Ministero della Salute

Transcription

1 Ministero della Salute Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti BANDO RICERCA FINALIZZATA GRADUATORIA PROGETTI ORDINARI Investigation of the role of extracellular ATP and the P2X7 receptor in the modulation of immunosuppression within tumour microenvironment Emilia Romagna Biomedical Immunology Oncology Defective Glucose Metabolism in Polycystic Kidney Disease Defines a Novel Therapeutic Strategy: a Pre Clinical Proof of Concept Study SAN RAFFAELE Milano Biomedical Digestive, Kidney and Urological Systems Gender and geographical specific circulating microrna signatures as biomarkers of atherosclerosis, atherosclerosis progression and vascular events MONZINO Clinical Vascular and Hematology 5, Defining the cis regulatory bases for variability in inflammatory gene expression in humans: a 3 D analysis in the nuclear space I.E.O. Biomedical Genes, Genomes and Genetics 5, To unravel the molecular basis of neurodevelopmental disorders CASA SOLLIEVO SOFFERENZA Biomedical Genes, Genomes and Genetics 5,5 Pagina 1 di 231

2 "Detection of pathological prion protein in cerebrospinal fluid by real time quaking induced conversion (QuIC): Evaluation and standardization of a novel disease specific laboratory test for the diagnosis of sporadic Creutzfeldt Jakob disease." Ist.Sci. Neurologiche Bologna Biomedical Brain Disorders and Clinical Immune, procoagulant and inflammatory responses in severe sepsis and septic shock MAGGIORE Biomedical Immunology Altered host virus interaction as cause of multiple sclerosis: focus on Epstein Barr virus and antiviral immune response ISS Biomedical Brain Disorders and Clinical Assessment of the macrophage role in the natural history of myeloproliferative neoplasms SAN RAFFAELE Milano Biomedical Oncology 1 Basic Translational Oncology 6, Dynamics and ultrastructure of stress sensing SAN RAFFAELE Milano Biomedical Cell Biology The new biotechnologies 6, New nano systems for targeted delivery of cytokines to tumors SAN RAFFAELE Milano Biomedical Oncology 2 Translational Clinical Oncology 6, Role of anoctamin 1 in iodide transport and implications for the efficacy of radioiodinebased cancer therapy. Emilia Romagna Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Oncology 6, Identification of critical p53 co regulators and effectors during tumor suppression I.E.O. Biomedical Genes, Genomes and Genetics Oncology 6,5 Pagina 2 di 231

3 Determinants of Type 1 Diabetes (T1DM) clinical onset and progression in paediatric immigrant population Piemonte Clinical Endocrinology, Metabolism, Nutrition and Reproductive 6, GENome wide association study to Evaluate genetic risk factors for cerebral sinusvenous thrombosis (GENESIS Study) MAGGIORE Biomedical Genes, Genomes and Genetics 6, Mitochondrial targeting in LRRK2 associated parkinsonism (PARK8) SANTA LUCIA Biomedical Brain Disorders and Clinical An integrated genomic, transcriptomic and epigenomic approach in multiplex multiple sclerosis families. SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics Production of novel diagnostic and therapeutic antibodies directed against stem cells in colorectal and lung cancer REGINA ELENA Biomedical Oncology 2 Translational Clinical Oncology Translational genetics of hereditary spinocerebellar degenerations: highthroughput exome sequencing and model organisms for the identification and characterization of novel disease genes CARLO BESTA Biomedical Genes, Genomes and Genetics Dysregulated RNA metabolism in multiple myeloma SAN RAFFAELE Milano Biomedical Oncology 1 Basic Translational Oncology N acetylcysteine in the treatment of neuropathic pain NEUROMED Biomedical Brain Disorders and Clinical 7 Pagina 3 di 231

4 Systemic Sclerosis and Chronic Graft versus Host Disease: application of novel predictive assays and generation of transgenic animal models Marche Biomedical Immunology CHANGES IN STRUCTURE AND RECRUITMENT OF MUSCLE SYNERGIES AFTER CORTICAL AND CEREBELLAR LESIONS SANTA LUCIA Biomedical Integrative, Functional, and Cognitive 7, Generation and functional characterization of artificial lymphoid organs with mutipotent stromal progenitors SAN RAFFAELE Milano Biomedical Biology of Development and Aging Oncology 7, Role of regulatory cells and cytokines in the extent of colonic involvement in patients with ulcerative colitis: implications for patient oriented therapy ISS Biomedical Digestive, Kidney and Urological Systems 7, Development of a second generation PCR Based Replicon Typing system to trace and control the antimicrobial resistance spread in Enterobacteriaceae ISS Biomedical Infectious Diseases and Microbiology 7, Enhanced cell therapy: novel strategies to improve transplanted cell survival and engraftment by protection from oxidative stress REGINA ELENA Biomedical Vascular and Hematology 7, Identification and validation of new therapeutic targets in Acute Myeloid Leukaemia I.E.O. Biomedical Oncology 1 Basic Translational Oncology 7,5 Pagina 4 di 231

5 Inherited arrhythmias: clinical characterization, genetic geography and experimental studies in the Calabria Region isolate. MAUGERI Biomedical Genes, Genomes and Genetics 7, Regulation of mitotic transitions I.E.O. Biomedical Cell Biology Oncology 7, ADIPOSE DERIVED MESENCHYMAL STEM CELLS AS NEW MINIMALLY INVASIVE REGENERATIVE TREATMENT TO TARGET EARLY OSTEOARTHRITIS: FROM PRE CLINICAL PROCEDURE SELECTION TO CLINICAL APPLICATION IN A RANDOMIZED DOUBLE BLINDED CONTROLLED TRIAL RIZZOLI Clinical Musculoskeletal, Oral and Skin The new biotechnologies 7, Steroid myopathy: pathogenesis and prevention MAUGERI Biomedical Musculoskeletal, Oral and Skin 7, The role of mechanobiology in establishment and progression of intima hyperplasia associated to vein coronary bypass grafts disease MONZINO Biomedical Vascular and Hematology 7, Evaluation of the potential application of bivalve shellfish as bioindicators of pollution for viral pathogens in coastal waters of southern Italy IZS Mezzogiorno Biomedical Veterinary Food safety and animal 7,5 welfare Skeletal muscle in Spinal and Bulbar Muscular Atrophy (SBMA): therapeutic target and delivery route for potential treatments Veneto Biomedical Brain Disorders and Clinical 7,5 Pagina 5 di 231

6 Stress Activated Protein Kinases MLK3 and p38 as novel therapeutic targets in chemokine driven leukocyte extravasation and non resolving inflammatory processes SAN RAFFAELE Milano Biomedical Immunology 7, ETHYL EICOSAPENTAENOIC ACID ADDED TO INTERFERON ß THERAPY IN RELAPSING REMITTING MULTIPLE SCLEROSIS: A RANDOMIZED PHASE II CLINICAL TRIAL. ISS Biomedical Brain Disorders and Clinical 7, An image analysis platform for automated in situ high content and resolution analysis of tumor heterogeneity: targeting genomic, epigenetic, and functional diversity in tissues by fluorescence microscopy I.E.O. Biomedical Bioengineering and Technologies Oncology 7, Epidrugs and cardiac differentiation: relevance for the 22q11.2 deletion syndrome NEUROMED Biomedical Cardiovascular and Respiratory From Bench to Bedside: an Integrated Approach to RASopathies ISS Biomedical Genes, Genomes and Genetics LEKTI, a multifunctional protein involved in skin desquamation and immunity: towards novel therapeutic approaches for rare and common skin diseases IDI Biomedical Musculoskeletal, Oral and Skin New Molecular Mechanisms of Leukemia Immune Evasion after Allogeneic Hematopoietic Stem Cell Transplantation SAN RAFFAELE Milano Biomedical Oncology 2 Translational Clinical Oncology 8 Pagina 6 di 231

7 Cell on chip technology as a novel tool to investigate the crosstalk between cancer and immune cells: role of the transcription factors Interferon Regulatory Factor 1 and 8 (IRF1, IRF8) in melanoma as a model system. ISS Biomedical Oncology 1 Basic Translational The new biotechnologies NEUROSTEROIDS AS DETERMINANTS OF ANTIEPILEPTIC DRUG REFRACTORINESS IN TEMPORAL LOBE EPILEPSY Emilia Romagna Biomedical Brain Disorders and Clinical New self powered devices for cochlear stimulation based on piezoelectric nanomaterials Toscana Biomedical Bioengineering and Technologies The new biotechnologies Dendritic cell based vaccine therapy in indolent non Hodgkin lymphoma patients: a phase I clinical study ISS Biomedical Oncology 2 Translational Clinical Oncology Investigation of a novel engineered probiotic to treat Clostridium difficile infection SAN RAFFAELE Milano Biomedical Infectious Diseases and Microbiology Hypoxia, Inflammation and redox status as determinants of malignant progression of cancer stem cells SAN RAFFAELE Pisana Roma Biomedical Oncology 1 Basic Translational Oncology Structure and biology of the Tat/Env complex and role of anti Tat/Env antibodies in HIV infection: implication for HIV/AIDS preventative vaccine development ISS Biomedical AIDS and Related Research 8 Pagina 7 di 231

8 ROLE OF THE NOVEL PRESYNAPTIC PROTEIN PRRT2 IN NEURONAL PHYSIOLOGY AND IN THE PATHOGENESIS OF PAROXYSMAL NEUROLOGICAL DISORDERS SAN RAFFAELE Milano Biomedical Molecular, Cellular, and Developmental Vitamin D deficiency and obesity after kidney transplantation: multicenter study on gene environment interactions leading to "complex phenotypes" in a human system associated with cardiovascular events and graft rejection. Piemonte Biomedical Digestive, Kidney and Urological Systems 8, Taking a step forwards the preparedness for preventing crises: Improving the molecular detection of emerging pathogens in food. IZS Piemonte, Liguria e Valle d'aosta Biomedical Veterinary Food safety and animal 8,5 welfare Tie2 monocyte mediated delivery of IFNalpha into the liver as a novel treatment for colorectal carcinoma (CRC) liver metastases. SAN RAFFAELE Milano Biomedical Oncology 2 Translational Clinical Oncology 8, Sensorimotor Integration. Physiology and Pathophysiology MAUGERI Biomedical Integrative, Functional, and Cognitive 8, Genomic complexity of chronic lymphocytic leukemia (CLL): clinicobiologc implications and pharmacoeconomic evaluation at the beginning of the kinasetargeted treatment era Emilia Romagna Clinical Oncology 2 Translational Clinical Oncology 8, Immunological Mechanisms Involved in The Pathogenesis of Primary Aldosteronism Veneto Clinical Endocrinology, Metabolism, Nutrition and Reproductive 8,5 Pagina 8 di 231

9 WHY ME? PROJECT (WM?P). INVESTIGATING WHITE MATTER CONNECTIVITY IN SCHIZOPHRENIA AT IMAGING, CELLULAR, AND TRANSPOSONE LEVELS IN MONOZYGOTIC DISCORDANT TWINS MEDEA Biomedical Brain Disorders and Clinical 8, Vibrio and viruses in shellfish: old and emerging pathogens. Evaluation of exposure levels for the implementation ofprevention strategies. ISS Biomedical Veterinary Food safety and animal 8,5 welfare THE ROLE OF THE BRAIN ADIPOCYTE AXIS ACTIVITY IN POTENTIATING ANTIDEPRESSANT EFFICACY ISS Biomedical Biobehavioral and Behavioral Processes 8, Does gut flora influence autoimmune responses in Multiple Sclerosis? The MAIT cell story. SANTA LUCIA Biomedical Immunology 8, CCL2/CCR2 blocking:molecular insights into a potential therapeutic strategy against HIV replication ISS Biomedical AIDS and Related Research 8, Specialized functionally connected membranes as caveolae and exosomes include molecular signature to decode melanoma progression mechanisms exploitable in clinical therapy ISS Biomedical Cell Biology Oncology 8, Electromagnetic guided in situ laser fenestration of endovascular endoprosthesis Toscana Biomedical Surgical, Biomedical Imaging, and Bioengineering 8,5 Pagina 9 di 231

10 From protein protein interaction studies new potential therapeutic targets to treat the MLL related acute lymphoblastic leukemias SDN Biomedical Oncology 1 Basic Translational Oncology 8, CARDIOriGEN MicroRNAs inducing cardiac regeneration From discovery towards clinical application Friuli Venezia Giulia Biomedical Cardiovascular and Respiratory 8, Beta adrenoceptor antagonism and biased agonism in the control of pathological neovascularization ISS Biomedical Biological Chemistry and Macromolecular Biophysics 8, Meeting senior members in the search for new associatesof the exclusive hamartromatous gene club Puglia Biomedical Digestive, Kidney and Urological Systems Oncology 8, A long ncrna point of view to FSHD muscular dystrophy pathophysiology and therapeutics. SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics 8, Exploring the role of the prokineticin system in experimental autoimmune encephalomyelitis: a preclinical study towards the definition of possible novel targets of therapy for human multiple sclerosis CARLO BESTA Biomedical Immunology Induced pluripotent stem cells (ipscs) as a tool to develop neuroprotective (autologous) neural stem cell based therapy in multiple sclerosis SAN RAFFAELE Milano Biomedical Brain Disorders and Clinical 9 Pagina 10 di 231

11 A new therapeutic window in neurorehabilitation FATEBENEFRATELLI Biomedical Biobehavioral and Behavioral Processes INFLAMMATORY AND THROMBOCCLUSIVE VASCULOPATHY: THE ROLE OF PROTEINS RELATED TO COMPLEMENT ACTIVATION. C.R.O. AVIANO Biomedical Vascular and Hematology Uncovering the molecular bases of the association of uromodulin common variants with hypertension and chronic kidney disease for the identification of novel therapeutic strategies SAN RAFFAELE Milano Biomedical Digestive, Kidney and Urological Systems Identification of therapeutic targets for neurological disorders: analysis of the mechanisms regulating cortical interneuronsdevelopment. SAN RAFFAELE Milano Biomedical Molecular, Cellular, and Developmental Individual risk in clinically isolated syndromes of conversion to multiple sclerosis and disease progression: an integrated public health clinical genomics approach SAN RAFFAELE Milano Clinical Brain Disorders and Clinical Clostridium difficile infection in Italy: do we know the true magnitude of the problem? SPALLANZANI Clinical Infectious Diseases and Microbiology MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF MECHANISMS INVOLVED IN IRON HOMESTASIS AND HEME SYNTHESIS IN ß THALASSEMIC ERYTHROPOIESIS MAGGIORE Biomedical Genes, Genomes and Genetics 9 Pagina 11 di 231

12 Radiation biodosimetry in emergency: validation of automated scoring and accuracy of dose prediction AOU San Martino IST Genova Biomedical Oncology 1 Basic Translational Diseases of environmental 9 origin, with reference also to the workplace Expression and function of P2 receptors in human psoriatic keratinocytes. Study of their role in psoriasis pathogenesis and research of new potential therapeutic targets Emilia Romagna Biomedical Musculoskeletal, Oral and Skin Low cost cardio pulmonary monitoring system for avoidable death prevention in the hospital general ward Piemonte Biomedical Cardiovascular and Respiratory The role of early systematic best palliative care versus on request palliative care consultation during standard oncologic treatment for patients with advanced gastric or pancreatic cancers: a randomized, controlled, multicenter trial IRST Meldola Clinical Healthcare Delivery and Methodologies Oncology GLP 1 agonists treatment vs endoscopic procedures in obesity and type II diabetes mellitus management: a randomized clinical trial. Piemonte Clinical Endocrinology, Metabolism, Nutrition and Reproductive Molecular regulation of the redox switch in inflamed skeletal muscle as a novel target to implement muscle regeneration and limit fibrosis in immune mediated myositis SAN RAFFAELE Milano Biomedical Musculoskeletal, Oral and Skin 9 Pagina 12 di 231

13 Identification and manipulation of immunosuppressive networks in tumor microenvironment of patients undergoing immunobiological therapies. SAN RAFFAELE Milano Biomedical Immunology Oncology Cortico cortical functional connectivity and recovery of post stroke spatial attention and awareness disorders SANTA LUCIA Biomedical Integrative, Functional, and Cognitive Impact of asbestos mediated inflammation in mesothelioma genesis and progression. Implication for early diagnosis, prognosis and therapy HUMANITAS Biomedical Oncology 1 Basic Translational Oncology Dominant optic atrophy (DOA) and OPAthies in Italy (ITA DOA): minimal prevalence, genetics and phenotypes, and cell models of disease towards a therapy. Ist.Sci. Neurologiche Bologna Biomedical Brain Disorders and Clinical Eco epidemiology of Mycobacterium bovis infection in Mediterranean area: a multidisciplinary approach. IZS Sicilia Biomedical Veterinary PRECLINICAL DEVELOPMENT OF THERAPEUTIC, ANTI BETA GLUCAN ANTIBODIES FOR UNIVERSAL PROTECTION AGAINST FUNGAL PATHOGENS ISS Biomedical Infectious Diseases and Microbiology Caffeine as a potential therapeutic option for Alzheimer's disease ISS Biomedical Brain Disorders and Clinical 9 Pagina 13 di 231

14 Human Ewing Sarcoma Family Tumor (ESFT) Revisited From Cancer Stem Cells (CSCs) to the Epigenetic Regulation: crosstalk between ncrna and DNA methylation Lombardia Biomedical Oncology 1 Basic Translational Oncology Potential role of HDL Cholesterol Efflux Capacity in the evaluation of cardiovascular risk in patients with Familial Hypercholesterolemia (FH) AOU San Martino IST Genova Biomedical Cardiovascular and Respiratory The low density lipoprotein associated protein prenylcysteine lyase: a novel player in atherosclerosis? MONZINO Biomedical Vascular and Hematology Constitutive Axl signaling in human melanoma: role in tumor biology and in resistance to BRAFV600E inhibitors IST.TUMORI MILANO Biomedical Oncology 1 Basic Translational Oncology Identification and validation of novel stem cell markers for the stratification of breast cancer patients. I.E.O. Biomedical Oncology 2 Translational Clinical Oncology Development of an immunotherapeutic strategy for an effective therapeutic HPV vaccine ISS Biomedical Oncology 2 Translational Clinical Oncology Towards a functional classification of human melanoma: dissecting the altered intracellular signaling profile by phosphoproteomics approaches IST.TUMORI MILANO Biomedical Oncology 1 Basic Translational Oncology 9 Pagina 14 di 231

15 Dietary advanced glycation end products and cardiovascular risk: animal and human studies ISS Biomedical Cardiovascular and Respiratory 9, CARPEDIEM Comorbidity And Risk Profiles Evaluation in Diabetes and heart Morbidities Toscana Clinical Healthcare Delivery and Methodologies 9, Inflammation and oxidative stress in preeclampsia: role of the maternal endothelium and of the placenta, potential role in early markers development Lombardia Biomedical Endocrinology, Metabolism, Nutrition and Reproductive The new biotechnologies 9, Analysis of the possible pathogenic roles of the inflammosome and the microbiota in Alzheimer's disease DON GNOCCHI Biomedical Brain Disorders and Clinical 9, Development of in vitro insulin producing biohybrid organ for the cure of type 1 diabetes Umbria Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 9, Involvement of ADAR1 and ADAR2 RNAediting activity on myeloid leukemia and myeloid cell differentiation: novel future therapeutic implications. OSPEDALE BAMBINO GESU' Biomedical Oncology 1 Basic Translational Oncology 9, Dissecting the role played by mechanotransduction on Cardiac Stem Cell and cardiomyocyte dysfunction. Friuli Venezia Giulia Biomedical Cardiovascular and Respiratory 9,5 Pagina 15 di 231

16 Phenotypic, functional and genomic characterization of bone fragility in children and adolescents and their relatives: exploring the susceptibility to fractures in youth for its prevention in adulthood SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics 9, Circulating endothelial progenitor cells as potential predictive and prognostic markers in metastatic colorectal cancer patients Toscana Biomedical Oncology 2 Translational Clinical Oncology 9, Developmental and genetic bases of Opitz G/BBB Syndrome towards better diagnosis and management of syndromic forms of intellectual disability BURLO GAROFALO Clinical Genes, Genomes and Genetics 9, A Nationwide Clinical Study on the Role of Functional HLA DPB1 Matching in Unrelated Hematopoietic Stem Cell Transplantation SAN RAFFAELE Milano Clinical Oncology 2 Translational Clinical Oncology 9, Immune therapy with T regulatory type 1 (Tr1) cells in patients with type 1 diabetes undergoing islet transplantation SAN RAFFAELE Milano Biomedical Immunology 9, The epigenetic basis of glioblastoma multiforme invasiveness and recurrence I.E.O. Biomedical Oncology 1 Basic Translational Oncology 9, Structural genomics/proteomics and solution characterization of proteins of biomedical interest: development of a comprehensive facility, application to therapeutic monoclonal antibodies, and to the fibrin(ogen) integrins cell matrix interactions model sy AOU San Martino IST Genova Biomedical Biological Chemistry and Macromolecular Biophysics Oncology 9,5 Pagina 16 di 231

17 Risk assessment of occupational and environmental exposure to benzene and other chemicals at low doses: from molecular mechanisms to biological monitoring Campania Biomedical Risk, Prevention and Health Behavior Diseases of environmental origin, with reference also to the workplace 9, Ghrelin as a new cardiometabolic risk biomarker: from population studies to tissue and cell biology in skeletal muscle and heart. Friuli Venezia Giulia Biomedical Endocrinology, Metabolism, Nutrition and Reproductive 9, Novel multi analyte point of care testing device for rapid diagnosis and management of sepsis and severe infection. Toscana Biomedical Interdisciplinary Molecular and Training 9, MicroRNA Signatures: Novel Biomarkers for early detection of Colorectal Cancer CASA SOLLIEVO SOFFERENZA Biomedical Oncology 2 Translational Clinical Oncology 9, Epigenetic signatures in human glioblastoma cells: implications for tumor biology and treatment AOU San Martino IST Genova Biomedical Oncology 1 Basic Translational Oncology 9, Regulatory mechanisms and therapeutic targeting of melanoma initiating cells Toscana Biomedical Oncology 1 Basic Translational Oncology 9, Phase IV clinical trial of anti viral treatment for Hepatitis C infection in compensated cirrhosis Sicilia Clinical Digestive, Kidney and Urological Systems 9, EXtending Computational Analysis of functional Images to define the total asset of Bone marrow and hematopoietic function in blood disordes (EXCALIBUR) AOU San Martino IST Genova Biomedical Bioengineering and Technologies Oncology 9,5 Pagina 17 di 231

18 Long term mechanisms of diabetes prevention and remission after bariatric surgery: study of glucose metabolism, insulin secretion and cardiovascular risk 7 years after Roux en Y Gastric bypass. Toscana Clinical Endocrinology, Metabolism, Nutrition and Reproductive 9, Development Of A Novel Adoptive Cell Transfer Approach (ACT) For Cancer Immunotherapy Based On The Use Of Autologous IFN DC For The Induction Of Anti Tumor Response And Implemented By Strategies Aimed At Extending The Replicative Lifespan Of The Anti Tumo ISS Biomedical Oncology 2 Translational Clinical Oncology 9, Search for new genetic biomarkers for early diagnosis and prevention of Familial Thoracic Aortic Aneurysms and Dissections Emilia Romagna Clinical Genes, Genomes and Genetics 9, Exploiting Immunoglobulin Stereotypy as a marker of prognosis and a target for therapy in Chronic Lymphocytic Leukemia SAN RAFFAELE Milano Biomedical Oncology 1 Basic Translational Oncology 9, Molecular portrait of heterogeneous lesions throughout the course of bovine tuberculosis Sardegna Biomedical Infectious Diseases and Microbiology Genomic architecture and clonal evolution of myelodysplastic syndromes and myeloproliferative neoplasms SAN MATTEO Biomedical Oncology 1 Basic Translational Oncology Engineering Commensal Bacteria for the Delivery of Therapeutic Proteins SAN RAFFAELE Milano Biomedical Bioengineering and Technologies 10 Pagina 18 di 231

19 Genetic dissection of cystic fibrosis host susceptibility to Pseudomonas aeruginosa infections using a highly genetically diverse mouse resource population, the Collaborative Cross mice SAN RAFFAELE Milano Biomedical Infectious Diseases and Microbiology Reverse transcriptase inhibitors in an innovative anticancer therapy ISS Biomedical Oncology 1 Basic Translational Oncology Disruption of white matter integrity in bipolar disorder: changes of diffusion tensor imaging measures as markers of the biological underpinnings of the progressive deterioration of cognition and of the cognitive control of emotions. SAN RAFFAELE Milano Clinical Brain Disorders and Clinical Searching for early and predictive markers of individual risk for head and neck cancer Toscana Biomedical Oncology 1 Basic Translational Oncology Optimization of plasma progranulin dosage for predicting null progranulin mutations in neurodegenerative diseases: A pilot Multicentre Italian Study for harmonization of procedures to be translated into clinical practice. FATEBENEFRATELLI Biomedical Brain Disorders and Clinical Improving social dysfunction through oxytocin administration in non human infants exposed to maternal neglect early during postnatal life ISS Biomedical Biobehavioral and Behavioral Processes 10 Pagina 19 di 231

20 IMPACT OF EXPOSURE TO ESTROGEN LIKE ENDOCRINE DISRUPTING CHEMICALS(EEDC) ON PUBERTAL DEVELOPMENT AND ESTABLISHMENT OF REFERENCERANGES FOR EXPOSITION IN CHILDHOOD. OSPEDALE BAMBINO GESU' Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Diseases of environmental origin, with reference also to the workplace Genetic factors influencing early plasma ribavirin cut off values in HCV therapy to reduce anemia toxicity and improve outcome. Piemonte Biomedical Infectious Diseases and Microbiology Effect of Ag nanoparticles in controlling Salmonella and Campylobacter in laying hens and clinical and food safety insights IZS Venezie Biomedical Veterinary Food safety and animal 10 welfare From the measure of guidelines adherence in oncology to the assessment of health system performance Lombardia Clinical Healthcare Delivery and Methodologies Oncology Innate immune response as a key factor aimed to optimize HCV patients therapy management SPALLANZANI Biomedical Immunology Tumor Infiltrating Lymphocytes (TIL) and melanoma: prognostic markers and new terapeutic targets IDI Biomedical Oncology 1 Basic Translational Oncology Targeted next generation sequencing as tool for molecular diagnosis of rare anemias Campania Biomedical Genes, Genomes and Genetics The new biotechnologies 10 Pagina 20 di 231

21 THE ROLE OF SOD1 IN THE NUCLEUS: NEW INSIGHTS INTO THE PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS (ALS) MONDINO Biomedical Molecular, Cellular, and Developmental Combining Unconventional T cells with Vaccination in Renal Cell Carcinoma Immunotherapy Puglia Biomedical Oncology 2 Translational Clinical Oncology modulation of HCN channels by GPR35 in chronic pain Toscana Biomedical Brain Disorders and Clinical DEVELOPMENT OF NOVEL ANTIBODY ENGINEERED GOLD NANOPARTICLES AS TARGETED DRUG DELIVERY FOR THE TREATMENT OF CHRONIC LUNG ALLOGRAFT DYSFUNCTION Veneto Biomedical Bioengineering and Technologies The new biotechnologies A NEW STRATEGY FOR THE CONTROL OF RHEUMATOID ARTHRITIS: DUAL ROLE OF THE ATYPICAL CHEMOTACTIC RECEPTOR CCRL2 AS A BIOMARKER AND THERAPEUTIC TARGET HUMANITAS Biomedical Immunology From lifestyle to mitochondrial benefits: study on a combined therapeutic approach to Huntington's disease ISS Biomedical Brain Disorders and Clinical New biomarkers for early SIRS/sepsis diagnosis in pediatric and adult patiens. Friuli Venezia Giulia Clinical Infectious Diseases and Microbiology 10 Pagina 21 di 231

22 Novel formula milks and neonatal gut microbiota: a dynamic interplay approached by systems biology OSPEDALE BAMBINO GESU' Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Food safety and animal welfare A Twist code of p53 inactivation in sarcomas: clinicopathological and therapeutic implications C.R.O. AVIANO Clinical Oncology 1 Basic Translational Oncology NEW ALLOCATION CRITERIA FOR LIVER TRANSPLANTATION IN PATIENTS WITH AND WITHOUT HEPATOCELLULAR CARCINOMA BASED ON TRANSPLANT BENEFIT PRINCIPLES: A MULTICENTER, PROSPECTIVE STUDY. Emilia Romagna Clinical Healthcare Delivery and Methodologies Oncology Innovative diagnostic approach for hereditary cardiomyopathies MULTIMEDICA Clinical Genes, Genomes and Genetics MOLECULAR CHARACTERIZATION OF COXIELLA BURNETII FROM DOMESTIC RUMINANTS AND WILDLIFE SPECIES BY MLVA AND NGS TECHNIQUES IZS Mezzogiorno Biomedical Infectious Diseases and Microbiology The new biotechnologies Investigating the molecular mechanisms leading to genome instability in tumours: analysis of role of the replicationstress response and its potential for early diagnosis and target therapy of cancer ISS Biomedical Oncology 1 Basic Translational Oncology Prospective Characterization of Circulating Tumor Cells in Patients with Hormone Receptor Positive Metastatic Breast Cancer I.E.O. Clinical Oncology 2 Translational Clinical Oncology 10 Pagina 22 di 231

23 IDENTIFICATION OF EPILEPTOGENIC NETWORKS IN SURGICAL EPILEPSIES BY A NON INVASIVE MULTIMODAL APPROACH CARLO BESTA Clinical Brain Disorders and Clinical Epithelial ovarian cancer: affecting tumor growth by targeting aberrant metabolism. IST.TUMORI MILANO Biomedical Oncology 2 Translational Clinical Oncology The extracellular matrix protein EMILIN1 as a novel structural and functional determinant of lymphangiogenesis and lymphedema C.R.O. AVIANO Biomedical Vascular and Hematology Oncology Nationwide study on trends in hospital admissions for major cardiovascular events and procedures among people with and without diabetes in Italy, Piemonte Clinical Healthcare Delivery and Methodologies Effects of Tumor associated Fibroblast and hypoxia on the availability of efficient NK cells within the tumor core: characterization of molecular targets for therapy in melanoma and colon cancer. AOU San Martino IST Genova Biomedical Immunology Oncology In vivo toxi omic signatures for brain and thyroid function: combined exposure to mixtures of endocrine disruptingchemicals and iodine deficiency in animal models and translation to epidemiological/clinical studies ISS Biomedical Endocrinology, Metabolism, Nutrition and Reproductive Diseases of environmental origin, with reference also to the workplace Non invasive assessment of liver steatosis and fibrosis in pediatric patients SAN MATTEO Clinical Digestive, Kidney and Urological Systems 10 Pagina 23 di 231

24 MicroRNA Signature of Vascular Complications in Type 1 Diabetes Piemonte Biomedical Cardiovascular and Respiratory HPV positive oropharyngeal cancer: characterization of immunological and viral profiles, and their role in the response to treatment SAN MATTEO Clinical Oncology 2 Translational Clinical Oncology Breast cancer with low risk of local recurrence: 3D Conformal Accelerated and Hypofractionated Partial Breast Irradiation vs. standard whole breast radiotherapy after conservative surgery Emilia Romagna Clinical Oncology 2 Translational Clinical Oncology The complement and coagulation systems as therapeutic targets in subarachnoid hemorrhage: studies in patients and in experimental models. MAGGIORE Biomedical Brain Disorders and Clinical RESPONSE ORIENTED MAINTENANCE IMMUNOTHERAPY IN PATIENTS WITH FOLLICULAR LYMPHOMA. Emilia Romagna Clinical Oncology 2 Translational Clinical Oncology Comparative analysis of genomic and epigenomic alterations induced by leukemogenic AML1 fusion proteins I.E.O. Biomedical Oncology 1 Basic Translational Oncology Genetic markers in elderly to estimate the risk for vascular diseases by using the peripheral arterial disease model. Sicilia Biomedical Genes, Genomes and Genetics 10,25 Pagina 24 di 231

25 A phase II, randomised, placebo controlled trial of neuroprotection with Raltegravir in Secondary Progressive Multiple Sclerosis ISS Biomedical Brain Disorders and Clinical 10, Implementation of Chronic Care Model, using Tele care and Home care, in patients with multiple comorbidities: evaluation of the cost effectiveness and quality of life Toscana Clinical Healthcare Delivery and Methodologies 10, A multi site international RCT comparing regional and general anesthesia in infants for effects on neurodevelopmental outcome at five year of age: The GAS Trial. GASLINI Clinical Brain Disorders and Clinical 10, Muscle imaging in neuromuscular disorders: conventional, high and ultrahigh field imaging studies for coming into a focus STELLA MARIS Biomedical Bioengineering and Technologies The new biotechnologies 10, The molecular basis of cognitive impairment in Williams Beuren Syndrome: a cell reprogramming based approach CASA SOLLIEVO SOFFERENZA Biomedical Genes, Genomes and Genetics 10, Naturally occurring and re programed cancer stem cells in ovarian carcinoma: functional role and clinical implications. I.E.O. Biomedical Oncology 1 Basic Translational Oncology 10, Autonomic cardiovascular evaluation in low respiratory tract infections MAGGIORE Biomedical Cardiovascular and Respiratory 10, Assessing colorectal cancer risk: are DNA viruses and genetic damage in circulating cells valuable biomarkers? Emilia Romagna Biomedical Oncology 1 Basic Translational Oncology 10,5 Pagina 25 di 231

26 Genomic approach for motor neuron diseases SAN RAFFAELE Milano Clinical Brain Disorders and Clinical 10, TRAIL producing UC MSCs as cytotherapy to defeat multiple myeloma: a preclinical study. ONCOLOGICO DI BARI Biomedical Oncology 2 Translational Clinical Oncology 10, Paratuberculosis in sheep and goats herds in Calabria and human exposure to Mycobacterium avium subspecies paratuberculosis (MAP) trough dairy products IZS Mezzogiorno Biomedical Veterinary Food safety and animal 10,5 welfare Surveillance of the circulation of rotaviruses in the infantile population of Sicily following the introduction of rotavirus vaccination Sicilia Biomedical Infectious Diseases and Microbiology 10, Investigation on the sensitivity of dorsal raphe serotonergic neurons to hypercapnic stimuli in a transgenic mouse model of Sudden Infant Death Syndrome (SIDS) characterized by selective alteration of serotonergic neuron autoinhibition. Toscana Biomedical Brain Disorders and Clinical 10, Project Title: Endoscopic Screening and oncologic appropriate removal of Early colorectal lesions. ENDOSCREEN Piemonte Biomedical Surgical, Biomedical Imaging, and Bioengineering The new biotechnologies 10, Studying the tumor microenvironment to find new therapeutic targets and strategies in Hodgkin lymphoma:the role of Mesenchymal stem cells C.R.O. AVIANO Biomedical Oncology 1 Basic Translational Oncology 10,5 Pagina 26 di 231

27 High throughput mutation profiling of Sézary Syndrome: implications for pathogenesis, classification, and potential therapeutic developments. IDI Biomedical Oncology 1 Basic Translational Oncology 10, METABOHEARTFAIL GRAPE mirnas IN REVERSING REMODELING THROUGH MODULATION OF CARDIAC AQUAPORIN 7 AND GLYCEROL UPTAKE IN A SWINE MODEL OF NON ISCHEMIC CHRONIC HEART FAILURE Toscana Biomedical Cardiovascular and Respiratory 10, Brain Mechanisms of Chronic Subjective Dizziness SANTA LUCIA Biomedical Integrative, Functional, and Cognitive 10, TRIMming away HIV 1. infection Role of TRIM proteins in establishement and maintenance of HIV 1 latency SAN RAFFAELE Milano Biomedical AIDS and Related Research 10, GISSI Outliers The CAPIRE (Coronary Atherosclerosis in outlier subjects: Protective and Individual Risk factor Evaluation) study The Life Style sub study MAUGERI Biomedical Risk, Prevention and Health Behavior 10, Exploiting neural stem cell targeted mouse models for improving the understanding of the pathogenetic mechanisms underlying Tuberous Sclerosis Complex and developing novel therapeutic approaches. SAN RAFFAELE Milano Biomedical Brain Disorders and Clinical 10, Cell senescence and age dependent decrease in heart function: role of HMGB1 protein IDI Biomedical Biology of Development and Aging 10,5 Pagina 27 di 231

28 Understanding Pancreatic Acinar Cell Carcinoma for better understanding Pancreatic Ductal Carcinoma SAN RAFFAELE Milano Biomedical Oncology 1 Basic Translational Oncology 10, Development of a service interface method ( WebService) beetween family care physicians operating in a primary care setting and nephrologists, for the prevention, diagnosis and treatment of kidney damage in patients with type II diabetes mellitus. Toscana Clinical Digestive, Kidney and Urological Systems 10, Containment of a region wide outbreak of Carbapenem resistant Klebsiella pneumoniae in seven lombardian hospital: molecular characterization, epidemiology and outcome. Lombardia Clinical Infectious Diseases and Microbiology 10, Dynamics of epigenetic landscape during phase specific colorectal cancer reprogramming of stem cells and tissues in a murine stress related carcinogenesis model and human tumor biopsies. CASA SOLLIEVO SOFFERENZA Biomedical Oncology 1 Basic Translational Oncology 10, MicroRNAs regulated by mutated p53 oncoproteins in colon cancer REGINA ELENA Biomedical Oncology 1 Basic Translational Oncology 10, Genetic manipulation of embryonic stem cells and induced pluripotent stem cells (ES and ips) for endorsing cardiac fate toward beating cardiomyocytes: novel strategies for cardiac regeneration in myocardial infarction. NEUROMED Biomedical Cardiovascular and Respiratory 10,5 Pagina 28 di 231

29 Food safety of bivalve molluscs: Development and application of molecular tools for identification, quantification and evaluation of antibiotic resistance and virulence potential of food associated enteric and autochthonous bacterial pathogens IZS Umbria e delle Marche Biomedical Veterinary Food safety and animal 10,5 welfare MicroRNA regulation in the pathogenesis of MD and in the mechanism of action of antidepressant drugs FATEBENEFRATELLI Biomedical Biobehavioral and Behavioral Processes 10, Dissecting the genetic etiology of epileptic encephalopathies by high throughput sequencing GASLINI Biomedical Brain Disorders and Clinical 10, Heterotypic interactions in thromboinflammatory processes associated with the thrombotic vascular occlusion in sepsis:the role of vitamin K dependent protein C SAN RAFFAELE Milano Biomedical Immunology 10, Pre clinical evaluation of safety and efficacy of intra arterial infusion of mesenchymal stems cells in experimental models ofneurodegenerative parkinsonisms and analysis of potential therapeutic mechanisms: en route for a clinical trial MONDINO Biomedical Brain Disorders and Clinical 10, One or more beta amyloids? Links between amyloid composition and phenotypic heterogeneity in Alzheimer's disease: implications for diagnosis and therapy CARLO BESTA Biomedical Brain Disorders and Clinical 10,5 Pagina 29 di 231

30 Genetic variability of Mycobacterium tuberculosis and its implications for transmission dynamics, pathogenesis and immune response SPALLANZANI Clinical Infectious Diseases and Microbiology 10, PHARMACOGENOMICS OF HYPERTENSION: A NEW APPROACH FOR A PERSONALIZED MEDICINE SAN RAFFAELE Milano Clinical Digestive, Kidney and Urological Systems 10, Regulation of SMN2 splicing: implications for novel therapeutic approaches to Spinal Muscular Atrophy SANTA LUCIA Biomedical Molecular, Cellular, and Developmental 10, From breast to brain: study of the molecular mechanisms mediating the development of brain metastasis I.E.O. Biomedical Oncology 1 Basic Translational Oncology 10, Role of mast cells in the pathogenesis of diabetic heart disease. SAN RAFFAELE Milano Biomedical Cardiovascular and Respiratory 10, Investigation on the role of iron and mitochondria in neurodegenerative disorders through the development of new human neuronal cellular systems CARLO BESTA Biomedical Brain Disorders and Clinical 10, A new predictive assay to assess the efficacy of combinatorial treatments against stem cells enriched cultures from metastatic melanoma patients PASCALE Biomedical Oncology 1 Basic Translational Oncology 10, Rethinking neuroinflammation in sporadic AD: exploring novel pathways to boost endogenous neuroprotective mechanisms ISS Biomedical Brain Disorders and Clinical 10,5 Pagina 30 di 231

31 Structural imaging in systemic amyloidosis: an inescapable step toward the optimization and validation of more effective therapeutic approaches SAN MATTEO Biomedical Biological Chemistry and Macromolecular Biophysics 10, DEVELOPMENT OF AN EXOSOME BASED IN VIVO TEST TO DETECT PRIONS IN BLOOD IZS Piemonte, Liguria e Valle d'aosta Biomedical Veterinary Food safety and animal 10,5 welfare Development of miniaturized assays for the timely diagnosis of rare diseases Piemonte Biomedical Musculoskeletal, Oral and Skin The new biotechnologies 10, Rescue of Transforming Growth Factorbeta 1 signaling as a new strategy for neuroprotection in Alzheimer's disease: role of antidepressant drugs OASI MARIA S.S. Biomedical Brain Disorders and Clinical 10, Unravelling the genetic basis of variable clinical expression in NF1: use of an integrated next generation sequencing platform to identify novel disease causing and modifier genes. CASA SOLLIEVO SOFFERENZA Biomedical Genes, Genomes and Genetics Oncology 10, MITOCHONDRIA AND AUTOPHAGY IN DEGENERATIVE SYNAPSES SANTA LUCIA Biomedical Molecular, Cellular, and Developmental 10, Evaluation of the efficacy of Rapamycin and a DPP 4 inhibitor (Vildagliptin) in improving beta cell function in type 1 diabetes of long duration, a perspective randomized study SAN RAFFAELE Milano Clinical Endocrinology, Metabolism, Nutrition and Reproductive 11 Pagina 31 di 231

32 Long term exposure to ambient air pollution and pregnancy outcomes in women of three large Italian longitudinal studies Lazio Clinical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace Evaluation of anti NA antibodies as possible correlates of protection from influenza disease: development of serological assays designed to detect a truly functional antibody response to influenza vaccination, with specific regard to the anti NA ISS Biomedical Immunology Senescence Associated micrornas (SAmiRs) in cellular senescence and organismal aging SDN Biomedical Biology of Development and Aging Postural sway and facial mimicry as behavioral markers of covert motor symptoms in Parkinson's disease in a new differential early diagnostic protocol. SANTA LUCIA Biomedical Biobehavioral and Behavioral Processes The use of top soils improvers from municipal wastewater treatment plants, on pasture: risk assessment of the associated microbial and organic chemical contamination on grazing food producing animals, and on food safety and food security (SOIL SAFE) ISS Biomedical Veterinary Food safety and animal 11 welfare Fighting impaired blood flow and supporting skeletal muscle regeneration in diabetes and peripheral artery disease (PAD): an approach based on unacylated ghrelin (UAG) administration Piemonte Biomedical Vascular and Hematology 11 Pagina 32 di 231

33 'Septosomes': System Biology and Pathogenetic Role of Exosomes in Sepsisassociated Immune paralysis and Organ Failures Piemonte Biomedical Immunology Use of Limbal Adult Stem Cells for Osteo and Condrocyte Differentiation and Application in Bone and in Cartilage Regeneration and Tissue Engineering (ABADIR PROJECT) Sicilia Biomedical Endocrinology, Metabolism, Nutrition and Reproductive The new biotechnologies Dissecting the pathogenesis and possible reversibility of cachexia in end stage chronic heart failure Sicilia Biomedical Musculoskeletal, Oral and Skin Transcriptomic profiling in circulating mesenchymal stem cells of patients with degenerative diseases. Veneto Biomedical Genes, Genomes and Genetics Fertility preservation in gonadotoxic treatments Emilia Romagna Clinical Oncology 2 Translational Clinical Oncology Co transcriptional and post transcriptional regulation of gene expression by EWS and EWS FLI1 in the pathogenesis of Ewing's Sarcoma SANTA LUCIA Biomedical Oncology 1 Basic Translational Oncology Identification of new therapeutical targets of cancer stem cells: study of the mechanistics of mitotic spindle alignment to cortical polarity in mammary stem cell asymmetric divisions I.E.O. Biomedical Biological Chemistry and Macromolecular Biophysics Oncology 11 Pagina 33 di 231

34 Early treatment of exercise induced pulmonary hypertension in systemic sclerosis Toscana Clinical Immunology TRAIL receptor embedding in membrane rafts could predict cancer cell susceptibility to TRAIL based molecularly targeted therapy ISS Clinical Oncology 2 Translational Clinical Oncology A translational approach to hereditary neuropathies AOU San Martino IST Genova Biomedical Molecular, Cellular, and Developmental Cord blood expanded endothelial progenitors in patients with no option critical limb ischemia. Lazio Biomedical Vascular and Hematology Screening for Autoimmune Polyglandular Syndrome Type 2 in patients with autoimmune thyroiditis: definition of methodology and cost benefit analysis. Toscana Clinical Endocrinology, Metabolism, Nutrition and Reproductive Imaging the fate of stem cells in vivo by near infrared technology: a translational study for longitudinal tracking in a rodent model of Parkinsons disease AUXOLOGICO Biomedical Emerging Technologies and Training in s The new biotechnologies Treatment of therapy refractory cancer in patients affected by Swachman Diamond syndrome or related inherited diseases due to alterations of the ribosomal apparatus. SAN RAFFAELE Milano Biomedical Genes, Genomes and Genetics Oncology 11 Pagina 34 di 231

35 The role of CRPs and SIRTs in modulating cellular stress response after myocardial infarction. SAN RAFFAELE Pisana Roma Biomedical Cardiovascular and Respiratory Early identification of left ventricular dysfunction due to anthracyclines and target therapy: role of novel imaging techniques and microrna. PASCALE Biomedical Cardiovascular and Respiratory Oncology Clinical and healthcare strategies for improving quality of life in persons affected by spinal cord injuries: Tuscany regionalnetwork and use of innovative technological devices Toscana Clinical Healthcare Delivery and Methodologies Follow up study of the relationship between telomere length and the onset of diabetic complications I.N.R.C.A. Biomedical Endocrinology, Metabolism, Nutrition and Reproductive NETWORK DEGENERATION IN MOTOR NEURON DISEASES (MND): A STUDY OF THE STRUCTURAL AND FUNCTIONAL CONNECTOMES IN AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MND SAN RAFFAELE Milano Clinical Brain Disorders and Clinical Investigation of genetic molecular mechanisms underlying the risk of cardiovascular events: role of rs5065 human atrial natriuretic peptide gene variant NEUROMED Biomedical Genes, Genomes and Genetics A new vaccine design to eliminate CCR5 expression and prevent HIV infection SAN RAFFAELE Milano Biomedical AIDS and Related Research 11 Pagina 35 di 231

36 Identification of Determinants of Healthy Aging in Italy (IDAGIT) CARLO BESTA Clinical Population and Epidemiology Diseases of environmental origin, with reference also to the workplace Enhancement of NKG2D ligands induced anti tumor response in Hodgkin and non Hodgkin lymphomas: ERp5 thiol isomerase and ADAM10 disintegrin metalloproteinase as possible therapeutic targets. SAN RAFFAELE Milano Biomedical Immunology Oncology Integrated diagnostic evaluation of PET/RM and molecular markers in the diagnosis of bone lesions SDN Clinical Oncology 2 Translational Clinical Oncology Next Generation Sequencing (NGS): from basic research to diagnostic tool for nephrotic syndrome. Puglia Biomedical Genes, Genomes and Genetics The new biotechnologies Characterization of the role of Mycobacterium avium subspecies paratuberculosis (Map) as a trigger in Type 1 Diabetes Sardegna Biomedical Infectious Diseases and Microbiology Development and evaluation of Influenza Virus Polymerase Inhibitors for combination antiviral therapy ISS Biomedical Infectious Diseases and Microbiology MECHANISMS REGULATING DENDRITIC CELL PROTUMORAL ACTIVITY WITHIN THE HYPOXIC MICROENVIRONMENT: POTENTIAL THERAPEUTIC APPLICATIONS IN NEUROBLASTOMA GASLINI Biomedical Oncology 1 Basic Translational Oncology 11 Pagina 36 di 231