A Cure for Sickle Cell Anemia and Thalassemia

Size: px
Start display at page:

Download "A Cure for Sickle Cell Anemia and Thalassemia"

Transcription

1 IV Simpósio Internacional de Hemoglobinopatias A Cure for Sickle Cell Anemia and Thalassemia Bertram Lubin, MD and Mark Walters, MD 4 September 2007

2 Topics to be covered Cord blood: Importance and biology Sibling cord blood banking for children with sickle cell anemia and thalassemia Related cord blood transplantation Future directions

3 Cord Blood Blood remaining in the placenta after an infant is born. Enriched in proliferative hematopoietic cells. Contains immunologically naive T cells. Less risk of CMV contamination than bone marrow. Can be easily cryopreserved. Can be used without a complete HLA match. Available immediately.

4 Cord Blood Stem Cell Biology Compared to adult blood, CB has more abundant naïve T cells, fewer suppressor T cells, and reduced NK activity Cells in CB respond rapidly to cytokine stimulation CB retains graft-versus-leukemia effect Stimulated CB T-cells have reduced production of IFN-γ and TNF-α

5 CB Transplant Background First related CBT 1988 sibling (E. Gluckman) First unrelated CBT 1991 NYBC (P. Rubinstein) Since 1993 >8,500 unrelated CB transplants have been performed worldwide Transplantation across HLA barriers is possible Access to transplant for underserved minorities Applications for adults using multiple units Overall and disease-free survival with mismatched UCB are similar to those with fully matched unrelated adult stem cells Less severe GVHD

6 The Present and Future for Cord Blood Transplants

7 Cord Blood Banks Public Private Sibling

8 CHORI Sibling Cord Blood Program: The only program of its kind in the world Families with children who have disorders that could be treated by transplantation. Prospective, full sibling pregnancies. Resource to collect, transport, characterize and cryopreserved cord blood units Remote sites & community hospitals, preimplantation diagnostic centers

9 Collection Bag and Custom Sterile Prep Kit

10 Program Logistics Family and physician contact staff and enroll following informed consent. Maternal and patient medical history obtained. Maternal testing for infectious disease. Collection kit sent to family. CB collected at time of delivery by the obstetrician/midwife and shipped to the lab for processing. Samples processed and cryopreserved within 48 hours of collection.

11 Cord Blood Stem Cell Laboratory Processing and storing Determine volume, cellular content, and cellular composition HLA typing Infectious disease testing Genetic testing: hemoglobinopathy Stored in liquid nitrogen and shipped to transplantation center upon request

12 Sibling Cord Blood Units Collected Malignant Disorders 30% 6% 14% Sickle Cell Disease Thalassemia 50% Other Hereditary or Rare Hematological Conditions

13 SDCB Units Collected Vs. Released for Transplantation # Collected # Released % Released Malignant diseases % Sickle Cell % Other/Rare % Thalassemia % Unknown % TOTAL % March 2006

14 SDCB Transplantation for Thalassemia and Sickle Cell Anemia 44 patients received SDCB transplants in 22 transplant centers between 6/94 and 6/01 with median f/u 27 (range, ) months Diagnosis: Sickle cell anemia (n=11) Thalassemia major (n=33) - Lucarelli Class I (n=19) Donor: HLA-identical sibling (n=41) 1-Ag (A-allele) mismatch (n=3) Locatelli et al, Blood 101: , 2003

15 SDCB Transplantation for Thalassemia and Sickle Cell Anemia Outcome (N=44) Disease-free survival: Overall 81% Sickle cell anemia: 90% Thalassemia: 79% OVERALL SURVIVAL: 100% Impact of MTX on DFS: CSP alone: 89% P<0.05 MTX + other: 55% Impact of Preparation : BU/CY/ +/-ATG: 62% P<0.05 Add thiotepa/flu: 94% Locatelli et al, Blood 101: , 2003

16 The CHORI Program: Whom to transplant and when? Patients with severe disease such as recurrent pain, recurrent ACS, stroke Patients at risk for adverse outcomes such as stroke (as determined by TCD) Patients who have transfusion dependent thalassemia Young patients (newborn screening)

17 SDCB Transplantation for SCD and β -thalassemia Major Treatment Day -9 to -6 Day -5 to -2 Day -1 Day 0 Post- Transplant Busulfan/Busulfex X Cyclophosphamide X Thymoglobulin X UCB Infusion X CSP X X Through Day +90 MMF X Through Day +35 April 2004

18 Sibling Donor Cord Blood Transplant for SCA/Thalassemia (N=33) Median follow-up 2.3 years (range: ) 90% 87% Percent Event = death, graft rejection, or disease recurrence. Time (years) after UCBT Oct 2006

19 Cure of Thalassemia Sibling Cord Blood Transplantation For Thalassemia

20 Sibling Cord Blood Transplant for Sickle Cell Anemia: Stroke recovery!

21 General CB Research Directions Cell biology and plasticity of subpopulations Homing and engraftment Immunologic applications: T regulatory cells Expansion of stem cell numbers Efficacy of combined cord blood and bone marrow Combined CB units for adults

22 Specific CB Research Questions Non-myeloablative transplant HLA diagnosis using maternal blood Pre-implantation genetic diagnosis Ideal conditioning regimen Indications Multicenter trials Unrelated donors

23 Cord Blood Banking in Brazil Justification for a national program Designated sibling collection Collaborative opportunities

UMBILICAL CORD BLOOD TRANSPLANTATION: KFSH EXPERIENCE

UMBILICAL CORD BLOOD TRANSPLANTATION: KFSH EXPERIENCE UMBILICAL CORD BLOOD TRANSPLANTATION: KFSH EXPERIENCE HIND AL HUMAIDAN, MD,FRCPA Director, Blood Bank (Donor & Transfusion Services) and Stem Cell Cord Blood Bank Consultant Hematopathologist INTRODUCTION

More information

Cord Blood: that other stem cell source. Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program

Cord Blood: that other stem cell source. Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program Cord Blood: that other stem cell source Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program CBMTG April 2012 The problem: In order to perform a BMT from one person to another one needs

More information

Sibling Donor Cord Blood Transplantation for Thalassemia Major: Experience of the Sibling Donor Cord Blood Program

Sibling Donor Cord Blood Transplantation for Thalassemia Major: Experience of the Sibling Donor Cord Blood Program Sibling Donor Cord Blood Transplantation for Thalassemia Major: Experience of the Sibling Donor Cord Blood Program MARK C. WALTERS, LYNN QUIROLO, ELIZABETH T. TRACHTENBERG, SANDIE EDWARDS, LISA HALE, JOANNA

More information

CORD BLOOD BANKING FAQ

CORD BLOOD BANKING FAQ CORD BLOOD BANKING FAQ Cord Blood & Stem Cells Q: What is umbilical cord blood (UCB)? A: Bone marrow, peripheral blood and UCB constitute the three primary sources of stem cells. Cord blood, which, until

More information

Cord Blood for Cellular Therapy: A Snapshot of this Evolving Market Landscape

Cord Blood for Cellular Therapy: A Snapshot of this Evolving Market Landscape GENReports: Market & Tech Analysis Cord Blood for Cellular Therapy: A Snapshot of this Evolving Market Landscape > Enal Razvi, Ph.D. Biotechnology Analyst, Managing Director SELECTBIO US enal@selectbio.us

More information

SAVE A LIFE... BY GIVING LIFE!

SAVE A LIFE... BY GIVING LIFE! SAVE A LIFE... BY GIVING LIFE! FOLLOW US ON: HÉMA-QUÉBEC PUBLIC CORD BLOOD BANK www.hema-quebec.qc.ca Scan this code with your smart phone to access the page Register to the Public Cord Blood Bank on the

More information

CHAPTER 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION

CHAPTER 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION CHAPTER 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION Chapter 1 BACKGROUND AND CORD BLOOD BANK (CBB) ORGANIZATION 1.1 OVERVIEW OF THE CORD BLOOD TRANSPLANTATION STUDY Bone marrow transplantation

More information

Pr Eliane Gluckman, MD, FRCP, Disclosure of Interest: Nothing to Disclose

Pr Eliane Gluckman, MD, FRCP, Disclosure of Interest: Nothing to Disclose Pr Eliane Gluckman, MD, FRCP, Hospital Saint Louis, University Paris- Diderot, France Should Haplo-identical transplantation be preferred to cord blood in patients without a matched donor? Disclosure of

More information

UMBILICAL CORD BLOOD, STEM CELL BANKING

UMBILICAL CORD BLOOD, STEM CELL BANKING UMBILICAL CORD BLOOD, STEM CELL BANKING Dr.Sharad Jain MD Blood Transfusion officer, & I/C Transfusion Medicine NSCB Medical College. Jabalpur.MP. Introduction: Every parent during childbirth DREAMS the

More information

Umbilical Cord Blood Transplantation

Umbilical Cord Blood Transplantation Umbilical Cord Blood Transplantation V Rocha MD, PhD Hopital Saint Louis, Paris University 7 CIBMTR Milwaukee Umbilical Cord blood transplantation Background History Clinical results in children and adults

More information

What we will discuss today

What we will discuss today Umbilical cord blood banking It s Utility? Dr. Nita Radhakrishnan Pediatric Hematology Oncology Unit, Sir Ganga Ram Hospital, New Delhi What we will discuss today What are stem cells? What are the sources

More information

Disclosures. I have no disclosures.

Disclosures. I have no disclosures. Not Your Own Marrow Jenni Krajewski, MD Clinical Assistant Professor, Rutgers New Jersey Medical School Attending Physician, Pediatric Blood and Marrow Transplantation The Institute for Pediatric Cancer

More information

Hematopoietic Stem Cell Transplantation. Imad A. Tabbara, M.D. Professor of Medicine

Hematopoietic Stem Cell Transplantation. Imad A. Tabbara, M.D. Professor of Medicine Hematopoietic Stem Cell Transplantation Imad A. Tabbara, M.D. Professor of Medicine Hematopoietic Stem Cells Harvested from blood, bone marrow, umbilical cord blood Positive selection of CD34 (+) cells

More information

Canadian Blood Services National Public Cord Blood Bank Give Life Twice Transfusion Medicine Residents

Canadian Blood Services National Public Cord Blood Bank Give Life Twice Transfusion Medicine Residents Canadian Blood Services National Public Cord Blood Bank Give Life Twice Transfusion Medicine Residents Eileen Quinlan Collection Supervisor, Brampton (GTA) 2015-11-10 History One Match Stem Cell and Marrow

More information

Not All Stem Cells are the Same

Not All Stem Cells are the Same Cord Blood Banking and Transplantation Jennifer Willert, M.D. Hematology/Oncology Blood and Marrow Transplant Rady Children s Hospital San Diego Clinical Professor UCSD Not All Stem Cells are the Same

More information

Cord Blood: Research Progress and Future Promise

Cord Blood: Research Progress and Future Promise Cord Blood: Research Progress and Future Promise By Al Staropoli, AABB Contributing Writer Sue Fister found out she had leukemia when she was 50 years old. Doctors suggested a bone marrow transplant as

More information

Your Cord Blood Donation Options

Your Cord Blood Donation Options Your Cord Blood Donation Options Our Mission To develop and maintain a statewide resource for potentially life-saving cord blood to treat children and adults. What is cord blood? Cord blood is the blood

More information

Cord Blood Stem Cell Transplantation

Cord Blood Stem Cell Transplantation LEUKEMIA LYMPHOMA MYELOMA FACTS Cord Blood Stem Cell Transplantation No. 2 in a series providing the latest information on blood cancers Highlights Umbilical cord blood, like bone marrow and peripheral

More information

Your Cord Blood Donation Options

Your Cord Blood Donation Options Your Cord Blood Donation Options What is cord blood? Cord blood is the blood that remains in the placenta after a baby is born. Cord blood has been found to be a rich source of stem cells and can be used

More information

Corporate Medical Policy Cord Blood as a Source of Stem Cells

Corporate Medical Policy Cord Blood as a Source of Stem Cells Corporate Medical Policy Cord Blood as a Source of Stem Cells File Name: Origination: Last CAP Review: Next CAP Review: Last Review cord_blood_as_a_source_of_stem_cells 2/2001 3/2015 3/2016 3/2015 Description

More information

Bone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? Federica Giannotti, MD Eurocord-Hôpital Saint Louis, Paris

Bone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? Federica Giannotti, MD Eurocord-Hôpital Saint Louis, Paris Bone Marrow, Peripheral Blood Stem Cells or Umbilical Cord Blood transplantation? Federica Giannotti, MD Eurocord-Hôpital Saint Louis, Paris Background Hematopoietic stem cell transplantation (HSCT) is

More information

Corporate Medical Policy Cord Blood as a Source of Stem Cells

Corporate Medical Policy Cord Blood as a Source of Stem Cells Corporate Medical Policy Cord Blood as a Source of Stem Cells File Name: Origination: Last CAP Review: Next CAP Review: Last Review cord_blood_as_a_source_of_stem_cells 2/2001 3/2015 3/2016 3/2015 Description

More information

Public Cord Blood Banking at the National Cord Blood Program (NCBP)

Public Cord Blood Banking at the National Cord Blood Program (NCBP) Public Cord Blood Banking at the National Cord Blood Program (NCBP) A. Scaradavou, MD Medical Director, National Cord Blood Program, New York Blood Center Associate Attending, Pediatric BMT Memorial Sloan-Kettering

More information

Umbilical Cord Blood Stem Cells Current Status & Future Potential

Umbilical Cord Blood Stem Cells Current Status & Future Potential Umbilical Cord Blood Stem Cells Current Status & Future Potential Natasha Ali Assistant Professor Haematology Department of Pathology & Laboratory Medicine/Oncology The Aga Khan University Email: natasha.ali@aku.edu

More information

The donor search: the best donor or cord blood unit

The donor search: the best donor or cord blood unit The donor search: the best donor or cord blood unit Dr Bronwen Shaw Consultant in haematopoietic cell transplantation Royal Marsden Hospital /Anthony Nolan Overview Where do we find donors/units for transplantation

More information

4. All cord blood banks should be subject to the same standards, regulations and accreditation requirements.

4. All cord blood banks should be subject to the same standards, regulations and accreditation requirements. WMDA Policy Statement on the Utility of Autologous or Family Cord Blood Unit Storage The WMDA Board adopted this policy on 25 th of May 2006. Policy updated _April 2011 The Cord Blood Working Group and

More information

Directed/Related Cord Blood Collection by NHS Blood and Transplant

Directed/Related Cord Blood Collection by NHS Blood and Transplant Directed/Related Cord Blood Collection by Jacqui Thompson Clinical Scientist Section Head of Specialist Procedures Stem Cells and Immunotherapies Department National Blood Service, NHSBT Birmingham Why

More information

Processing & Utilization of Cord Blood for Transplant

Processing & Utilization of Cord Blood for Transplant Processing & Utilization of Cord Blood for Transplant 2010-Jan Jan-15 Nicole L. Prokopishyn, PhD HPC Processing Laboratory Director Calgary Laboratory Services Overview Cord Blood Processing Pre-Freeze

More information

Pros and Cons of Stem Cell Sources and their availability in Africa. Dr Jaimendra Singh Inkosi Albert Luthuli Central Hospital Durban, South Africa

Pros and Cons of Stem Cell Sources and their availability in Africa. Dr Jaimendra Singh Inkosi Albert Luthuli Central Hospital Durban, South Africa Pros and Cons of Stem Cell Sources and their availability in Africa Dr Jaimendra Singh Inkosi Albert Luthuli Central Hospital Durban, South Africa Introduction The ability to perform a haematopoietic stem

More information

EUROCORD. in 49 countries and 484 transplant centres* 264 EBMT 4847 (73%) cases 220 Non-EBMT 1797 (27%) cases

EUROCORD. in 49 countries and 484 transplant centres* 264 EBMT 4847 (73%) cases 220 Non-EBMT 1797 (27%) cases ! 21%! EUROCORD 6756 cord blood transplantations performed from 1988 to March 2010 in 49 countries and 484 transplant centres* 264 EBMT 4847 (73%) cases 220 Non-EBMT 1797 (27%) cases * missing center

More information

UMBILICAL CORD BLOOD COLLECTION

UMBILICAL CORD BLOOD COLLECTION UMBILICAL CORD BLOOD COLLECTION by Frances Verter, PhD Founder & Director, Parent's Guide to Cord Blood Foundation info@parentsguidecordblood.org and Kim Petrella, RN Department of Obstetrics and Gynecology

More information

Advances in HSC Transplantation for Myelodysplasia: Cord Blood Transplantation & RIC

Advances in HSC Transplantation for Myelodysplasia: Cord Blood Transplantation & RIC Advances in HSC Transplantation for Myelodysplasia: Cord Blood Transplantation & RIC -7-6 -5-4 -3-2 -1 0 30 100 CSA/ MMF Juliet N. Barker, MBBS (Hons), FRACP Associate Attending Director Cord Blood Transplant

More information

The Power & Potential of Cord Blood

The Power & Potential of Cord Blood The Power & Potential of Cord Blood Donna Regan, MT(ASCP)SBB, Director St. Louis Cord Blood Bank & Cellular Therapy Laboratory SSM Cardinal Glennon Children s Medical Center September 18, 2013 Objectives

More information

cord blood saves lives...

cord blood saves lives... cord blood saves lives... ...by providing a rich source of blood stem cells that can be used to treat over 80 different diseases including leukemia, lymphoma, thalassemia, Tay-Sachs and sickle cell anemia.

More information

Fetal Maternal Immunity and Antileukemia Activity in Cord Blood Transplant. Recipients

Fetal Maternal Immunity and Antileukemia Activity in Cord Blood Transplant. Recipients Fetal Maternal Immunity and Antileukemia Activity in Cord Blood Transplant Recipients Filippo Milano, 1 J. Lee Nelson, 1, 2 Colleen Delaney 1,3 1 Clinical Research Division, Fred Hutchinson Cancer Research

More information

The Power & Potential of Cord Blood

The Power & Potential of Cord Blood The Power & Potential of Cord Blood Donna Regan, MT(ASCP)SBB, Director St. Louis Cord Blood Bank & Cellular Therapy Laboratory SSM Cardinal Glennon Children s Medical Center April 30, 2014 Objectives Since

More information

5. All cord blood banks should be subject to the same standards, regulations and accreditation requirements.

5. All cord blood banks should be subject to the same standards, regulations and accreditation requirements. WMDA Policy Statement for the Utility of Autologous or Family Cord Blood Unit Storage (This policy statement has been approved and adopted by the WMDA board on the 25 th of May 2006) The Cord Blood Registries

More information

10 th Annual International Cord Blood Transplantation Symposium June 7-9, 2012 Preliminary Scientific Program. Thursday, June 7

10 th Annual International Cord Blood Transplantation Symposium June 7-9, 2012 Preliminary Scientific Program. Thursday, June 7 10 th Annual International Cord Blood Transplantation Symposium June 7-9, 2012 Preliminary Scientific Program Thursday, June 7 7:00 8:00 AM Breakfast in Exhibit Hall Session IA 8:00 10:00 AM Advances in

More information

Outcome of Unrelated HSCT in Patients Lacking HLA Matched Related Donors: Iranian Stem Cell Donor Program (ISCDP)

Outcome of Unrelated HSCT in Patients Lacking HLA Matched Related Donors: Iranian Stem Cell Donor Program (ISCDP) Outcome of Unrelated HSCT in Patients Lacking HLA Matched Related Donors: Iranian Stem Cell Donor Program (ISCDP) October 18, 2014 19th Congress of APBMT, Hangzhou, China AMIR ALI HAMIDIEH, MD Iranian

More information

Cord Blood Market Trends, circa 2014

Cord Blood Market Trends, circa 2014 GENReports: Market & Tech Analysis Cord Blood Market Trends, circa 2014 > Enal Razvi, Ph.D. Managing Director Select Biosciences, Inc. enal@selectbio.us Topic Introduction and Scope The focus of this GEN

More information

Program Co-Chairmen: Dr. John Wagner, University of Minnesota Dr. Richard Champlin, M.D. Anderson Cancer Center

Program Co-Chairmen: Dr. John Wagner, University of Minnesota Dr. Richard Champlin, M.D. Anderson Cancer Center (last updated May 13, 2004) This is an activity offered by CBBS, a CMA accredited provider. Physicians attending this course may report up to 13.25 hours of Category 1 credits toward the California Medical

More information

Statement of Joanne Kurtzberg, M.D.

Statement of Joanne Kurtzberg, M.D. Statement of Joanne Kurtzberg, M.D. President of the Cord Blood Association Jerome Harris Distinguished Professor of Pediatrics and Pathology Chief Scientific Officer and Medical Director, Robertson Clinical

More information

Summary of Advisory Council on Blood Stem Cell Transplantation: Recommendations and Status

Summary of Advisory Council on Blood Stem Cell Transplantation: Recommendations and Status of Advisory Council on Blood Stem Cell Transplantation: Recommendations and Shelley Grant Branch Chief, Blood Stem Cell Transplantation Program September 11, 2015 Overview December 20, 2005 - HRSA began

More information

How To Treat Cord Blood

How To Treat Cord Blood Published:October2011 Thestudyreviews,analyzesandprojects theglobalmarketforcordbloodstem Cels fortheperiod2006-2015 2011alrightsreserved PRODUCT SEGMENTATION Cord blood stem cells are those adult stem

More information

Donation of Umbilical Cord Blood. A precious life offer. for everyone!

Donation of Umbilical Cord Blood. A precious life offer. for everyone! Donation of Umbilical Cord Blood A precious life offer for everyone! Donation of Umbilical Cord Blood A precious life offer for everyone! Page 3 Hellenic Cord Blood Bank Page 4 Haematopoietic Progenitor

More information

Stem Cell Background Paper

Stem Cell Background Paper Stem Cell Background Paper Introduction...2 Stem Cell Basics...3 Stem Cell Process Flow...9 Comparison of Blood, Stem Cells, Tissues and Organs Processes...10 Responsibilities for the Blood, Stem Cells,

More information

How to select a donor and product for allogeneic HCT

How to select a donor and product for allogeneic HCT How to select a donor and product for allogeneic HCT Dr Bronwen Shaw 10 February 2015 Overview Who (and where) are the donors What factors determine how we choose between them Acquisition Clinical Donor

More information

Cord Blood Collections for the Texas Cord Blood Bank. Obstetrical Providers Training Module

Cord Blood Collections for the Texas Cord Blood Bank. Obstetrical Providers Training Module Cord Blood Collections for the Texas Cord Blood Bank Obstetrical Providers Training Module The Texas Cord Blood Bank The Texas Cord Blood Bank is a network of maternity hospitals and a central laboratory

More information

CRYOPRESERVATION FACILITIES/STORAGE BANKS

CRYOPRESERVATION FACILITIES/STORAGE BANKS Chapter Eight CRYOPRESERVATION FACILITIES/STORAGE BANKS The concept of storing human tissue for future use by either the donor or an anonymous person is a concept that arose during the last half of the

More information

A Gift for life. HTA Licence No. 22653

A Gift for life. HTA Licence No. 22653 A Gift for life HTA Licence No. 22653 2 3 the best possible gift for your new born child. 4 6 8 9 10 12 14 16 19 what is cord blood current treatments services contents properties for treatment process

More information

Therapeutic Treatment Options: Chronic Blood Transfusions Bone Marrow Transplantation. Marianne E. McPherson Yee, MD, MSc

Therapeutic Treatment Options: Chronic Blood Transfusions Bone Marrow Transplantation. Marianne E. McPherson Yee, MD, MSc Therapeutic Treatment Options: Chronic Blood Transfusions Bone Marrow Transplantation Marianne E. McPherson Yee, MD, MSc Sickle Cell Treatment Options Supportive Care Newborn Screen PCN Immunizations Education

More information

CORD BLOOD TRANSPLANTATION: PAST, PRESENT AND FUTURE

CORD BLOOD TRANSPLANTATION: PAST, PRESENT AND FUTURE CORD BLOOD TRANSPLANTATION: PAST, PRESENT AND FUTURE Dennis M. Todd, Ph.D. The New Jersey Cord Blood Bank a Division of Bergen Community Regional Blood Center Montvale, NJ Hematopoietic Stem Cell Transplantation

More information

Jamie Peregrine, MD, PGY-4 KU-Wichita, OB/GYN Wesley Medical Center

Jamie Peregrine, MD, PGY-4 KU-Wichita, OB/GYN Wesley Medical Center Jamie Peregrine, MD, PGY-4 KU-Wichita, OB/GYN Wesley Medical Center Uses for umbilical cord stem cells Describe the indications and uses for umbilical cord stem cells. Counsel patients on the advantages

More information

Navelstrengbloed tegen kanker

Navelstrengbloed tegen kanker Navelstrengbloed tegen kanker THERAPIEDAG 2008: "Zorgtrajecten in kanker" Zaterdag 27 september 2008 Gasthuisberg, Leuven. Hélène Schoemans, MD KUL, Stem Cell Institute Leuven Cord blood Collection and

More information

Preparation of cord blood for infusion: bedside thaw, dilute and wash, or somewhere in between

Preparation of cord blood for infusion: bedside thaw, dilute and wash, or somewhere in between Preparation of cord blood for infusion: bedside thaw, dilute and wash, or somewhere in between Donna Wall, MD Director, Manitoba Blood and Marrow Transplant Program ISCT 2012 Disclosures: none The problem:

More information

A Public Cord Blood Bank for South Africa? i

A Public Cord Blood Bank for South Africa? i No. 42/2007 A Public Cord Blood Bank for South Africa? i By Dr Robert Crookes MBChB (Wits), Dip. Internal Medicine (American Board of Internal Medicine, USA) Transfusion Medicine Consultant. South African

More information

Selection of the Optimal Umbilical Cord Blood Unit

Selection of the Optimal Umbilical Cord Blood Unit Karen Ballen, MD Selection of the Optimal Umbilical Cord Blood Unit Massachusetts General Hospital September, 2013 OUTLINE Cell Dose HLA Match Allele Level HLA C KIR Directional Mismatch NIMA HLA Antibodies

More information

Cord Cor Blood Banking Scott N. Furlan, MD Ellen S. Plummer, Plummer MD

Cord Cor Blood Banking Scott N. Furlan, MD Ellen S. Plummer, Plummer MD Cord Blood Banking Scott N. Furlan, MD Ellen S.Plummer, MD Overview Background Biology of Stem Cell Transplant Opportunities i at Parkland Logistics of Banking Potential Barriers Indications for HCT Cancer

More information

Public Cord Blood Tissue Bank Committee on Health Care Services and Representative Peaden

Public Cord Blood Tissue Bank Committee on Health Care Services and Representative Peaden HOUSE OF REPRESENTATIVES COMMITTEE ON HEALTH CARE SERVICES ANALYSIS BILL #: HB 2337 (PCB HCS 00-07) RELATING TO: SPONSOR(S): TIED BILL(S): Public Cord Blood Tissue Bank Committee on Health Care Services

More information

It s not something you want to think about, but it s something you want to prepare for.

It s not something you want to think about, but it s something you want to prepare for. It s not something you want to think about, but it s something you want to prepare for. StemCyte cord blood banking offers your family a new lifesaving treatment alternative Why Bank Take the once-in-alifetime

More information

Stem Cell Transplantation In Patients with Fanconi Anemia

Stem Cell Transplantation In Patients with Fanconi Anemia Stem Cell Transplantation In Patients with Fanconi Anemia FARF Annual Family Meeting 6/28/15 Casco, ME Parinda A. Mehta, M.D. Cincinnati Children s Hospital Medical Center Improvements in Unrelated Donor

More information

STEM CELLS FROM THE UMBLICAL CORD BLOOD AND UMBLICAL CORD TISSUE

STEM CELLS FROM THE UMBLICAL CORD BLOOD AND UMBLICAL CORD TISSUE STEM CELLS FROM THE UMBLICAL CORD BLOOD AND UMBLICAL CORD TISSUE What are Stem Cells? Stem cells are the basic building blocks of all the cells, tissues and organs in the human body. The role of the stem

More information

Corporate Medical Policy

Corporate Medical Policy Corporate Medical Policy Hematopoietic Stem-Cell Transplantation for CLL and SLL File Name: Origination: Last CAP Review: Next CAP Review: Last Review: hematopoietic_stem-cell_transplantation_for_cll_and_sll

More information

CLIENT AGREEMENT. Copyright 2014 MiracleCord Inc. All rights reserved.

CLIENT AGREEMENT. Copyright 2014 MiracleCord Inc. All rights reserved. CLIENT AGREEMENT MiracleCord, Inc. is a provider of services for the collecting, testing, processing, cryopreserving and storing of cells collected from a newbornʼs umbilical cord blood ( Cord Blood )

More information

UMBILICAL CORD BLOOD BANKING A guide for parents

UMBILICAL CORD BLOOD BANKING A guide for parents UMBILICAL CORD BLOOD BANKING A guide for parents 2 nd EDITION INTRODUCTION The cells contained in the umbilical cord blood have therapeutic value for the treatment of blood disorders and immune diseases.

More information

Hematopoiesis i starts from. HPC differentiates t to sequentially more mature. HPC circulate in very low

Hematopoiesis i starts from. HPC differentiates t to sequentially more mature. HPC circulate in very low Upstate Cord Blood Bank Hematopoietic Progenitor Cells Hematopoiesis i starts from self renewing HPC HPC differentiates t to sequentially more mature blood cells HPC circulate in very low numbers in adults

More information

How To Transplant Cord Blood

How To Transplant Cord Blood MP 7.01.38 Placental/Umbilical Cord Blood as a Source of Stem Cells Medical Policy Section Surgery Issue 12:2013 Original Policy Date 12:2013 Last Review Status/Date Reviewed with literature search/12:2013

More information

In contrast to the very high transplant-related

In contrast to the very high transplant-related Cord Blood: an Alternative Stem Cell Source or a New Standard? Juliet N. BARKER Memorial Sloan-Kettering Cancer Center, NY, ABD In contrast to the very high transplant-related mortality (TRM) associated

More information

Stem Cell Transplantation in Severe Aplastic Anemia

Stem Cell Transplantation in Severe Aplastic Anemia Stem Cell Transplantation in Severe Aplastic Anemia Dr. D. Goodyear MD, FRCPC Division of Hematology and Hematological Malignancies, University of Calgary 1 of 11 Introduction Most cases of aplastic anemia

More information

In a number of genetic, hematologic, and oncologic

In a number of genetic, hematologic, and oncologic AMERICAN ACADEMY OF PEDIATRICS Cord Blood Banking for Potential Future Transplantation: Subject Review ABSTRACT. In recent years, umbilical cord blood, which contains a large number of hematopoietic stem

More information

Cord Blood Banking A new horizon

Cord Blood Banking A new horizon Cord Blood Banking A new horizon Dr. Sushma Sharma Professor Obst. & Gyn., MIMER Medical College, Talegaon Dabhade, Pune. Abstract : Background : Umbilical cord blood is a potential vast source of primitive

More information

Umbilical Cord Blood: An Alternative Allogeneic Stem Cell Source for Transplantation

Umbilical Cord Blood: An Alternative Allogeneic Stem Cell Source for Transplantation Umbilical Cord Blood: An Alternative Allogeneic Stem Cell Source for Transplantation Mary J. Laughlin, MD Associate Professor of Medicine and Pathology Dr. Donald and Ruth Weber Goodman Professor of Innovative

More information

Hydroxyurea Treatment for Sickle Cell Disease

Hydroxyurea Treatment for Sickle Cell Disease Hydroxyurea Treatment for Sickle Cell Disease Before hydroxyurea After hydroxyurea Hydroxyurea Treatment for Sickle Cell Disease 1 This document is not intended to take the place of the care and attention

More information

How To Be A Good Donor

How To Be A Good Donor 1 of 26 pages World Marrow Donor Association International Standards for Unrelated Hematopoietic Progenitor Cell Donor Registries Document Type: Standards WG/Committee: STDC World Document Reference: 20140101-STDC-

More information

Selecting an appropriately matched donor for hematopoietic

Selecting an appropriately matched donor for hematopoietic Transplant Outcomes in Acute Leukemia (I) Mary Eapen a and John E. Wagner b Umbilical cord blood (UCB) has gradually emerged over the last decade as an alternative source of hematopoietic cells for transplantation

More information

UMBILICAL CORD BANKING. (formerly Unistem Biosciences Pvt.Ltd.)

UMBILICAL CORD BANKING. (formerly Unistem Biosciences Pvt.Ltd.) UMBILICAL CORD BANKING (formerly Unistem Biosciences Pvt.Ltd.) INITIATIVES OF CELLUGEN BIOTECH PVT.LTD. (formerly Unistem Biosciences Pvt.Ltd.) UMBILICAL CORD BANKING UMBILICAL CORD STEM CELL THERAPY Stem

More information

umbilical cord blood banking A guide for parents

umbilical cord blood banking A guide for parents umbilical cord blood banking A guide for parents 2 nd Edition 2016 This guide has been elaborated by the Council of Europe European Committee on Organ Transplantation (CD-P-TO). For more information, please

More information

ASSEMBLY, No. 2591 STATE OF NEW JERSEY. 212th LEGISLATURE INTRODUCED FEBRUARY 23, 2006

ASSEMBLY, No. 2591 STATE OF NEW JERSEY. 212th LEGISLATURE INTRODUCED FEBRUARY 23, 2006 ASSEMBLY, No. STATE OF NEW JERSEY th LEGISLATURE INTRODUCED FEBRUARY, 00 Sponsored by: Assemblywoman CHARLOTTE VANDERVALK District (Bergen) SYNOPSIS Requires hospitals to provide information to pregnant

More information

Beyond Cell Dose: Selection of the Optimal Umbilical Cord Blood Unit. Karen Ballen, MD Massachusetts General Hospital June, 2012

Beyond Cell Dose: Selection of the Optimal Umbilical Cord Blood Unit. Karen Ballen, MD Massachusetts General Hospital June, 2012 Beyond Cell Dose: Selection of the Optimal Umbilical Cord Blood Unit Karen Ballen, MD Massachusetts General Hospital June, 2012 OUTLINE Cell Dose HLA Typing HLA C and KIR HLA Antibodies ABO and Racial/Ethnic

More information

11/10/2011. History of CBUs. 10-CBA providing access to unlicensed cord blood units. The FDA s involvement. The FDA s involvement, cont.

11/10/2011. History of CBUs. 10-CBA providing access to unlicensed cord blood units. The FDA s involvement. The FDA s involvement, cont. History of CBUs First CBU transplant done in 1988 10-CBA providing access to unlicensed cord blood units Using the NMDP IND to access unlicensed cord blood units Amy Hays, Sr. Clinical Research Specialist,

More information

INFORMATION ON STEM CELLS/BONE MARROW AND REINFUSION/TRANSPLANTATION SUR703.002

INFORMATION ON STEM CELLS/BONE MARROW AND REINFUSION/TRANSPLANTATION SUR703.002 INFORMATION ON STEM CELLS/BONE MARROW AND REINFUSION/TRANSPLANTATION SUR703.002 COVERAGE: SPECIAL COMMENT ON POLICY REVIEW: Due to the complexity of the Peripheral and Bone Marrow Stem Cell Transplantation

More information

Cord Blood Transplant Past and Future. E. Gluckman Eurocord ISCT Paris 24/04/2014

Cord Blood Transplant Past and Future. E. Gluckman Eurocord ISCT Paris 24/04/2014 Cord Blood Transplant Past and Future E. Gluckman Eurocord ISCT Paris 24/04/2014 Background Since 1988, umbilical cord blood (CB) has been successfully used to treat children and adults needing stem cell

More information

Phone: +44 20 8123 2220 Fax: +44 207 900 3970 office@marketpublishers.com http://marketpublishers.com

Phone: +44 20 8123 2220 Fax: +44 207 900 3970 office@marketpublishers.com http://marketpublishers.com Global Stem Cell Umbilical Cord Blood (UCB) Market (Storage Service, Therapeutics, Application, Geography) - Size, Share, Global Trends, Analysis, Opportunities, Growth, Intelligence and Forecast, 2012-2020

More information

Do you have anything to add? If so, I d love to hear from you! Jessica Robinson Conference Manager Life Sciences @jessbiopharma

Do you have anything to add? If so, I d love to hear from you! Jessica Robinson Conference Manager Life Sciences @jessbiopharma 1 Who is the most influential figure in cord blood around the world? What is the biggest challenge to overcome in the use of cord blood as a source of stem cells? We asked 10 leading experts in the cord

More information

The availability of haematopoietic stem or progenitor

The availability of haematopoietic stem or progenitor Update Article Umbilical Cord Blood Transplantation: Newer Trends MB Agarwal Abstract During last ten years, over 4000 umbilical cord blood transplantations have been performed worldwide. The interest

More information

Asian Harmonization via Cord Blood Bank Network

Asian Harmonization via Cord Blood Bank Network Asian Harmonization via Cord Blood Bank Network Introduced by Shigetaka Asano Of Tokyo Cord Blood Bank SCA 200, Seoul Country China Indonesia Philippines Vietnam Japan Thailand Myanmar Korea Malaysia Cambodia

More information

Guidelines for Collection, Processing, and Storage of Cord Blood Stem Cells Second Edition March 2003

Guidelines for Collection, Processing, and Storage of Cord Blood Stem Cells Second Edition March 2003 Guidelines for Collection, Processing, and Storage of Cord Blood Stem Cells Second Edition March 2003 New York State Council on Human Blood and Transfusion Services New York State Department of Health

More information

Stem cells from Cord Blood: Myths, reality and potential. Elisabeth Semple, PhD Scientific Director Cells for Life Cord Blood Institute

Stem cells from Cord Blood: Myths, reality and potential. Elisabeth Semple, PhD Scientific Director Cells for Life Cord Blood Institute Stem cells from Cord Blood: Myths, reality and potential Elisabeth Semple, PhD Scientific Director Cells for Life Cord Blood Institute Learning objectives Understand the current usage of stem cells from

More information

Bone Marrow/Stem Cell Transplant

Bone Marrow/Stem Cell Transplant Blue Distinction Centers for Transplants Program Selection Criteria for 2010 Mid-Point Designations To qualify as a Blue Distinction Center for Transplants (), each facility must satisfy s quality based

More information

On April 4, a group of physicians at the 37th annual

On April 4, a group of physicians at the 37th annual By Ronale Tucker Rhodes, MS Better gene sampling and newer transplant regimens are making stem cell transplantation possible for a host of disease states that previously were rarely considered for this

More information

Dr Saeed Al Amoudi. Consultant Hematologist King s college hospital Director of Regional Lab Jeddah

Dr Saeed Al Amoudi. Consultant Hematologist King s college hospital Director of Regional Lab Jeddah Dr Saeed Al Amoudi Consultant Hematologist King s college hospital Director of Regional Lab Jeddah MAGIC BULLET Cord Blood Banking What is Cord Blood? Cord blood is the blood left in the placenta and umbilical

More information

Ethical issues in stem cell research and application

Ethical issues in stem cell research and application Ethical issues in stem cell research and application Dr. Jeff Blackmer MD MHSc FRCPC Vice President Medical Professionalism Canadian Medical Association Ottawa, ON May 2016 Outline Ethics and stem cells

More information

The Value of Cord Blood Stem Cells. Mona Shafey, MD, FRCPC Medical Grand Rounds October 25 th, 2011

The Value of Cord Blood Stem Cells. Mona Shafey, MD, FRCPC Medical Grand Rounds October 25 th, 2011 The Value of Cord Blood Stem Cells Mona Shafey, MD, FRCPC Medical Grand Rounds October 25 th, 2011 Objectives To discuss umbilical cord blood as a stem cell source and the role of umbilical cord blood

More information

GAO NATIONAL CORD BLOOD INVENTORY. Practices for Increasing Availability for Transplants and Related Challenges. Report to Congressional Committees

GAO NATIONAL CORD BLOOD INVENTORY. Practices for Increasing Availability for Transplants and Related Challenges. Report to Congressional Committees GAO United States Government Accountability Office Report to Congressional Committees October 2011 NATIONAL CORD BLOOD INVENTORY Practices for Increasing Availability for Transplants and Related Challenges

More information

The Danish Bone Marrow Donor Registry DBMDR

The Danish Bone Marrow Donor Registry DBMDR The DBMDR Vision To achieve and maintain a position as an internationally recognized hematopoietic stem cell donor registry with respect to high quality of donor data base and HLA typing, individualized,

More information

information for payers and referrers

information for payers and referrers a d u lt s t e m c e l l t r a n s p l a n tat i o n p r o g r a m information for payers and referrers Spring 2014 For more information, visit www.dfbwcc.org/bmt. o u r expertise Since its founding in

More information

Red Blood Cell Transfusions for Sickle Cell Disease

Red Blood Cell Transfusions for Sickle Cell Disease Red Blood Cell Transfusions for Sickle Cell Disease Red Blood Cell Transfusions for Sickle Cell Disease 1 Produced by St. Jude Children s Research Hospital, Departments of Hematology, Patient Education,

More information

42 USC 274k. NB: This unofficial compilation of the U.S. Code is current as of Jan. 4, 2012 (see http://www.law.cornell.edu/uscode/uscprint.html).

42 USC 274k. NB: This unofficial compilation of the U.S. Code is current as of Jan. 4, 2012 (see http://www.law.cornell.edu/uscode/uscprint.html). TITLE 42 - THE PUBLIC HEALTH AND WELFARE CHAPTER 6A - PUBLIC HEALTH SERVICE SUBCHAPTER II - GENERAL POWERS AND DUTIES Part I - C.W. Bill Young Cell Transplantation Program 274k. National Program (a) Establishment

More information

UMBILICAL CORD BLOOD BANKING. A guide for parents

UMBILICAL CORD BLOOD BANKING. A guide for parents UMBILICAL CORD BLOOD BANKING A guide for parents This guide has been elaborated by the Council of Europe European Committee on Organ Transplantation (CD-P-TO). For more information, please visit https://go.edqm.eu/transplantation.

More information