Biology 271: Heredity, Fall 2016

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1 Biology 271: Heredity, Fall 2016 Biology 271, 3.0 credits Tuesday and Thursday 1:00 PM 2:15 PM Room: ISC 131 Prerequisites: college level biology course or permission Note: This class cannot be used for credit toward the biology major but can be used for the biology minor! Instructor Dr. Hristina Nedelkovska Office: ISC 139B Telephone: Office hours: Monday 11:00 12:30, Tuesday 11:00-12:00, Wednesday 11:00-12:30, and by appointment. Course Description Heredity (Biology 271) reviews the principles of human genetics and the many ways in which genetics and biotechnology affect our lives. The topics covered include transmission genetics, cytogenetics, DNA structure and function, biotechnology, population genetics, genetic disorders, mutations, and cancer. Student groups will investigate current topics in genetics and present their work to the class followed by discussion. Learning Outcomes At the conclusion of the course.. Students will be able to explain the fundamental principles of transmission genetics, molecular genetics, and population genetics at the level appropriate for educated, nonbiology majors. Students will be able to describe the causes, characteristics, and management strategies for common human genetic diseases. Students will have practiced problem solving, critical thinking, and communication skills both generally and with respect to genetic problems. Students will be able to describe current issues in genetics and biotechnology, and explain how they shape society. Students will be able to describe the fundamental genetic principles underlying current issues in genetics and biotechnology. Textbook Human Genetics: Concepts and Applications, 9 th edition (you can also use other editions), by Ricki Lewis (McGraw Hill, 2008, ISBN is the main text for the course and is available in the bookstore. There is a case studies manual for this text as well, but we will not be using it.

2 Grading points each 300 points Comprehensive final exam 200 points Group project 50 points Quizzes, class participation 50 points Homework 100 points 700 points total The following scale will be used to calculate final grades. A (93-100%) A- (90-92%) B+ (87-89%) B (83-86%) B- (80-82%) C+ (77-79%) C (73-76%) C- (70-72%) D (60-69%) E (<60%) Exams: There will be three in class exams worth 100 points each and a final exam half of which will cover the material from the last quarter and the other half will review the entire course. The final will be worth 200 points. *Make up exams will only be administered in special circumstances (e.g. qualified medical excuses). Exams cannot be missed for any other reason including weddings, vacations, or travel. Class participation and quizzes: I will give a question of the day to be answered in class on most days. It is recommended that you work on it in groups of 2-4 students. In addition there will be in class quizzes that may or may not be announced. Finally discussions/questions following student group presentations are also included in your participation grades. *Attendance will be taken at each class by individual sign in. Group Presentations: Groups of 3 students will investigate one of the topics listed below and present their findings to the class. Each group will give a 10 minute, illustrated and engaging presentation to the class, and will have 5 minutes to answer questions and lead class discussion on the topic. A one to two page written summary of the topic will be turned in (hard copy) by the group on the day of the presentation in class. Make sure you include citations and references both in your summary and presentation (please use valid sources). The presentation should be illustrated, focused and interesting. In addition to the professors evaluation there will also be a student evaluation component that will be integrated into the final score for the presentation. The presentation and summary will be worth a total of 50 points. Presentation Topics (for presentation dates please refer to class schedule below): 1. Genetic counselor as a profession 2. Genetic testing, GINA 3. Embryonic, adult, and induced pluripotent stem cells 4. Gene patents 5. Genetics in art and literature 6. Preimplantation genetic diagnosis 7. Behavior disorder: Autism 2

3 8. Behavior disorder: Schizophrenia 9. GMO Foods (Need both sides pros/cons) 10. Recombinant Drugs 11. Gene Therapy 12. Molecular Clocks, mtdna and human evolution 13. Cancer Group Homework: There will be 4, 25 point homework assignments. The assignments will be passed out in class. These assignment need to be completed in groups of 4, although each group member needs to submit their own copy at the end. All students in the same group will receive the same grade on the assignment. Late work will be penalized 20% per day and no credit will be given if not submitted by the next class. Accommodations: SUNY Geneseo will make reasonable accommodations for persons with documented physical, emotional, or cognitive disabilities. Accommodations will also be made for medical conditions related to pregnancy or parenting. Students should contact Dean Buggie-Hunt in the Office of Disability Services or ) and their faculty to discuss needed accommodations as early as possible in the semester. ***The schedule is subject to adjustment during the semester! 3

4 Date Subject Required Reading Aug. 30 DNA and Chromosomes Structure Ch. 9.1, 9.2, 13.1, 13.2 Sept. 1 DNA Replication, PCR Ch. 9.3, 19.2 Mitosis, Stem Cells Sept. 6 Genetic Counselor 20 (396-98) Ch. 2 Sept. 8 Transcription Ch. 10 Sept. 13 Translation Stem Cells 2 (18, 37-41), 11 (204-5) Ch. 10 Sept. 15 Disease Inborn Errors of Metabolism Homework #1 Due Ch. 2 Sept. 20 Genetic Testing 1 (1,12,14), 20 ( ) Sept. 22 Exam 1 Ch. 1, 2, 9, 10, , 19.2 Sept. 27 Meiosis Ch ARTS, Gene Expression Sept. 29 PGD 21 ( ) Ch. 11, 21.3 Oct. 4 Human Development Ch Chromosomal Abnormalities Oct. 6 Gene Therapy 20 (395, ) Ch Oct. 11 Oct.13 MID SEMESTER BREAK Mendel Genetics Art and Literature Ch. 4 Oct. 18 Mendel, Homework #2 Due Ch. 4 Oct. 20 Molecular clocks 16 ( ) Oct. 25 Exam 2 Ch. 3, 4, 11, , 21.3 Oct. 27 Beyond Mendel s Laws Ch. 5 Nov. 1 Beyond Mendel s Laws Ch. 5 Nov. 3 Solving Linkage Problems Schizophrenia 8 ( ) Ch. 5.4 Nov. 8 Sex Autism 8 (154, ) Ch. 6 Nov. 10 Multifactorial Traits, Homework #3 Due Ch. 7 Nov. 15 GMO Foods 1 (12-13) Nov. 17 Exam 3 Ch. 5, 6, 7 Nov. 22 Genetic Technologies Gene Patents 19 ( ) Ch. 19 Nov. 24 Nov. 29 THANKSGIVING BREAK Genomics Recombinant Drugs 19 (358-88) Ch.22 Dec. 1 Allele Frequencies Ch. 14 Dec. 6 Gene Mutations Ch. 12 Cancer, Homework #4 Due Dec. 8 Cancer Ch. 18 Dec. 20 FINAL 8:00 10:30 4

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