Greater Toronto Area Value Proposition for Life Science Businesses. Your ideal destination for international expansion

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1 Greater Toronto Area Value Proposition for Life Science Businesses Your ideal destination for international expansion

2 Life Sciences Sector: Ontario One of North America s largest biomedical sectors. Over 1,200 life sciences firms and $15 billion in revenues with $5 billion generated by exports. The region s growing reputation for excellence in bio life sciences research has attracted major private and public R&D investment, including $1 billion from pharmaceutical companies for advanced drug development programs, and $347 million over five years from the Ontario government for the new Ontario Institute for Cancer Research (OICR).

3 Multi-National Firms Life Science s Industry Profile Key companies in the Life Sciences sector. Company GTA Location Company GTA Location Pfizer Amgen Novartis Baxter Sanofi Pasteur Toronto Gamma-Dynacare Brampton GlaxoSmithKline Genzyme Astra Zeneca GE Healthcare Toronto Roche INC Research Johnson & Johnson Markham Nucro-Technics Toronto Eli Lilly Toronto Patheon Agfa Healthcare Toronto Teva Toronto Apotex Toronto Therapure Biopharma The Toronto Region is home to Canada s largest Life Sciences cluster. Over 37,000 people are employed in the Life Sciences industry in the Toronto Region, compromising 30% of the Canadian Life Sciences workforce.

4 Established Business Base & Support Services More than 200 companies provide specialized services for the Life Sciences sector. Contract Research Provide pre-clinical studies, study design, patient monitoring and site management. Manufacturing Producing regular or small runs, first runs, experimental runs and packaging for clinical trials. Regulatory Providing specialized expertise to ensure compliance with law and regulations. Global Logistics & Distribution Integrated firms managing the unique requirements associated with the acquisition and transport of pharmaceuticals. Healthcare Marketing An extensive range of marketing, advertising and communication firms that specialize in prescription, over-the-counter and direct-toconsumer products.

5 Life Science Support Environment in GTA Life Science s Industry Profile Industry BIOTECanada Research Innovation Commercialization Centre (RIC) Markham Convergence Centre Innovation Synergy Centre York biotech Technology Association Business Information Technology Network Innovation Durham Northumberland HalTech Innovation Centre Life Science Ontario Medec Ontario Bioscience Government Ontario Centre of Excellence (OCE) MaRS Discovery District- Business Project Funding Ontario Emerging Technologies Fund MRI Innovation Demonstration Fund; Commercialization Investment Funds NSERC Collaborative Research and Development Grants Ministry of Economic Development AND MORE

6 Innovation Hotspot Toronto region is Canada's largest centre for research and education - received one-third ($841 million) of research funding from the three major Canadian science granting councils in % of all R&D conducted in Canada takes place in the Toronto Regio.n Global leader in competitive R&D costs - 45% less expensive than London, 41% less than Frankfurt, 37% less than New York, and 20% less than Paris.

7 GTA: Research Institutes Institute York University Centennial College University of Toronto Research Centers Sherman Health Science Research Centre New Life Sciences Building, 2011 fmri brain-imaging and virtual reality research laboratories Health Informatics Technology program University of Toronto medical school ranks third in the world for research publication citations. Master of Science in Biomedical Communications program Academy of Medicine Centre for Applied Biosciences and Biotechnology The Genes, Environment, Nervous System and Behaviour (GENAB) Unit The Centre for Research on Biological Communication Systems Ryerson University Seneca College Ontario College of Art & Design University of Ontario Institute of Technology Humber College Biomedical Engineering Program Doctorate and Master s Degrees in Molecular physics and biomedical physics Nursing Program Health & Wellness program Inclusive Design Research Centre (IDRC) Specialization in Biological Science School of Health Sciences

8 Recent Life Science Research Highlights University of Toronto researchers were part of an international team that uncovered three genes in the Salmonella bacteria critical for it to cause disease and withstand antibiotic treatment, and may hold the key to improved disease treatment. The team found that three bacterial genes called poxa, yjek and efp work together to protect the bacterial cell from stresses it encounters during infection and antibiotic treatment. These genes exist in other bacteria that cause disease including E. coli, providing new insight into the development and treatment of these potentially lethal diseases. The study was published in the journal Molecular Cell. (TRRA 2011). As communities of cancer survivors continue to grow, the Electronic Living Laboratory for Interdisciplinary Cancer Survivorship Research (ELLICSR) located at Toronto General Hospital represents a first of its kind research centre in Canada. This unique area of interdisciplinary research will look at ways to improve the cancer experience by exploring novel ways to learn from expert survivors, develop new survivorship communities and study how to engage, empower and activate cancer survivors to adopt healthier behaviors that minimize the negative impact of cancer and its treatment. (TRRA 2011). SOURCE: Invest In Canada, 2011 Edition

9 Major Life Sciences Centre The GTA is of one of North America's largest biomedical sectors with: More than 1,200 life sciences firms 140,000 employees $8 billion in pharma revenues in Ontario Medical & Assistive Devices Over 360 innovative companies clustered offering a wide range of products and services, The sector is supported by many academic institutions providing over 50 programs related to medical devices and biomedical engineering Stem Cells & Regenerative Medicine 78 scientists and investigators focus on five broad areas: cancer stem cells, adult stem cells, embryonic stem cells, regenerative medicine, and bioengineering Stem research activity in the Toronto Region is comparable to Boston and California Immunology & Vaccines Toronto is home to 55% of Canada's pharmaceutical companies, making the Toronto region the largest pharmaceutical cluster in the nation. sanofi pasteur, the world s largest company devoted entirely to human vaccines, is based in the region with 1 of 2 global research centres, and 1 of 3 global vaccine process development and production centres

10 Ontario consumer digital health companies stand out as leaders in customer-centric product design. A strong culture of collaboration exists between the spheres of medicine, information technology and the arts. Growth drivers in consumer digital health Strong culture of collaboration Health Design Lab (St. Michael s hospital Li Ka Shing Knowledge Institute) Create and customize media integrating health information access. Office of Research and Innovation (George Brown College, Ryerson, OCAD, St. Michael s hospital) Develop interactive approaches for the health and wellness industry. MaRS Market Insights, 2010

11 The GTA is home to 12 teaching hospitals and more than 300 research institutes. Terrence Donnelly Centre for Cellular and Biomolecular Research University of Toronto, TORONTO

12 Success Story- GlaxoSmithKline Inc. Life Science s Industry Profile GLAXOSMITHKLINE, MISSISSAUGA, GTA Top 15 investor in Canadian research and development, contributing more than $144 million in In 2009, GSK invested close to $38 million in clinical trials in Canada, conducting more than 90 trials and enrolling over 4,000 patients. In 2011, GSK expanded its state-of-the-art advanced manufacturing facility in. Our Canadian headquarters and state-of-the-art manufacturing and product development facility are in the heart of Toronto Region s Life Science cluster. The tax situation, location and infrastructure here are favourable, and the local educational institutions have created the academic infrastructure and talent pool that supports the sector. Paul N. Lucas, President & CEO, GlaxoSmithKline Inc., Canada SOURCE: VANTAGE Greater Toronto, ICT Issue

13 Pharmaceutical Investments in the GTA In September 2011, Eisai Inc, a pharmaceutical company established its Canadian headquarters in. Eisai s expansion into Canada will increase access to a variety of therapies and medications, including treatments for advanced breast cancer, Alzheimer s disease, and epilepsy. Eisai will also continue to invest in clinical trials here, supporting Ontario suppliers, both public and private research institutions and organizations. In August 2011, Roche Holding AG, through its Roche Canada unit, announced that it will invest $190 million over the next five years at its plant, with a $7.8 million Ontario Government commitment. A new research centre, with a staff of 200, will manage all Roche s clinical trials for new drugs in cooperation with the multi-national s five existing world research centers. SOURCE: Invest In Canada, 2011 Edition

14 Pharmaceutical Investments in the GTA In June 2011, Sanofi Pasteur, a subsidiary of Sanofi-Aventis based in France, built a $101 million research and development center in Toronto. The new research and development center will focus on research and development of public health vaccines. Sanofi Pasteur produces and markets 20 vaccines protecting against bacterial and viral diseases as diphtheria, hepatitis, polio, and meningitis. In May 2010, TEVA Pharmaceuticals announced their investment of $56 million to expand the Stouffville, Ontario production plant. Ontario is providing a $6.5 million grant from the Next Generation Jobs Fund to TEVA. More than half the drugs produced by TEVA in Canada are exported globally. SOURCE: Invest In Canada, 2011 Edition

15 Incentives for Life Science Sector SUPPORT PROGRAMS/INCENTIVES CRITERIA HOW MUCH Scientific Research & Experimental Development (SR&ED) Canadian businesses of all sizes and in all sectors to conduct research and development (R&D) in Canada that will lead to new, improved, or technologically advanced products or processes. Earn an investment tax credit (ITC) of 35% up to the first $3 million of qualified expenditures for SR&ED carried out in Canada, and 20% on any excess amount. Ontario Business Research Institute Tax Credit (OBRITC) Must incur qualified expenditures in respect of scientific research and experimental development (SR&ED) under an eligible contract with an eligible research institute (ERI) 20% refundable tax credit for SR&ED expenditures incurred in Ontario under an eligible contract with an ERI. The maximum amount a corporation can claim is $4 million To review additional Ontario Life Sciences Incentives browse the following links: -Ontario Life Sciences Incentives -Other

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