CELL , Cellular Biochemistry Spring Norman Mayer 101

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1 CELL , Cellular Biochemistry Spring 2006 Instructor: Nancy Hopkins Office Hours: Tuesday 10-11:30 am Office: Stern Hall, Room 4009 or by appointment Phone: Meeting times: MWF 9-9:50 pm Norman Mayer 101 Textbook: Essential Biochemistry, by Pratt and Cornely. Textbook website: Other required materials: An H-ITT transmitter in good working order. If you purchased one for another Tulane course, you do not need a new one. If you need one, these are available in the bookstore. Course Goal: The goal of this course is to understand the chemical interactions that are the molecular basis of biological processes. This course gives a foundation of the structures of the molecules of life, on the mechanism of enzyme catalysis and the pathways and integration of control of the chemical reactions involved in life. Attendance, Readings and Supplementary Material: You should plan to attend every class. Excessive absences may result in your being dropped from the class. Attendance will be taken each class using the H-ITT transmitters. If you need to miss class due to medical or graduate school interviews, etc, you should me in advance with the dates and reason for your absence. You are expected to conduct yourself in an appropriate manner in class. All discussions will be carried out so that everyone can hear the individual who is speaking. Students should respect others and not talk when the instructor or another student is speaking. Cell phones should be turned off or at least set on silent mode during class. Students who are disturbing class by reading newspapers, talking on the phone or other distracting behavior will be ask to leave class. Headphones of any type will not be allowed during exams. Suggested readings from Pratt & Cornely are given in the Class Schedule. You should read the chapters prior to coming to class. After class, you should reread the text and review and supplement your notes. You should expect to spend approximately 2-3 hours on the material for every hour you spend in class. It is much better to learn the material as you go than to try to cram for hrs before an exam. The textbook website has helpful outlines, questions and links. You will find the syllabus, chapter outlines, helpful links and resources at the Blackboard Website- If you do not check your Tulane account regularly, you should have your Tulane forwarded to the account that you check regularly. Reminders and announcements will be sent to the class via Blackboard e- mail.

2 I will post the PowerPoint slides that I use in class on Blackboard prior to class. Although I will use these in class, having a copy of the lecture slides does not replace attending class. I will be supplementing the slides with other material during class and the slides contain only an outline of the lecture. If you print off the slides prior to class, you will be able to make notes directly on the pages and will have the diagrams I teach from available. Important Dates: January 17 February 13 February 26 March 6 March 17 April April 28 TBA Classes begin Last day to drop without record Mardi Gras Break begins Classes resume Last day to drop Easter Holidays Last day of classes Final Exam Tulane Honor Code: Students are expected to adhere to the principles of the Tulane Honor Code at all times. Any violations of this code will not be tolerated. You must report violations to the code as outlined within the code. A copy of the Tulane Honor Code may be obtained from your Dean s office. Tentative Class Schedule: Date Topic Reading January 18 Introduction, Chemical Basis of Life Chapters 1 20 Aqueous Chemistry Chapter 2 23 Molecular Biology Review & Protein Chapter 3 & 4 Structure, General 25 Myoglobin & Hemoglobin Chapter 4 27 Hemoglobin & Cytoskeleton Chapter 4 & 5 30 Motor Proteins; Enzymes Chapter 5 & 6 February 1 Enzymes and Catalysis Chapter 6 3 Enzyme Kinetics Chapter 7 6 Enzyme Kinetics & Inhibition Chapter 7 8 Enzyme Inhibition; Biological Membranes Chapter 7 & 8 10 Biological Membranes Chapter 8 13 Exam I Chapters Overview of Metabolism Chapter 9 17 Glycolysis Chapter Glycolysis Chapter Glycolysis & Gluconeogenesis Chapter Gluconeogenesis & Pentose Pathway; Summary of Glucose Metabolism Chapter 10

3 Date Topic Reading Feb 27- Mardi Gras Holiday Mar 3 March 6 Pyruvate Dehydrogenase & The Citric Acid Chapters 11 Cycle 8 The Citric Acid Cycle Chapter The Citric Acid Cycle & Citric Acid Cycle Chapter 11 in Context 13 Redox Rxn.; Mitochondrial Electron Chapter 12 Transport 15 Exam II Chapters Mitochondrial Electron Transport, Chapter 12 Chemiosmosis & ATP Synthesis 20 ATP Synthesis & Photosynthesis Chapter 12 & Photosynthesis Chapter Photosynthesis & Fatty Acid Oxidation Chapter 13 &14 27 Fatty Acid Oxidation Chapter Fatty Acid Oxidation & Fatty Acid Chapter 14 Synthesis 31 Fatty Acid Synthesis Chapter 14 April 3 Fatty Acid Synthesis & Other Lipid Chapter 14 Biosynthesis 5 Other Lipid Biosynthesis & Nitrogen Chapter 14 & 15 Fixation & Transamination 7 Transamination; Amino Acid Anabolism & Chapter 15 Catabolism 10 Exam III Chapters Chapter Amino Acid Anabolism & Catabolism Chapter Easter Break 19 Amino Acid Catabolism The Urea Cycle Chapter The Urea Cycle Chapter Regulation of Metabolism; Insulin Chapter Regulation of Metabolism; Insulin Chapter Glucagon; Diabetes Chapter 16 TBA Final Exam Grading: Grades will be determined by the following: 3 exams- 100 pts each; quizzes- 100 pts total; assignments and problem sets, 100 pts total; and the final exam 200 pts. The lowest exam grade or the quiz total, if it is lower than the lowest exam grade, will be dropped. The grades will be determined on a basis of 600 pts.

4 Exams There will be three midterm exams spaced through the semester. There will be NO makeup exams. If you know you will miss exam prior to the exam date, you should contact me as soon as possible prior to the exam and arrange to take the exam. You must take the exam before the graded exams are returned to the students. A missed exam will be given a grade of zero and will be the grade that is dropped. Each exam will primarily cover the material in the assigned chapters. Although the exams are not comprehensive, the material is cumulative by nature and many concepts build on previous ones and metabolism is only truly understood in an integrated manner. If you do poorly on an exam, you should seek to master the material as soon as possible in order to understand the new material. Quizzes Announced and unannounced quizzes will be given on a regular basis. There will be at least 12 quizzes (10 pts each) given during the semester. The 10 best scores will be used to determine your quiz point total. Quizzes will be given using H-ITT technology and your H- ITT transmitter. You should bring your transmitter to every class and be sure that it is in good working order. There will be NO make up quizzes. Problem sets/assignments Written homework will be given. The due date will be announced when the assignment is made. A reduction of 10% of the possible point total will be made for every 24 hours (or fraction there of) that the assignment is late. Assignments will be posted on Blackboard as well as being handed out in class. Final Exam The final exam is comprehensive. It will determine one-third of the final grade (200 pts). Approximately 35% of the exam will cover the new material since the last midterm exam and approximately 65% will be over previously covered material. Missed Exams You are expected to take all exams at the assigned date and time. If you miss an exam, you will be allowed to take the exam only if you have a valid excuse, and if you contact me prior to the exam. If you fail to contact me prior to the exam, you must submit a written excuse and you may be allowed to take the exam only if there is a compelling, unforeseen reason (over sleeping and car trouble are not compelling reasons). If you have an interview, a family celebration, etc, you may take an exam if you make arrangements in advance. Otherwise a missed exam will be recorded as a zero. If you have a severe illness or a family emergency, you should contact the Dean s office. If you are allowed to take a missed exam, you must take it at the time agreed on or you will be given a zero. The final exam must be taken during the assigned time. Any make up of the final exam requires a written excuse submitted to the Dean.

5 Final Grades Final grades will be based on the student s performance versus that of the class as a whole. Class attendance and participation will be used to determine borderline grades. There will be no assigned extra credit work. Accommodations for Disabilities If you need have a disability that requires special accommodation for class or testing, please contact the ERC as soon as possible to obtain the help you need. It is your responsibility to contact the counselors in the ERC to arrange for note takers, special arrangements for testing or any of the other service that they provide. You need to arrange to meet with me to complete the paperwork and to be sure that I am aware of your needs. I am more than willing to help you in any way that I can, but if you fail to make the proper arrangements, you can t retake an exam or otherwise correct what has already taken place. If you need extra time for an exam, you will need to take the exam at the ERC as there is no place available in our department and there are classes before and after ours. It is your responsibility to remind me when you will be taking each exam so that I will have it delivered in time. The best way to do this is by

6 Accommodations for Students with Disabilities Accommodations for students with special needs will be made. Students should inform the instructor of the need for these accommodations as soon as possible. If special seating is needed, this should be addressed immediately, preferably the first day of class, so that arrangements can be made. It is the student s responsibility to obtain the proper paperwork from the Office of Disabilities for accommodations. It is imperative that I be given my copy of the paperwork for my records. If you need accommodations for testing, you should take care of this far in advance of the first exam. Students who need extra time for exams will be required to take the exam at the ERC.