How To Understand And Understand Cancer

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1 Profolio of Researchers and Research Teams GALICIAN ONCOLOGICAL RESEARCH GROUP (Last update 21/04/2006) Code: GI-1230 Department: Fisioloxía Contact: Domínguez Puente, Fernando Telf ext Center of Innovation and Thecnology Transfer Telf.: Research field - Translational Cancer Research Technology services -.-Ginecology.-Hematology.-Pathology :-Nuclear Medicine.-Oncology.-Genetic Diagnosis Key words Tumoral Markers; Prognostic Factors; Genomics and proteomics; Pharmacogenomic Páxina 1/8

12258 Center of Innovation and Thecnology Transfer Telf.

2 Researchers Name Domínguez Puente,F. Bello López,J.L. Cameselle Teijeiro,J.M. Codesido López,J. Conde Freire,R.F. Forteza Vila,J. Fraga Rodríguez,M.F. Novo Domínguez,A. Paredes Cotore,J.P. Potel Lesquereux,J. Caamaño Vara,M.P. González Martínez,M.T. de la Fuente Martínez,M. Hernández Urueña,M. Torrecilla Cillero,D. External collaborators Name Alvaro Ruibal Morell Rafael López López Loidi Fernández de Troconiz, Lourdes Quinteiro García,C Carneiro Freire, María Carmen Marta González Rodríguez Campos Suárez R, Sanmartín Troitiño Lidia Juan Fernando Cueva Duarte Francisco Javier Barón Duarte Sonia Maria Candamio Folgar Maria Teresa Curiel Garcia Luis Angel León Mateos Begoña Gabriela Graña Suarez Señán Llarena S., Parajes Castro Silvia Position Coordinator IFP IFP PA PA PA Institution RTD PROJECTS ( period: ) Genómica del cáncer Tipology: Proxectos FISss Duration: 23/12/ /12/2006 Main investigator: Domínguez Puente, Fernando Nuevas estrategias en el tratamiento de tumores: Nanopartículas poliméricas funcionalizadas para la orientación selectiva de moléculas activas (Subproyecto 2) Tipology: Plan Nacional Duration: 13/12/ - 13/12/2007 Main investigator: Domínguez Puente, Fernando Genómica del cancer. Páxina 2/8

External collaborators Name Alvaro Ruibal Morell Rafael López López Loidi Fernández de Troconiz, Lourdes Quinteiro García,C Carneiro Freire, María Carmen Marta González Rodríguez Campos Suárez R,

3 Tipology: Proxectos FISss Duration: 01/01/ - 31/07/2006 Main investigator: Domínguez Puente, Fernando Technological customers and partners - CYTYC IBERIA, S.L. - Dako Diagnósticos, S.A. - Dakocytomation - Fundación Instituto Galego de Oftalmoloxía - Fundación Mútua Madrileña Automovilista (MMA) - GRUPO IMEDIC-ADESLAS SCIENTIFIC PRODUCTION ( period: - ) Articles in the Journal Citation Reports Poorly differentiated oxyphilic (Hürthle Cell) carcinoma arising in lingual thyroid: a case report and review of the literature Journal: ENDOCRINE PATHOLOGY, ISSN: p63 expression in solid cell nests of the thyroid> further evidence for a stem cell origin Journal: MODERN PATHOLOGY, ISSN: Primary anaplastic large cell lymphoma of the Central Nervous System Journal: AMERICAN JOURNAL OF SURGICAL PATHOLOGY, ISSN: E cadherin loss rather than B catenin alterations is a common feature of poorly differenciated thyroid carcinomas Journal: HISTOPATHOLOGY, ISSN: TGF B induced apoptosis in human thyrocytes is mediated by p27 reduction and is overridden in neoplastic thyrocytes by NF kb activation Journal: ONCOGENE, ISSN: A novel loss of function mutation N48K in th PTEN Gene in a spanish patient with cowden disease Journal: JOURNAL OF INVESTIGATIVE DERMATOLOGY, ISSN: X Predictors of malignant behaviour in gastrointestinal stromal tumours. A clinicopathological study of 34 cases. Páxina 3/8

- Dakocytomation - Fundación Instituto Galego de Oftalmoloxía - Fundación Mútua Madrileña Automovilista (MMA) - GRUPO IMEDIC-ADESLAS SCIENTIFIC PRODUCTION ( period: - ) Articles in the Journal

4 Journal: EUROPEAN JOURNAL OF SURGERY, ISSN: Hodgkin and reed stenberg cells harbor alternations in the major tumo suppressor pathways and cell cycle checkpoints. analyses using tissue microarrays. Journal: NEOPLASIA, ISSN: Cellular localization of orexin receptors in human adrenal gland, adrenocortical adenomas and pheochromocytomas Journal: REGULATORY PEPTIDES, ISSN: T Cell histiocyte rich large B cell lymphoma is a disseminated aggresive neoplasm. Differential diagnosis from Hodgkin lymphoma Journal: HISTOPATHOLOGY, ISSN: DNA ploidy and cytonuclear area of peritumoral and paratumoral samples of mastectomy specimens. A useful prognostic marker. Journal: EUROPEAN JOURNAL OF SURGERY, ISSN: Bilateral adrenal metastases from hepatocellular carcinoma after liver transplantation Journal: LIVER ( journal title changes ), ISSN: Predictive value of p53, BCL2, and BAX in advanced head and neck carcinoma Journal: AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS, ISSN: MOC 31 Ep CAM inmunoreactivity in Merkel cells and Merkel cell carcinomas Journal: HISTOPATHOLOGY, ISSN: Novel mutation involving the translation initiation codon of the growth hormone receptor gene (GHR) in a patient with Laron Syndrome. Journal: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, ISSN: X Inhibition of Cdk4 actiivity enhances translation of p27 kip1 in quiescent Rb-negative cells. Journal: JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN: Páxina 4/8

Journal: NEOPLASIA, ISSN: 1522-8002 Cellular localization of orexin receptors in human adrenal gland, adrenocortical adenomas and pheochromocytomas Journal: REGULATORY PEPTIDES, ISSN: 0167-0115 T

5 TGF-beta.induced apoptosis in human thyrocytes is mediated by p27 kip1 reduction and is overridden in neoplastic thyrocytes by NF-kB activation. Journal: ONCOGENE, ISSN: Phenotypic gender differences in subjects with familial partial lipodystrophy (dunnigan variety) Due to a nuclear lamin A/C R482W mutation Journal: HORMONE AND METABOLIC RESEARCH, ISSN: Amniotic membrane as support for human retinal pigment epithelium (RPE) cell growth Journal: ACTA OPHTHALMOLOGICA SCANDINAVICA, ISSN: Spindle cell variant of papillary thyroid carcinoma Journal: HISTOPATHOLOGY, ISSN: Signet-ring cell change in pseudomembranous colitis versus signet-ring cell carcinoma Journal: AMERICAN JOURNAL OF SURGICAL PATHOLOGY, ISSN: BRAF mutations typical of papillary thyroid carcinoma are more frequently detected in undifferentiated than in insular and insular-like poorly differentiated carcinomas Journal: VIRCHOWS ARCHIV, ISSN: Telomerase expression and proliferative activity suggest a stem cell role for thyroid solid cell nests Journal: MODERN PATHOLOGY, ISSN: Artefeacts in oral incisional biopsies in general dental practice: a pathology audit. Journal: ORAL DISEASES, ISSN: X Mesenchymal hamartoma of the liver clinicopathological, immunohistochemical and flow cytometric study of two cases Journal: HEPATOLOGY RESEARCH, ISSN: Building an outcome predictor model for diffuse large B-Cell lymphoma Journal: AMERICAN JOURNAL OF PATHOLOGY, ISSN: Páxina 5/8

METABOLIC RESEARCH, ISSN: 0018-5043 Amniotic membrane as support for human retinal pigment epithelium (RPE) cell growth Journal: ACTA OPHTHALMOLOGICA SCANDINAVICA, ISSN: 1395-3907 Spindle cell

6 Liver-cell adenomas with heavy iron deposition Journal: INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, ISSN: Abnormal cell cycle regulation in primary human uveal melanoma cultures Journal: JOURNAL OF CELLULAR BIOCHEMISTRY, ISSN: Clinical Heterogeneity of Mutations in the Androgen Receptor Gene: Androgen Insensitivity Syndrome (AIS) and Spinobulbar Muscular Atrophy Journal: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, ISSN: X Combined Pituitary Hormone Deficiency: Clinical Characterization and Genetic Analysis (PROP1 and POU1F1) Journal: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, ISSN: X Abnormal Cell Cycle Regulation in Primary Human Uveal Melanoma Cultures Journal: JOURNAL OF CELLULAR BIOCHEMISTRY, ISSN: Chapter: Tumores de estómago DE LOS SIGNOS Y SÍNTOMAS AL DIAGNÓSTICO Y TRATAMIENTO EN PATOLOGÍA DIGESTIVA ( )Publicación: Editorial: Sociedad Española de Patología Digestiva, AstraZeneca, Solitary fibrous tumour Pathology and Genetics. Tumours of Endorine Organs ( )Publicación: Editorial: IARCPress, Mucoepidermoid carcinoma Pathology and Genetics. Tumours of Endorine Organs ( )Publicación: Páxina 6/8

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, ISSN: 0334-018X Combined Pituitary Hormone Deficiency: Clinical Characterization and Genetic Analysis (PROP1 and POU1F1) Journal: JOURNAL OF PEDIATRIC

7 Editorial: IARCPress, Mucinous carcinoma Pathology and Genetics. Tumours of Endorine Organs ( )Publicación: Editorial: IARCPress, Distopsias Obstetricia y Ginecología ( )Publicación: Editorial: Editorial Ariel S.A., Infecciones ginecológicas Obstetricia y Ginecología ( )Publicación: Editorial: Editorial Ariel S.A., Tumores del ovario Obstetricia y Ginecología ( )Publicación: Editorial: Editorial Ariel S.A., Doctoral theses: Estudio inmunohistoquimico de la actividad proliferativa de las celulas neoplasicas y no neoplasicas de la glandula tiroides humana Date of dissertation: 22/07/ Director: Jerónimo Forteza Vila, José Manuel Cameselle Teijeiro, Supervisor: Jerónimo Forteza Vila, Author: Julio Moldes Boullosa, Valor pronostico de p53, Bcl 2 y BAX en carcinoma epidermoide de cabeza y cuello Date of dissertation: 03/05/ Director: Jerónimo Forteza Vila, Supervisor: Jerónimo Forteza Vila, Author: Susana Casado Cobo, Mecanismo de acción de p16ink4a en células D3T3Rb-/- Páxina 7/8

A., Tumores del ovario Obstetricia y Ginecología (84-344-3712-0)Publicación: Editorial: Editorial Ariel S.A., Doctoral theses: Estudio inmunohistoquimico de la actividad proliferativa de las celulas

8 Date of dissertation: 13/07/ Director: Fernando Domínguez Puente, Juan Bautista Zalvide Torrente, Author: Mª Teresa González Martínez, Mecanismos celulares del TGF-beta1 en Neoplasias de trioides humanos Date of dissertation: 17/01/ Director: M. Clara Álvarez Villamarín, Fernando Domínguez Puente, Author: Susana Belén Bravo López, Estudio de los factores moleculares implicados en el melanoma Uveal Humano Date of dissertation: 18/03/ Director: Fernando Domínguez Puente, Author: MARÍA PARDO PÉREZ, Proliferación y apoptosis en hepatocitos en cultivo: protimosina alfa y gliceraldehido 3 fosfato deshidrogenasa Date of dissertation: 17/02/ Director: Fernando Domínguez Puente, Félix Víctor Vega Lisi, Author: Luciana Fernanda Barbini, Meduloblastoma Factores pronósticos clínicos y terapeúticos experiencia multi-institucional Date of dissertation: 01/10/ Director: Fernando Domínguez Puente, Author: Luis Alberto Pérez Romasanta, Valor de la presencia de ADN de Mycobacterium tuberculosis en lesiones de eritema indurado Date of dissertation: 20/02/ Director: José Manuel Suárez Peñaranda, Jerónimo Forteza Vila, Author: Begoña Vieites Pérez-Quintela, Análisis de los genes PROP1, POU1F1, GH1, RHG y SHOX en pacientes con talla baja Date of dissertation: 13/12/ Director: Fernando Domínguez Puente, Author: Celsa Quinteiro García, Análisis de los genes PROP1, POU1F1, GH1, RGH y SHOX en pacientes con talla baja Date of dissertation: 13/12/ Director: Fernando Domínguez Puente, Manuel Arturo Pombo Arias, Supervisor: Santiago Rodríguez-Segade Villamarín, Author: Celsa Quinteiro García, Páxina 8/8

Clara Álvarez Villamarín, Fernando Domínguez Puente, Author: Susana Belén Bravo López, Estudio de los factores moleculares implicados en el melanoma Uveal Humano Date of dissertation: 18/03/

Access to hormone receptor testing and other basic diagnostic pathology services in Colombia

Access to hormone receptor testing and other basic diagnostic pathology services in Colombia Dr Fernando Perry Clínica de seno y tejidos blandos Instituto Nacional de Cancerología de Colombia Breast cancer