Ministero della Salute

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1 Ministero della Salute Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti BANDO 2010 RICERCA FINALIZZATA GRADUATORIA PROGETTI ORDINARI Role of circulating and tissutal markers of low grade chronic inflammation for defining the clinical phenotype of complicated obesity MAUGERI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 4, mir 221&222/miR 126&126* interconnected networks: novel molecular markers and potential therapeutic values in melanoma. Istituto Superiore di Sanita' Oncology 1 Basic 4, Toward Chronic Lymphocytic Leukemia (CLL): dissecting the role of genetic lesions in Monoclonal B cell Lymphocytosis (MBL) through a genome wide sequencing approach Oncology 1 Basic 4, EMILIN1 in tumor microenvironment: role in neoplastic growth and lymphatic spread C.R.O. AVIANO Oncology 1 Basic 4, Immunotherapy with dendritic cells loaded with cancer stem like cells: a phase I study in glioblastoma CARLO BESTA Oncology strategy for developing rationale combinations of molecularly targeted agents in primary refractory Hodgkin lymphoma Piemonte Oncology TUMOR ASSOCIATED MACROPHAGES: NEW MARKERS FOR MOLECULAR TARGETING HUMANITAS Oncology 1 Basic Pagina 1 di 142

2 STUDIES ON THE INVOLVEMENT OF GENETIC, EPIGENETIC AND ENVRINOMENTALFACTORS IN THE PATHOGENESIS OF CONGENITAL HYPOTHYROIDISM.NOVEL PERSPECTIVES FOR THE MANAGEMENT OF A LARGELY UNEXPLAINED DISORDER AUXOLOGICO Endocrinology, Metabolism, Nutrition and Reproductive Sciences Therapeutic potential and safety assessment of induced dopaminergic neuronal (idan) cells directly reprogrammed from adult skin fibroblasts Molecular, Cellular, and Developmental Exploiting immune cross reactivity to influenza viral antigens for successful pre pandemic vaccines. Istituto Superiore di Sanita' Immunology Recovery of cholinergic neurotransmission dysfunction in DYT1 dystonia SANTA LUCIA Brain Disorders and The role of hypoxia in regulating micrornas and target genes in cancer biology: identification of new therapeutic targets Istituto Superiore di Sanita' Oncology 1 Basic Gene therapy for thalassemia: preclinical studies of efficacy and safety Genes, Genomes and Genetics Plasma microrna profiling as first line screening test for lung cancer detection: a prospective study ISTITUTO TUMORI MILANO Oncology Building a state of the art whole room indirect calorimeter, a tool to accurately investigate the role of energy expenditure and substrate oxidation in endocrine and metabolic disorders Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 5, Italian Network for autosomal dominant Alzheimer s disease and frontotemporal lobar degeneration FATEBENEFRATELLI Brain Disorders and 5, Volatile anesthetics to reduce mortality in cardiac surgery. A multicentre randomized controlled study. Surgical Sciences, Biomedical Imaging, and Bioengineering 5, Thrombolysis in Minor Stroke Emilia Romagna Brain Disorders and 5, Pagina 2 di 142

3 The Renal Damage Risk Study in children with Vesico Ureteral Reflux grade III to V Emilia Romagna Digestive, Kidney and Urological Systems 5, Effect of supervised exercise training on risk of fractures in subjects with type 2 diabetes Lazio Endocrinology, Metabolism, Nutrition and Reproductive Sciences 5, Assessment of short and long term risk benefit profile of biologics through healthcare database network in Italy Sicilia Population Sciences and Epidemiology 5, Modulation of metabolic mechanisms in muscle loss disorders: involvement of autophagy and apoptosis. SAN RAFFAELE PISANA Musculoskeletal, Oral and Skin Sciences 5, Oculo auriculo vertebral spectrum: use of an integrated high throughput platform to identify the disease causing genes and implications in clinical diagnostics CASA SOLLIEVO SOFFERENZA Genes, Genomes and Genetics 5, NEW THERAPEUTICS AND IMMUNOGENS GENERATED BY INCORPORATING SHORT RNAs AND PROTEIN ANTIGENS IN EXOSOMES Istituto Superiore di Sanita' Bioengineering Sciences and Technologies 5, A multidisciplinary study to investigate the molecular bases of hereditary tubulointerstitial nephritis Digestive, Kidney and Urological Systems 5, Biomolecular and functional analysis of pathogenetic mechanisms of neuropathic pain in genetic and acquired small fibre neuropathies. Istituto Scienze Neurologiche Molecular, Cellular, and Developmental 5, IDENTIFICATION OF GENES FOR RARE DEVELOPMENTAL DISORDERS BY NEXT GENERATION SEQUENCING GASLINI Genes, Genomes and Genetics 5, Alternative splicing as a tool to develop novel diagnostic and therapeutic approaches to control cancer growth. MAUGERI Oncology 1 Basic 5, (2) Neuropsychological, neurofunctional and epigenetic effects of structured group patient education in type 2 diabetes. Piemonte Endocrinology, Metabolism, Nutrition and Reproductive Sciences 5, Pagina 3 di 142

4 TRANSLATING MELANOMA EPIGENETICS IN THE NICAL SETTING OF COMBINED CHEMO IMMUNOTHERAPIES Toscana Oncology 2 5, RH Project: Advanced Serological and Molecular Investigation for the RhD Variants Definition Lazio Cell Biology IL 6 related inflammation signatures as a predictive marker of recurrence in liver cancer patients ISTITUTO TUMORI MILANO Oncology THE ITALIAN REGISTRY FOR MYOTONIC DYSTROPHIES SAN DONATO Population Sciences and Epidemiology Repetitive TMS modulation of the default mode network to clarify the pathophysiology of Alzheimer s disease and prompt a new therapeutic perspective SANTA LUCIA Brain Disorders and PHASE I/II TRIAL OF NOGA GUIDED ENDOCAVITARY INJECTION OF BONE MARROW DERIVED CD133+ CELLS IN ISCHEMIC REFRACTORY CARDIOMYOPATHY (RECARDIO TRIAL) MONZINO Cardiovascular and Epigenetic drugs for human diabetic foot ulcer treatment ISTITUTO DERMOPATICO DELL'IMMACOLATA Musculoskeletal, Oral and Skin Sciences And yet they MOve: immobile patients re enter the physical world through embodiment in avatar or robot surrogates SANTA LUCIA Biobehavioral and Behavioral Processes IS DES ACYL GHRELIN THE KEY MEDIATOR OF KETOGENIC DIET? Emilia Romagna Brain Disorders and B7.1 on podocytes: a new therapeutic target for diabetic nephropathy Digestive, Kidney and Urological Systems Development and preclinical validation of a nanotechnological platform that targets the minimal residual disease (MRD) in Cancer Calabria Oncology Pagina 4 di 142

5 FSHD muscular dystrophy: molecular pathogenesis and prospects for therapy. Genes, Genomes and Genetics Relevance of the CD4+ T lymphocytes and synoviocytes cross talk in the pathogenesis of human rheumatoid arthritis and juvenile idiopathic arthritis diseases. Toscana Immunology Improving balance through gravity cues embedded in free falling target SANTA LUCIA Biobehavioral and Behavioral Processes Molecular mechanisms underlying the skin inflammation triggered by Epidermal Growth Factor inhibitors and search for molecular targets for its correction ISTITUTO DERMOPATICO DELL'IMMACOLATA Musculoskeletal, Oral and Skin Sciences Mechanisms of neurodegeneration and phenotypic heterogeneity in inherited prion diseases: physiopathological involvement of prion proteins in membrane trafficking and signaling Lombardia Brain Disorders and "Epigenetic mechanisms in the control of viral transcription/replication in chronic HBV patients antiviral treatments: an integrated approach to the new biomarkers identification and rational clinical decisions. MAGGIORE Digestive, Kidney and Urological Systems Humanized tumor mice: a new model that improves translational biomedical research to develop new personalized therapies in ovarian cancer. PASCALE Oncology 1 Basic Cognitive efficiency and functional connectivity across the lifespan. Is there a signature of abnormal cognitive decline? S.CAMILLO Brain Disorders and THE IRON INFLAMMATION LIPID CONNECTION REVEALED BY HEPCIDIN REGULATION STUDIES: RELEVANCE FOR THE CORRESPONDING NICAL DISORDERS Vascular and Hematology Separation anxiety, CO2 Hypersensitivity and Panic: Epigenetic Mechanisms in Response to Adversities in Animal and Man Population Sciences and Epidemiology Pagina 5 di 142

6 MECHANISMS OF VASCULAR DYSFUNCTION IN OBESITY RELATED METABOLIC SYNDROME. Lazio Vascular and Hematology 6, Phenotyping COPD patients and assessing disease severity by means of a standardized model Toscana Cardiovascular and 6, The use of OXT as adjunctive therapy for the treatment of schizophrenia: a randomized, double blind trial FATEBENEFRATELLI Biobehavioral and Behavioral Processes 6, Identification and validation of new therapeutic targets in Acute Myeloid Leukaemia I.E.O. Oncology 1 Basic 6, Pancreas transplantation in type 1 diabetic patients revealed a potential novel stem cell based mechanism that revert diabetic enteropathy Digestive, Kidney and Urological Systems 6, Genetics of Hearing loss: from basic research to clinical applications BURLO GAROFALO Genes, Genomes and Genetics 6, Mapping progressive neurodegeneration in amyotrophic lateral sclerosis (ALS): a multiparametric study combining clinical, cognitive, genetic, and neuroimaging assessment to identify predictors of ALS evolution Brain Disorders and 6, A PERSONALIZED MEDICAL APPROACH TO TREAT BACTERIAL INFECTIONS IN PATIENTS WITH LIVER CIRRHOSIS. Emilia Romagna Digestive, Kidney and Urological Systems 6, CAPNAF FD. A Computer Assisted Procedure for Nasal Air Flow assessment with modern Fluid Dynamics techniques. applications: individual surgical planning of nasal breathing difficulties treatment aimed at optimizing surgical procedures towards max Lombardia Surgical Sciences, Biomedical Imaging, and Bioengineering 6, Novel markers based on autophagy proteins in Parkinson's disease NEUROMED Brain Disorders and 6, Genotype phenotype characterization of the pathogenetic expansion of the C9ORF72 gene in a large series of Italian familial and sporadic ALS patients Piemonte Brain Disorders and 6, Pagina 6 di 142

7 Investigation on the sensitivity of dorsal raphe serotonergic neurons to hypercapnic stimuli in a transgenic mouse model of Sudden Infant Death Syndrome (SIDS) characterised by selective alteration of serotonergic neuron autoinhibition. Toscana Molecular, Cellular, and Developmental 6, Mechanisms of diabetes resolution after bariatric surgery: role of the gut Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 6, Regulation of mitotic transitions I.E.O. Cell Biology 6, Development of new experimental models for intellectual disabilities syndromes studying IL1RAPL1 function in synapse formation CARLO BESTA Molecular, Cellular, and Developmental 6, ALZHEIMER'S DISEASE LYSOSOMAL ENZYMES: NEW DIAGNOSTIC AND THERAPEUTIC TOOLS Umbria Brain Disorders and 6, Pathogenesis, diagnosis and course of familial and sporadic Alzheimer s disease and Frontotemporal Lobar Degeneration: epigenetics and proteomics as new tools for disease mechanisms and biomarker discovery MAGGIORE Brain Disorders and 6, Liver targeted cell therapy: applications to experimental Glycogen Storage Disease type 1a GASLINI Genes, Genomes and Genetics 6, Tipping the balance between adaptive/maladaptive endoplasmic reticulum stress responses to counter degenerative and storage diseases Cell Biology 6, Neural and behavioural recovery based on Rho GTPases modulation in a mouse model of Rett syndrome Istituto Superiore di Sanita' Brain Disorders and 6, DRUG TRANSPORTERS AND RESISTANCE TO TREATMENT OF OVARIAN CARCINOMA ISTITUTO TUMORI MILANO Oncology 2 6, Pagina 7 di 142

8 Structural genomics/proteomics and solution characterization of proteins of biomedical interest: development of a comprehensive facility, application to therapeutic monoclonal antibodies quality control, and to the fibrin(ogen) integrins cell matrix inter IRCCS AOU San Martino IST (Genova) Biological Chemistry and Macromolecular Biophysics 6, A phase I II clinical trial with central memory donor T cells expressing a suicide gene in the context of haploidentical hematopoietic stem cell transplantation for the treatment of chemoresistant acute leukemia. Oncology 2 6, The role of DNA repetitive elements mobilization in DMD pathogenesis, progression and treatment SANTA LUCIA Genes, Genomes and Genetics 6, Molecular regulation of the redox switch in inflamed skeletal muscle as a novel target to implement muscle regeneration and limit fibrosis in immune mediated myositis Musculoskeletal, Oral and Skin Sciences 6, Assessment of safety parameters in cultured mesenchymal stromal cells for use in regenerative medicine. Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Veterinary 6, Search for genetic risk factors in sporadic Amyotrophic Lateral Sclerosis by exome sequencing in patients with a distinct phenotype. SAN RAFFAELE PISANA Brain Disorders and 6, Characterization of human amniotic mesenchymal stem cells (ha MSCs) isolated from obese women at delivery to identify gene or protein alterations predisposing the newborn to obesity. SDN Endocrinology, Metabolism, Nutrition and Reproductive Sciences 6, Prognostic value of a combined panel of soluble and genetic biomarkers in patients with early arthritis RIZZOLI Musculoskeletal, Oral and Skin Sciences Reorganization of cortical function after surgery for lesional epilepsy in children Toscana Brain Disorders and GRID based System for the Evaluation of the effects of Cognitive Rehabilitation in Patients with Alzheimer s Disease and Parkinson s Disease SAN RAFFAELE PISANA Brain Disorders and Pagina 8 di 142

9 Improving strategies for preventing pertussis in infants OSPEDALE BAMBINO GESU' Infectious Diseases and Microbiology Mutations in ANKRD26 cause a novel inherited thrombocytopenia at risk of developing acute leukemia: dissecting the clinical and molecular consequences of ANKRD26 mutations to better understand the mechanisms of both thrombocytopenia and leukemia SAN MATTEO Genes, Genomes and Genetics Extracorporeal Life Support in Acute Respiratory Distress Syndrome (ELSA) Lombardia Cardiovascular and SALUTE CKD (SALt lowering by Urine sodium selfmeasurement Trial in Chronic Kidney DiseasE) Calabria Risk, Prevention and Health Behavior Anterior Cruciate Ligament Reconstruction: biomechanical modeling for treatment selection to prevent Osteoarthritis RIZZOLI Musculoskeletal, Oral and Skin Sciences Peptides from lactoferrin as new therapeutic agents against Influenza virus infection Istituto Superiore di Sanita' Infectious Diseases and Microbiology To unravel the molecular basis of neurodevelopmental disorders CASA SOLLIEVO SOFFERENZA Genes, Genomes and Genetics Role of APOBEC1 in the initiation and progression of cancer Toscana Oncology 1 Basic Angelman Syndrome: a clinical and functional imaging, molecular and biochemical investigation to uncover new therapeutic strategies MEDEA Brain Disorders and Epidrugs and cardiac differentiation: relevance for the 22q11.2 deletion syndrome NEUROMED Cardiovascular and Inflammation and oxidative stress in preeclampsia: role of the maternal endothelium and of the placenta potential role in early markers development Lombardia Biology of Development and Aging Dissection of metabolic pathways involved in therapeutic plasticity of mesenchymal stem cells IRCCS AOU San Martino IST (Genova) Immunology Pagina 9 di 142

10 Enhanced cell proliferation for muscle repair and regenerative medicine Istituto Superiore di Sanita' Musculoskeletal, Oral and Skin Sciences Cytokines as biomarkers of disease and therapeutic targets in laminopathies RIZZOLI Biology of Development and Aging Mitochondrial targeting in LRRK2 associated parkinsonism (PARK8) SANTA LUCIA Brain Disorders and A novel anti CXCR4 drug RFF 1: a Phase I/II clinical trial. PASCALE Oncology PRENICAL DEVELOPMENT OF THERAPEUTIC, ANTI BETA GLUCAN ANTIBODIES FOR UNIVERSAL PROTECTION AGAINST FUNGAL PATHOGENS Istituto Superiore di Sanita' Infectious Diseases and Microbiology Towards a functional classification of human melanoma: dissecting the altered intracellular signaling profile by phosphoproteomics approaches. ISTITUTO TUMORI MILANO Oncology 1 Basic Skeletal muscle in Spinal and Bulbar Muscular Atrophy (SBMA): therapeutic target and delivery route for potential treatments Veneto Brain Disorders and A translational approach to restrain local recurrence in early breast cancer patients C.R.O. AVIANO Oncology 1 Basic CCL2/CCR2 BLOCKING: MOLECULAR INSIGHTS INTO A POTENTIAL THERAPEUTIC STRATEGY AGAINST HIV REPLICATION Istituto Superiore di Sanita' AIDS and Related Research Production of novel diagnostic and therapeutic antibodies directed against stem cells in colorectal and lung cancer REGINA ELENA Oncology Investigating the molecular mechanisms leading to genome instability in tumours: analysis of role of the replication stress response and its potential for early diagnosis and target therapy of cancer Istituto Superiore di Sanita' Oncology 1 Basic Pagina 10 di 142

11 Dysregulated RNA metabolism in multiple myeloma. Oncology 1 Basic Adoptive immunotherapy for the prevention of Hepatitis C Virus (HCV) recurrence after liver transplantation Sicilia Infectious Diseases and Microbiology Interaction between genetic and epigenetic variation of BDNF on cognition, brain activity and risk for schizophrenia CASA SOLLIEVO SOFFERENZA Brain Disorders and Identification of new genes involved in the pathogenesis of rare congenital hemolytic anemias. MAGGIORE Genes, Genomes and Genetics 7, Innovative molecular platform for tick borne diseases: suspension array and pyrosequencing for the rapid, accurate and cost effective multi pathogen detection in ticks and biological samples Istituto Zooprofilattico Sperimentale delle Venezie Veterinary 7, IDENTIFICATION OF INNOVATIVE MARKERS AND TECHNOLOGIES FOR SCREENING, DIAGNOSIS AND PROGNOSTIC EVALUATION OF PROSTATE CANCER: CORRELATION WITH ESTABLISHED NICAL PARAMETERS MULTIMEDICA Oncology 2 7, (2) From carcinogenesis to tumor progenitor cells: mirnaome/methylome reprogramming impact on diagnostic and therapeutic innovative options in colorectal cancer CASA SOLLIEVO SOFFERENZA Oncology 1 Basic 7, Immunological monitoring of advanced cancer patients undergone active specific immunotherapy with a new anti cancer poly peptide vaccine directed against the thymidylate synthase enzyme. Toscana Oncology 2 7, Integrated program of clinical research to reduce the mortality rate of patients on the waiting list for lung transplantation Piemonte Cardiovascular and 7, White Blood Cells expression profiles as a tool for predicting Metformin Efficacy in Patients with Type 2 Diabetes CASA SOLLIEVO SOFFERENZA Genes, Genomes and Genetics 7, Pagina 11 di 142

12 Evaluation of interaction between NK cells and colorectal carcinoma cells for development of NK cellbased immunotherapy in patients with refractory disease SAN MATTEO Oncology 2 7, Role of estrogen receptors in the pathogenesis and response to treatment of chronic lymphocytic leukemia Istituto Superiore di Sanita' Oncology 1 Basic 7, Innovative approaches for the treatment of Pompe disease: characterization and identification of potential therapeutic targets in patients with the splicing c T>G common mutation and pharmacological chaperoning of alpha glucosidase Friuli Venezia Giulia Genes, Genomes and Genetics 7, Aedes albopictus in northern Italy: molecular markers and mathematical models to predict its potential future spread and the impact of control strategies Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Veterinary 7, Role of the RNA binding protein Sam68 in the regulation of SMN2 splicing: implications for novel therapeutic approaches to Spinal Muscular Atrophy SANTA LUCIA Genes, Genomes and Genetics 7, IMPACT OF CDKL5 ON NEURONAL FUNCTIONS: GENETIC AND PROTEIN TARGETS, MOLECULAR PATHWAYS AND NEURONAL CIRCUITS Molecular, Cellular, and Developmental 7, Structural and functional imaging markers of motor control dysfunction in Tourette syndrome. GALEAZZI Brain Disorders and 7, CROHN'S DISEASE: MECHANISMS OF INTESTINAL FIBROSIS, GENETIC PREDISPOSITION, AND POSSIBLE IMPLICATIONS FOR THERAPEUTIC AND DIAGNOSTIC INTERVENTION CASA SOLLIEVO SOFFERENZA Genes, Genomes and Genetics 7, AUTOPHAGY AS A NOVEL POTENTIAL DRUG TARGET IN DUCHENNE MUSCULAR DYSTROPHY:IDENTIFICATION OF THE PATHWAYS AND NEW PHARMACOLOGICAL STRATEGIES MEDEA Musculoskeletal, Oral and Skin Sciences 7, Role of novel modulators of ectopic mineralization during aortic valve disease progression Veneto Vascular and Hematology 7, Pagina 12 di 142

13 Circulating nucleic acids in colorectal cancer patients as markers of tumor stroma interactions: new tools for early diagnosis and risk assessment ISTITUTO TUMORI MILANO Oncology 2 7, GENETIC AND MOLECULAR STUDIES OF TWO AUTISM GENES WITH DIRECT NICAL IMPLICATIONS SANTA LUCIA Brain Disorders and 7, INHIBITION OF BACTERIAL FILMS: NEW MOLECULAR STRATEGIES TARGETING CYC DI GMP METABOLISM Lazio Infectious Diseases and Microbiology 7, MicroRNAs regulated by mutated p53 oncoproteins in colon cancer REGINA ELENA Oncology 1 Basic 7, The role of the EGFR in the interaction between mesenchymal stem cells and breast cancer cells: implications for novel therapeutic approaches PASCALE Oncology 1 Basic 7, Modulation by IL 1beta of GABAA Receptors function in human and experimental epilepsy: a novel therapeutic approach against adult and childhood intractable epilepsies. SAN RAFFAELE PISANA Brain Disorders and 7, Role of MSY3 in skeletal muscle maturation and degeneration: a new potential target for therapies against muscle wasting disorders. SAN RAFFAELE PISANA Musculoskeletal, Oral and Skin Sciences 7, Parenteral Iron Supplementation, Chemoreflex Response, Quality of Life And Exercise Capacity In Patients With Chronic Heart Failure AUXOLOGICO Cardiovascular and 7, Electronic health databases as a source of reliable information for effective health policy Puglia Healthcare Delivery and EFFICACY OF TELEMEDICINE FOR IMPROVING DEPRESSION OUTCOMES IN PRIMARY CARE FATEBENEFRATELLI Healthcare Delivery and Hyperpolarized 13C Magnetic Resonance Metabolic Imaging as Sensitive Biomarker in a cardiac translational study of Heart Failure Toscana Cardiovascular and Pagina 13 di 142

14 Role of antiviral treatment on the course of severe liver disease due to chronic HCV infection Sicilia Digestive, Kidney and Urological Systems Toward the development of an in vitro test for ALS: largescale validation of PBMC protein biomarkers Lombardia Brain Disorders and Does calorie restriction ameliorate renal function and cardiometabolic health in obese type 2 diabetic patients? Istituto Superiore di Sanita' Endocrinology, Metabolism, Nutrition and Reproductive Sciences Towards development of a next generation sequencing strategy for molecular genetic testing of inherited diseases with blood cell reduction BURLO GAROFALO Vascular and Hematology A multicenter collaborative research network for the identification and study of rare undiagnosed patients: the impact on the rare disease National Health Service network (UnRareNet) OSPEDALE BAMBINO GESU' Healthcare Delivery and MiRNAs in Forebrain Neurogenesis Biology of Development and Aging Role of autophagy in growth, progression and vascular mimicry of neuroblastoma GASLINI Oncology 1 Basic MOLECULAR EVENTS RESPONSIBLE FOR MIGRATORY PLASTICITY AND INVADOPODIA FORMATION IN BONE METASTASIS FROM BREAST CARCINOMA GALEAZZI Oncology 1 Basic Role of microrna regulation by estrogen receptor beta in hormone responsive breast cancer CROB Oncology 1 Basic Germline predictors of survival and response to therapy in malignant melanoma: from GWAS to high resolution mapping and functional analysis IRCCS AOU San Martino IST (Genova) Oncology 1 Basic Development of novel cell products for their clinical use in cancer immunotherapy Istituto Superiore di Sanita' Oncology Pagina 14 di 142

15 MALIGNANT MESOTHELIOMA. ROLE OF INFLAMMATION IN TUMOUR PROGRESSION UNDER HYPOXIC CONDITIONS: IDENTIFICATION OF NEW MARKERS AND THERAPEUTIC TARGETS. REGINA ELENA Oncology 1 Basic Immunomodulation by mesenchymal stem cells as a potential therapeutic strategy for endometriosis Endocrinology, Metabolism, Nutrition and Reproductive Sciences Monitoring and development of innovative therapies through microvesicle analysis in kidney and in liver transplantation Piemonte Digestive, Kidney and Urological Systems NACHNOLOGY FOR THE DELIVERY OF ZOLEDRONIC ACID: A NEW OPPORTUNITY AGAINST CANCER REGINA ELENA Oncology Identification of novel disease genes for Noonan syndrome and related RASopathies and insights into pathogenetic mechanisms for supporting diagnosis, management and treatment Istituto Superiore di Sanita' Genes, Genomes and Genetics Evaluation of the potential neuroprotective, antiepileptogenic and anticonvulsive properties of Palmitoylethanolamide (PEA) Calabria Brain Disorders and Histaminergic H4 receptor may have a role in autoimmune and inflammatory neuropathologies: studies on the selective H4R agonists and antagonists in animal models in vivo. Toscana Brain Disorders and Functional and gene expression profile of VH1 69+ primary cutaneous B cell lymphomas and HCV associated lymphomas ISTITUTO DERMOPATICO DELL'IMMACOLATA Oncology 1 Basic Functional characterization and identification of corrective strategies for SCN5A mutations causing Long QT Syndrome 3 and brugada Syndrome. MAUGERI Cardiovascular and NOVEL THERAPIES FOR TUBERCULOSIS Istituto Superiore di Sanita' Infectious Diseases and Microbiology Pagina 15 di 142

16 Identification of therapeutic targets for neurological disorders: analysis of the mechanisms regulating cortical interneurons development. Molecular, Cellular, and Developmental Targeting CD99 to treat sarcomas RIZZOLI Oncology Modeling the neurological features of Tuberous Sclerosis Complex by exploiting neural stem cells: translating the results of basic research into predictive preclinical tools. Brain Disorders and Characterization of micro vesicles in plasma and urine of Alzheimer s disease patients: possible new biomarkers of neurodegeneration S.CAMILLO Brain Disorders and Novel therapeutic strategies for Amyotrophic Lateral Sclerosis: testing the efficacy of cell permeable peptides in preclinical models MAUGERI Brain Disorders and Kinetochore spindle binding as a new anticancer drug target. I.E.O. Oncology IMPROVING SAFETY OF GENE TRANSFER FOR GENE THERAPY APPLICATIONS Genes, Genomes and Genetics Preclinical evaluation of isoform specific PI3K inhibitors' effects in pulmonary fibrosis models for novel potential therapies of Idiopathic pulmonary fibrosis (IPF) Sicilia Cardiovascular and The rehabilitation of attention in patients with mild cognitive impairment and brain subcortical vascular changes using the Attention Process Training II Toscana Brain Disorders and Evaluation of the activity of HIV protease or reverse transcriptase inhibitors against experimental models of uterine cervical tumours Istituto Superiore di Sanita' Oncology Pagina 16 di 142

17 Optimization of alloreactive natural killer (NK) cell and invariant NKT (inkt) cell mediated anti leukemia effect in children with hematological malignancies given a T cell depleted hematopoietic stem cell transplantation (HSCT) from an HLA disparate rel OSPEDALE BAMBINO GESU' Oncology MSC based therapy for the bone marrow and solid organs transplantations Lombardia Oncology Effects of resveratrol on inflammation in type 2 diabetic patients. A double blind randomised controlled trial Piemonte Endocrinology, Metabolism, Nutrition and Reproductive Sciences Advanced MRS, ASL perfusion and structural MRI in pediatric migraine: a longitudinal study and correlations with clinical and neurophysiological findings. OSPEDALE BAMBINO GESU' Brain Disorders and A pathology for the MET oncogene: "cancers of unknown primary origin" (CUPs) Piemonte Oncology 1 Basic EPIDEMIOLOGICAL SURVEY ON FRESHWATER FISH BORNE PARASITIC ZOONOSES: STUDY OF TIC AND ATIC FACTORS INFLUENCING THE OCCURRENCE OF ZOONOTIC HELMINTHS IN FRESHWATER FISH POPULATIONS FROM NORTHERN ITALY AND IDENTIFICATION OF MAIN RISK FACTORS CONTRIBUTIN Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary The novel low density lipoprotein associated protein prenylcysteine lyase: understanding its functional role Evaluation of anti NA antibodies as possible correlates of protection from influenza disease: development of serological assays designed to detect a truly functional antibody response to influenza vaccination, with specific regard to the anti NA antibody MONZINO Vascular and Hematology Istituto Superiore di Sanita' Immunology Familial breast cancer cases from an isolated population: detection of new risk alleles by exome sequencing and depiction of mutation spectrum in known susceptibility genes. Lombardia Oncology 1 Basic 8, Pagina 17 di 142

18 THE RESPONSIVENESS TO CLOPIDOGREL AND STENT THROMBOSIS 3 (RECLOSE 3) TAILORED THERAPY Toscana Cardiovascular and 8, LKB1/AMPK status and glycolytic phenotype as biomarkers of response of lung cancer to bevacizumab I. O. V. Oncology 2 8, The tumorigenic action of eif6 translational network: 1. evaluation of eif6 inhibition in anticancer therapy and isolation of downstream eif6 targets; 2. generation of SBDS mutated cancer cells and evaluation of their drug sensitivity. Oncology 1 Basic 8, Direct Acting Antivirals (DAAs) for HCV infection: a nationwide research project to evaluate virological and clinical outcomes, to design appropriate treatment algorithms, and to assess cost effectiveness of the new combination therapies Istituto Superiore di Sanita' Infectious Diseases and Microbiology 8, Identification of treatment dependent and treatment independent biological predictors of chemorefractoriness and outcome in a phase III trial of high risk diffuse large B cell lymphoma (DLCL04) Provincia autonoma Bolzano Oncology 2 8, Anti idiotypic Network to Anti transglutaminase Antibodies in the Prevention of Celiac Disease Enteropathy. BURLO GAROFALO Digestive, Kidney and Urological Systems 8, An opportunistic screening strategy to improve the triage of skin cancer by primary care physicians A randomized study ARCISPEDALE Healthcare Delivery and 8, The contribution of ICT to patient safety in surgical process Emilia Romagna Healthcare Delivery and 8, Non inferiority trials for cutting drug expenses in neurology: comparing 2 interferon beta 1b regimes in Multiple Sclerosis Lazio Brain Disorders and 8, Pagina 18 di 142

19 Perioperative Optimization of Care in Obesity: Acronym: POCO Toscana Surgical Sciences, Biomedical Imaging, and Bioengineering 8, Investigation on the prognostic value of biochemical markers in the cerebrospinal fluid for the functional outcome of spinal cord injured patients Emilia Romagna Brain Disorders and 8, MOLECULAR EPIDEMIOLOGY OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN A THIRD LEVEL PAEDIATRIC UNIVERSITY HOSPITAL Toscana Infectious Diseases and Microbiology 8, Care pathway for dementia: effects on professional practice, patient outcomes, and costs for the NHS. CARLO BESTA Brain Disorders and 8, Development and testing of an entirely automated system, based on administrative data, to stratify prognosis of older patients accessing an Emergency Department Toscana Healthcare Delivery and 8, Development of new antiinflammatory/immunosuppressive therapy to improve the outcome of brain injury. NEUROLESI Brain Disorders and 8, Ceruloplasmin oxidation in Parkinson s disease cerebrospinal fluid: role in pathological mechanisms Brain Disorders and 8, Targeting Toll like receptors (TLRs) and their endogenous ligand high mobility group box 1 (HMGB1) as novel therapeutic strategy for Amyotrophic Lateral Sclerosis. Lombardia Brain Disorders and 8, ISCHEMIC REMOTE POST CONDITIONING AS A NEW THERAPEUTIC STRATEGY TO TREAT CEREBRAL ISCHEMIA SDN Molecular, Cellular, and Developmental 8, Genomics, epigenomics and transcriptomic investigation of defective peripheral tolerance in IPEX like patients Genes, Genomes and Genetics 8, The use of an innovative microarray platform into the clinical setting Sicilia Genes, Genomes and Genetics 8, Pagina 19 di 142

20 Impact of asbestos mediated inflammation in mesothelioma genesis and progression. Implication for early diagnosis, prognosis and therapy HUMANITAS Oncology 1 Basic 8, THE ROLE OF CELL FUSION INDUCED BY TETRASPANIN CD81/CD9 MULTIPROTEIN COMPLEX AS MECHANISM OF CHEMORESISTANCE IN COLON CARCINOMA Toscana Oncology 2 8, Paracrine role of Mesenchymal Stem Cells (MSCs) for cell therapy in ALS Piemonte Molecular, Cellular, and Developmental 8, Searching for a common pathogenetic pathway causing muscle misfunctioning in different laminopathies RIZZOLI Cell Biology 8, DNA damage response and metabolic alterations of obesity Istituto Superiore di Sanita' Endocrinology, Metabolism, Nutrition and Reproductive Sciences 8, Recovery to heart donation of donor hearts with neurogenic stunning identified as eligible by stress echo viability assessment. Emilia Romagna Surgical Sciences, Biomedical Imaging, and Bioengineering 8, MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF MECHANISMS INVOLVED IN IRON HOMESTASIS AND HEME SYNTHESIS IN BETA THALASSEMIC ERYTHROPOIESIS MAGGIORE Genes, Genomes and Genetics 8, Radiation biodosimetry in emergency: validation of automated scoring and accuracy of dose prediction. IRCCS AOU San Martino IST (Genova) Oncology 1 Basic 8, Investigation of the role of extracellular ATP and the P2X7 receptor in the modulation of imunosuppression within tumour microenvironment. Emilia Romagna Immunology 8, Search for disease associated genes and their functional mutations in high risk neuroblastoma by parallel massive coding sequences analysis and identification of druggable targets. IRCCS AOU San Martino IST (Genova) Oncology 1 Basic 8, Pagina 20 di 142