TABLES OF RADIATION ABSORBED DOSE TO THE EMBRYO/FETUS FROM RADIOPHARMACEUTICALS LATEST REVISION DATE: 1/21/98
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- Anis Goodman
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1 TABLES OF RADIATION ABSORBED DOSE TO THE EMBRYO/FETUS FROM RADIOPHARMACEUTICALS LATEST REVISION DATE: 1/21/98 The material in this document is taken from the Master's thesis of Ms. Joy Russell (University of Tennessee, Master's Degree conferred August 1995). The data below, and the methods and assumptions used to derive them, are published in two documents in the Health Physics Journal (73(5): , 1997 and 73(5): , 1997) and also in the Proceedings of the Sixth International Radiopharmaceutical Dosimetry Symposium. Please contact the center with any questions or comments about the data. Richard E. Toohey, phone, fax, Audrey T. Stelson, phone, fax, Please note our area code changes from 423 to 865 effective October 1, Dose estimates in /MBq may be converted to rem/mci by multiplying by a factor of
2 Table 1. Residence times used to produce the dose estimates in this study Co-57 Vitamin B-12, Normal-Flushing 7.17E+00 hr Small Intestine 1.20E+00 hr 1.00E+00 hr 3.89E+00 hr 3.90E+00 hr 1.71E+03 hr 1.21E+00 hr 8.56E+02 hr Co-57 Vitamin B-12, Normal-No Flushing 7.17E+00 hr Small Intestine 1.20E+00 hr 1.00E+00 hr 3.89E+00 hr 2.56E+03 hr 1.29E+03 hr Co-57 Vitamin B-12, Pernicious Anemia-Flushing 2.18E+01 hr Small Intestine 3.64E+00 hr 1.00E+00 hr 1.18E+01 hr 4.90E-01 hr 2.20E+02 hr 1.52E-01 hr 1.06E+02 hr Co-57 Vitamin B-12, Pernicious Anemia-No Flushing 2.18E+01 hr Small Intestine 3.64E+00 hr 1.00E+00 hr 1.18E+01 hr 3.23E+02 hr 1.66E+02 hr 2
3 Co-58 Vitamin B-12, Normal-Flushing 7.09E+00 hr Small Intestine 1.20E+00 hr 1.00E+00 hr 3.88E+00 hr 1.40E+00 hr 6.03E+02 hr 9.79E-01 hr 3.03E+02 hr Co-58 Vitamin B-12, Normal-No Flushing 7.09E+00 hr Small Intestine 1.20E+00 hr 1.00E+00 hr 3.88E+00 hr 9.04E+02 hr 4.55E+02 hr Co-58 Vitamin B-12, Pernicious Anemia-Flushing 2.15E+01 hr Small Intestine 3.64E+00 hr 1.00E+00 hr 1.18E+01 hr 1.70E-01 hr 7.80E+01 hr 1.23E+01 hr 3.70E+01 hr Co-58 Vitamin B-12, Pernicious Anemia-No Flushing 2.15E+01 hr Small Intestine 3.64E+00 hr 1.00E+00 hr 1.18E+01 hr 1.14E+02 hr 5.86E+01 hr 3
4 Co-60 Vitamin B-12, Normal-Flushing 7.20E+00 hr Small Intestine 1.20E+00 hr 1.00E+00 hr 3.90E+00 hr 8.80E+00 hr 3.85E+03 hr 1.66E+00 hr 1.93E+03 hr Co-60 Vitamin B-12, Normal-No Flushing 7.20E+00 hr Small Intestine 1.20E+00 hr 1.00E+00 hr 3.90E+00 hr 5.77E+03 hr 2.89E+03 hr Co-60 Vitamin B-12, Pernicious Anemia-Flushing 2.19E+01 hr Small Intestine 3.64E+00 hr 1.00E+00 hr 1.18E+01 hr 1.10E+00 hr 4.95E+02 hr 2.09E-01 hr 2.39E+02 hr Co-60 Vitamin B-12, Pernicious Anemia-No Flushing 2.19E+01 hr Small Intestine 3.64E+00 hr 1.00E+00 hr 1.18E+01 hr 7.28E+02 hr 3.72E+02 hr 4
5 F-18 FDG Brain Heart Wall Ovaries Pancreas F-18 Sodium Fluoride Cortical Bone Trabecular Bone 9.80E-02 hr 9.24E-02 hr 2.11E-02 hr 8.45E-02 hr 6.34E-02 hr 2.60E-04 hr 9.00E-03 hr 2.90E-02 hr 3.67E-01 hr 1.85E+00 hr 2.50E-02 hr 5.60E-01 hr 5.60E-01 hr 4.99E-01 hr 3.36E-01 hr Ga-67 Citrate (nonpregnant) Adrenals 5.00E-02 hr 1.54E+00 hr Small Intestine 3.48E-01 hr 1.01E+00 hr 7.40E-01 hr 4.45E+00 hr Red Marrow 3.66E+00 hr Cortical Bone 5.75E+00 hr Trabecular Bone 5.75E+00 hr 4.01E-01 hr 6.33E+01 hr 5
6 Ga-67 Citrate (3 months) Adrenals 5.00E-02 hr 1.54E+00 hr Small Intestine 3.48E-01 hr 1.01E+00 hr 7.40E-01 hr 3.58E+00 hr Red Marrow 3.66E+00 hr Cortical Bone 4.78E+00 hr Trabecular Bone 4.78E+00 hr 4.01E-01 hr 2.27E+00 hr 5.32E+01 hr Ga-67 Citrate (6 and 9 months) Adrenals 5.00E-02 hr 1.54E+00 hr Small Intestine 3.48E-01 hr 1.01E+00 hr 7.40E-01 hr 3.58E+00 hr Red Marrow 3.66E+00 hr Cortical Bone 4.78E+00 hr Trabecular Bone 4.78E+00 hr 4.01E-01 hr 2.27E+00 hr Placenta 2.28E+01 hr 5.32E+01 hr I-123 Hippuran I-123 IMP Brain 1.04E-01 hr 4.02E+00 hr 2.23E-01 hr 6.00E-01 hr 1.65E-01 hr 1.46E+00 hr 6.51E-01 hr 1.15E+01 hr 6
7 I-123 mibg Adrenals Heart Wall Thyroid 3.40E-03 hr 1.36E-01 hr 3.45E+00 hr 1.06E-01 hr 9.40E-04 hr 1.20E+00 hr 6.30E+00 hr I-123 Sodium Iodide Small Intestine 1.03E+00 hr 9.07E-01 hr 1.13E-01 hr Thyroid 3.28E+00 hr 1.25E+00 hr 3.65E+00 hr (3 month) 4.00E-03 hr (6 month) 1.37E-01 hr (9 month) 2.71E-01 hr I-124 Sodium Iodide Small Intestine 1.44E+00 hr 1.27E+00 hr 5.75E-01 hr Thyroid 3.26E+01 hr 1.83E+00 hr 5.20E+00 hr I-125 HSA Brain Heart Wall I-125 IMP Brain 1.03E+01 hr 1.98E+01 hr 2.68E+00 hr 1.11E+01 hr 2.07E+01 hr 3.50E+00 hr 1.85E+00 hr 4.16E+02 hr 1.34E+00 hr 3.49E-01 hr 3.45E+00 hr 2.38E+00 hr 4.29E+01 hr 7
8 I-125 mibg Adrenals Heart Wall Thyroid 2.60E-02 hr 1.28E+00 hr 1.66E+01 hr 1.37E+00 hr 5.00E-02 hr 2.52E+00 hr 3.23E+01 hr I-125 Sodium Iodide Small Intestine 1.72E+00 hr 1.53E+00 hr 6.39E+00 hr Thyroid 2.74E+02 hr 2.21E+00 hr 1.54E+01 hr I-126 Sodium Iodide Small Intestine 1.55E+00 hr 1.37E+00 hr 1.90E+00 hr Thyroid 9.39E+01 hr 1.98E+00 hr 7.70E+00 hr I-130 Sodium Iodide Small Intestine 1.01E+00 hr 8.88E-01 hr 1.09E-01 hr Thyroid 3.01E+00 hr 1.22E+00 hr 2.85E+00 hr I-131 Hippuran 1.04E-01 hr 4.53E+00 hr 2.30E-01 hr 8
9 I-131 HSA Brain Heart Contents I-131 MAA I-131 mibg Adrenals Thyroid 9.45E+00 hr 1.81E+01 hr 2.46E+00 hr 1.02E+01 hr 1.89E+01 hr 3.22E+00 hr 7.77E-01 hr 1.27E+02 hr 1.08E-01 hr 2.60E+01 hr 1.85E+01 hr 1.48E+00 hr 7.78E+00 hr 1.90E-02 hr 9.98E+00 hr 8.00E-01 hr 1.20E-02 hr 2.31E+00 hr 1.90E+01 hr I-131 Sodium Iodide Small Intestine 1.50E+00 hr 1.33E+00 hr 1.16E+00 hr Thyroid 6.10E+01 hr 1.92E+00 hr 6.40E+00 hr (3 month) 8.20E-02 hr (6 month) 2.21E+00 hr (9 month) 4.71E+00 hr 9
10 I-131 Rose Bengal Gall Bl Contents 4.83E-01 hr 1.98E+01 hr Small Intestine 3.75E+00 hr 1.16E+01 hr 4.20E-03 hr 2.04E+00 hr 1.65E-01 hr 1.80E-01 hr In-111 DTPA Small Intestine 2.88E-02 hr 2.25E-02 hr 7.48E-02 hr 6.22E-02 hr Muscle 2.23E-01 hr 4.50E-03 hr 3.60E+00 hr 2.23E+00 hr In-111 Pentetreotide Gall Bl Contents Small Intestine Thyroid In-111 Platelets Red Marrow In-111 Red Blood Cells Red Marrow 1.95E-02 hr 3.91E-01 hr 9.20E-02 hr 2.64E-01 hr 4.66E+00 hr 1.21E+00 hr 1.42E+00 hr 2.94E-02 hr 3.26E+00 hr 8.13E+00 hr 1.43E+01 hr 3.94E+00 hr 2.18E+01 hr 7.06E-01 hr 5.70E+01 hr 2.78E+00 hr 1.39E+00 hr 2.78E+00 hr 9.07E+01 hr 10
11 In-111 White Blood Cells Red Marrow Kr-81m Gas Kr-81m Injection Heart Contents Kr-81m Oral N-13 Ammonia Brain P-32 Phosphate Cortical Bone Trabecular Bone Tc-99m Albumin Microspheres Thyroid 2.45E+01 hr 3.92E+01 hr 2.45E+01 hr 9.80E+00 hr 5.20E-03 hr 4.00E-03 hr 1.16E-03 hr 7.90E-07 hr 5.20E-03 hr 1.65E-02 hr 1.70E-02 hr 7.17E-03 hr 1.99E-01 hr 7.42E+01 hr 7.42E+01 hr 1.30E+02 hr 1.22E-01 hr 4.29E-01 hr 2.00E-01 hr 6.72E-01 hr 4.28E+00 hr 2.00E-02 hr 2.09E-01 hr 2.40E+00 hr 11
12 Tc-99m Disofenin Gall Bl Contents Small Intestine Tc-99m DMSA Placenta Tc-99m DTPA (nonpregnant) Tc-99m DTPA (3 month) Tc-99m DTPA (6 month) Placenta Tc-99m DTPA (9 month) Placenta 7.70E-01 hr 1.14E+00 hr 1.79E+00 hr 2.34E+00 hr 1.20E-02 hr 8.00E-01 hr 5.30E-01 hr 1.40E-01 hr 3.81E+00 hr 3.16E-01 hr 2.61E-02 hr 1.82E-01 hr 2.94E+00 hr 9.20E-02 hr 1.84E+00 hr 2.84E+00 hr 9.20E-02 hr 1.84E+00 hr 6.05E-04 hr 2.84E+00 hr 9.20E-02 hr 1.84E+00 hr 2.00E-03 hr 8.77E-04 hr 2.84E+00 hr 9.20E-02 hr 1.84E+00 hr 1.20E-01 hr 5.50E-03 hr 2.84E+00 hr 12
13 Tc-99m DTPA Aerosol (nonpregnant) 5.60E-02 hr Small Intestine 8.79E-02 hr 3.21E-02 hr 1.14E-01 hr 4.00E-02 hr 1.03E+00 hr 7.48E-01 hr 1.41E+00 hr Tc-99m DTPA Aerosol (3 month) Small Intestine Tc-99m DTPA Aerosol (6 month) Small Intestine Placenta Tc-99m DTPA Aerosol (9 month) Small Intestine Placenta 5.60E-02 hr 8.79E-02 hr 3.21E-02 hr 1.14E-01 hr 4.00E-02 hr 1.03E+00 hr 7.48E-01 hr 6.05E-04 hr 1.41E+00 hr 5.60E-02 hr 8.79E-02 hr 3.21E-02 hr 1.14E-01 hr 4.00E-02 hr 1.03E+00 hr 7.48E-01 hr 2.00E-03 hr 8.77E-04 hr 1.41E+00 hr 5.60E-02 hr 8.79E-02 hr 3.21E-02 hr 1.14E-01 hr 4.00E-02 hr 1.03E+00 hr 7.48E-01 hr 1.20E-01 hr 5.50E-03 hr 1.41E+00 hr 13
14 Tc-99m Glucoheptonate Placenta Tc-99m HDP Cort Bone Trab Bone Placenta Tc-99m HEDP Cort Bone Trab Bone Tc-99m HMPAO Brain Gall Bl Contents Small Intestine Thyroid 8.64E-01 hr 1.30E-01 hr 1.77E+00 hr 1.65E-02 hr 2.00E-02 hr 2.68E+00 hr 8.61E-02 hr 2.02E+00 hr 2.02E+00 hr 4.83E-01 hr 4.34E-02 hr 4.34E-02 hr 2.14E+00 hr 1.64E-01 hr 7.30E-01 hr 7.30E-01 hr 9.54E-01 hr 2.22E+00 hr 4.16E-01 hr 3.48E-01 hr 2.44E-01 hr 3.83E-01 hr 4.98E-01 hr 6.42E-01 hr 9.38E-01 hr 7.13E-01 hr 4.60E-02 hr 6.17E-01 hr 2.44E+00 hr 14
15 Tc-99m Human Serum Albumin Brain Heart Contents Tc-99m MAA Placenta Tc-99m MAG3 Tc-99m MDP Cort Bone Trab Bone Placenta 4.24E-01 hr 8.13E-01 hr 1.10E-01 hr 4.57E-01 hr 8.47E-01 hr 1.44E-01 hr 5.53E-02 hr 5.67E+00 hr 1.78E-02 hr 1.04E+00 hr 4.89E+00 hr 2.17E-01 hr 5.20E-02 hr 7.89E-01 hr 1.68E+00 hr 7.57E-02 hr 3.33E+00 hr 2.30E-01 hr 1.48E-01 hr 1.36E+00 hr 1.36E+00 hr 7.82E-01 hr 2.34E-02 hr 2.08E-02 hr 1.64E+00 hr 15
16 Tc-99m MIBI-Rest Gall Bl Contents Small Intestine Heart Wall Tc-99m MIBI-Stress Gall Bl Contents Small Intestine Heart Wall Tc-99m Pertechnetate Thyroid Placenta Tc-99m PYP Cort Bone Trab Bone Placenta 7.35E-02 hr 6.44E-01 hr 1.01E+00 hr 1.31E+00 hr 5.30E-02 hr 2.90E-01 hr 1.86E-01 hr 4.90E-02 hr 2.40E-02 hr 7.80E-01 hr 3.86E+00 hr 1.48E-01 hr 5.08E-01 hr 7.97E-01 hr 1.04E+00 hr 6.60E-02 hr 2.35E-01 hr 7.20E-02 hr 4.50E-02 hr 1.40E-02 hr 5.50E-01 hr 3.89E+00 hr 4.90E-01 hr 3.03E-01 hr 7.90E-01 hr 3.80E-02 hr 7.95E-01 hr 3.34E-01 hr 9.54E-01 hr 5.02E+00 hr 9.23E-02 hr 1.50E+00 hr 1.50E+00 hr 5.45E-01 hr 6.08E-02 hr 6.95E-02 hr 3.00E+00 hr 16
17 Tc-99m RBC - Heat Treated Tc-99m RBC - in vitro Labeling Heart Contents Placenta Tc-99m RBC - in vivo Labeling Heart Contents Placenta 7.78E+00 hr 8.64E-01 hr 5.70E-01 hr 7.80E-02 hr 3.22E-01 hr 5.97E-01 hr 1.01E-01 hr 4.50E-01 hr 8.67E-03 hr 9.70E-02 hr 5.38E+00 hr 8.64E-01 hr 8.00E-02 hr 3.34E-01 hr 6.19E-01 hr 1.05E-01 hr 2.80E-01 hr 8.67E-03 hr 9.70E-02 hr 5.96E+00 hr Tc-99m Sulfur Colloid - Normal (nonpregnant) 7.37E+00 hr Red Marrow 4.33E-01 hr 6.07E-01 hr 2.60E-01 hr Tc-99m Sulfur Colloid - Normal (3 month) 7.37E+00 hr Red Marrow 4.33E-01 hr 6.07E-01 hr 7.70E-03 hr 2.52E-01 hr 17
18 Tc-99m Sulfur Colloid - Normal (6 months) 7.37E+00 hr Red Marrow 4.33E-01 hr 6.07E-01 hr 2.50E-02 hr Placenta 6.90E-02 hr 1.66E-01 hr Tc-99m Sulfur Colloid - Normal (9 months) 7.37E+00 hr Red Marrow 4.33E-01 hr 6.07E-01 hr 4.40E-02 hr Placenta 1.01E-01 hr 1.15E-01 hr Tc-99m Sulfur Colloid - Disease 2.78E+00 hr Red Marrow 2.17E+00 hr 2.60E+00 hr 1.76E-01 hr 1.13E+00 hr Tc-99m Teboroxime Brain Gall Bl Contents Small Intestine Heart Wall Tc-99m White Blood Cells Red Marrow 1.70E-01 hr 2.00E-01 hr 4.55E-01 hr 7.14E-01 hr 9.28E-01 hr 4.20E-01 hr 1.20E+00 hr 3.70E-01 hr 1.76E-01 hr 2.65E+00 hr 2.17E+00 hr 3.47E+00 hr 2.17E+00 hr 8.67E-01 hr 18
19 Tl-201 Chloride Brain Small Intestine Heart Wall Testes Thyroid 1.86E+00 hr 2.70E+00 hr 1.10E+01 hr 2.19E+00 hr 3.60E+00 hr 2.53E+00 hr 4.02E+00 hr 3.61E+00 hr 8.00E-01 hr 1.05E+00 hr 4.30E-01 hr 9.13E-02 hr 5.15E+01 hr Xe-127, 5 Minute Rebreathing, 5 Liter Spirometer Volume 2.20E-02 hr 2.44E-01 hr Xe-127, 5 Minute Rebreathing, 7.5 Liter Spirometer Volume 1.70E-02 hr 1.34E-01 hr Xe-127, 5 Minute Rebreathing, 10 Liter Spirometer Volume 1.30E-02 hr 1.47E-01 hr Xe-133, 5 Minute Rebreathing, 5 Liter Spirometer Volume 2.20E-02 hr 2.44E-01 hr Xe-133, 5 Minute Rebreathing, 7.5 Liter Spirometer Volume 1.70E-02 hr 1.34E-01 hr Xe-133, 5 Minute Rebreathing, 10 Liter Spirometer Volume 1.30E-02 hr 1.47E-01 hr Xe-133, Injection Heart Contents 1.84E-02 hr 8.76E-02 hr 2.60E-03 hr 19
20 Table 2. Absorbed Dose Estimates to the Embryo/ Per Unit Activity of Radiopharmaceutical Administered to the Mother (shading indicates maternal and fetal self dose contributions). Radiopharmaceutical Early /MBq 3 Month /MBq 6 Month /MBq 9 Month /MBq Co-57 Vitamin B-12, Normal- 1.0E E E E-01 Flushing Co-57 Vitamin B-12, Normal-No Flushing 1.5E E E E+00 Co-57 Vitamin B-12, PA- Flushing 2.1E E E E-01 Co-57 Vitamin B-12, PA-No 2.8E E E E-01 Flushing Co-58 Vitamin B-12, Normal- Flushing 2.5E E E E+00 Co-58 Vitamin B-12, Normal- No Flushing 3.7E E E E+00 Co-58 Vitamin B-12, PA-Flushing 8.3E E E E-01 Co-58 Vitamin B-12,PA-No 9.8E E E E-01 Flushing Co-60 Vitamin B-12, Normal- Flushing 3.7E E E E+01 Co-60 Vitamin B-12, Normal - No Flushing 5.5E E E E+01 Co-60 Vitamin B-12, PA-Flushing 5.9E E E E+00 20
21 Radiopharmaceutical Early /MBq 3 Month /MBq 6 Month /MBq 9 Month /MBq Co-60 Vitamin B-12,PA-No Flushing 8.3E E E E+00 F-18 FDG 2.7E E E E-03 F-18 Sodium Fluoride 2.2E E E E-03 Ga-67 Citrate 9.3E E E E-01 I-123 Hippuran 3.1E E E E-03 I-123 IMP 1.9E E E E-03 I-123 MIBG 1.8E E E E-03 I-123 Sodium Iodide 2.0E E E E-03 I-124 Sodium Iodide 1.4E E E E-02 I-125 HAS 2.5E E E E-02 I-125 IMP 3.2E E E E-03 I-125 MIBG 2.6E E E E-03 I-125 Sodium Iodide 1.8E E E E-03 21
22 Radiopharmaceutical Early /MBq 3 Month /MBq 6 Month /MBq 9 Month /MBq I-130 Sodium Iodide 1.8E E E E-02 I-131 Hippuran 6.4E E E E-02 I-131 HAS 5.2E E E E-01 I-131 MAA 6.7E E E E-02 I-131 MIBG 1.1E E E E-02 I-131 Sodium Iodide 7.2E E E E-01 I-131 Rose Bengal 2.2E E E E-02 In-111 DTPA 6.5E E E E-02 In-111 Pentetreotide 8.2E E E E-02 In-111 Platelets 1.7E E E E-02 In-111 Red Blood Cells 2.2E E E E-02 In-111 White Blood Cells 1.3E E E E-02 22
23 Radiopharmaceutical Early /MBq 3 Month /MBq 6 Month /MBq 9 Month /MBq Tc-99m Albumin Microspheres 4.1E E E E-03 Tc-99m Disofenin 1.7E E E E-03 Tc-99m DMSA 5.1E E E E-03 Tc-99m DTPA 1.2E E E E-03 Tc-99m DTPA Aerosol 5.8E E E E-03 Tc-99m Glucoheptonate 1.2E E E E-03 Tc-99m HDP 5.2E E E E-03 Tc-99m HEDP 7.2E E E E-03 Tc-99m HMPAO 8.7E E E E-03 Tc-99m Human Serum Albumin 5.1E E E E-03 Tc-99m MAA 2.8E E E E-03 Tc-99m MAG3 1.8E E E E-03 Tc-99m MDP 6.1E E E E-03 Tc-99m MIBI-rest 1.5E E E E-03 23
24 Radiopharmaceutical Early /MBq 3 Month /MBq 6 Month /MBq 9 Month /MBq Tc-99m MIBI-stress 1.2E E E E-03 Tc-99m Pertechnetate 1.1E E E E-03 Tc-99m PYP 6.0E E E E-03 Tc-99m RBC-Heat Treated 1.7E E E E-03 Tc-99m RBC- in vitro 6.8E E E E-03 Tc-99m RBC- in vivo 6.4E E E E-03 Tc-99m Sulfur Colloid - normal 1.8E E E E-03 Tc-99m Sulfur Colloid- Disease 3.2E E E E-03 Tc-99m Teboroxime 8.9E E E E-03 Tc-99m White Blood Cells 3.8E E E E-03 T1-201 Chloride 9.7E E E E-02 Xe-127, 5 minute rebreathing, 5 liter spirometer volume 4.3E E E E-04 Xe-127, 5 minute rebreathing, 7.5 liter spirometer volume 2.3E E E E-05 24
25 Early /MBq 3 Month /MBq 6 Month /MBq 9 Month /MBq Radiopharmaceutical Xe-127, 5 minute rebreathing, 10 liter spirometer volume 2.3E E E E-05 Xe-133, 5 minute rebreathing, 5 liter spirometer volume 4.1E E E E-05 Xe-133, 5 minute rebreathing, 7.5 liter spirometer volume 2.2E E E E-05 Xe-133, 5 minute rebreathing, 10 liter spirometer volume 2.5E E E E-05 Xe-133, injection 4.9E E E E-06 25
26 Table 3. Fetal Dose Estimates from Various Nuclear Medicine Procedures (shading indicates maternal and fetal self dose contributions) Procedure Co-57 Vitamin B-12 Normal- Flushing Co-57 Vitamin B-12 Normal- No Flushing Co-57 Vitamin B-12 Pernicious Anemia-Flushing Co-57 Vitamin B-12 Pernicious Anemia-No Flushing Co-58 Vitamin B-12 Normal-Flushing Co-58 Vitamin B-12 Normal-No Flushing Co-58 Vitamin B-12 Pernicious Anemia- No Flushing F-18 FDG Ga-67 Citrate Activity MBq (mci) 0.04 (0.001) 0.04 (0.001) 0.04 (0.001) 0.04 (0.001) 0.03 (0.0008) 0.03 (0.0008) 0.03 (0.0008) 370 (10) 190 (5) Early 4.0E-02 (4.0E-03) 6.0E-02 (6.0E-03) 8.4E-03 (8.4E-004) 1.1E-02 (1.1E-03) 7.5E-02 (7.5E-03) 1.1E-01 (1.1E-02) 2.9E-02 (2.9E-03) 1.0E+01 (1.0E+00) 1.8E+01 (1.8E+00) 3 Month 2.7E-02 (2.7E-03) 4.0E-02 (4.0E-03) 6.8E-03 (6.8E-04) 8.4E-03 (8.4E-04) 5.7E-02 (5.7E-03) 8.4E-02 (8.4E-03) 2.6E-02 (2.6E-03) 6.3E+00 (6.3E-01) 3.8E+01 (3.8E+00) 6 Month 3.4E-02 (3.4E-030) 4.8E-02 (4.8E-03) 6.8E-03 (6.8E-04) 8.8E-03 (8.4E-04) 6.3E-02 (6.3E-03) 9.3E-02 (9.3E-03) 2.3E-02 (2.3E-03) 3.5E+00 (3.5E-01) 3.4E+01 (3.4E+00) 9 Month 3.5E-02 (3.5E-03) 5.2E-02 (5.2E-03) 6.0E-03 (6.0e-04) 8.0E-03 (8.0E-04) 6.3E-02 (6.3E-03) 9.3E-02 (9.3E-03) 1.8E-02 (1.8E-03) 3.0E+00 (3.0E-01) 2.5E+01 (2.5E+00) 26
27 Procedure Hg-197 Chlormerodrin I-123 Hippuran I-123 IMP Activity MBq (mci) 4 (0.1) 75 (2) 200 (5.5) Early 4.4E-02 (4.4E-03) (2.3E-01) 3.8E+00 (3.8E-01) 3 Month 3.0E-02 (3.0E-03) 1.8E+00 (1.8E-01) 2.2E+00 (2.2E-01) 6 Month 2.7E-02 (2.7E-03) 6.3E-01 (6.3E-02) 1.4E+00 (1.4E-01) 9 Month 2.8E-02 (2.8E-03) 539E-01 (5.9E-02) 1.2E+00 (1.2E-01) I-123 mibg phaeochromocytoma cecholamine tumor 350 (9.5) 80 (2) 6.3E+00 (6.3E-01) 1.4E+00 (1.4E E+00 (4.2E-01) 9.6E-01 (9.6E-02) 2.4E+00 (2.4E-01) 5.4E-01 (5.4E-02) 2.2E+00 (2.2E-01) 5.0E-01 (5.0E-02) I-123 Sodium Iodide thyroid uptake study thyroid imaging I-125 HAS I-125 NaI 30 (0.8) 15 (0.4) 2 (0.05) 1 (0.03) 6.0E-01 (6.0E-02) 3.0E-01 (3.0E-02) 5.0E-01 (5.0E-02) 1.8E-02 (1.8E-03) 4.2E-01 (4.2E-02) 2.1E-01 (2.1E-02) 1.6E-01 (1.6E-02) 9.5E-03 (9.5E-04) 3.3E-01 (3.3E-02) 1.7E-01 (1.7E-02) 7.6E-02 (7.6E-03) 3.5E-03 (3.5E-04) 2.9E-01 (2.9E-02) 1.4E-02 (1.4E-03) 5.2E-02 (5.2E-03) 2.3E-03 (2.3E-04) I-131 Hippuran renal function 1.3 (0.035) 8.3E-02 (8.3E-03) 6.5E-02 (6.5E-03) 2.5E-02 (2.5E-03) 2.3E-02 (2.3E-03) 27
28 Procedure I-131 Hippuran renal imaging I-131 HSA Activity MBq (mci) 1.3 (0.035) 0.5 (0.013) Early 8.3E-02 (8.3E-03) 2.6E-01 (2.6E-02) 3 Month 6.5E-02 (6.5E-03) 9.0E-02 (9.0E-03) 6 Month 2.5E-02 (2.5E-03) 8.0E-02 (8.0E-03) 9 Month 2.3E-02 (2.3E-03) 6.5E-02 (6.5E-03) I-131 MAA I-131 MIBG 55 (1.5) 20 (0.5) 3.7E+00 (3.7E-01) 2.2e+00 (2.2e-01) 2.3E+00 (2.3E-01) 1.1E+00 (1.1E-01) 2.2E+00 (2.3E-01) 7.6E-01 (7.6E-02) 2.3E+00 (2.3E-01) 7.0E-01 (7.0E-02) I-131 NaI (Diagnostic) thyroid uptake 0.55 (0.015) 4.0E-02 (4.0E-03) 3.7E-02 (3.7E-03) 1.3E-01 (1.3E-02) 1.5E-01 (1.5E-02) scintiscanning 4 (0.11) 2.9E-01 (2.9E-02) 2.7E-01 (2.7E-02) 9.2E-01 (9.2E-02) 1.1E+00 (1.1E-01) localization of extrathyroid metastases I-131 NaI (Therapeutic) hyperthyroidism 40 (1.1) 350 (9.5) 2.9E+00 (2.9E-01) 2.5E+01 (2.5E+00) 2.7E+00 (2.7E-01) 2.3E+01 (2.3E+00) 9.2E+00 (9.2E-01) 8.1E+01 (8.1E+00) 1.1E+01 (1.1E+00) 9.5E+01 (9.5E+00) ablation of normal thyroid tissue 1900 (50) 1.4E+02 (1.4E+01) 1.3E+02 (1.3E+01) 4.4E+02 (4.4E+01) 5.1E+02 (5.1E+01) 28
29 Procedure I-131 Rose Bengal In-111 DTPA Activity MBq (mci) 0.04 (0.001) 20 (0.5) Early 8.8E-03 (8.8E-04) 1.3E+00 (1.3E-01) 3 Month 8.8E-03 (8.8E-04) 9.6E-014 (9.6E-02) 6 Month 6.4E-03 (6.4E-04) 4.0E-01 (4.0E-02) 9 Month 3.6E-03 (3.6E-04) 3.6E-01 (3.6E-02) In-111 Pentetreotide planar imaging SPECT imaging In- 111 Platelets 110 (3) 230 (6) 10 (0.25) 9.0E+00 (9.0E-01) 1.9E+01 (1.9E+00) 1.7E+00 (1.7E-01) 6.6E+00 (6.6E-01) 1.4E+01 (1.4E+00) 1.1E+00 (1.1E-01) 3.8E+00 (3.8E-01) 8.0E+00 (8.0E-01) 9.9E-01 (9.9E-02) 3.4E+00 (3.4E-01) 7.0E+00 (7.0E-01) 8.9E-01 (8.9E-02) In-111 White Blood Cell Kr-81m Gas Tc-99m Disofenin Tc-99m DMSA 20 (0.5) 600 (15) 350 (9.5) 220 (6) 2.6E+00 (2.6E-01) 1.1E-04 (1.1E-05) 6.0E+00 (6.0E-01) 1.1E+00 (1.1E-01) 1.9E+00 (1.9E-01) 1.0E-04 (1.0E-05) 5.2E+00 (5.2E-01) 1.0E+00 (1.0E-01) 1.9E+00 (1.9E-01) 1.6E-04 (1.6E-05) 4.2E+00 (4.2E-01) 8.8E-01 (8.8E-02) 1.9E+00 (1.9E-01) 2.0E-04 (2.0E-05) 2.3E+00 (2.3E-01) 7.5E-01 (7.5E-02) Tc-99m DTPA kidney imaging & glomerular filtration 750 (20) 9.0E+00 (9.0E-01) 6.5E+00 (6.5E-01) 3.1E+00 (3.1E-01) 3.5E+00 (3.5E-01) 29
30 Procedure Activity MBq (mci) Early 3 Month 6 Month 9 Month Tc-99m DTPA brain imaging & renal perfusion 750 (20) 9.0E+00 (9.0E-01) 6.5E+00 (6.5E-01) 3.1E+00 (3.1E-01) 3.5E+00 (3.5E-01) 1 st. pass gastric reflux hypertension 350 (9.5) 10 (0.27) 800 (22) 4.2E+00 (4.2E-01) 1.2E-01 (1.2E-02) 9.6E+00 (9.6E-01) 3.0E+00 (3.0E-01) 8.7E-02 (8.7E-03) 7.0E+00 (7.0E-01) 1.4E+00 (1.4E-01) 4.1E-02 (4.1E-03) 3.3E+00 (3.3E-01) 1.6E+00 (1.6E-01) 4.7E-02 (4.7E-03) 3.8E+00 (3.8E-01) residual urine determination 350 (9.5) 4.2E+00 (4.2E-01) 3.0E+00 (3.0E-01) 1.4E+00 (1.4E-01) 1.6E+00 (1.6E-01) Tc-99m DTPA Aerosol 40 (1.1) Tc-99m Glucoheptonate 2.3E-01 (2.3E-02) 1.7E-01 (1.7E-02) 9.2E-02 (9.2E-03) 1.2E-01 (1.2E-02) renal imaging brain imaging 750 (20) 750 (20) 9.0E+00 (9.0E-01) 9.0E+00 (9.0E-01) 8.2E+00 (8.2E-01) 8.2E+00 (8.2E-01) 4.0E+00 (4.0E-01) 4.0E+00 (4.0E-01) 3.4E+00 (3.4E-01) 3.4E+00 (3.4E-01) Tc-99m HDP 750 (20) 3.9E+00 (3.9E-01) 4.0E+00 (4.0E-01) 2.3E+00 (2.3E-01) 1.9E+00 (1.9E-01) 30
31 Procedure Tc-99m HMPAO Activity MBq (mci) 750 (20) Early 6.5E+00 (6.5E-01) 3 Month 5.0E+00 (5.0E-01) 6 Month 3.6E+00 (3.6E-01) 9 Month 2.7E+00 (2.7E-01) Tc-99m Human Serum Albumin 200 (5.5) 1.0E+00 (1.0E-01) 6.0E-01 (6.0E-02) 5.2E-01 (5.2E-02) 4.4E-01 (4.4E-02) Tc-99m MAA hepatic artery perfusion 150 (4) 200 lung imaging (5.5) 220 isotopic venography (6) 4.2E-01 (4.2E-02) 4.2E-01 (4.2E-02) 6.2E-01 (6.2E-02) 6.0E-01 (6.0E-02) 6.0E-01 (6.0E-02) 8.8E-01 (8.8E-02) 7.5E-01 (7.5E-02) 7.5E-01 (7.5E-02) 1.1E+00 (1.1E-01) 6.0E-01 (6.0E-02) 6.0E-01 (6.0E-02) 8.0E-01 (8.0E-02) LeVeen shunt patency 110 (3) 750 Tc-99m MAG3 (20) 750 Tc-99m MDP (20) 1100 Tc-99m MIBI-rest (30) 1100 Tc-99m MIBI-stress (30) 3.1E-01 (3.1E-02) 1.4E+00 (1.4E+00) 4.6E+00 (4.6E-01) 1.7E+01 (1.7E+00) 1.3E+01 (1.3E+00) 4.4E-02 (4.4E-02) 1.0E+01 (1.0E+00) 4.0E+00 (4.0E E+01 (1.3E+00) 1.0E+01 (1.0E+00) 5.5E-01 (5.5E-02) 4.1E+00 (4.1E-01) 2.0E+00 (2.0E-01) 9.2E+00 (9.2E-01) 7.6E+00 (7.6E-01) 4.4E-01 (4.4E-02) 3.9E+00 (3.9E-01) 1.8E+00 (1.8E-01) 5.9E+00 (5.9E-01) 438E+00 (4.8E-01) 31
32 Procedure Tc-99m Pertechnetate brain imaging thyroid imaging Activity MBq (mci) 1100 (30) 400 (11) Early 1.2E+01 (1.2E+00) 4.4E+00 (4.4E-01) 3 Month 2.4E+01 (2.4E+00) 8.8E+00 (8.8E-01) 6 Month 1.5E+01 (1.5E+00) 5.6E+00 (5.6E-01) 9 Month 1.0E+01 (1.0E+00) 3.7E+00 (3.7E-01) salivary gland imaging 200 (5.5) 2.2E+00 (2.2E-01) 4.4E+00 (4.4E-01) 2.8E+00 (2.8E-01) 1.9E+00 (1.9E-01) placental localization 110 (3) 1100 blood pool imaging (30) 1.1E+00 (1.1E-01) 1.1E+01 (1.1E+00) 2.4E+00 (2.4E-01) 2.4E+01 (2.4E+00) 1.5E+00 (1.5E-01) 1.4E+01 (1.4E+00) 1.0E+00 (1.0E-01) 1.0E+01 (1.0E+00) cardiovascular shunt detection 1 st pass 550 (15) 550 (15) 6.0E+00 (6.0E-01) 6.0E+00 (6.0E-01) 1.2E+01 (1.2E+00) 1.2E+01 (1.2E+00) 7.7E+00 (7.7E-01) 7.7E+00 (7.7E-01) 5.1E+00 (5.1E-01) 5.1E+00 (5.1E-01) Tc-99m PYP skeletal imaging cardiac imaging blood pool imaging 550 (15) 700 (19) 700 (19) 3.3E+00 (3.3E-01) 4.2E+00 (4.2E-01) 4.2E+00 (4.2E-01) 3.6E+00 (3.6E-01) 4.6E+00 (4.6E-01) 4.6E+00 (4.6E-01) 2.0E+00 (2.0E-01) 2.5E+00 (2.5E-01) 2.5E+00 (2.5E-01) 1.6E+00 (1.6E-01) 2.0E+00 (2.0E-01) 2.0E+00 (2.0E-01) 32
33 Procedure Activity MBq (mci) Early 3 Month 6 Month 9 Month Tc-99m RBC - in vitro labeling Tc-99m RBC - in vivo labeling rest exercise lower GI bleeding Tc-99m Sulfur Colloidnormal 930 (25) 550 (15) 930 (25) 930 (25) 6.3E+00 (6.3E-01) 3.5E+00 (3.5E-01) 6.0E+00 (6.0E-01) 6.0E+00 (6.0E-01) 4.4E+00 (4.4E-01) 2.4E+00 (2.4E-01) 4.0E+00 (4.0E-01) 4.0E+00 (4.0E-01) 3.2E+00 (3.2E-01) 1.8E+00 (1.8E-01) 3.1E+00 (3.1E-01) 3.1E+00 (3.1E-01) 2.6E+00 (2.6E-01) 1.5E+00 (1.5E-01) 2.5E+00 (2.5E-01) 2.5E+00 (2.5E-01) liver -spleen imaging 300 (8) 5.4E-01 (5.4E-02) 6.3E-01 (6.3E-02) 9.6E-01 (9.6E-02) 1.1E+00 (1.1E-01) bone marrow imaging 450 (12) 8.1E-01 (8.1E-02) 9.5E-01 (9.5E-02) 1.4E+00 (1.4E-01) 1.7E+00 (1.7E-01) Pulmonary aspiration 20 (0.5) 3.6E-02 (3.6E-03) 4.2E-02 (4.2E-03) 6.4E-02 (6.4E-03) 7.4E-02 (7.4E-03) LeVeen shunt patency 110 (3) 2.0E-01 (2.0E-02) 2.3E-01 (2.3E-02) 3.5E-01 (3.5E-02) 4.1E-02 (4.1E-02) 33
34 Procedure Activity MBq (mci) Early 3 Month 6 Month 9 Month Tc-99m White Blood Cells 200 (5.4) 7.6E-01 (7.6E-02) 5.6E-01 (5.6E-02) 5.8E-01 (5.8E-02) 5.6E-01 (5.6E-02) Tl-201 Chloride planar imaging SPECT imaging 150 (4) 110 (3) 1.5E+01 (1.5E+00) 1.1E+01 (1.1E+00) 8.7E+00 (8.7E-01) 6.4E+00 (6.4E-01) 7.0E+00 (7.0E-01) 5.2E+00 (5.2E-01) 4.0E+00 (4.0E-01) 3.0E+00 (3.0E-01) Myocardial perfusion 55 (1.5) 80 thyroid imaging (2.2) 5.3E+00 (5.3E-01) 7.8E+00 (7.8E-01) 3.2E+00 (3.2E-01) 4.6E+00 (4.6E-01) 2.6E+00 (2.6E-01) 3.8E+00 (3.8E-01) 1.5E+00 (1.5E-01) 2.2E+00 (2.2E-01) Xe-133, injection muscle blood flow 20 (0.5) 9.8E-05 (9.8E-06) 2.0E-05 (2.0E-06) 2.8E-05 (2.8E-06) 3.2E-05 (3.2E-06) Pulmonary function with imaging 1100 (30) 5.4E-03 (5.4E-04) 1.1E-03 (1.1E-04) 1.5E-03 (1.5E-04) 1.8E-03 (1.8E-04) 34
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