Circulating microvesicles for non-invasive remission monitoring in Hodgkins Lymphoma M. Pegtel, D. de Jong de, J. Zijlstra. CCA

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1 Circulating microvesicles for non-invasive remission monitoring in Hodgkins Lymphoma M. Pegtel, D. de Jong de, J. Zijlstra. CCA Proteomics analysis of brain tissue derived from patients with Alzheimer's disease and tangle only dementia to identify biomarkers and gain insight into molecular disease mechanisms J.M. Rozemuller, D. Hondius, S.M. van der Vies, J. Hoozemans. NCA Samenwerking CRI 2013 Saskia van der Vies S.M. van der Vies. SCIRE Science Creative Interdisciplinaire Recherche Education TRACER Genomic biomarkers to predict development of RA (VERA, ERA), and therapy responsiveness (ESRA) (WP5) C. Verweij, J. Lübbers, E. Mantel, A.E. Voskuyl, R. Out, C. Verweij, Dept. of Pathology, Dept. of Rheumatology, Flexgen. CTMM TRACER Protein arrays and metabolite biomarkers to predict development of RA and response to therapy (WP8) C. Verweij, J. Wesseling, A.E. Voskuyl, P. van der Putte, C. Verweij, Dept. of Pathology, Dept. of Rheumatology, Flexgen. CTMM TRACER ICT C. Verweij, S. de Ridder, J. Beliën, C. Verweij, Dept. of Pathology. CTMM Cervix-care: biomarkers-based triage diagnostics for HPV positive women to detect cervical cancer C.J.L.M. Meijer. Eurostrats Health-economic modelling of prevention strategies for HPV related diseases in European Countries C.J.L.M. Meijer, J. Berkhof. ZonMw Health-economic modelling of prevention strategies for HPV related diseases in European Countries C.J.L.M. Meijer, J. Berkhof. EU Humavac: Comprehensive analysis of the long term oncogenic capacity and in vitro transforming property of the 15 high-risk human papillomavirus types C.J.L.M. Meijer, D.M. Schütze, R. van Baars, J. van der Marel, P.J.F. Snijders, R.D.M. Steenbergen, W. Quint, C.J.L.M. Meijer. Dept. of Pathology, VU University Medical Center, Amsterdam. Humavac Epstein Barr Virus Activation and Cytolytic Antiviral Therapy in Nasopharyngeal Carcinoma Patients J.M. Middeldorp, "O. Ramayanti1, A.E. Greijer1, I.B. Tan2, J. Kurnianda3, J.M. Middeldorp1 1Dept of Pathology, VU University Medical Center, 2Dept. Of Head and Neck Surgery & Medical Oncology, NKI, Amsterdam, 3Dept Medicine, Gadjah Mada University. KWF VU Profiling of aberrant microrna methylation events that are functionally relevant during cervical carcinogenesis P.J.F. Snijders, S.M. Wilting, R.D.M. Steenbergen, P.J.F. Snijders. KWF VU Clinical evaluation of methylation markers for risk assessment of high-risk HPV-positive women for cervical cancer and its high grade precursors D.A.M. Heideman, "L. de Strooper, C.J.L.M. Meijer, P.J.F. Snijders, D.A.M. Heideman. Dept. Of Pathology, VU University Medical Center Amsterdam. KWF VU Autoantibodies to neurofilaments in the pathogenesis of axonal damage and grey matter pathology in MS S. Amor, P. van der Valk, H. Herrman (German Cancer Institute), J.M. van Noort (prot. Chemistry TNO), C.D. Dijkstra (Mol. Cellbiology), L. Boven (Neuroimmunology), C. Linington (Aberdeen University), C. Polman (Neurology, VUmc). MS stichting Understanding neurodegeneration and moving towards neuroprotection: from molecule to mind P. van der Valk, H.E. de Vries1, C.D. Dijkstra1, J. van Horssen2, S. Amor3, J.J.G. Geurts4, H. Vrenken5, F. Barkhof5, J. Kilestein6, C.H. Polman6. 1 Dept. Of Mol. Cell Biology VUmc, 2 Dept. Of Neuropathology SMSR, 3 Dept. Of Pathology VUmc, 4 Dept. Of Neuroanatomy and neurosciences, 5 Dept. of Radiology, 6 Dept. of Neurology. MS stichting

2 CTMM algemeen G.A. Meijer, M. van Engeland1, C.J.H. van de Velde2, G.A. Meijer3, Dept of Pathology, MUMC1, LUMC2, VU University Medical Center Amsterdam3 CTMM. CTMM Development of screening tests for early detection of CRC (A1) G.A. Meijer, L. Bosch1, B. Carvalho1, M. van der Wiel1, V. Coupé1, M. van Engeland4, Y. van der Burgt5, W. van Criekinge6, C.R. Jimenez2, R. Fijneman1, C.J. Mulder3, G.A. Meijer1, 1Dept. Of Pathology, 2Dept. Medical Oncology (OncoProteomics Laboratory), 3Dept. Gastroenterology, VU University Medical Center, 4MUMC, 5LUMC, MdXHEalth, 6Univ Gent. CTMM Development of screening tests for early detection of CRC (A2) G.A. Meijer, B. Carvalho1, M. van der Wiel1, V. Coupé1, M. van Engeland2, Y. van der Burgt3, W. van Criekinge4, G.A. Meijer Dept. Of Pathology, VUmc1, MUMC2, LUMC3, MdXHEalth, Univ Gent4. CTMM Molecular imaging of early stage disease (B1) G.A. Meijer, "M. de Wit, R. Fijneman, M. van der Wiel, R. Lamerichs, C.R. Jimenez, J. Stoker, G.A. Meijer, Dept. Of Pathology, VU University Medical Center, Amsterdam, AMC, Philips. CTMM Molecular imaging of early stage diesease (B2) G.A. Meijer, M. de Wit, R. Fijneman, M. van der Wiel, R. Lamerichs, C.R. Jimenez, J. Stoker, G.A. Meijer, Dept. Of Pathology, VU University Medical Center, Amsterdam, AMC, Philips. CTMM Molecular imaging of early stage diesease (B3) G.A. Meijer, M. de Wit, R. Fijneman, M. van der Wiel, R. Lamerichs, C.R. Jimenez, J. Stoker, G.A. Meijer, Dept. Of Pathology, VU University Medical Center, Amsterdam, AMC, Philips. CTMM Laboratory tests in primary colorectal cancer G.A. Meijer, B. Carvalho1, M. van Engeland2, W. Corver3, B. Janssen4, W. van Criekinge5, G.A. Meijer1, Dept. Of 1Pathology, VU University Medical Center, Amsterdam, 2MUMC, 3LUMC, 4ServiceXS, MDXHEalth, Univ. Gent. CTMM Metastatic colorectal molecular laboratory tests (E) G.A. Meijer, B. Ylstra1, B. Carvalho1, M. van Engeland2, W. Corver3, B. Janssen4, W. van Criekinge5, G.A. Meijer1, Dept. Of 1Pathology, VU University Medical Center, Amsterdam, 2MUMC, 3LUMC, 4ServiceXS, MDXHEalth, Univ. Gent. CTMM Personalized therapy in recurrent colorectal cancer (F1) G.A. Meijer, J. Goos1, R. Fijneman1, A.A. Geldof2, O.S. Hoekstra2, L. Perk3, G.A. Meijer1, Dept. Of 1Pathology, 2Nuclear Medicine & PET research, VU University Medical Center, Amsterdam, 3 BV Cyclotron. CTMM Personalized therapy in recurrent colorectal cancer (F2) G.A. Meijer, J. Goos1, R. Fijneman1, A.A. Geldof2, O.S. Hoekstra2, L. Perk3, G.A. Meijer1, Dept. Of 1Pathology, 2Nuclear Medicine & PET research, VU University Medical Center, Amsterdam, 3 BV Cyclotron. CTMM ICT and data analysis G.A. Meijer, J. Beliën, G.A. Meijer. CTMM Medical technology assessment G.A. Meijer, C. Uyl, V. Coupé, G.A. Meijer, Dept. Of Pathology, VU University Medical Center, Amsterdam. CTMM Projectmanagement G.A. Meijer, M. van Engeland1, C.J.H. van de Velde2, G.A. Meijer2, Dept of Pathology, MUMC1, VU University Medical Center Amsterdam2, LUMC. CTMM Development of an improved molecular test for population-wide colorectal cancer screening G.A. Meijer, A.C. Hiemstra, B. Carvalho, R.J.A. Fijneman, C.R. Jimenez, C.J. Mulder, G.A. Meijer, Dept. of Pathology, Medical Oncology and Gastroenterology, VU University Medical Center, Amsterdam Vrienden van het CCA. Vrienden van het CCA Translational Research IT G.A. Meijer, R. Fijneman, C.R. Jimenez, B. Ylstra, J.W. Boiten, J. Beliën, G.A. Meijer, Dept. of Pathology, VU University Medical Center, Dept. of Medical Oncology, VU University Medical Center, CTMM. CTMM

3 Dutch National Tissue Portal G.A. Meijer, C. Steegers, F. van Kemenade, G.A. Meijer, Dept. of Pathology, VU University Medical Center. BBMRI-NL Building data bridges and services between biological and medical infrastructures in Europe G.A. Meijer, R. Voorham, J. van Denderen, J. Beliën, J.W. Boiten, G.A. Meijer, Dept. of Pathology VU University Medical Center, CTMM. EU-KP7 Comprehensive molecular characterisation of a longitudinal in virto model of high-risk HPV-mediated transformation S. Wilting, V. Miok1, S.M. Wilting1, R.D.M. Steenbergen1, W.N. van Wieringen2, P.J.F. Snijders1, Dept. Pathology1 and Epidemiology & Biostatistics2, VU University Medical Center Amsterdam. St. VUmc CCA Identification of clinically relavant genetic aberrations in pediatric glioneuronal tumors B. Ylstra, B. Ylstra1, P. Wesseling1, E. Aronica2, Schouten2, Dept. Of Pathology, 1VU University Medical Center Amsterdam, 2Amsterdam Medical Center. Edli Foundation Predictive genomic biomarker methods for combination bevacizumab (AVASTIN) therapy in metastatic colorectal cancer B. Ylstra. EU EU KP7 Natural control of inflammation in preactive Multiple Sclerosis lesions S. Amor, P. van der Valk. EU Analysis of human macrophage and microglia responses to either free or microparticle-encapsulated alpha B Crystallin S. Amor, M. Bsibsi, H. van Noort, Delta Crystallon, Leiden. Delta Crystallon pre-active MS lesions hold clues for the reversal of inflammation S. Amor, P. van der Valk, M. Kipp. MS stichting Bayesian statistics and Bioinformatics for Biomarker validation using Biobanks in Alzheimer's Disease S.M. van der Vies. Agentschap NL Personalized Medicine in the treatment of rheumatoid atrhritis C. Verweij. Netherlands Genomics Initiative Towards a molecular understanding of the preclinical phase and therapy responsiveness in rheumatoid arthritis C. Verweij. Reumafonds B cells in the clinical phase of rheumatoid arthritis C. Verweij. Reumafonds EBV non-coding RNAs hijack components of the mirna machinery promoting viral oncogenesis D.M. Pegtel, D. Koppers-Lalic, J.M. Middeldorp, G. Scheffer, R.J. Scheper, C.R. Jimenez, D.M. Pegtel. AICR Genomic biomarkers in tumor vesicles for minimally-incasive cancer diagnosis D.M. Pegtel. KWF Exploration of novel therapeutic options for refractory CD (RCD) and EATL S. Cillessen, S. Cillessen, M. von Blomberg, H.J. Bontkes, G. Bouma, C. Mulder, Dept. Of Pathology and Gastroenterology, VU University Medical Center, Amsterdam. Celiac disease Consortium (CDC) Identification of targeted therapies for anaplastic large cell lymphoma based on apoptosis expression profiles S. Cillessen, C.J.L.M. Meijer, G.J. Ossenkoppele. KWF Novartis teaching course S. Amor.

4 Charcot Tapestry education grant S. Amor. BSI and UK MS society Atherosclerosis of the aortic heart valve J.W.M. Niessen. SRP Inflammation in wound healing J.W.M. Niessen. GGD/SRP Complement in infectious diseases J.W.M. Niessen. Sanquin/SRP Structural chromosomal rearrangements in colorectal cancer R.J.A. Fijneman, E. van den Broek, R.J.A. Fijneman, G.A. Meijer, Dept. Of Pathology, VU University Medical Center, Amsterdam V-ICI. VUmc-CCA Tumor-specific protein biomarkers for early detection of colorectal cancer R.J.A. Fijneman, C.R. Jimenez, G.A. Meijer. KWF VU Molecular Self Screening for Cervical Cancer Prevention C.J.L.M. Meijer. EU ERC advanced grant Molecular Self Screening for Cervical Cancer Prevention C.J.L.M. Meijer. European Research Council CRCbioscreen G.A. Meijer, B. Carvalho, R.J.A. Fijneman, C.R. Jimenez. CTMM New therapy for Epstein-Barr virus driven tumours by targeting the virus itself J.M. Middeldorp. KWF VU C1-esterase remmer om locale en systemische complicaties bij brandwonden te voorkomen J.W.M. Niessen, D. Uhlrich. Nederlands Brandwonden Centrum WO/ Understanding blood brain barrier alterations underlying capillary amyloid angiopathy: a route to novel diagnostics? J.M. Rozemuller. EU -- The Education, audiovisual and Culture Executive Agency Pentraxin 3 - a key to improved control over inflammation during MS? S. Amor. MS stichting MS Construction of a discriminatory, biologically relevant mirna marker panel for triage in hrhpv-based cervical cancer screening S. Wilting. KWF VU Regulation of interferon acitivity by rituximab in rheumatoid arthritis C. Verweij. Reumafonds NK NIRG J. Hoozemans. Alzheimer association Continued collaboration of HOVON within the Lunenberg Lymphoma Biomarker consortium (LLBC): application for funding of technical support D. de Jong. Lunenburg Lymphoma Biomarker Consortium Foundation Het toedienen van C1-esterase remmer om locale en systemische complicaties bij brandwonden te voorkomen J.W.M. Niessen. Nederlandse Brandwonden Stichting

5 Circulating microvesicles containing inflammatory viral RNA (EBER1) as indicators of SLE activity and renal involvement M. Pegtel. Reumafonds NK13744 Next Generation Sequencing: from Prostate to Colorectal cancer R.J.A. Fijneman. CTMM Vulvar carcinogenesis: assessment of molecular alterations in vulvar SCC and precursor lesions M. Bleeker. CGOA Molecular stool test for post-polypectomy surveillance G.A. Meijer, Dekker E (AMC), Engeland M (UMCM). KWF VU Towards the implementation of personalized treatment of diffuse large B-cell lymphoma in the Netherlands; preparations for a biomarker-based Bayesian trial D. de Jong, Lugtenburg, PJ (ErasmusMC), J.M. Zijlstra (VUmc). KWF VU Development of a HOVON Lymphoma Biobank Facility D. de Jong, Kluin, D (UMCG), Chamuleau MED (VUmc) VUmc - CCA Drylab G.A. Meijer. CCA DCR1 and its role in response of colorectal cancer patients to irinotecan treatment L. Bosch. KWF VU Adaption of a novel specific stem cell targeting technique for application in humans P. Krijnen. ZonMW Molecular profiling of IBD-associated dysplasia S. de Vries. Sacha Swarttouw-Hijmans 2014 p5 Identifying pathways involved in colorectal adenoma-to-carcinoma progression B. Carvalho, C.R. Jimenez, G.A. Meijer. KWF Immuno primed microglia: a factor underlying progressive multiple sclerosis S. Amor. National Multiple Sclerosis society Age-dependent Toll-like receptor signalling in Alzheimer's disease brain J. Hoozemans. Alzheimer association Analysis of the genetic content of EV for cander biomarker discovery (project 3.1) M. Pegtel.STW projectnummer High-throughput functional validation of altered micrornas associated with HPV-induced anchorage independent growth R. Steenbergen. CCA CCA Improving classification of molecular tumour profiles from impure clinical material by the use of co-data S. Wilting. CCA CCA Prevention of overdiagnosis and overtreatment of HPV-positive women by methylation marker testing D.A.M. Heideman. KWF VU CAVIA: Cerebral Amyloid Angiopathy: Vascular Imaging and fluid markers of Amyloid deposition J.M. Rozemuller, M.M. Verbeek (UMCN). ZonMW

6 Molecular Diagnostics in Rheumatoid Arthritis C. Verweij. ZonMW samenwerking GGZ: cytokine analysis in NESDA H. Bontkes. GGZ Uncovering the role of exosome-educated mesenchymal stem cells in osteosarcoma Progression D.M. Pegtel. AICR icare 2014 Non Small Cell Lung Cancer (NSCLC) ALK IHC positive, registry study E. Thunnissen. Pfizer A randomized, double-blinded, controlled with Gardasil, Phase 3 clinical trial to study the immunogenevity and tolerability of V503 in 16 to 26 year-old men C.J.L.M. Meijer. Sanofi Monoclonalen afdelingshoofd. PAT0003 OMS-TCL-1 C.J.L.M. Meijer. OMS OMS-TCL-1 Genmab J.W.M. Niessen. Genmab Diverse Div 5 beheer BV projecten. EQA en ETOP E. Thunnissen. European Thoracic Oncology Platform E. Thunnissen. ETOP