Nutritional Support in Management of Joint Discomfort and Chronic Inflammation. The Chiropractic Perspective Mark Kaye, DC
|
|
- Kelly Hopkins
- 7 years ago
- Views:
Transcription
1 Nutritional Support in Management of Joint Discomfort and Chronic Inflammation The Chiropractic Perspective Mark Kaye, DC
2 Joint discomfort Joint pain and discomfort are the leading causes of disability among U.S. adults 1 Joint pain is the main complaint of the 2 most common types of arthritis, osteoarthritis (OA) and rheumatoid arthritis (RA) Data show 30% of U.S. adults report experiencing some type of joint pain every month % men and 23.5% women 60 y report knee pain 3 1. Murphy L and Helmick C. The impact of osteoarthritis in the United States: a population-health perspective. Am J Nurs 2012;112(3):S National Health Interview Survey MMWR 2008;57(17): Andersen RE et al. Prevalence of significant knee pain among older Americans; results from NHANES III. J Am Geriatr Soc 1999;47(12):
3 Common underlying causes of OA and RA Etiology of OA and RA involve Synovial inflammation Immune cell infiltration More immune cells with pro-inflammatory cytokines found in synovial tissues of RA patients as compared to OA patients Chrondrocyte pathology Leading to unresolved inflammation 1. Berenbaum F. Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). Osteoarthritis Cartilage. 2013;21: Hoff P, et al. Osteoarthritis synovial fluid activates pro-inflammatory cytokines in primary human chondrocytes. Int Orthop. 2013;37: Otero M and Goldring MB. Cells of the synovium in rheumatoid arthritis. Chondrocytes. Arthritis Res Ther. 2007;9: De Lange-Brokaar BJ, et al. Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review. Osteoarthritis Cartilage. 2012;20:
4 Unresolved inflammation and chronic joint discomfort Recruitment of inflammatory cells & Primary lesion TNF-α, IL-6, IL-1 Activation of proteinases Cartilage extracellular matrix breakdown Aggrecanases, MMPs Chondrocyte death and cartilage loss Bone exposure Proteoglycan production Gupta PK et al. Mesenchymal stem cells for cartilage repair in osteoarthritis. Stem Cell Research & Therapy 2012;3:25.
5 Normal vs. unresolved inflammation Normal inflammatory response Unresolved resolution of inflammation Ψ Max PMN T Max Apoptotic PMN M Ф Prolonged PMN Survival M Ф X Defective MФ Efferocytosis Magnitude T 50 MФ Efferocytosis Magnitude R i Time Time Spite et al. Cell Metab. 2014;19:21-36
6 Nutritional solutions to manage joint discomfort and inflammation Current options include: UC-11 and n THIAA, Xanthohumol and curcumin, omega-3 fatty acids
7 Undenatured collagen and kinase inhibitors: UC-II and nthiaa Undenatured type II collagen (UC-II) Reduces inflammatory response via oral tolerance 1-3 n-enriched tetrahydro iso-alpha acids (nthiaa) Reduces pro-inflammatory mediators and inhibits bone and cartilage degradation in experimental models 4,5 Data from the Functional Medicine Research Center s 12-week open-case series demonstrated that UC-II and nthiaa combination is safe and efficacious in subjects with OA and RA 6 Improvements were observed as early as 2 weeks Subjects were able to discontinue or reduce dosages of analgesic 1. Lugo JP et al. Journal of the International Society of Sports Nutrition 2013;10: Crowley DC et al. International Journal of Medical Sciences 2009;6(6): Lugo JP et al. Nutrition Journal 2016;15(1):14 4. Desai A et al. Inflammation Research 2009;58(5): Konda VR et al. Arthritis & Rheumatism 2010;62(6): Lerman RH et al. Integrative Medicine: a Clinician s Journal 2015;14(5):52-61.
8 Anti-inflammatory supplements: Xanthohumol and curcumin Anti-oxidant and anti-inflammatory properties 1 Enhanced bioavailability through innovative technology Xanthohumol Curcumin XNT ProMatrix: a proprietary protein matrix using spent hop 2 CurQfen: a patented blend of a stable curcuminoid & galactomannan compound (from fenugreek) 3 1. Liu M, et al. Molecules. 2015;20: Konda V, et al. Abstract presented at Scripps Natural Supplement Conference, January Manuscript submitted for publication
9 Omega-3 fatty acids (EPA & DHA) EPA DHA Low pro-inflammatory potential Anti-inflammatory & pro-resolving properties
10 Novel nutritional supplement: specialized pro-resolving mediators Providing targeted and rapid anti-inflammatory results with endogenous molecules
11 Signaling Pathways of Resolution: Specialized Pro-Resolving Mediators (SPMs) EPA and DHA are Converted to SPMs that Resolve Inflammation But the conversion is inefficient in the face of inflammation SPMs EPA DHA 18-HEPE 17-HDHA Resolvins (E-series/D-series) Protectins HO HO OH Conversion from EPA and DHA is a multi-step process that may be affected by a person s health status CO OH O H COO H O H O H COO H Different SPMs work together to resolve the immune response and inflammation. Serhan CN. Nature. 2014;510:92-101
12 SPM (Specialized pro-resolving mediators) Tissue Impacted Progression Unresolved inflammation Resolution of inflammation SPMs Supporting the Resolution of inflammation: Curtail excessive neutrophil activity Trigger macrophages to remove dead neutrophils and debris Aid tissue remodeling Support return to homeostasis
13 Decision tree for clinical management of inflammation YES Does clinical evaluation suggest the presence of chronic inflammation requiring therapeutic management? Initiate condition-specific Medical Nutrition Therapy (MNT) Address dietary and life-style factors or other pro-inflammatory triggers and initiate MNT intervention to reduce magnitude of inflammation initiation as appropriate Nutrients to consider: curcumin, xanthohumol, polyphenol-rich extracts Co-initiate therapy with SPMs to actively facilitate inflammation resolution Oral intake of SPM supplements with maintenance dose of 2 SPMs softgels QD Higher intakes may be used for transitory periods for active management of inflammation load depending on clinical presentation Was positive change seen at 4-week evaluation of symptoms and biomarkers? YES NO Continue with therapeutic program MNT with SPM supplementation Evaluate recommended dose and increase for 4 weeks Ensure adherence to other diet and lifestyle recommendations Was positive change seen at 8 week evaluation of symptoms and biomarkers? YES NO Progress to maintenance dose of SPMs: 2 softgels QD Continue to monitor and avoid dietary and lifestyle triggers of inflammation and assess biomarkers of inflammation as routine GCPs Consider increasing SPM dose for additional 4 weeks Continue to monitor and avoid dietary and lifestyle triggers of inflammation, and biomarkers of inflammation as routine GCPs May consider additional treatments to manage disease
14 Summary of managing patients with chronic inflammation and joint pain Current supplements UC-II and n-enriched THIAA offer evidence based support in nutritional management of patients with joint discomfort Safe Effective Well tolerated Consider other bioavailable phytonutrients targeting inflammation Xanthohumol Curcumin Recommend using SPMs as a novel strategy to actively manage associated symptoms of chronic inflammation to provide resolution Balance inflammation initiation and resolution Manage trigger factors such as underlying diet and body weight
15 Relevance to the chiropractic clinician: Chiropractors are considered by patients to be pain specialists Relief of symptoms, and the underlying contributions to the pain, is a key focus of the chiropractic clinician and their patients Many patients are nutrient-deficient including omega-3 fats, phytonutrient protectant compounds (hops) Dietary and common lifestyle factors results in prolongation of inflammation (lack of resolution) Foods communicate with the immune system and some nutrients (UCII) may moderate immune response leading to clinical improvement
16 To learn more check out the following resources at Informational videos, podcasts, roundtable discussions and downloadable publications on nutritional solutions for chronic inflammation Posters from national and international congresses Nutritional Approach for Relief of Joint Discomfort: A 12-week, Open-case Series and Illustrative Case Report Total Antioxidant Capacity of Diet and Plasma Markers of Oxidant/antioxidant Status are Associated with Low-Grade Chronic Inflammation
Diet and Arthritis. Dr Áine O Connor Nutrition Scientist. British Nutrition Foundation. 2011 The British Nutrition Foundation
Diet and Arthritis Dr Áine O Connor Nutrition Scientist British Nutrition Foundation Outline Background What is arthritis? What are the common forms? Body weight and arthritis Diet and arthritis Nutrients
More informationAcne vulgaris, mental health and omega-3 fatty acids. Lipids in Health and Disease. October 13, 2008
Acne vulgaris, mental health and omega-3 fatty acids 1 Lipids in Health and Disease October 13, 2008 Mark G Rubin, Katherine Kim, Alan C Logan FROM ABSTRACT Acne vulgaris is a common skin condition, one
More informationRestore and Maintain treatment protocol
Restore and Maintain treatment protocol Combating inflammation through the modulation of eicosanoids Inflammation Inflammation is the normal response of a tissue to injury and can be triggered by a number
More informationThe Most Common Autoimmune Disease: Rheumatoid Arthritis. Bonita S. Libman, M.D.
The Most Common Autoimmune Disease: Rheumatoid Arthritis Bonita S. Libman, M.D. Disclosures Two googled comics The Normal Immune System Network of cells and proteins that work together Goal: protect against
More informationPharmacology of the Respiratory Tract: COPD and Steroids
Pharmacology of the Respiratory Tract: COPD and Steroids Dr. Tillie-Louise Hackett Department of Anesthesiology, Pharmacology and Therapeutics University of British Columbia Associate Head, Centre of Heart
More informationX-Plain Rheumatoid Arthritis Reference Summary
X-Plain Rheumatoid Arthritis Reference Summary Introduction Rheumatoid arthritis is a fairly common joint disease that affects up to 2 million Americans. Rheumatoid arthritis is one of the most debilitating
More informationPROVEN NON-INVASIVE TREATMENT FOR RHEUMATOID ARTHRITIS
PROVEN NON-INVASIVE TREATMENT FOR RHEUMATOID ARTHRITIS BIONICARE HAND SYSTEM Non-drug, non-invasive Adjunctive therapy For patients symptomatic despite current therapy For patients intolerant to drug
More informationGLUCOSAMINE, CHONDROITIN, AND MSM
GLUCOSAMINE, CHONDROITIN, AND MSM Compiled by Campbell M Gold (2009) (This material was compiled from various unverified sources) CMG Archives http://campbellmgold.com IMPORTANT The health information
More informationOMEGA-3 FISH OIL The perfect complement to chiropractic care
OMEGA-3 FISH OIL The perfect complement to chiropractic care WHAT ARE OMEGA-3S? Omega-3s are essential fatty acids nutrients that are required for optimal health but cannot be produced by our bodies, and
More informationBIOM 255 - Firestein, Winter 2009. Rheumatoid arthritis. Page 1
Rheumatoid arthritis Page 1 Vascular events in RA Synovium in rheumatoid arthritis Non-extra articular RA Extra articular RA Turesson, et al. Ann Rheum Dis. 2007;66:60 Normal Rheumatoid Arthritis Major
More informationRheumatoid Arthritis
Rheumatoid Arthritis Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints. Autoimmune diseases are illnesses that occur when the body's tissues are mistakenly
More informationRheumatoid Arthritis. Treating Inflammation. Sequoia Education Systems, Inc http://www.functionalmedicineuniversity.com 1. How is RA Diagnosed?
Rheumatoid Arthritis Causes, Assessment and Treatment How is RA Diagnosed? The following labs make up the basics of ruling in or out RA. Citrullinated Peptide (anti-ccp) Antibodies Rheumatoid factor Erythrocyte
More informationStickler Syndrome and Arthritis
Stickler Syndrome and Arthritis Arthritis Foundation Pacific Region, Nevada Office Presented by: Crystal Schulz, MPH Community Development Manager Arthritis Foundation Improving lives through leadership
More informationYour Life Your Health Cariodmetabolic Risk Syndrome Part VII Inflammation chronic, low-grade By James L. Holly, MD The Examiner January 25, 2007
Your Life Your Health Cariodmetabolic Risk Syndrome Part VII Inflammation chronic, low-grade By James L. Holly, MD The Examiner January 25, 2007 The cardiometabolic risk syndrome is increasingly recognized
More informationRHEUMATOID ARTHRITIS: PRIMARILY AN AUTOIMMUNE DISEASE JOHNATHON DUFTON, MD
RHEUMATOID ARTHRITIS: PRIMARILY AN AUTOIMMUNE DISEASE JOHNATHON DUFTON, MD RHEUMATOID ARTHRITIS: PRIMARILY AN AUTOIMMUNE DISEASE ACTIVITY DESCRIPTION Rheumatoid arthritis (RA) is an inflammatory type of
More informationArthritis www.patientedu.org
written by Harvard Medical School Arthritis www.patientedu.org Arthritis is the most common chronic disease in the world, and it s the leading cause of disability in the United States. There are more than
More informationNorbert Weber, Lilly Ostrovsky. Musculoskeletal Transplant Foundation (MTF), Edison, NJ, USA. Disclosures: N. Weber: None. L. Ostrovsky: None.
Immunogenicity of Biopharmaceuticals in Large Animal Models: Timedependent Formation of Antibodies and Detection of TNF-alpha in Serum and Synovial Fluid Norbert Weber, Lilly Ostrovsky. Musculoskeletal
More informationEating For Injury Recovery John M Berardi, PhD, CSCS Ryan Andrews, RD, MA, MS www.precisionnutrition.com
Eating For Injury Recovery John M Berardi, PhD, CSCS Ryan Andrews, RD, MA, MS www.precisionnutrition.com To most sport and exercise professionals, the idea that nutrition can play a powerful role in injury
More informationNEWS LETTER #1 Clair Thunes, PhD (916)248-8987 clair@summit-equine.com www.summit-equine.com
NEWS LETTER #1 Clair Thunes, PhD (916)248-8987 clair@summit-equine.com www.summit-equine.com As we look outside our windows many of us are seeing the emergence of Spring a welcome relief to the drudgery
More informationArthritis: An Overview. Michael McKee, MD, MPH February 23, 2012
Arthritis: An Overview Michael McKee, MD, MPH February 23, 2012 Supporters Deaf Health Talks is possible through the support of: Rochester Recreation Club for the Deaf ( REAP ) Deaf Health Community Committee
More informationLESSON OVERVIEW. Objectives: By the end of the lesson, the Lay Health Worker will be able to:
Objectives: LESSON OVERVIEW By the end of the lesson, the Lay Health Worker will be able to: 1. Describe what arthritis is in general terms. 2. Identify common myths and beliefs about arthritis that may
More informationDoctor Discussion Guide for Osteoarthritis
Doctor Discussion Guide for Osteoarthritis How to Talk to Your Doctor About Osteoarthritis of the Knee With more than 10 million people affected, osteoarthritis of the knee is the most common type of osteoarthritis.
More informationStem Cell Treatment for Lung Disease (1 of 3)
Stem Cell Treatment for Lung Disease (1 of 3) Overview Lung disease can be debilitating. As physicians, you know that providing treatment options to your patients is important. Until recently, options
More informationRHEUMATOID ARTHRITIS. Dr Bruce Kirkham Rheumatology Clinical Lead
RHEUMATOID ARTHRITIS Dr Bruce Kirkham Rheumatology Clinical Lead RHEUMATOID ARTHRITIS (RA) RA is a common disease: 0.8 per cent of the population RA more common in females: female to male ratio 3:1 RA
More informationResults of the first clinical study on a new treatment for Psori asis: the T.M.S.T. method
MINERAL MOR LTD Results of the first clinical study on a new treatment for Psori asis: the TMST method Marco Harari MD 12122012 Conclusions: 1 No side effects were recorded during the 5week study period
More informationRheumatoid arthritis: an overview. Christine Pham MD
Rheumatoid arthritis: an overview Christine Pham MD RA prevalence Chronic inflammatory disease affecting approximately 0.5 1% of the general population Prevalence is higher in North America (approaching
More informationEdna P. Schwab, M.D. Associate Professor of Clinical Medicine. Philadelphia VAMC
Impact of Arthritis in the Elderly l Edna P. Schwab, M.D. Associate Professor of Clinical Medicine Division of Geriatrics Philadelphia VAMC University of Pennsylvania Medical Center Arthritis America
More informationUnique Effects of Dried Apple Peel Powder (DAPP) on Inflammation and Joint Pain
Unique Effects of Dried Apple Peel Powder (DAPP) on Inflammation and Joint Pain Boning up on the problem The human body contains more than 300 joints, working together with muscles and bones to allow movement
More informationA Genetic Analysis of Rheumatoid Arthritis
A Genetic Analysis of Rheumatoid Arthritis Introduction to Rheumatoid Arthritis: Classification and Diagnosis Rheumatoid arthritis is a chronic inflammatory disorder that affects mainly synovial joints.
More informationCancer Treatment Moringa Oleifera for Cancer Prevention or Treatment
Cancer Treatment Moringa Oleifera for Cancer Prevention or Treatment As we learn more about cancer, we are empowered to use more of the tools which nature has created for us to help battle this terrible
More information483.25(i) Nutrition (F325) Surveyor Training: Interpretive Guidance Investigative Protocol
483.25(i) Nutrition (F325) Surveyor Training: 1 With regard to the revised guidance F325 Nutrition, there have been significant changes. Specifically, F325 and F326 were merged. However, the regulatory
More informationUSANA MICRO-NUTRITIONAL PRODUCTS KEY BENEFITS
USANA Micro-nutritional Products Updated Apr 2014 USANA MICRO-NUTRITIONAL PRODUCTS KEY BENEFITS Introduction USANA Micro-nutritional Products is a guideline for USANA ANZ Associates regarding allowable
More informationStem cell treatments of rheumatoid. arthritis and the implications of. their use in treating the condition
Stem cell treatments of rheumatoid arthritis and the implications of their use in treating the condition BY Samuel House Mark Strangwood Grade awarded: Pass with Merit Research paper based on pathology
More informationFacts About Aging and Bone Health
Facts About Aging and Bone Health A Guide to Better Understanding and Well Being with the compliments of Division of Health Services Diocese of Camden Exercise as treatment Along with medication, proper
More informationA. Ketorolac*** B. Naproxen C. Ibuprofen D. Celecoxib
1. A man, 66 years of age, with a history of knee osteoarthritis (OA) is experiencing increasing pain at rest and with physical activity. He also has a history of depression and coronary artery disease.
More informationTAKING CARE OF YOUR RHEUMATOID ARTHRITIS
TAKING CARE OF YOUR RHEUMATOID ARTHRITIS RHEUMATOID ARTHRITIS (RA) FAST FACTS What is Rheumatoid Arthritis? Rheumatoid arthritis (RA) is a chronic disease that can affect your ability to function and be
More informationSummary and conclusion 2013
The work presented in the thesis is focused on the problems related to the prostate gland. Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are the two major problems associated with prostate.
More informationThe Many Causes of Joint Pain
I n t r o d u c t i o n The Many Causes of Joint Pain there are about a hundred different forms of arthritis, an umbrella term for diseases with symptoms that include joint and musculoskeletal pain. And
More informationMethotrexate (Rheumatoid Arthritis) - Forecast and Market Analysis to 2023
Brochure More information from http://www.researchandmarkets.com/reports/3128342/ Methotrexate (Rheumatoid Arthritis) - Forecast and Market Analysis to 2023 Description: Methotrexate (Rheumatoid Arthritis)
More informationRheumatology. Rheumatoid Arthritis
Rheumatology Rheumatoid Arthritis The Rheumatology service specialises in the diagnosis and treatment of diseases affecting the musculoskeletal system. Other than providing inpatient and outpatient consultation,
More informationAutoimmunity and immunemediated. FOCiS. Lecture outline
1 Autoimmunity and immunemediated inflammatory diseases Abul K. Abbas, MD UCSF FOCiS 2 Lecture outline Pathogenesis of autoimmunity: why selftolerance fails Genetics of autoimmune diseases Therapeutic
More informationElbow Injuries and Disorders
Elbow Injuries and Disorders Introduction Your elbow joint is made up of bone, cartilage, ligaments and fluid. Muscles and tendons help the elbow joint move. There are many injuries and disorders that
More informationLocal Clinical Trials
Local Clinical Trials The Alzheimer s Association, Connecticut Chapter does not officially endorse any specific research study. The following information regarding clinical trials is provided as a service
More informationOther Noninfectious Diseases. Chapter 31 Lesson 3
Other Noninfectious Diseases Chapter 31 Lesson 3 Diabetes Diabetes- a chronic disease that affects the way body cells convert food into energy. Diabetes is the seventh leading cause of death by disease
More informationRheumatoid Arthritis. Nicole Klett,, M.D.
Rheumatoid Arthritis Nicole Klett,, M.D. Rheumatoid Arthritis Systemic Chronic Inflammatory Primarily targets the synovium of diarthrodial joints Etiology likely combination genetic and environmental Diarthrodial
More informationUnderstanding Rheumatoid Arthritis
Understanding Rheumatoid Arthritis Understanding Rheumatoid Arthritis What Is Rheumatoid Arthritis? 1,2 Rheumatoid arthritis (RA) is a chronic autoimmune disease. It causes joints to swell and can result
More information.org. Arthritis of the Hand. Description
Arthritis of the Hand Page ( 1 ) The hand and wrist have multiple small joints that work together to produce motion, including the fine motion needed to thread a needle or tie a shoelace. When the joints
More informationFish Oil Benefits For Arteria
Fish Oils and Rheumatoid Arthritis Summaries of the latest research concerning fish oils and rheumatoid arthritis Fish oils benefit patients with lupus BELFAST, NORTHERN IRELAND. Systemic lupus erythematosus
More informationOnce the immune system is triggered, cells migrate from the blood into the joints and produce substances that cause inflammation.
HealthExchange Points For Your Joints An Arthritis Talk Howard Epstein, MD Orthopaedic & Rheumatologic Institute Rheumatic & Immunologic Disease Cleveland Clinic Beachwood Family Health & Surgery Center
More informationARTHRITIS INTRODUCTION
ARTHRITIS INTRODUCTION Arthritis is the most common disease affecting the joints. There are various forms of arthritis but the two that are the most common are osteoarthritis (OA), and rheumatoid arthritis
More informationOsteoporosis and Arthritis: Two Common but Different Conditions
and : Two Common but Different Conditions National Institutes of Health and Related Bone Diseases ~ National Resource Center 2 AMS Circle Bethesda, MD 20892 3676 Tel: 800 624 BONE or 202 223 0344 Fax:
More informationPolymyalgia Rheumatica www.arthritis.org.nz
Polymyalgia Rheumatica www.arthritis.org.nz Did you know? Arthritis affects one in six New Zealanders over the age of 15 years. Polymyalgia rheumatica is a common rheumatic condition. It affects more women
More informationWhat You Need to Know for Better Bone Health
What You Need to Know for Better Bone Health A quick lesson about bones: Why healthy bones matter The healthier your bones The more active you can be Bone health has a major effect on your quality of life
More informationStrokes and High Blood Pressure
Strokes and High Blood Pressure Quick Review from last Week: What is a Stroke Stroke: blood supply to the brain is severely limited or cut off With no blood to carry oxygen to them, brain cells will die
More informationCHRONIC D ISEASES AND EXERCISE
Chapter 8 CHRONIC D ISEASES AND EXERCISE You will remember from Chapter 4 that having a chronic disease usually doesn t mean that a person can t exercise. If you have a client with a chronic disease, both
More informationNutraceutical. Practical Oncology Nutritional Alternatives for Cancer Wendy Blount, DVM. NOT Nutraceuticals. Quality Control. Governmental regulation
Nutraceutical Practical Oncology Nutritional Alternatives for Cancer Wendy Blount, DVM NAVNA - North American Veterinary Nutraceutical Association Non-drug substance Purified and extracted Administered
More informationForté White Paper. Fortéé. Joint. Science-based, Targeted Nutritional Support for Superior Joint Health. revitalize
Forté White Paper Fortéé Joint Science-based, Targeted Nutritional Support for Superior Joint Health revitalize PREPARE / RECOVER joint product Key Nutrients and Their Impact on Joint Health and Osteoarthritis
More informationarthritis 1 arthritisconnect.com
arthritis What is Arthritis? There are more than 100 forms of arthritis currently identified. The common thread among these 100-plus conditions is that they all affect the musculoskeletal system and specifically
More information2nd MuscleTech Network Workshop. From translational Research to translational Medicine. CONCLUSIONS AND CLOSING REMARKS Dr.
2nd MuscleTech Network Workshop. From translational Research to translational Medicine. CONCLUSIONS AND CLOSING REMARKS Dr. Carles Pedret MUSCLE AND TENDON WORKSHOP HEALTH AND GENERAL POPULATION SPORTS
More informationRheumatoid Arthritis
Rheumatoid Arthritis Carole Callaghan Principal Pharmacist NHS Lothian Aim To update pharmacists on the current management of rheumatoid arthritis and explore ways to implement pharmaceutical care for
More informationRheumatoid Arthritis. Disease RA Final.indd 2 15. 6. 10. 11:23
Rheumatoid Arthritis Disease RA Final.indd 2 15. 6. 10. 11:23 Understanding what to expect can help you prepare for your transition into treatment. Rheumatoid Arthritis What You Need To Know About Rheumatoid
More informationIntroduction To The Zone
Introduction To The Zone Why Do We Gain Weight, Get Sick, and Age Faster? Overview of Anti- Inflammatory Nutrition Unique Roles For Each Dietary Intervention Zone Diet Reduction of insulin resistance Omega-3
More informationTotal Hip Joint Replacement. A Patient s Guide
Total Hip Joint Replacement A Patient s Guide Don t Let Hip Pain Slow You Down What is a Hip Joint? Your joints are involved in almost every activity you do. Simple movements such as walking, bending,
More informationGlucosamine: Only Part of the Puzzle. Joint Discomfort: An American Affliction. The COX Problem. For Rapid Relief, Trust Perluxan Soft Gels
With the prevalence of joint discomfort and the risks presented by standard remedies, it s no surprise that sales of joint health supplements have soared. In fact, the joint health category has surpassed
More informationThe application of nanotechnology in the treatment of Rheumatoid Arthritis and Osteoarthritis. By Aniketa Khushu PASS WITH MERIT
The application of nanotechnology in the treatment of Rheumatoid Arthritis and Osteoarthritis By Aniketa Khushu PASS WITH MERIT Research Paper based on Pathology Lectures at Medlink 2010 1 Abstract: Introduction:
More informationPlatelet-Rich Plasma (PRP) Injections for Osteoarthritis and Chronic Tendinitis. How will you benefit from a PRP injection?
Platelet-Rich Plasma (PRP) Injections for Osteoarthritis and Chronic Tendinitis How will you benefit from a PRP injection? Emory Healthcare patients can now benefit from a treatment called platelet-rich
More informationNATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE. Health Technology Appraisal
NATIONAL INSTITUTE FOR HEALTH AND CLINICAL EXCELLENCE Health Technology Appraisal Adalimumab, etanercept, infliximab, rituximab and abatacept for the treatment of rheumatoid arthritis after the failure
More informationDisclosures. Consultant and Speaker for Biogen Idec, TEVA Neuroscience, EMD Serrono, Mallinckrodt, Novartis, Genzyme, Accorda Therapeutics
Mitzi Joi Williams, MD Neurologist MS Center of Atlanta, Atlanta, GA Disclosures Consultant and Speaker for Biogen Idec, TEVA Neuroscience, EMD Serrono, Mallinckrodt, Novartis, Genzyme, Accorda Therapeutics
More informationNIMULID MD. 1. Introduction. 2. Nimulid MD Drug delivery system
NIMULID MD 1. Introduction Nimulid MD is a flavoured dispersible Nimesulide tablet with fast mouth dissolving characteristics thereby providing immediate relief. Nimesulide is a non-steroidal antiinflammatory
More informationImmune modulation in rheumatology. Geoff McColl University of Melbourne/Australian Rheumatology Association
Immune modulation in rheumatology Geoff McColl University of Melbourne/Australian Rheumatology Association A traditional start to a presentation on biological agents in rheumatic disease is Plasma cell
More informationAnti-Inflammatory Drugs from Plant and Marine Sources
D. A. Lewis Anti-Inflammatory Drugs from Plant and Marine Sources 1989 BirkhauserVerlag Basel Boston Berlin TABLE OF CONTENTS Page No. Preface. Acknowledgements..12 SECTION I : INFLAMMATION AND INFLAMMATORY
More informationCOMMITTEE FOR PROPRIETARY MEDICINAL PRODUCTS (CPMP)
The European Agency for the Evaluation of Medicinal Products Evaluation of Medicines for Human Use London, 17 December 2003 CPMP/EWP/556/95 rev 1/Final COMMITTEE FOR PROPRIETARY MEDICINAL PRODUCTS (CPMP)
More informationDOCTOR DISCUSSION GUIDE FOR RHEUMATOID ARTHRITIS
DOCTOR DISCUSSION GUIDE FOR RHEUMATOID ARTHRITIS Talking your Doctor About Rheumatoid Arthritis Preparing for your Doctor s Appointment Early and aggressive treatment can help you forestall the joint damage
More informationOutline. Personal profile & research interests. Rheumatology research in Ireland. Current standing. Future plans
Outline Personal profile & research interests Rheumatology research in Ireland Current standing Future plans Personal profile 1983 MB Queens University 1990-3 ARUK Clinical Research Fellowship 1990-93
More informationIntroduction. Pathogenesis of type 2 diabetes
Introduction Type 2 diabetes mellitus (t2dm) is the most prevalent form of diabetes worldwide. It is characterised by high fasting and high postprandial blood glucose concentrations (hyperglycemia). Chronic
More informationRheumatoid Arthritis www.arthritis.org.nz
Rheumatoid Arthritis www.arthritis.org.nz Did you know? Rheumatoid arthritis (RA) is the third most common form of arthritis Approximately 40,000 New Zealanders have RA RA can occur at any age, but most
More informationNutritional Support of the Burn Patient
Nutritional Support of the Burn Patient Objectives To understand the principles of normal nutrient utilization and the abnormalities caused by burn injury To be able to assess nutrient needs To be able
More informationNURS 821 Alterations in the Musculoskeletal System. Rheumatoid Arthritis. Type III Hypersensitivity Response
NURS 821 Alterations in the Musculoskeletal System Margaret H. Birney PhD, RN Lecture 12 Part 2 Joint Disorders (cont d) Rheumatoid Arthritis Definition: Autoimmune disorder occurring in genetically sensitive
More informationCanine Arthritis. April, 2006
Canine Arthritis April, 2006 Arthritis is inflammation in a joint. This can result in changes to the joint cartilage, the joint fluid, the bones involved in the joint and the actual capsule of the joint.
More information(Intro to Arthritis with a. Arthritis) Manager of Education & Services for the Vancouver Island Region of The Arthritis Society
Arthritis 101 (Intro to Arthritis with a Focus on Rheumatoid Arthritis) by Cari Taylor by Cari Taylor Manager of Education & Services for the Vancouver Island Region of The Arthritis Society What You Will
More informationRheumatoid Arthritis
Rheumatoid Arthritis While rheumatoid arthritis (RA) has long been feared as one of the most disabling types of arthritis, the outlook has dramatically improved for many newly diagnosed patients. Certainly
More informationHormone Restoration: Is It Right for You? Patricia A. Stafford, M.D. Founder, Wellness ReSolutions
Hormone Restoration: Is It Right for You? Patricia A. Stafford, M.D. Founder, Wellness ReSolutions IMPORTANCE OF HORMONE BALANCE Importance of Hormone Balance Help you live a long, healthy life Help you
More informationHow will we prevent rheumatoid arthritis? Kevin Deane, MD/PhD Division of Rheumatology University of Colorado
How will we prevent rheumatoid arthritis? Kevin Deane, MD/PhD Division of Rheumatology University of Colorado Outline 1) Brief overview of natural history of RA and how current understanding of disease
More informationTHE ENDOCANNABINOID SYSTEM AS A THERAPEUTIC TARGET FOR LIVER DISEASES. Key Points
December 2008 (Vol. 1, Issue 3, pages 36-40) THE ENDOCANNABINOID SYSTEM AS A THERAPEUTIC TARGET FOR LIVER DISEASES By Sophie Lotersztajn, PhD, Ariane Mallat, MD, PhD Inserm U841, Hôpital Henri Mondor,
More informationArthritis in Children: Juvenile Rheumatoid Arthritis By Kerry V. Cooke
Reading Comprehension Read the following essay on juvenile rheumatoid arthritis. Then use the information in the text to answer the questions that follow. Arthritis in Children: Juvenile Rheumatoid Arthritis
More informationDemystifying Stem Cells. Brent Bost M.D., CPA, MBA, FACOG
Demystifying Stem Cells Brent Bost M.D., CPA, MBA, FACOG Disclaimers Author currently serves on Board of Directors of CordTrack Most applications discussed today are not currently FDA approved and are,
More informationYour Certified Professional Cancer Coach. An Integrative Answer to Cancer Exclusive Professional Program for Patients with Cancer
Your Certified Professional Cancer Coach An Integrative Answer to Cancer Exclusive Professional Program for Patients with Cancer The CPCC Patient Program Nutrition & Lifestyle Oncology A Cancer Diagnosis
More informationTechnological platforms
Advitech Advitech is a life sciences & technology company Its mission is to discover and commercialize proprietary and evidence-based natural health products Focus on milk, whey and bovine colostrum R&D,
More informationArthroscopy of the Hand and Wrist
Arthroscopy of the Hand and Wrist Arthroscopy is a minimally invasive procedure whereby a small camera is inserted through small incisions of a few millimeters each around a joint to view the joint directly.
More informationNutrient Reference Values for Australia and New Zealand
Nutrient Reference Values for Australia and New Zealand Questions and Answers 1. What are Nutrient Reference Values? The Nutrient Reference Values outline the levels of intake of essential nutrients considered,
More informationWeek 12 study results
Week 12 study results 15 April 2015 Copyright 2015 Galapagos NV Disclaimer This document may contain certain statements, including forward-looking statements, such as statements concerning the safety and
More informationW40 Total prosthetic replacement of knee joint using cement
Bedfordshire and Hertfordshire Priorities Forum statement Number: 33 Subject: Referral criteria for patients from primary care presenting with knee pain due to ostoarthritis, and clinical threshold for
More informationArthritis of the Shoulder
Arthritis of the Shoulder In 2011, more than 50 million people in the United States reported that they had been diagnosed with some form of arthritis, according to the National Health Interview Survey.
More informationSupplements in Psychiatry: N-Acetylcysteine, Omega-3 Fatty Acids & Melatonin. March 19, 2004 David A. Graeber, MD UNM Department of Psychiatry
Supplements in Psychiatry: N-Acetylcysteine, Omega-3 Fatty Acids & Melatonin March 19, 2004 David A. Graeber, MD UNM Department of Psychiatry 1 N-Acetylcysteine = NAC NAC modulates Neurotransmitters: 1.
More informationEndocrine Responses to Resistance Exercise
chapter 3 Endocrine Responses to Resistance Exercise Chapter Objectives Understand basic concepts of endocrinology. Explain the physiological roles of anabolic hormones. Describe hormonal responses to
More informationRheumatoid Arthritis www.arthritis.org.nz
Rheumatoid Arthritis www.arthritis.org.nz Did you know? RA is the second most common form of arthritis Approximately 40,000 New Zealanders have RA RA can occur at any age, but most often appears between
More information16. ARTHRITIS, OSTEOPOROSIS, AND CHRONIC BACK CONDITIONS
16. ARTHRITIS, OSTEOPOROSIS, AND CHRONIC BACK CONDITIONS Goal Reduce the impact of several major musculoskeletal conditions by reducing the occurrence, impairment, functional limitations, and limitation
More informationOmega-3 fatty acids improve the diagnosis-related clinical outcome. Critical Care Medicine April 2006;34(4):972-9
Omega-3 fatty acids improve the diagnosis-related clinical outcome 1 Critical Care Medicine April 2006;34(4):972-9 Volume 34(4), April 2006, pp 972-979 Heller, Axel R. MD, PhD; Rössler, Susann; Litz, Rainer
More informationReview of Mesenchymal Stem Cells (MSCs) and Osteoarthritis
Review of Mesenchymal Stem Cells (MSCs) and Osteoarthritis Scott E. Powell, MD Stetson Powell Orthopedics and Sports Medicine Osteoarthritis (OA) Most frequent cause of disability in US 10%< adult US population
More informationLOOK, FEEL AND LIVE BETTER. Topical Skin Care
LOOK, FEEL AND LIVE BETTER Topical Skin Care Pycnogenol in Topical Skin Care Pycnogenol is widely used in topical and oral applications for various dermatological indications. A unique combination of pharmacological
More information