PROGRAM. Workshop Computational Modeling of the Structure of G-protein Coupled Receptors
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1 The 17 th Annual Joint Meeting of the Great Lakes GPCR Retreat and Le Club des Récepteurs à Sept Domains Transmembranaires du Québec Chicago, USA, October 13-15, 2016 Wednesday, October 12 th Arrival, Registration, Welcome dinner Thursday, October 13 th Workshop Computational Modeling of the Structure of G- protein Coupled Receptors Workshop Computational Modeling of the Structure of G-protein Coupled Receptors 9:00 Welcoming Remarks by Organizers 9:15 Rocco Moretti, Vanderbilt University, USA 10:30-10:45 Coffee Principles of GPCR Protein Structure Modeling 10:45 Rocco Moretti, Vanderbilt University, USA 12:00-13:00 Lunch Setting-up and Running Modeling Computations
2 Hyman Niznik Memorial Lecture 13:00 Brigitte Kieffer, McGill University, Canada GPCRs in Psychiatric Research SESSION 1: GPCRs in Pain and Addiction 14:00 Michael Bruchas, Washington University, USA Dissecting VTA Opioid Receptor Function in Reward and Aversion 14:30 Short Talk selected from abstracts TBA 15:00 John Traynor, University of Michigan, USA Allosteric Modulation of the µ-opioid Receptor: Mechanism and Implications 15:30 Paul Slesinger, Mt. Sinai University, USA Mechanisms of Plasticity in GABA-B Receptor and GIRK Channel Signaling in the Reward Pathway 16:00 Amynah Pradhan, University of Illinois at Chicago, USA Ligand Biased Signaling at the δ-opioid Receptor 16:30-16:45 Coffee
3 SESSION 2: GPCRs in Cell Differentiation, Proliferation, and Survival 16:45 Asrar Malik, University of Illinois at Chicago, USA Role of Par-1 Signaling in Pluripotent Stem Cell Differentiation 17:15 Joshua Snyder, Duke University, USA Driving Cell Fate by Pharmacological and Genetic Control of Lgr5 Trafficking 17:45 Nickolai Dulin, University of Chicago, USA Targeting GPCR Signaling to Inhibit Myofibroblast Differentiation and Organ Fibrosis 18:15 Madan Babu, Cambridge University, UK Common structural principles in GPCR-G protein signaling 18:45-20:45 Poster Session 1 20:45-22:00 Dinner Friday, October 14 th SESSION 3: Compartmentalized GPCR Signaling GPCR Conference 8:45 Mark Von Zastrow, University of California, San Francisco, USA Relationships between GPCR Signaling and Membrane Traffic 9:15 JoAnn Trejo, University of California, San Diego, USA Integration of Protease-activated Receptor 1 Inflammatory Signaling by Ubiquitin 9:45 Manojkumar Puthenveedu, Carnegie Melon University, USA Spatial Regulation of Opioid Receptor Trafficking and Signaling 10:15 Philip Wedegaertner, Thomas Jefferson University, USA G protein Regulation of Golgi Function 10:45 Christine Lavoie, Université de Sherbrooke, Canada 11:15-13:00 Lunch The Role of Gαs Protein in Receptor Endosomal Sorting
4 SESSION 4: Hubert van Tol Symposium GPCRs in Mood and Anxiety 13:00 Richard Neubig, Michigan State University, USA GPCRs in Epilepsy: GNAO1 as an Epilepsy Gene Driving Seizure and Movement Disorders 13:30 Martin Beaulieu, Université Laval, Canada Targeting arrestin-akt Interface in Mood Disorders 14:00 Emily Jutkiewicz, University of Michigan, USA The Role of δ-opioid Receptors in Mood Disorders 14:30 Mark Rasenick, University of Illinois at Chicago, USA G-protein Localization and the Biology of Depression 15:00 Paul Albert, Ottawa Hospital Research Institute, Canada 15:00-15:30 15:30-16:00 Coffee In vivo Roles of Serotonin-1A Receptor Regulation in Depression and Anxiety Phenotypes SESSION 5: Regulation of GPCR Function 16:00 Vadim Cherezov, University of Southern California Structure and Function of Angiotesin Receptors 16:30 Sergi Ferre, National Institute on Drug Abuse, USA Allosterism within GPCR Oligomers: Back to Symmetry 17:00 Kirill Martemyanov, Scripps Florida, USA Fingerprinting Catalytic Activity of GPCRs in Living Cells 17:30 Jeffrey Benovic, Thomas Jefferson University, USA Biasing β2-adrenergic Receptor Signaling 18:00 Bryan Roth, University of North Carolina, USA Creating GPCR Therapeutics via Atomic-level Insights 18:30-20:45 Poster Session 2 20:45-22:00 Dinner
5 Saturday, October 15 th GPCR Conference SESSION 6: Adhesion GPCRs 8:45 Gregory Tall, University of Michigan, USA New Pharmacological Tools to Modulate Adhesion GPCR Tethered Peptide Agonism 9:15 Tobias Langenhan, University of Wurzburg, Germany Adhesion GPCRs in Mechanosensation 9:45 Kelly Monk, University of Washington, USA Adhesion GPCRs in Nervous System Development and Repair 10:15 Demet Arac, University of Chicago, USA Structural and Functional Basis of Adhesion GPCR Activation 10:45-11:00 Coffee 11:00 Poster Presentation Awards Ceremony Closing Remarks 12:00 Lunch and Farewell
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