Chemistry and Biochemistry

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1 SUBJECT OUTLINE Subject Name: Chemistry and Biochemistry SECTION 1 GENERAL INFORMATION Subject Code: BIOB111 Award/s: Total course credit points: Level: Bachelor of Health Science (Naturopathy) 128 Core 1 st Year Bachelor of Health Science (Homeopathy) 112 Core 1 st Year Bachelor of Health Science (Nutritional Medicine) 96 Core 1 st Year Bachelor of Health Science (Western Herbal Medicine) 96 Core 1 st Year Bachelor of Health Science (Musculoskeletal Therapy) 96 Core 1 st Year Bachelor of Complementary Medicine 48 Elective 3 rd Year Duration: 1 Semester Subject Coordinator: Dr Eric Sekyere (Sydney campus) Subject is: Core or Elective as noted Subject Credit Points: 4 Student Workload: No. timetabled hours per week: 6 No. personal study hours per week: 4 Total hours per week: 10 Delivery Mode: Face to face 2 x 2 hour lectures 2 x 1 hour tutorials E-Learning Details: Narrated Powerpoint presentations Tutorials - Asynchronous tutor moderated discussion forum and activities Student handouts, web-based resources Intensive delivery Full Time Part Time Summer school - offered 5.25 hours per day, 3 days per week for 5 weeks combination lecture and tutorial activities. Quizzes offered in Weeks 2 and 4, final exam held in Week 6 of Summer School period.. Pre-requisites: Co-requisites: Nil Nil SECTION 2 ACADEMIC DETAILS Subject Rationale The first part of this subject introduces the student to Basic and Organic Chemistry and explores the nature and reactivity of matter. This provides the foundation for the second part Biochemistry which examines the relationship between the structure and function of complex biomolecules. Students will study important aspects of gene expression and mutation, the role of enzymes, coenzymes and cofactors in energy metabolism, and metabolic pathways involving glucose, fatty acid and amino acid providing knowledge of the metabolic processes that occur in human body. This is a foundational subject for later study of nutrition, pharmacology, immunology, herbal medicine and clinical sciences. Learning Outcomes 1. Describe elements, atoms, ions, chemical bonding, chemical reactions, the significance of energy transfer and catalysts in biochemical systems. Australian College of Natural Medicine Pty Ltd (ACNM) trading as Endeavour College of Natural Health Page 1 of 5

2 2. Discuss states of matter, gases, equilibrium, mixtures and solutions and their applications to physiological processes and metabolism. 3. Identify and apply nomenclature and common chemical reactions associated with organic functional groups. 4. Describe the processes associated with DNA replication and gene expression through protein synthesis. 5. Illustrate and analyse the chemical nature of major biochemical groups including carbohydrates, lipids, proteins and nucleic acids. 6. Discuss the major biochemical pathways and relate the knowledge to nutrition and health. Assessment Tasks Type Learning Outcomes Assessed Session Content Delivered Session Due Weighting Quiz 1 Multiple choice and definitions (40 minutes) 1,2 1-8 Sunday following Session 10 25% Quiz 2 Multiple choice and definitions (40 minutes) 2, Sunday following Session 18 25% Final Examination Multiple choice, short answers, definitions, extended responses and problem solving questions (2.5 hours) Final Examination Period 50% Prescribed readings: 1. Stoker, HS 2013, General, Organic, and Biological Chemistry, 7 th edn, Brooks Cole Cengage, USA 2. Summers, J & Smith, B 2014, Communication skills handbook, 4th edn, Wiley, Milton, Qld Recommended readings: 1. Alberts, B, Johnson, A, Lewis, J, Raff, M, Roberts, K & Walter P 2008, Molecular biology of the cell, 5 th edn, Garland Science, New York. 2. Berg, JM, Tymoczko, JL & Stryer, L 2012, Biochemistry, 7 th edn, W.H. Freeman, New York. 3. Bettelheim, FA, Brown, WH, Campbell, MK, Farrell, SO & Torres, OJ 2013, Introduction to general, organic and biochemistry, 10 th edn, Brooks/Cole, Cengage Learning, Belmont, CA. 4. Dominiczak, MH 2007, Flesh and bones of metabolism, Elsevier Mosby, Edinburgh. 5. Timberlake, KC 2013, General, organic, and biological chemistry: structures of life, 4 th edn, Pearson, Boston 6. Tortora, GJ & Derrickson, B 2014, Principles of anatomy and physiology, 14th edn, Wiley, Hoboken, NJ.. Subject Content Week Lectures Tutorial 1. Session 1 Introduction: (Subject Outline / Subject Aims / Assessment / Teaching Resources) Introduction to chemistry Review of atom/subatomic particles, Periodic table, and electronic configuration. Animations on electron configuration. Australian College of Natural Medicine Pty Ltd (ACNM) trading as Endeavour College of Natural Health Page 2 of 5

3 Matter and the structure of the atom, Periodic table of elements, use of the Periodic Table to predict physical and chemical properties of elements, electronic configuration and the octet rule, formation of ions, significance of isotopes. Session 2 Chemical bonding 2. Session 3 Ionic and covalent bonding, polyatomic ions, electro negativity and polarity of bonds, naming ionic and molecular compounds. Chemical reactions Chemical change, chemical equations, mole, formula weights, balancing equations, classification of chemical reactions, heat of reaction. Session 4 Reaction rates 3. Session 5 Le Châtelier's Principle and equilibrium. Physical states of matter Solids, liquids and gases, Boyle s law, Dalton s law, transition between states of matter and intermolecular forces, solubility, kinetic molecular theory Session 6 Acids and bases 4. Session 7 Reactions of acids and bases, ph and buffers. Introduction to organic chemistry Functional groups and nomenclature, structural isomers, stereo isomers. Session 8 5. Session 9 Alkanes, alkenes, alkynes, aromatics. Phenols, alcohols, ethers, aldehydes, ketones, carboxylic acids. Session Session 11 Amines, esters and amides. Carbohydrates function of carbohydrates. Session 12 Lipids Review of writing and naming compounds. Review of balancing equations. Review of factors affecting chemical equilibrium. Review of different states of matter, Gas laws, types of solutions, solubility, osmosis and dialysis. Animations on different states of matter. Review of Acids and Bases, ph and buffer. Virtual labs on the use of indicators in distinguishing acids and bases. Review of various functional groups using molecular models. Review of alkanes, alkenes, alkynes, aromatics. Review of phenols, alcohols, ethers, aldehydes, ketones, carboxylic acids. Review of amines, esters and amides. Review of carbohydrates. Concept maps on carbohydrate types. Review of lipids. Concept maps on lipid types. Australian College of Natural Medicine Pty Ltd (ACNM) trading as Endeavour College of Natural Health Page 3 of 5

4 function of lipids. 7. Session 13 Amino Acids function of amino acids. Session 14 Proteins function of proteins. Review of amino acids. Review of proteins. Animations on the structure and formation of different levels of protein organisation. 8. MID SEMESTER BREAK Semester 1 - This break aligns with the week after Easter so it may fall between weeks 6 to 8. Semester 2 - Week 8 Online students - Please continue studying during this week. Instead of mid-semester break you will observe your break as an extra study week after Week Session 15 Enzymes and co-enzymes The different classes of enzymes are studied and the types of reactions they catalyse. Session 16 Biochemical nature of the cell membrane 10. Session 17 Nucleic Acids Classification, structure, nucleosides and nucleotides DNA double helix, DNA replication. Session 18 Nucleic Acids 11. Session 19 The genetic code Protein synthesis Mutations and viruses. Bioenergetics and catabolic pathways An overview of the role and integration of the common catabolic pathways is provided. Session Session 21 Digestion of carbohydrates Glycolysis, pyruvate pathways Glycogen metabolism. Gluconeogenesis The Cori Cycle The Citric Acid Cycle. Session 22 Review of enzymes. Virtual lab on the effect of various factors on enzyme activity. Review of cell membrane. Review of types of nucleic acids, DNA replication. DVD on DNA structure and its replication. Review of the genetic code, Protein synthesis. Virtual lab and DNA extraction. Review of cell structure, role of ATP and co-enzymes, significance of ATP. Review of carbohydrate metabolism. Concept map on carbohydrate metabolism. Review of electron transport chain / oxidative phosphorylation. Australian College of Natural Medicine Pty Ltd (ACNM) trading as Endeavour College of Natural Health Page 4 of 5

5 Electron transport chain Animations of ATP synthesis. Oxidative phosphorylation. 13. Session 23 Lipid β-oxidation, ketogenesis, fatty acid synthesis. Session 24 Lipid continued Fatty acid synthesis Protein Urea cycle. 14. Session 25 Protein continued Urea cycle and synthesis of amino acids. Session 26 Integrating the metabolic pathway.s Review of metabolism of lipids. Review of metabolism of proteins. Concept map on protein metabolism. Concept map on integration of carbohydrates, protein and fat metabolism. 15. Study Week Study Week Exam Week 1 On campus enrolled students: please refer to the Exam Timetable for your local campus for the exact day and time of exam. Online enrolled students: You are required to sit examinations on campus per the Examination Policy - Higher Education. The Exam Week for subjects offered online is identified in the Online Calendar. 18. Exam Week 2 Please refer to the Exam Timetable for your local campus for the exact day and time of exam. Australian College of Natural Medicine Pty Ltd (ACNM) trading as Endeavour College of Natural Health Page 5 of 5

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