Hormone Restoration: Is It Right for You? Patricia A. Stafford, M.D. Founder, Wellness ReSolutions

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1 Hormone Restoration: Is It Right for You? Patricia A. Stafford, M.D. Founder, Wellness ReSolutions

2 IMPORTANCE OF HORMONE BALANCE

3 Importance of Hormone Balance Help you live a long, healthy life Help you create wealth Physical Emotional Financial Spiritual

4 Hormones Biochemical messengers Regulate cellular functions Turn genes on and off Affect metabolism, mood, growth, immunity, inflammation, and more Two key hormones: estrogen & testosterone

5 Menopause & Andropause Average menopause age around 51 Symptoms of menopause can begin 15 years earlier Hypogonadism 20% of males >50

6 Hormones & Aging As hormones decline, aging progresses Women age lose 50% of testosterone production Men ages lose 1-3% of testosterone production per year

7 Estrogen Maintains bone density Helps maintain memory Maintains collagen in skin Increases serotonin & dopamine Controls hot flashes Reduces risk of colon cancer

8 Testosterone Men and Women Provides major symptom relief Protects Brain Breasts Heart Bones & joints Relationships!

9 Benefits of Testosterone for Women & Men Energy / vitality Feeling of well-being Depression relief Anxiety relief Mental clarity Improved memory Sleep improvement Cardiovascular protection Prostate protection Breast protection Increased bone strength Increased muscle strength Reduced body fat Lower cholesterol Enhanced libido Enhanced performance

10 SYMPTOMS OF HORMONE IMBALANCE

11 Women: How Do You Feel? Tired, especially in the afternoon Mood swings Stressed Sleep problems Concentration & memory loss Decreased sex drive Depression Hot flashes & night sweats Weight gain Muscle and joint pain, weakness Headaches Vaginal dryness Urinary incontinence

12 Men: How Do You Feel? Depression Anxiety & irritability Weight gain Sleep loss Muscle & joint pain Headaches Loss of memory & focus Loss of erectile ability Afternoon fatigue 3-4 o clock hit a wall?

13 Hormone Lab Tests Lab reference ranges are not necessarily optimal ranges Best thought of as expected ranges Example: Testosterone Women ideal Men ideal

14 HORMONE REPLACEMENT METHODS

15 Pills - Estrogen Peaks and valleys First pass metabolism Estrogens increase clotting factor production by liver increases risk of heart attack, stroke, blood clots Take pill every day

16 2002 Women s Health Initiative 41% increase in stroke 29% increase in heart attacks 26% increase in breast cancer Twice the rate of blood clots 76% increase in Alzheimer s dementia A flawed study?

17 Synthetic Progestins NOT progesterone Increase breast cancer risk Increase heart disease risk Increase fluid retention Increase incidence of blood clots DVT, Pulmonary embolism Stroke Cause weight gain

18 Women Need Estrogen Widespread rejection of estrogen therapy after the 2002 WHI study has most likely led to 50,000 unnecessary deaths over the last 10 years among women aged 50 to 69 who have had a hysterectomy. Yale School of Medicine

19 Patches - Estrogen Not processed by liver like oral estrogen Absorption problem up to 45% do not absorb hormones through skin Adhesive problem Change 1-2 times weekly Estradiol levels better than pills, but not as steady as pellets

20 Creams Estrogen & Peaks and valleys Testosterone Once or twice daily application Be certain to apply correct amount Applied topically (to skin) Up to 20% don t absorb well Can transfer to people & pets

21 Pellets Estrogen & Testosterone Estradiol and testosterone Biologically identical to human form Derived from yam or soy Inserted under the skin Absorbed directly into bloodstream Steady levels Hassle-free - last 3-5 months for women, 5-6 months in men

22 Pills vs Patches vs Pellets Pellets Estradiol level Patch Pills

23 MEDICAL STUDIES

24 Hormones & Breast Cancer Women in WHI estrogen-only arm had 23% lower risk of breast cancer Oral methyl-testosterone (Estratest) increased breast cancer risk in postmenopausal women Non-oral testosterone prevents the stimulation of breast tissue, lowers risk of breast cancer

25 Hormones & Breast Cancer Synthetic E does not cause breast cancer Synthetic Pg & T increases risk Bio-identical Pg and T may be protective Hormonal imbalance (low ratio E3: E1 & E2 + low Pg) more important than any one hormone Toxins (e.g. BPA, EtOH) increase risk Nutritional factors affect risk

26 Hormones & Osteoporosis Testosterone, the bone builder Pellets demonstrated 4-fold increase in bone density over oral estrogen and 2.5 times greater than patches 8.3% per year for pellet therapy 3.5% per year for E patches 1-2% per year for oral estrogen Studd (1990) AM, Journal OB/GYN

27 Hormones & Alzheimer s Disease Women develop Alzheimer s 8:1 over men Women who begin HT within 5 years of menopause are 30% less likely to develop Alzheimer s Men with low testosterone are 3x more likely to develop Alzheimer s disease

28 Hormones & Cardiovascular Health Estrogen Improves cholesterol levels Promotes healthy blood vessels Estrogen + testosterone Reduce fat mass Testosterone Many studies show beneficial effects on heart Improved insulin sensitivity Remember, the heart is a muscle!

29 Hormones & Arthritis 10% of men & 18% of women > 60 have OA Chondrogenic progenitor cells are present in arthritic tissue Both estrogen and testosterone stimulate these cells Arthritis and Rheumatism, April 2010

30 Hormones & Prostate Cancer High testosterone levels are not associated with increased prostate cancer risk Chronically low T levels associated with Higher risk for prostate cancer Higher grade cancers at diagnosis

31 IN CLOSING

32 What Women are Saying Increased energy levels Restored interest in life Increased sexual drive Consistency in moods Anxiety, depression relief Increased mental clarity Decreased body fat Greater capacity for getting the body in shape

33 Thanks for your attention!

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