Asian Harmonization via Cord Blood Bank Network

Transcription

1 Asian Harmonization via Cord Blood Bank Network Introduced by Shigetaka Asano Of Tokyo Cord Blood Bank SCA 200, Seoul Country China Indonesia Philippines Vietnam Japan Thailand Myanmar Korea Malaysia Cambodia Taiwan Laos Hong Kong Singapore Brunei Population X 0 6, Birthrate , SCA 200, Seoul Deliveries X 0 6 /Year

2 PUC Collection Banking Clinical Research Basic Research How can the transmission of communicable diseases be prevented? What processing controls are necessary? How can clinical safety and effectiveness be assured? What labeling is necessary, and what kind of promotion is permissible, for proper use of the products? Potential Clinical Benefits for Patients with Intractable Diseases SCA 200, Seoul 3 Cord Blood Cell Transplantation. Lower GVHD incidence/high tolerance HLA mismatches (Acceptance of -2 antigen mismatched HLA units). 2. Large number of potential donors/ethnic balance 3. No risk to donors (mothers and infants) /easy harvest. Low prevalence of infections 5. Quick supply of cord blood units. CBT Frequency BMT PBCT SCA 200, Seoul Years 2

3 Biotechnology Revolutions allowing: Production of large quantities of growth factors Cellular & Molecular Therapy Separation of specific cells Production of large numbers of human cells outside the body Modification of cell properties, e g by inserting genes into cells Progress in Stem Cell Biology and Genome Sciences The next 0 years should be a very exciting period in the development of this field. SCA 200, Seoul 5 However, there remain scientific, clinical, and regulatory hurdles/problems to be overcome. Low cell recovery, High cost and hard labor, Lack of common methodology, Low utilization rate, Financial difficulties, etc. Our major issues have been on how to organize, to regulate and to practice the on-demand exchange system, so that they can bring the full potential benefits of cell therapy to patients. SCA 200, Seoul 6 3

4 Newborn Babies Japan CB Bank Network Fresh PUC Tissues BM & PB P CB Foundation Regional Public CB Bank Consortium Research Bank (CERES) Patients National Research Hospital GMP-grade Cells Technical Instruction Research Consignment Supportive Cooperation Department of Cell Processing University Cell Preparation Services TR Supporting Center PUC: placental & umbilical cord, CB: cord blood, P: placenta, BM: bone marrow, PB: peripheral blood SCA 200, Seoul 7 Tokyo Seoul Beijing Taipei Tianjin Organized in 999 HoChiMinh City Bangkok SCA 200, Seoul 8

5 Current Status of AsiaCORD City Inventory Transplant Children Adults Beijing 5, Tianjin, Seoul 3, Taipei 5, Ho Chi Minh,050 0 Bangkok 35 0 Tokyo 5, Total 35, SCA 200, Seoul 9 Statute and By Laws, Standards SOP: Nov. 200 SCA 200, Seoul 0 5

6 Mutual Inspection Beijing Tianjin Tokyo Seoul Ho Chi Minh City Taipei SCA 200, Seoul Request for Search ( as of Sep. 2003) Actual Number of Search Request : 30 Countries : China (Hong Kong): 3, Viet Nam: 8, Korea: 2, China:, Taiwan:, USA: 2, unknown : 3. Year : 200: 5, 2002: 8, 2003: 7. Age : 6 month 67 years (mean 5. years, adults: ) Disease : ALL: 6, AML: 6, CML: 8, Thalassemia: 5, JML:, MDS:, NHL:, RAEBt:, X- linked Lymphoproliferative disease:, Aplastic Anemia:, unknown : 3. SCA 200, Seoul 2 6

7 Exchange of Scientific Information By Tokyo International Symposia on Cord Blood Transplantation Year Subtitle st 996 Current status of cord blood stem cell transplantation 2nd 998 Responding to diversity and information exchange in cord blood banking 3rd 999 Network of cord blood banks worldwide th 2000 Future of cord blood transplantation 5th 200 Placenta/umbilical cord and regenerative biology 6th 2002 Focusing on current issues in cord blood transplantation 7th 2003 Global collaboration and harmonization SCA 200, Seoul 3 AsiaCORD Network : 2005 CB Bank AsiaCORD/NETCORD NETCORD (Tokyo Server) (Düsseldorf Server) AsiaCORD Asia CORD Data & WEB CB Bank CB Bank CB Bank CB Bank Asia CORD Cell Transplantion Center CB Data Data search SCA 200, Seoul 7

8 SCA 200, Seoul 5 Co-operative Works in Keeping the Public Cell Bank Activity Obstetricians Basic Scientists Clinical Scientists Citizens Companies Bank Medical Staffs Journalists Government Such cooperation will provide a lot of chances for ethical, legal, and social implication researches and may contribute to establish a public intellectual base for advanced medicine. SCA 200, Seoul 6 8