Journal of Internal Medicine Symposium. Atherosclerotic plaque inflammation and repair mechanisms, detection and therapy
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1 Preliminary program Thursday, August 28 th Lunch Journal of Internal Medicine Symposium Atherosclerotic plaque inflammation and repair mechanisms, detection and therapy Welcome Göran K. Hansson August 28-30th, 2014 Elite Marina Tower Hotel, Stockholm Opening lecture: Pathophysiology and mitigation of the thrombotic complications of atherosclerosis Peter Libby, Boston Session: Innate immunity and cardiovascular disease Innate immunity and cardiovascular disease Filip Swirski, Boston Macrophage content and inflammatory state during the regression of atherosclerosis in mouse models Edward Fisher, New York Gut microbiota and heart disease Stanley Hazen, Cleveland Coffee Session: Plaque antigen autoimmunity and tolerance Regulation of T Cells in Atherosclerosis Andrew Lichtman, Boston Induction of immune tolerance to atherosclerosis Alain Tedgui, Paris Modulation of co-simulation in vascular disease: from mechanisms to therapy Esther Lutgens, Amsterdam
2 17.10 Circulating cells and cardiovascular risk Harry Björkbacka, Malmö An inability to maintain homeostasis of regulatory T cells in coronary artery disease Lena Jonasson, Linköping Poster viewing Dinner Friday, August 29 th Session: Translating novel genomic findings into plaque pathophysiology Translating novel genomic findings into plaque pathophysiology Heribert Schunkert, Munich Genetics reveals important differences in causal factors for type 2 diabetes and cardiovascular disease Marju Orho-Melander, Malmö Remnant lipoproteins, but not LDL or lipoprotein(a), as a cause of plaque inflammation Börge Nordestgaard, Copenhagen The BiKE project: Gene expression signatures, pathways and networks in human carotid atherosclerosis Ljubica Perisic, Stockholm Ser251Pro missense polymorphism in perilipin 2 and its effect on carotid intimamedia thickness and cell death/cell survival pathways Joëlle Magné, Stockholm Coffee Session: Mechanisms of cardiovascular complications in autoimmune diseases Premature vascular damage in systemic autoimmunity: lessons learned from lupus Mariana J Kaplan, NIH Mechanisms of cardiovascular complications in autoimmune diseases Lars Klareskog, Stockholm The role of gut microbiota in shaping regulatory B cell response in healthy and in inflammation Claudia Mauri, London
3 Selected abstract presentation: Decreased levels of antibodies against ApoB100 epitope p45 in SLE patients Maria Wigren, Malmö Lunch Session: Regulation of inflammation Defective inflammation resolution in atherosclerosis: Mechanisms and therapeutic potential Ira Tabas, New York Novel mechanisms of chemokines and micrornas in atherosclerosis Christian Weber, Munich Regulation of vascular inflammation by lipid mediators Magnus Bäck, Stockholm Deficiency in natural IgM antibodies leads to increased IgE plasma titers resulting in aggravated atherosclerosis Dimitrios Tsiantoulas, Vienna Role of Indoleamine 2,3-dioxygenase (Ido) in atherosclerosis development Soraya Taleb, Paris Coffee Session: Extracellular matrix and tissue repair responses Extracelluar matrix and tissue repair responses Shukti Chakravarti, Baltimore Oxidation-specific epitopes are major targets of innate immunity in atherosclerosis Christoph Binder, Vienna Retention of atherogenic lipoproteins Jan Borén, Gothenburg Transforming growth factor-beta signaling in T cells promotes stabilization of atherosclerotic plaques through an interleukin-17 dependent pathway Anton Gisterå, Stockholm Lumican in human carotid atherosclerotic plaques Christoffer Tengryd, Malmö
4 16.30 Poster viewing Dinner cruise Saturday, August 30 th Session: Detecting vulnerable plaques Detecting vulnerable plaques Mattias Nahrendorf, Boston Atherosclerotic genetically modified mice: how valid is the translation to human disease? Gerard Pasterkamp, Utrecht Ultrasound-based Plaque Structure Analysis (UPSA) Isabel Goncalves, Malmö Circulating neutrophils and their secreted mediator S100A8/A9 correlate with carotid artery disease and predict cardiovascular events in healthy individuals Alexandru Schiopu, Malmö Direct in-vivo quantification of intraplaque hemorrhage by magnetic resonance imaging Ebo de Muinck, Linköping Coffee Session: Emerging therapies to stabilize plaques Emerging therapies to stabilize plaques Peter Libby, Boston Therapeutic modulation of the immune response in atherosclerosis Johan Kuiper, Leiden Immunoregulatory mechanisms and therapeutic potential of PECAM-1 agonists in atherosclerosis Giuseppina Caligiuri, Paris Selected abstract presentation: mir-210 induces atherosclerotic plaque stability through repression of apoptotic pathways in vascular smooth muscle cells Lars Maegdefessel, Stockholm
5 11.50 Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates atherosclerosis in hypercholesterolemic mice Daniel Ketelhuth, Stockholm Summary and conclusions Jan Nilsson Lunch Elite Marina Tower Hotel, Stockholm Organisers: Jan Nilsson, Lund University (chair), Göran K. Hansson, Karolinska Institutet, Anders Hamsten, Karolinska Institutet, Anna Hultgårdh Nilsson, Lund University, and Karl Gertow, Karolinska Institutet
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