BSCI222 Principles of Genetics Winter 2014 TENTATIVE

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1 BSCI222 Principles of Genetics Winter 2014 Instructor: Dr. O Brien Office Hours: Office: 3118 Plant Sciences Building Phone: Please do not hesitate to come see me to discuss course material. My office hours reflect times that I guarantee to be in my office. If those times are not convenient, please so that we can set up an alternative time. However, please understand that I am not a personal tutor nor will I give personal lectures. If you miss a class or are late it is your responsibility to obtain the missed information from a fellow classmate. Course Meeting Times: o Discussion: will meet for the last 30 minutes of class each day (all discussion are held in the Plant Sciences Building) o Labs: on-line labs (approx 15 hours per week performed on your own time) Prerequisite: BSCI105 (C or better) All students enrolled in this class need a working knowledge of basic cell functions, cell division, a background in mathematics and a molecular biology course that is the equivalent of BSCI105. You will need background to succeed in this course. Course Description: Principles of Genetics examines the principles and mechanisms of heredity and gene expression in plants, animals and microbes. There is no substitute for effort in this class as BSCI222 is a 4-credit class for a reason. It is expected that you will spend at least 20 hours a week outside of the classroom working on problems and assignments. Please do not underestimate the amount of time necessary needed to earn an A in this class. Mathbench modules, homework, computer exercises and case studies along with problems from the text that we do in discussion, all help you understand this very complex topic and prepare you for the upper level classes. Course Objectives: o To learn the basic principles, concepts, theories, and language that constitutes the discipline of genetics. o To provide a framework for understanding how genetic information is organized, changes, and influences biological processes. o To provide an understanding as to how genetics is used for addressing biological problems. Required material: Textbook: Pierce Genetics: A Conceptual Approach. (4th Ed.) Freeman Publishing Company. If you purchase at campus bookstore, it is packaged with MEGA-Manual Text Solutions for FREE ISBN

2 Genetics Version Lab Manual for Biology Labs On-line (ISBN ) You will also need to register for the genetics on-line labs There will be 6 on-line labs performed this semester. There is a one-time registration fee to sign up for use of these labs. Each student must register for these labs. Please buy this immediately, so you can start the labs now. Web-based Information: Use of the Enterprise Learning Management System or Blackboard is mandatory for students in BSCI222 as discussion material as well as lecture material will be found on the website. Everyone who has a University ID and password has a Blackboard account. Other instructions can be found on the entry page. Please contact OIT with problems logging on to Blackboard. You must be officially registered for class to use the site. This is an OIT and registrar regulation. In addition, please review all the exercises on the Mathbench website Lecture Information: o If you arrive late or for you need to leave early, please sit at the end of the row and near an exit so as not to disturb other students. o It is your responsibility to note any changes in the syllabus or other information that is announced in lecture or posted to the class Blackboard site o Please turn off all cell phones before coming into the classroom. I reserve the right to answer any ringing phone J A ringing cell phone in class will also result in a LOSS OF 15 POINTS. Please turn off your cell phone (do not set to vibrate, turn it off). o You are welcome to tape lectures (most students who do this find it best to sit down front in the room). o Lecture outlines will be available on Blackboard. Please print and READ them PRIOR to coming to class. o These lecture notes should NOT be used as a substitute for coming to lecture or reading the textbook. They reduce the amount of writing that takes place in lecture, but do not eliminate it. Please be careful about this as students who use the notes exclusively tend to do poorly in my classes. Discussion information: o You will be required to meet with your discussion session after lecture. You must actively participate in this on-line discussion to receive points. o All late assignments will have 10% points from the total score deducted each day it is late after class begins, there is no grace period o Attendance is mandatory as your participation is part of your grade. Each unexcused absence will result is loss of any participation and quiz points. o During discussion you will be given a 10 minute lab quiz. Your TA will then cover a topic from the lecture material and answering questions. o There is no substitute for effort in this class. BSCI222 is a 4-credit class for a reason. It is expected that you will spend a minimum of 20 hours a week hours a week outside of the classroom working on lab exercises, problems, discussion and assignments. Please do not underestimate the amount of time necessary needed to earn an A in this class. 2

3 Exam information: o There will be three examinations during the semester. o The final will be cumulative, with an emphasis on the last lectures. No make-up will be given for the final. Any student reporting late for an exam will NOT be given extra time. o Exams will be mixed format. Multiple choice, essay, math-based problem solving, matching and true-false questions may appear on the exams. o The exam questions will ONLY include the material covered in lecture, and thus the lectures are the best indicator of the depth and breadth of topics for which I develop exam questions. o The textbook will be useful for further clarification of material, as well as providing a different perspective on some of the same issues. o The WWW can be used for additional information on the cutting edge of genomic studies that postdate the textbook. Please use caution when reviewing information from the internet, it is not always correct or accurate. Exam Regrade Policy: Carefully review the exam key before submitting an exam for regrade. Please note the following points: 1. Only exams done in non-erasable ink will be eligible for regrades. 2. Requests for a regrade must be submitted (typed), along with your original exam answers, the next class after the exam is returned to the class with a statement indicating which question(s) is/are to be reviewed and why. Either a non-specific plea to review the material or to review the entire examination will not be considered. No exams will be considered after this deadline. Random exams are Xeroxed and kept on file to reduce cheating. 3. Be advised that the entire exam may be subject to review if you submit it for a regrade (and so the grade may go up or down). 4. Regrades given are final (no appeals). Accommodations for Students with Disabilities: Students with documented disabilities should see me sometime prior to the end of schedule adjustment so that appropriate accommodations may be arranged. Please note: In accordance with school policy, it is the students responsibility to inform the instructors of any intended absences for religious observances or school-sanctioned activities in advance. Notice should be provided as soon as possible but NO LATER than the end of the schedule adjustment period. Honor Code: The Code of Academic Integrity of the University of Maryland will be enforced in this course. Any student found breaking any aspect of this code will be reported to the Honor Council. The Honor Council will have the option of giving an XF grade for any breach of the code. Acts of dishonesty include: Cheating: Intentionally using or attempting to use unauthorized materials, information or study aids in any academic exercise. Fabrication: Intentional and unauthorized falsification or invention of any information or citation in an academic exercise. Facilitating Academic Dishonesty: Intentionally or knowingly helping or attempting to help another to commit an act of academic dishonesty. Plagiarism: Intentionally or knowingly representing the words or ideas of another as one's own in any academic exercise. 3

4 Academic dishonesty will not be tolerated. The University has a nationally recognized Code of Academic Integrity available on the web at The code prohibits students from cheating on exams, plagiarizing papers, submitting the same paper for credit in two courses without authorization, buying papers, submitting fraudulent documents, and forging signatures. To further exhibit your commitment to academic integrity, remember to sign the Honor Pledge on all examinations and assignments I pledge on my honor that I have not given or received any unauthorized assistance on this examination (or assignment). Compliance with the code is administered by Student Honor Council, which strives to promote a community of trust on the Campus. Allegations of academic dishonesty can be reported directly to the Honors Council ( ) by any member of the campus community. Religious Observances: The University System of Maryland policy "Assignments and Attendance on Dates of Religious Observance" states that students should not be penalized in any way for participation in religious observances and that, whenever feasible, they be allowed to make up academic assignments that are missed due to such absences. However, the student must personally hand the instructor a written notification of the projected absence within two weeks of the start of the semester. The request should not include travel time. Determination of Grade: Final grades in BSCI222 are based out of 900 total points. The percentage of points you earn out of 870 will determine the final grade you earn in this course. 2 Exams (150 pts each) (1.5 hours each) 300 points Final Exam (200 points/cumulative) (2 hours) 200 points Worksheets: Blast, Gene annotation, Phylogeny 20 points each X 3 modules 60 points Discussion Quizzes (in every discussion session) 100 points 10 X 10 pts each Problem Solving Mathbench Quizzes on Blackboard 50 points 5 quizzes total X 10 pts each Lab Exercises 120 points 6 labs X 20 points each Lecture Essay Questions 40 points 4 X 10 pts each TOTAL POINTS 870 points 97% and above =A %=A %=A %=B %=B %=B %=C %=C %=C- 69.9%-60%=D 60% and below=f Since there is little demonstration of mastery of Genetics for anyone earning less than a 70%, +/- will not be issued below a C- Please note the following concerning the final grades, there will be no curve, you have the points or you don t. 4

5 DUE DATES. You are welcome (and encouraged) to turn in any assignment in early. Mathbench quizzes on Blackboard 5 quizzes must be taken on-line no later than January 6, 2013 at 8:00pm *You will be given 2 attempts for each quiz On-line Lab Exercise: #1 Translation Lab (ISBN ) Write up from lab manual due January 7, 2013 at 6:00pm #2 Hemoglobin Lab (ISBN ) Write up from lab manual due January 9, 2013 at 6:00pm #3 Fly Lab (ISBN ) Write up from lab manual due January 13, 2013 at 6:00pm #4 Population Genetics Lab (ISBN ) Write up from lab manual due January 15, 2013 at 6:00pm #5 Evolution Lab (ISBN ) Write up from lab manual due January 16, 2013 at 6:00pm #6 Pedigree Lab (ISBN X) Write up from lab manual due January 17, 2013 at 6:00pm Blast, Gene annotation, Phylogeny Worksheets Write up from Blackboard due January 21, 2013 at 6:00pm 10% points will be deducted from the total point available for every 24 hours an assignments is late. No assignments will be accepted after 11:00am on January 22, 2013 Hints for academic success: To be successful in BSCI 222 you need to think about the material, integrate it, and put it all together. That is why we advocate doing part of your studying with small groups of students. Try to take the time to try and explain the concepts to yourself and to try and put ideas together. For example, we will discuss several different topics under the general heading of genomics. It is going to be your responsibility to see how these come together. Ask yourself how the parts are interrelated and how they interact. If you cannot explain every topic to yourself, then you do not understand the material. Study groups work the same way, but they challenge you even more since you have to explain ideas and concepts, not just facts, to others. In effect, you are teaching the material. If you don't understand the material yourself, you cannot teach it to others. Keep in mind that study groups don't have to include the brains of the class. Each of you knows and understands different material, and you can share this no matter how good the students in the group are, as long as you have students of different knowledge levels. Remember that the crux of BSCI 222 is its concepts. Facts are the foundation upon which concepts are built and you need to understand and memorize the facts. But, much of the exams 5

6 will require that you put the facts together in a way that shows you understand the concepts and not just memorize them. The only way to prepare is to THINK about the material, not just memorize, and not just recite facts. o Start early! Begin the lab exercises and readings now. o Attend ALL lectures and discussion sessions. o Copy your lecture notes into a second notebook within 24 hours of the lecture. o Read over the assigned material in your textbook. Read quickly before the lecture and a second time after hearing the lecture material. If you 'highlight' the text, do so the second time. o Create note cards with key terms on one side and definitions on the other side. o Also create note cards with questions on one side and answers on the other. Use these note cards to quiz yourself and your study partners. o Practice writing and answering questions about the material. o Answer recommended study questions listed on Blackboard. o Before an examination, concentrate your study efforts on the lecture notes. o There is no substitute for effort. You should be spending an average hours per week outside of class and discussion working on BSCI 222 material and assignments. o Remember you are taking an intense 4 credit course in only 3 weeks. This means you will have to work VERY hard and dedicate a lot of time in these 3 weeks to earn an A+ in this course. Lecture Schedule BSCI222 Date Lecture Topics Text Readings Jan. 2 Class Policies, Introduction, Cell Division (mitosis and meiosis), Molecular Structure of DNA, Chromosome Structure Ch 1-2 Ch Jan. 3 Mendelian Genetics Segregation, Independent Assortment, Ch 3-6 Probability, Pedigrees, Extensions of Mendel Jan. 6 Extensions and Modifications of Mendel, Hypotheses testing, Ch 4-7, 24 Sex linkage, Sex determination, Extensions and Modifications of Mendel Jan. 7 EXAM 1 Ch 1-7, 10-11, 24 Jan. 8 Population Genetics, Evolutionary Genetics, Recombination, Ch 22, Linkage, Gene mapping, Physical Maps Jan. 9 DNA Replication, DNA Repair, Transcription Ch Jan. 10 Transcription, RNA and Processing, Translation Ch Jan. 13 Gene regulation Prokaryotes and Eukaryotes, Transposable Ch 8, Elements Jan. 14 EXAM 2 Ch 8-9, 11-18, 21-22, Jan. 15 Gene Mutations, Genetic Diseases, Chromosome Variation, Ch 9,11,18, 21 Eugenics and Medical Genetics Jan. 16 Developmental Biology, Comparative Genomics, Proteomics, Ch 20, 22, 26 Evolutionary Genetics Jan. 17 Recombinant DNA Technology, Genomics Ch Jan. 21 The Genetics of Cancer: when good genes go bad Ch 23 Jan. 22 FINAL EXAM CUMULATIVE Ch 1-26 With the exception of the exam dates which are part of a binding contract between you (the student) and me (the instructor) the schedule is tentative. If class is cancelled due to inclement weather on a scheduled exam day, the exam will be given at the next lecture class. 6

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