths each day. As the population ages, this

More information

Course Curriculum for Master Degree in Medical Laboratory Sciences/Clinical Biochemistry

Course Curriculum for Master Degree in Medical Laboratory Sciences/Clinical Biochemistry Course Curriculum for Master Degree in Medical Laboratory Sciences/Clinical Biochemistry The Master Degree in Medical Laboratory Sciences /Clinical Biochemistry, is awarded by the Faculty of Graduate Studies

More information

Pipeline Pilot Enterprise Server. Flexible Integration of Disparate Data and Applications. Capture and Deployment of Best Practices

Pipeline Pilot Enterprise Server. Flexible Integration of Disparate Data and Applications. Capture and Deployment of Best Practices overview Pipeline Pilot Enterprise Server Pipeline Pilot Enterprise Server (PPES) is a powerful client-server platform that streamlines the integration and analysis of the vast quantities of data flooding

More information

School of Nursing. Presented by Yvette Conley, PhD

School of Nursing. Presented by Yvette Conley, PhD Presented by Yvette Conley, PhD What we will cover during this webcast: Briefly discuss the approaches introduced in the paper: Genome Sequencing Genome Wide Association Studies Epigenomics Gene Expression

More information

Medical Informatics An Overview Saudi Board For Community Medicine

Medical Informatics An Overview Saudi Board For Community Medicine Medical Informatics An Overview Saudi Board For Community Medicine Ahmed AlBarrak PhD Medical Informatics Associate Professor of Health Informatics, Family & Community Med, Chairman, Medical Informatics,

More information

How Can Institutions Foster OMICS Research While Protecting Patients?

How Can Institutions Foster OMICS Research While Protecting Patients? IOM Workshop on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials How Can Institutions Foster OMICS Research While Protecting Patients? E. Albert Reece, MD, PhD, MBA Vice

More information

Regulatory Issues in Genetic Testing and Targeted Drug Development

Regulatory Issues in Genetic Testing and Targeted Drug Development Regulatory Issues in Genetic Testing and Targeted Drug Development Janet Woodcock, M.D. Deputy Commissioner for Operations Food and Drug Administration October 12, 2006 Genetic and Genomic Tests are Types

More information

The College of Science Graduate Programs integrate the highest level of scholarship across disciplinary boundaries with significant state-of-the-art

The College of Science Graduate Programs integrate the highest level of scholarship across disciplinary boundaries with significant state-of-the-art GRADUATE PROGRAMS The College of Science Graduate Programs integrate the highest level of scholarship across disciplinary boundaries with significant state-of-the-art research centers and experiential

More information

Vision for the Cohort and the Precision Medicine Initiative Francis S. Collins, M.D., Ph.D. Director, National Institutes of Health Precision

Vision for the Cohort and the Precision Medicine Initiative Francis S. Collins, M.D., Ph.D. Director, National Institutes of Health Precision Vision for the Cohort and the Precision Medicine Initiative Francis S. Collins, M.D., Ph.D. Director, National Institutes of Health Precision Medicine Initiative: Building a Large U.S. Research Cohort

More information

The Spectrum of Biomedical Informatics and the UAB Informatics Institute

The Spectrum of Biomedical Informatics and the UAB Informatics Institute The Spectrum of Biomedical Informatics and the UAB Informatics Institute Molecular and Cellular Pathology Seminar September 22, 2015 James J. Cimino, MD Director, Informatics Institute University of Alabama

More information

Next Generation Sequencing Informatics Markets

Next Generation Sequencing Informatics Markets Next Generation Sequencing Informatics Markets Greg Caressi SVP Healthcare & Life Sciences November, 2014 Personalization, Communication, Decentralization, Collaboration From... One Size Fits All APPROACH...To

More information

Integration of genomic data into electronic health records

Integration of genomic data into electronic health records Integration of genomic data into electronic health records Daniel Masys, MD Affiliate Professor Biomedical & Health Informatics University of Washington, Seattle Major portion of today s lecture is based

More information

BIOSCIENCES COURSE TITLE AWARD

BIOSCIENCES COURSE TITLE AWARD COURSE TITLE AWARD BIOSCIENCES As a Biosciences undergraduate student at the University of Westminster, you will benefit from some of the best teaching and facilities available. Our courses combine lecture,

More information

Delivering the power of the world s most successful genomics platform

Delivering the power of the world s most successful genomics platform Delivering the power of the world s most successful genomics platform NextCODE Health is bringing the full power of the world s largest and most successful genomics platform to everyday clinical care NextCODE

More information

Anforderungen der Life-Science Industrie an die Hochschulen. Hans Widmer Novartis Institutes for BioMedical Research

Anforderungen der Life-Science Industrie an die Hochschulen. Hans Widmer Novartis Institutes for BioMedical Research Anforderungen der Life-Science Industrie an die Hochschulen Hans Widmer Novartis Institutes for BioMedical Research There s nothing more extraordinary than a normal life 2 What does industry expect from

More information

Bioinformatics: course introduction

Bioinformatics: course introduction Bioinformatics: course introduction Filip Železný Czech Technical University in Prague Faculty of Electrical Engineering Department of Cybernetics Intelligent Data Analysis lab http://ida.felk.cvut.cz

More information

Name: Period: Date: Biotechnology refers to technology used to DNA. The procedures are often referred to as. DNA is cut into small pieces using (RE).

Name: Period: Date: Biotechnology refers to technology used to DNA. The procedures are often referred to as. DNA is cut into small pieces using (RE). Name: Period: Date: I. OVERVIEW OF GENETIC ENGINEERING: Biotechnology refers to technology used to DNA. The procedures are often referred to as. is the genetic material of all living organisms. o All organisms

More information

treatments) worked by killing cancerous cells using chemo or radiotherapy. While these techniques can

treatments) worked by killing cancerous cells using chemo or radiotherapy. While these techniques can Shristi Pandey Genomics and Medicine Winter 2011 Prof. Doug Brutlag Chronic Myeloid Leukemia: A look into how genomics is changing the way we treat Cancer. Until the late 1990s, nearly all treatment methods

More information

Electronic Medical Records and Genomics: Possibilities, Realities, Ethical Issues to Consider

Electronic Medical Records and Genomics: Possibilities, Realities, Ethical Issues to Consider Electronic Medical Records and Genomics: Possibilities, Realities, Ethical Issues to Consider Daniel Masys, M.D. Affiliate Professor Biomedical and Health Informatics University of Washington, Seattle

More information

Biotechnical Engineering (BE) Course Description

Biotechnical Engineering (BE) Course Description Biotechnical Engineering (BE) Course Description The major focus of the Biotechnical Engineering TM (BE) course is to expose students to the diverse fields of biotechnology including biomedical engineering,

More information

Intro to Bioinformatics

Intro to Bioinformatics Intro to Bioinformatics Marylyn D Ritchie, PhD Professor, Biochemistry and Molecular Biology Director, Center for Systems Genomics The Pennsylvania State University Sarah A Pendergrass, PhD Research Associate

More information

Powering Cutting Edge Research in Life Sciences with High Performance Computing

Powering Cutting Edge Research in Life Sciences with High Performance Computing A Point of View Powering Cutting Edge Research in Life Sciences with High Performance Computing High performance computing (HPC) is the foundation of pioneering research in life sciences. HPC plays a vital

More information

#Aim2Innovate. Share session insights and questions socially. Genomics, Precision Medicine and the EHR 6/17/2015

#Aim2Innovate. Share session insights and questions socially. Genomics, Precision Medicine and the EHR 6/17/2015 Genomics, Precision Medicine and the EHR Making Genomics part of everyday practice Andrew Ury, M.D. CEO and founder, ActX, Inc. June 17, 2015 DISCLAIMER: The views and opinions expressed in this presentation

More information

Hemophilia Care. Will there always be new people in the world with hemophilia? Will hemophilia be treated more effectively and safely in the future?

Hemophilia Care. Will there always be new people in the world with hemophilia? Will hemophilia be treated more effectively and safely in the future? Future of This chapter provides answers to these questions: Will there always be new people in the world with hemophilia? Will hemophilia be treated more effectively and safely in the future? Will the

More information

Biological Sequence Data Formats

Biological Sequence Data Formats Biological Sequence Data Formats Here we present three standard formats in which biological sequence data (DNA, RNA and protein) can be stored and presented. Raw Sequence: Data without description. FASTA

More information

CCR Biology - Chapter 9 Practice Test - Summer 2012

CCR Biology - Chapter 9 Practice Test - Summer 2012 Name: Class: Date: CCR Biology - Chapter 9 Practice Test - Summer 2012 Multiple Choice Identify the choice that best completes the statement or answers the question. 1. Genetic engineering is possible

More information

Graduate and Postdoctoral Affairs School of Biomedical Sciences College of Medicine. Graduate Certificate. Metabolic & Nutritional Medicine

Graduate and Postdoctoral Affairs School of Biomedical Sciences College of Medicine. Graduate Certificate. Metabolic & Nutritional Medicine Graduate and Postdoctoral Affairs School of Biomedical Sciences College of Medicine Graduate Certificate in Metabolic & Nutritional Medicine Graduate Certificate Metabolic & Nutritional Medicine Purpose

More information

Comprehensive Examinations for the Program in Bioinformatics and Computational Biology

Comprehensive Examinations for the Program in Bioinformatics and Computational Biology Comprehensive Examinations for the Program in Bioinformatics and Computational Biology The Comprehensive exams will be given once a year. The format will be six exams. Students must show competency on

More information

Big Data in Drug Discovery

Big Data in Drug Discovery Big Data in Drug Discovery David J. Wild Assistant Professor & Director, Cheminformatics Program Indiana University School of Informatics and Computing djwild@indiana.edu - http://djwild.info Epochs in

More information

Health Informatics Research and Development in Europe

Health Informatics Research and Development in Europe Workshop on Health Informatics Research and Development, London, 18 July 2002 Health Informatics Research and Development in Europe Sofie Nørager European Commission Information Society Technologies Program

More information

SAP HANA Enabling Genome Analysis

SAP HANA Enabling Genome Analysis SAP HANA Enabling Genome Analysis Joanna L. Kelley, PhD Postdoctoral Scholar, Stanford University Enakshi Singh, MSc HANA Product Management, SAP Labs LLC Outline Use cases Genomics review Challenges in

More information

FACULTY OF MEDICAL SCIENCE

FACULTY OF MEDICAL SCIENCE Doctor of Philosophy in Biochemistry FACULTY OF MEDICAL SCIENCE Naresuan University 73 Doctor of Philosophy in Biochemistry The Biochemistry Department at Naresuan University is a leader in lower northern

More information

Big data in cancer research : DNA sequencing and personalised medicine

Big data in cancer research : DNA sequencing and personalised medicine Big in cancer research : DNA sequencing and personalised medicine Philippe Hupé Conférence BIGDATA 04/04/2013 1 - Titre de la présentation - nom du département émetteur et/ ou rédacteur - 00/00/2005 Deciphering

More information

Scientists don t yet fully

Scientists don t yet fully Alzheimer s Disease Genetics FACT SHEET Scientists don t yet fully understand what causes Alzheimer s disease. However, the more they learn about this devastating disease, the more they realize that genes*

More information

Global and Discovery Proteomics Lecture Agenda

Global and Discovery Proteomics Lecture Agenda Global and Discovery Proteomics Christine A. Jelinek, Ph.D. Johns Hopkins University School of Medicine Department of Pharmacology and Molecular Sciences Middle Atlantic Mass Spectrometry Laboratory Global

More information

Acceleration for Personalized Medicine Big Data Applications

Acceleration for Personalized Medicine Big Data Applications Acceleration for Personalized Medicine Big Data Applications Zaid Al-Ars Computer Engineering (CE) Lab Delft Data Science Delft University of Technology 1" Introduction Definition & relevance Personalized

More information

Biochemistry Major Talk 2014-15. Welcome!!!!!!!!!!!!!!

Biochemistry Major Talk 2014-15. Welcome!!!!!!!!!!!!!! Biochemistry Major Talk 2014-15 August 14, 2015 Department of Biochemistry The University of Hong Kong Welcome!!!!!!!!!!!!!! Introduction to Biochemistry A four-minute video: http://www.youtube.com/watch?v=tpbamzq_pue&l

More information

Big Data Healthcare. Fei Wang Associate Professor Department of Computer Science and Engineering School of Engineering University of Connecticut

Big Data Healthcare. Fei Wang Associate Professor Department of Computer Science and Engineering School of Engineering University of Connecticut Big Data Healthcare Fei Wang Associate Professor Department of Computer Science and Engineering School of Engineering University of Connecticut Healthcare Is in Crisis Hersh, W., Jacko, J. A., Greenes,

More information

FACULTY OF ALLIED HEALTH SCIENCES

FACULTY OF ALLIED HEALTH SCIENCES FACULTY OF ALLIED HEALTH SCIENCES 102 Naresuan University FACULTY OF ALLIED HEALTH SCIENCES has focused on providing strong professional programs, including Medical established as one of the leading institutes

More information

Medical Informatics. Institute for Genomics and Bioinformatics

Medical Informatics. Institute for Genomics and Bioinformatics Medical Informatics Zlatko Trajanoski Institute for Genomics and Bioinformatics Graz University of Technology http://genome.tugraz.at zlatko.trajanoski@tugraz.at Institute for Genomics and Bioinformatics

More information

Human Genome and Human Genome Project. Louxin Zhang

Human Genome and Human Genome Project. Louxin Zhang Human Genome and Human Genome Project Louxin Zhang A Primer to Genomics Cells are the fundamental working units of every living systems. DNA is made of 4 nucleotide bases. The DNA sequence is the particular

More information

The role of big data in medicine

The role of big data in medicine The role of big data in medicine November 2015 Technology is revolutionizing our understanding and treatment of disease, says the founding director of the Icahn Institute for Genomics and Multiscale Biology

More information

University of Medicine and Dentistry of New Jersey (UMDNJ)

University of Medicine and Dentistry of New Jersey (UMDNJ) University of Medicine and Dentistry of New Jersey (UMDNJ) Dual-Degree Program between the UMDNJ Graduate School of Biomedical Sciences (GSBS) And the UMDNJ School of Public Health (SPH) Leading to the:

More information

Genetic diagnostics the gateway to personalized medicine

Genetic diagnostics the gateway to personalized medicine Micronova 20.11.2012 Genetic diagnostics the gateway to personalized medicine Kristiina Assoc. professor, Director of Genetic Department HUSLAB, Helsinki University Central Hospital The Human Genome Packed

More information

FOR TEXTILES. o Kuchipudi-I] textiles. Outdoor Activity Based Courses. Camp

FOR TEXTILES. o Kuchipudi-I] textiles. Outdoor Activity Based Courses. Camp SEMESTER I Basic Sciences Courses o General Chemistry o Biology for Engineers o Fundamentals of Mathematics o Applied Physics-I for Life Science Behavioural Science o Understanding Self for Effectiveness

More information

Netherlands escience Center

Netherlands escience Center Netherlands escience Center ICT Synergy Hub, Amsterdam Research & Innovation in the Big Data Era CWI in Bedrijf Centrum Wiskunde & Informatica Op 5 oktober 2012 Prof. dr. Jacob de Vlieg ¹ ² 1. CEO & Scientific

More information

14.3 Studying the Human Genome

14.3 Studying the Human Genome 14.3 Studying the Human Genome Lesson Objectives Summarize the methods of DNA analysis. State the goals of the Human Genome Project and explain what we have learned so far. Lesson Summary Manipulating

More information

Course Curriculum for the Master Degree in Dentistry/Orthodontics

Course Curriculum for the Master Degree in Dentistry/Orthodontics Jordan University of Science and Technology Faculty of Graduate Studies Course Curriculum for the Master Degree in Dentistry/Orthodontics The Master Degree in Dentistry/ Orthodontics is awarded by the

More information

2019 Healthcare That Works for All

2019 Healthcare That Works for All 2019 Healthcare That Works for All This paper is one of a series describing what a decade of successful change in healthcare could look like in 2019. Each paper focuses on one aspect of healthcare. To

More information

The Healing Power of Data

The Healing Power of Data The Healing Power of Data The Healing Power of Data A Message from the Dean and Vice President for Health Sciences Imagine living in a world in which: a mobile device predicts when you are at high risk

More information

INTERNATIONAL CONFERENCE ON HARMONISATION OF TECHNICAL REQUIREMENTS FOR REGISTRATION OF PHARMACEUTICALS FOR HUMAN USE E15

INTERNATIONAL CONFERENCE ON HARMONISATION OF TECHNICAL REQUIREMENTS FOR REGISTRATION OF PHARMACEUTICALS FOR HUMAN USE E15 INTERNATIONAL CONFERENCE ON HARMONISATION OF TECHNICAL REQUIREMENTS FOR REGISTRATION OF PHARMACEUTICALS FOR HUMAN USE ICH HARMONISED TRIPARTITE GUIDELINE DEFINITIONS FOR GENOMIC BIOMARKERS, PHARMACOGENOMICS,

More information

The Future of the Electronic Health Record. Gerry Higgins, Ph.D., Johns Hopkins

The Future of the Electronic Health Record. Gerry Higgins, Ph.D., Johns Hopkins The Future of the Electronic Health Record Gerry Higgins, Ph.D., Johns Hopkins Topics to be covered Near Term Opportunities: Commercial, Usability, Unification of different applications. OMICS : The patient

More information

What is Medical Informatics? Sanda Harabagiu Human Language Technology Research Institute DEPARTMENT OF Computer Science sanda@hlt.utdallas.

What is Medical Informatics? Sanda Harabagiu Human Language Technology Research Institute DEPARTMENT OF Computer Science sanda@hlt.utdallas. What is Medical Informatics? Sanda Harabagiu Human Language Technology Research Institute DEPARTMENT OF Computer Science sanda@hlt.utdallas.edu Erroneous opinions and misconceptions There is great confusion

More information

Lecture What does data mean in Bio-sciences? Bioinformatics course. Definitions. Bioinformatics

Lecture What does data mean in Bio-sciences? Bioinformatics course. Definitions. Bioinformatics W pliku nie można odnaleźć części obrazu z identyfikatorem relacji rid2. 2014-10-06 What does data mean in Bio-sciences? Lecture 1 Introduction to bioinformatics Basic definitions Scope of the course Internet

More information

The Human Genome Project. From genome to health From human genome to other genomes and to gene function Structural Genomics initiative

The Human Genome Project. From genome to health From human genome to other genomes and to gene function Structural Genomics initiative The Human Genome Project From genome to health From human genome to other genomes and to gene function Structural Genomics initiative June 2000 What is the Human Genome Project? U.S. govt. project coordinated

More information

OpenMedicine Foundation (OMF)

OpenMedicine Foundation (OMF) Scientific Advisory Board Director Ronald Davis, Ph.D. Genome Technology Center Paul Berg, PhD Molecular Genetics Mario Capecchi, Ph.D Genetics & Immunology University of Utah Mark Davis, Ph.D. Immunology

More information

An EVIDENCE-ENHANCED HEALTHCARE ECOSYSTEM for Cancer: I/T perspectives

An EVIDENCE-ENHANCED HEALTHCARE ECOSYSTEM for Cancer: I/T perspectives An EVIDENCE-ENHANCED HEALTHCARE ECOSYSTEM for Cancer: I/T perspectives Chalapathy Neti, Ph.D. Associate Director, Healthcare Transformation, Shahram Ebadollahi, Ph.D. Research Staff Memeber IBM Research,

More information

Web-Based Genomic Information Integration with Gene Ontology

Web-Based Genomic Information Integration with Gene Ontology Web-Based Genomic Information Integration with Gene Ontology Kai Xu 1 IMAGEN group, National ICT Australia, Sydney, Australia, kai.xu@nicta.com.au Abstract. Despite the dramatic growth of online genomic

More information

Year 10: The transmission of heritable characteristics from one generation to the next involves DNA

Year 10: The transmission of heritable characteristics from one generation to the next involves DNA 1 Overview In this activity, students identify an unknown code (Activity 1) and then apply it to identify the message in an unknown text (Activity 2). Discussion questions consolidate the learning,and

More information

Molecular Biotechnology Master s Degree Program

Molecular Biotechnology Master s Degree Program > APPLIED LIFE SCIENCES Master s Degree Program: > FULL TIME Molecular Biotechnology Master s Degree Program www.fh-campuswien.ac.at My Occupational Future. Your Career Opportunities Biotechnology is one

More information

New Millennium Indian Technology Leadership Initiative

New Millennium Indian Technology Leadership Initiative New Millennium Indian Technology Leadership Initiative A Unique Indian Public-Private Partnership Dr. D. Yogeswara Rao Head Technology Networking and Business Development Division Council of Scientific

More information

Genomics and Health Data Standards: Lessons from the Past and Present for a Genome-enabled Future

Genomics and Health Data Standards: Lessons from the Past and Present for a Genome-enabled Future Genomics and Health Data Standards: Lessons from the Past and Present for a Genome-enabled Future Daniel Masys, MD Professor and Chair Department of Biomedical Informatics Professor of Medicine Vanderbilt

More information

Big Data Trends A Basis for Personalized Medicine

Big Data Trends A Basis for Personalized Medicine Big Data Trends A Basis for Personalized Medicine Dr. Hellmuth Broda, Principal Technology Architect emedikation: Verordnung, Support Prozesse & Logistik 5. Juni, 2013, Inselspital Bern Over 150,000 Employees

More information

TRACKS GENETIC EPIDEMIOLOGY

TRACKS GENETIC EPIDEMIOLOGY Dr. Priya Duggal, Director In the post-genomic era where larger amounts of genetic data are now readily available, it has become increasingly important to design studies and use analytical techniques that

More information

Kazan (Volga region) Federal University, Kazan, Russia Institute of Fundamental Medicine and Biology. Master s program.

Kazan (Volga region) Federal University, Kazan, Russia Institute of Fundamental Medicine and Biology. Master s program. Kazan (Volga region) Federal University, Kazan, Russia Institute of Fundamental Medicine and Biology Master s program Bioinformatics I. THEORETICAL BASIS The development of effective technologies of theoretical

More information

PerCuro-A Semantic Approach to Drug Discovery. Final Project Report submitted by Meenakshi Nagarajan Karthik Gomadam Hongyu Yang

PerCuro-A Semantic Approach to Drug Discovery. Final Project Report submitted by Meenakshi Nagarajan Karthik Gomadam Hongyu Yang PerCuro-A Semantic Approach to Drug Discovery Final Project Report submitted by Meenakshi Nagarajan Karthik Gomadam Hongyu Yang Towards the fulfillment of the course Semantic Web CSCI 8350 Fall 2003 Under

More information

BIOCHEMISTRY THE CAREER GUIDE FOR 16-18 YEAR OLDS CONSIDERING THEIR OPTIONS

BIOCHEMISTRY THE CAREER GUIDE FOR 16-18 YEAR OLDS CONSIDERING THEIR OPTIONS BIOCHEMISTRY THE CAREER GUIDE FOR 16-18 YEAR OLDS CONSIDERING THEIR OPTIONS THE IMPACT OF BIOCHEMISTRY Over the past 100 years, biochemists have been responsible for a huge number of important scientific

More information

Information for patients and the public and patient information about DNA / Biobanking across Europe

Information for patients and the public and patient information about DNA / Biobanking across Europe Information for patients and the public and patient information about DNA / Biobanking across Europe BIOBANKING / DNA BANKING SUMMARY: A biobank is a store of human biological material, used for the purposes

More information

Watson in Healthcare. Thomas F. Anglero Innovation Director

Watson in Healthcare. Thomas F. Anglero Innovation Director Watson in Healthcare Thomas F. Anglero Innovation Director Thomas.Anglero@no.IBM.com 2015 International Business Machines Corporation - Nephrology Advisor 2 2015 International Business Machines Corporation

More information

BS in Pharmaceutical Science (BSPS) degree program University of Rhode Island

BS in Pharmaceutical Science (BSPS) degree program University of Rhode Island To prepare students for careers in the pharmaceutical, biotechnical, consumer product and health care industries. Types of work include laboratory, regulatory oversight, engineering, economics, marketing,

More information

Data, Measurements, Features

Data, Measurements, Features Data, Measurements, Features Middle East Technical University Dep. of Computer Engineering 2009 compiled by V. Atalay What do you think of when someone says Data? We might abstract the idea that data are

More information

Human Genetics: Online Resources

Human Genetics: Online Resources Human Genetics: Online Resources David A Adler, ZymoGenetics, Seattle, Washington, USA There is a large source of information concerning human genetics available on a variety of different Internet sites,

More information

Bioethics Education in Professional Science Master s Programs at California State University Channel Islands

Bioethics Education in Professional Science Master s Programs at California State University Channel Islands ETHICS AND THE PSM Bioethics Education in Professional Science Master s Programs at California State University Channel Islands Ching-Hua Wang, M.D., Ph.D., Director of MS Biotechnology and Bioinformatics

More information

Exploring the Life Sciences

Exploring the Life Sciences Exploring the Life Sciences The California Society for Biomedical Research P.O. Box 19340, Sacramento, CA 95819-0340 www.ca-biomed.org/csbr Life-Science Crossword Puzzle Fill in the missing words in the

More information

College of Pharmacy & Pharmaceutical Sciences Graduate Catalog 2015-2016

College of Pharmacy & Pharmaceutical Sciences Graduate Catalog 2015-2016 College of Pharmacy & Pharmaceutical Sciences Graduate Catalog 2015-2016 Degrees Offered Doctor of Philosophy in Experimental Therapeutics Doctor of Philosophy in Medicinal Chemistry Master of Science

More information

NATIONAL HEALTH COUNCIL

NATIONAL HEALTH COUNCIL NATIONAL HEALTH COUNCIL RESOLUTION Nº 340, 8 TH JULY 2004 The National Health Council Plenary Assembly, in its 144 th Ordinary Meeting, held from the 7 th to the 8 th July 2004, in the use of its regimental

More information

Lecture 13: DNA Technology. DNA Sequencing. DNA Sequencing Genetic Markers - RFLPs polymerase chain reaction (PCR) products of biotechnology

Lecture 13: DNA Technology. DNA Sequencing. DNA Sequencing Genetic Markers - RFLPs polymerase chain reaction (PCR) products of biotechnology Lecture 13: DNA Technology DNA Sequencing Genetic Markers - RFLPs polymerase chain reaction (PCR) products of biotechnology DNA Sequencing determine order of nucleotides in a strand of DNA > bases = A,

More information

Syllabus of B.Sc. (Bioinformatics) Subject- Bioinformatics (as one subject) B.Sc. I Year Semester I Paper I: Basic of Bioinformatics 85 marks

Syllabus of B.Sc. (Bioinformatics) Subject- Bioinformatics (as one subject) B.Sc. I Year Semester I Paper I: Basic of Bioinformatics 85 marks Syllabus of B.Sc. (Bioinformatics) Subject- Bioinformatics (as one subject) B.Sc. I Year Semester I Paper I: Basic of Bioinformatics 85 marks Semester II Paper II: Mathematics I 85 marks B.Sc. II Year

More information

The NIH Roadmap: Re-Engineering the Clinical Research Enterprise

The NIH Roadmap: Re-Engineering the Clinical Research Enterprise NIH BACKGROUNDER National Institutes of Health The NIH Roadmap: Re-Engineering the Clinical Research Enterprise Clinical research is the linchpin of the nation s biomedical research enterprise. Before

More information

ITT Advanced Medical Technologies (Ileri Tip Teknolojileri)

ITT Advanced Medical Technologies (Ileri Tip Teknolojileri) ITT Advanced Medical Technologies (Ileri Tip Teknolojileri) ITT Advanced Medical Technologies (Ileri Tip Teknolojileri) is a biotechnology company (SME) established in Turkey. Its activity area is research,

More information

TIBCO Spotfire Helps Organon Bridge the Data Gap Between Basic Research and Clinical Trials

TIBCO Spotfire Helps Organon Bridge the Data Gap Between Basic Research and Clinical Trials TIBCO Spotfire Helps Organon Bridge the Data Gap Between Basic Research and Clinical Trials Pharmaceutical leader deploys TIBCO Spotfire enterprise analytics platform across its drug discovery organization

More information

Testimony of Timothy Coetzee, Ph.D. Representative of a Patient Advocacy Organization President, Fast Forward LLC

Testimony of Timothy Coetzee, Ph.D. Representative of a Patient Advocacy Organization President, Fast Forward LLC Testimony of Timothy Coetzee, Ph.D. Representative of a Patient Advocacy Organization President, Fast Forward LLC Committee on Oversight and Government Reform Domestic Policy Subcommittee U.S. House of

More information